Faculty of Health and Life Sciences

Mrs Tina A. Schrader

Mrs Tina A. Schrader

Senior Research Technician

 T.Schrader@exeter.ac.uk

 2174

 01392-722174

 Geoffrey Pope 210

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

I received my technical education and degree at the Ruprecht Karls University of Heidelberg, Germany, with particular focus on cell biology, anatomy and biochemistry. I obtained international experience at the Johns Hopkins University, USA and in Portugal. Besides academia, I also worked in a company with focus on drug development in cancer research. In 2012, I joined the University of Exeter and I am involved in several inter-disciplinary research projects to understand the dynamics and cooperation of subcellular compartments and their link to human disease. I have profound technical expertise in several research areas including molecular cell biology, biochemistry, tumour biology, and histology. Besides involvement in several research projects, I am managing the cell culture facility including our cell bank as well as general needs of the whole group.

Qualifications

1993–1997 Professional Education as Research Technician, University of Heidelberg, Germany

Professionally registered at the Industrie und Handelskammer, Baden-Wuerttemberg, Germany

Career

2017-ongoing Senior Research Technician, Biosciences, CLES, University of Exeter, UK                        

9/2014-03/2015 Laboratory Manager (Maternity cover), Biosciences, CLES, University of Exeter, UK

2012-2017 Research Technician, Biosciences, CLES, University of Exeter, UK 

PREVIOUS APPOINTMENTS

2008-2011 Voluntary Research Technician, Centre for Cell Biology & Dept. of Biology, University of Aveiro, Portugal

06/2001-06/2004 Full Time Senior Research Technician, Vectron Therapeutics AG, Marburg, Germany

01/1999-05/2001 Full Time Research Technician, Institute for Molecular Biology and Tumour Research (IMT), Philipps-University, Marburg, Germany (Prof. Dr. R. Müller)

08/1997-10/1998 Voluntary Research Technician, Dept. of Biology, Johns Hopkins University, Baltimore, MD/USA (Prof. Dr. T. A. Schroer)

02/1997-04/1997 Full time Research Technician, Institute for Anatomy and Cell Biology II, University of Heidelberg, Germany (Profs. Dr. Dr. A. Völkl and H. D. Fahimi)

Links

Research group links

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Research

Research projects

Involvement and support of research projects (2012 –ongoing)

2013-14 ISSF Strategic Seed Corn Fund, Wellcome Trust Institutional Strategic Support Award (WT097835MF), University of Exeter, UK

2013-14 Bridging the gaps “Super-resolution imaging of peroxisomes” with Prof C.Soeller, Physics, University of Exeter

2015 Cooperative international project  “ Characterisation of Pex11 function” with the University of Groningen, The Netherlands; ongoing research on human Pex11

2015 Cooperative international project with the University of Aveiro, Portugal

2015-16 CLES Strategic Development Fund, CLES, University of Exeter, UK

2016 ISSF2 Strategic Seed Corn Fund, Wellcome Trust Institutional Strategic Support Award (WT105618MA), University of Exeter, UK (Project: Modelling of peroxisomal membrane dynamics in health and disease)

2016-19 Research Grant Application, BBSRC (BB/N01541X/1) (Project: Unveiling novel functions of peroxisomal lipid-binding proteins in interorganellar cooperation and regulation of lipid metabolism)

2017-18 Confidence in Concept Platform, MRC

2018-21 Research Grant Application, BBSRC (BB/R016844/1) (Project: Unveiling the molecular mechanisms to modulate peroxisome dynamics and abundance for improvement of cell performance)

