Dr Eduarda Santos
Associate Professor in Environmental Biology
Geoffrey Pope 222
Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK
Eduarda Santos and Tamsyn Uren-Webster
Illumina HiSeq 2000
I am an environmental biologist investigating reproductive development and function and the susceptibility of these processes to disruption by environmental stressors. My research focuses on fish and has ranged from investigating the endocrine control of reproduction to addressing the population level effects of chemical exposure for wild fish, using systems biology strategies. I am part of the Environmental Biology research group.
Please contact me if interested in discussing MRes of PhD studies within my research group.
2010 Postgraduate Certificate in Academic Practice, University of Exeter, UK
2002 PhD in Fish Reproductive Endocrinology, Brunel University, UK
1995 Degree in Aquatic Sciences, University of Porto, Portugal
2019 - Present Associate Professor in Environmental Biology, University of Exeter
2014-2019 Senior Lecturer in Environmental Biology, University of Exeter
2008-2014 Lecturer in Environmental Biology, University of Exeter
2005-2008 NERC Postdoctoral Researcher, University of Exeter
2001-2005 BBSRC Postdoctoral Researcher, University of Exeter
Research group links
Tamsyn Uren-Webster in the lab
Dr Eduarda Santos
Tamsyn Uren-Webster in the lab
The research focus in my group is to understand the dynamics of sexual development and function, and how environmental stressors impact on reproduction and health in fish. This area of research is a vast and exiting one and potentially benefits aquaculture and fisheries as well as environmental and human health.
Our research to date spanned from investigations into the endocrine regulation of oocyte development in rainbow trout (Oncorhynchus mykiss), to the identification of the gene pathways underlying sexual dimorphism in the zebrafish (Danio rerio) and how they are disrupted by exposure to oestrogens. This work established links between the gene pathways disrupted by ethinyloestradiol, a potent oestrogen present in the contraceptive pill and widespread in the environment, and the decrease in fecundity in zebrafish colonies. The project raised wide interest and was presented at the Royal Society’s Summer Science Exhibition in 2004.
Further research has aimed to establishing the effects of exposure to model environmental chemicals (including a synthetic oestrogen (ethinyloestradiol), a metal (copper) and a polyaromatic hydrocarbon (dibenzanthracene)) at the individual and population levels, in three-spined stickleback (Gasterosteus aculeatus). This work resulted in the discovery of the involvement of the cholesterol biosynthesis pathway in the toxicological response to copper in this species. These studies were conducted using a systems biology approach where genomics, transcriptomics, metabolomics and population level datasets are integrated to generate a global picture of the consequences of exposure to environmental chemicals in wild populations of fish.
Current projects in my laboratory are focusing on the effects of chemicals stressors on the brown trout (Salmo trutta), a species of ecological and economic importance in UK waters. To address this issue, we are sequencing the transcriptome of the brown trout and using RNA-Seq strategies to provide a comprehensive analysis of the mechanisms of toxicity of a range of chemicals on this species.
We are also investigating the effects of combined stressors on the physiology of a number of fish species, to provide a more realistic analysis of the stressors that fish encounter in their environment.
- 2013 PhD studentship (SWDTP)
Using integrative physiology to improve the sustainability of fish aquaculture. Co-I.
- 2013 PhD studentship (Fisheries Society of the British Isles)
Differential susceptibility to copper in wild populations of three-spined stickleback. PI.
- 2012 Visiting PhD Studentship (National Taiwan University)
The role of DNA methylation on sexual determination and development in zebrafish germ cells. PI
- 2012 PhD Studentship (CEFAS and University of Exeter)
Effects of hypoxia on the toxicity of model chemicals in the three-spined stickleback (Gasterosteus aculeatus). PI
- 2012 Society for Reproduction and Fertility
The role of DNA methylation on sex determination and development in zebrafish germ cells. PI
- 2012 Cefas and University of Exeter
Building a Molecular Platform for Understanding the Host-Pathogen Interface in Invertebrates. CoI
- 2011 Cefas
Investigating the potential molecular mechanisms associated with white spot virus resistance in Carcinus maenas. CoI
- 2011 Fisheries Society of the British Isles
Searching for evidence of adaptation to copper in a population of three-spined stickleback. PI
- 2011 Wellcome Trust
Influence of hypoxia on chemical toxicity during embryogenesis. PI
- 2011 BBSRC PhD Studentship
Physiology of gut carbonate production by marine fish - roles of hypoxia and sex hormones. CoI
- 2009 NERC CASE Studentship (open competition)
PhD studentship (with the Salmon and Trout Association) - Endocrine disrupting chemicals (EDCs) and the sustainability of brown trout populations in the UK: relative impact of EDCs compared with other environmental stressors. PI
- 2009 AstraZeneca
DTI KTP - Implementation of Molecular Tools into chemical testing. CoI
- 2008 Royal Society Travel Grant
Travel grant to attend the SETAC Europe 18th Annual Meeting
- 2008 Royal Society Research Grant
Identifying the molecular basis of sexual dominance in male zebrafish.
- 2004 Fisheries Society of the British Isles
Travel Grant to attend the 5th International Symposium on Fish Endocrinology.
Publications by category
Publications by year
eduarda_santos Details from cache as at 2020-02-21 09:23:10
External Engagement and Impact
Reviewer for a number of international journals including, Environmental Science and Technology, Environmental Health Perspectives, Environmental Toxicology and Chemistry, General and Comparative Endocrinology, Aquatic Toxicology, Journal of Fish Biology, Aquaculture, PLOS One, Molecular Biology Reports and Comparative Physiology and Biochemistry.
Top Reviewer Award from Environmental Science and Technology (2012).
Top Reviewer Award from General and Comparative Endocrinology (2009).
11th International Congress on the Biology of Fish, August 2014, Edinburgh (Plenary Speaker)
Cardill University, December 2013
Cardiff University, December 2012.
20th Annual Meeting of Society of Environmental Toxicology and Chemistry (SETAC), May 2010, Seville, Spain.
NERC-KT workshop on Fish Toxicogenomics. May 2009, Exeter, UK.
NERC International workshop on fish toxicogenomics moving into monitoring and regulation April 2008, Environment Canada, North Vancouver, Canada.
SEB Annual Main Meeting, April 2006, Canterbury, UK.
Our research on endocrine disrupting chemicals has been communicated widely to the public and received extensive press coverage over time.
In 2004, our work on the application of transcriptomics approaches to understand the effects of oestrogenic chemicals in fish was presented at the Royal Society Summer Science Exhibition.
In 2011, our work on endocrine disrupting chemicals received the Exeter Impact Award for Outstanding Impact in Public Policy and Services.
In 2013, our work on metal tolerance in brown trout received extensive local, national and international media coverage and was featured in the ITV news.
Chair of Knowledge Transfer workshop on Analysis of gene expression using next generation sequencing. Exeter, 2011.
Chair of the session Endocrine Disruption, SETAC Europe 18th Annual Meeting, Warsaw, Poland, 2008.
Member of the organising committee of the UK-Japan consortium on endocrine disruptors.
Member of the organising committee of the Credo workshop on Ecological Relevance of Chemically Induced Endocrine Disruption in Wildlife, Exeter 2004.
Chair of the session Effects of Anthropogenic and Environmental Factors on the Endocrine System, 5th International Symposium on Fish Endocrinology, Spain, 2004.
In my teaching activities I use innovative approaches that deliver state-of-the-art, research-led teaching in formats that engage student participation, to give students the best possible experience and preparation for their future careers.
I act as a personal tutor for over 50 undergraduate and postgraduate students.
- NSC1003 Foundations in Natural Sciences
- NSC1001 Frontiers in Science
- BIO2092 Genomics and Introductory Bioinformatics
- Deputy Director for the Aquatic Biology and Resource Management MSc.
Information not currently available
Supervision / Group
- Dr Lisa Bickley (Cefas and Open Inovation Platform; CoI with Dr Ronny van Aerle and Prof Charles Tyler). Building a Molecular Platform for Understanding the Host-Pathogen Interface in Invertebrates.
- Sylvia Dimitriadou (CoI with Dr Safi Darden). Behavior in fish.
- Emily Dow (MRes). Developing the zebrafish as a model to understand reproductive aging
- Jennifer Fitzgerald (CEFAS and University of Exeter). Effects of hypoxia on the toxicity of model chemicals in the three-spined stickleback (Gasterosteus aculeatus).
- IC Hung (National Science Council, Taiwan). The role of DNA methylation on sexual determination and development in zebrafish germ cells.
- Lauren Laing (Fisheries Society of the British Isles). Differential susceptibility to copper in wild populations of three-spined stickleback.
- Hannah Littler
- Rebecca Millard
- Nicholas Rogers (NERC; CoI with Dr Rod Wilson). Physiology of gut carbonate production by marine fish - roles of hypoxia and sex hormones.
- Bas Verbruggen (Cefas and Open Inovation Platform; CoI with Dr Ronny van Aerle and Prof Charles Tyler). Building a Molecular Platform for Understanding the Host-Pathogen Interface in Invertebrates.
- Joana Viana (CoI with Prof Jon Mill). Modeling epigenetic responses to schizophrenia-associated environmental risks and antipsychotic medication.
- Louisa Taplin (BBSRC; Co-I with Dr Rod Wilson). Using integrative physiology to improve the sustainability of fish aquaculture.
- Tamsyn Uren Webster (NERC CASE Studentship with the Salmon and Trout Association). Endocrine disrupting chemicals (EDCs) and the sustainability of brown trout populations in the UK: relative impact of EDCs compared with other environmental stressors.