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Publications

Journal articles

Schrader TA, Islinger M, Schrader M (In Press). Detection and immunolabelling of peroxisomal proteins. Methods in Molecular Biology
Costello J, Castro I, Schrader TA, Islinger M, Schrader M (In Press). Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations. Cell Cycle
Schrader TA, Schrader M (In Press). siRNA-mediated Silencing of Peroxisomal Genes in Mammalian Cells. Methods in Molecular Biology
Bishop A, Kamoshita M, Passmore J, Hacker C, Schrader T, Waterham H, Costello J, Schrader M (2019). Fluorescent tools to analyse peroxisome-ER interactions in mammalian cells. Contact, 2
Castro IG, Richards DM, Metz J, Costello JL, Passmore JB, Schrader TA, Gouveia A, Ribeiro D, Schrader M (2018). A role for Mitochondrial Rho GTPase 1 (MIRO1) in motility and membrane dynamics of peroxisomes. Traffic, 19(3), 229-242.
Costello JL, Castro IG, Hacker C, Schrader TA, Metz J, Zeuschner D, Azadi AS, Godinho LF, Costina V, Findeisen P, et al (2017). ACBD5 and VAPB mediate membrane associations between peroxisomes and the ER. The Journal of Cell Biology, 216, 331-342. Abstract.
Costello JL, Castro IG, Cam oes F, Schrader TA, McNeall D, Yang J, Giannopoulou EA, Gomes S, Pogenberg V, Bonekamp NA, et al (2017). Predicting the targeting of tail-anchored proteins to subcellular compartments in mammalian cells. Journal of Cell Science, 130, 1675-1687. Abstract.
Schrader M, King SJ, Stroh TA, Schroer TA (2000). Real time imaging reveals a peroxisomal reticulum in living cells. J Cell Sci, 113 ( Pt 20), 3663-3671. Abstract.  Author URL.
Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (1998). Expression of PEX11β Mediates Peroxisome Proliferation in the Absence of Extracellular Stimuli. Journal of Biological Chemistry, 273(45), 29607-29614.

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External Engagement and Impact

Awards

Papin Prize Award (Highly Commended) at the Higher Education Technicians Summit 2017

http://blogs.exeter.ac.uk/technicalservices/2017/06/12/research-technician-wins-award-at-the-higher-education-technicians-summit-2017/)


Committee/panel activities

Member of the Technician Commitment Committee, University of Exeter


Conferences and invited presentations

  • Health and Medical Research Showcase, Exeter, 2014
  • IRLA Launch, London, 2014
  • EU FP7 Marie Curie ITN PERFUME Workshop “Peroxisomes in Health and Disease”, 2014. Exeter, UK (involved in organisation)
  • Technical Services Conference, Exeter, 2015
  • Higher Education Technicians Summit, University of Warwick, 2017
  • Technical Service Conference, Exeter, 2017
  • Zellweger UK Charity, Patient-centred session, Exeter, 2017
  • Technical Service Conference, Exeter, 2018
  • ZUK Family Meeting, Devon, 2018

International recognition, such as international research collaborations, visiting research posts in overseas institutions, involvement at senior levels in international research associations, acting as referee for national and international research councils.

2015 – ongoing  Visit of international partner laboratories for cooperative research


Media Coverage

Press Release “Pulling power reveals new insights into membrane dynamics in human cells“, Research News, University of Exeter, 25 January 2018,

http://www.exeter.ac.uk/research/newsandevents/news/title_635625_en.html

N. Hunt, Zellweger UK Charity (23.11.2017, BIO3086 Patient-centred session) http://www.zellweger.org.uk/index.php/news-2/lr-151655/

https://www.facebook.com/zellwegeruk/posts/1130082373792943

Technical Services news and events “Research technician wins award at the higher education technicians summit 2017“, University of Exeter, 12 June 2017,

http://blogs.exeter.ac.uk/technicalservices/2017/06/12/research-technician-wins-award-at-the-higher-education-technicians-summit-2017/

Press Release “Weather forecasting technology used to predict where proteins anchor within human cells“, Featured News, University of Exeter, 30 March 2017,

http://www.exeter.ac.uk/news/research/title_576535_en.html

Press Release “Breakthrough by Exeter cell biologists - We all need contacts – how organelles hug in cells“, Featured News, University of Exeter, 20 January 2017, http://www.exeter.ac.uk/news/featurednews/title_565173_en.html

Press Release “Scientists discover an additional function for the peroxisome protein Pex11p”, Research News, Biosciences, University of Exeter, 14 May 2015,

http://biosciences.exeter.ac.uk/news/featurednews/title_451624_en.html

Press Release “Prestigious European training network comes to Biosciences”, Research News, Biosciences, University of Exeter, 1 December 2014,

http://biosciences.exeter.ac.uk/news/featurednews/title_424671_en.html

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Teaching

TRAINING ACTIVITIES AND SKILLS DEVELOPMENT 

  • Training of project students
  • Instructor/training of master students, PhD students and Post-doctoral researchers
  • Laboratory training of guest scientists, technical staff
  • Work experience placements
  • Participation in institutional seminars, weekly lab meetings and journal clubs

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