Rick Titball | Biosciences | University of Exeter

Professor Rick Titball

Emeritus Professor

R.W.Titball@exeter.ac.uk

Overview

I am a molecular bacteriologist with a strong interest in the molecular basis of bacterial pathogenicity. This information is exploited to devise improved vaccines and antibacterial therapies for disease in humans and animals. More recently I have been working on insects as infection models, and as sources of novel antimicrobial compounds.

Qualifications

2001 DSc Prophylaxis of disease caused by bacterial pathogens of man, University of Plymouth UK
1980-1983 PhD Microbiology, Plymouth Polytechnic UK
1976-1979 BSc Biological Sciences, Plymouth Polytechnic UK

Career

2021 Emeritus Professor of Molecular Microbiology, University of Exeter
2019 Visiting Professor, Mahidol University, Bangkok, Thailand
2019 Visiting Scholar, Siriraj Hospital, Mahidol University, Bangkok, Thailand
2018 Founder and Chief Scientific Officer, Entec Nutrition Limited
2017 Honorary Professor, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
2016 Founder and Chief Scientific Officer, Biosystems Technology Limited
2011-2015 Head of Biosciences Department, University of Exeter
2005 Society for General Microbiology Colworth Prize Lectureship
2004 Visiting Professor, University of Glasgow
2003 Elected Fellow of the Royal College of Pathologists
2003 Senior Fellow, Defence Science and Technology Laboratory Porton Down
2002 Visiting Professor of Bacterial Pathogenesis, University of Plymouth
2002 Honorary Professor, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, University of London
1995 Individual Merit promotion to Grade 6 (IM)
1992 Head of Microbiology Department, Defence Science and Technology Laboratory Porton Down
1983 Post Doctoral Researcher, Defence Science and Technology Laboratory Porton Down
1983 PhD University of Plymouth
1979 BSc Biological Sciences University of Plymouth

Research group links

Biochemistry and Molecular Microbiology

Research

Research interests

Molecular Biology of bacterial pathogens of humans and animals, with a strong emphasis on research leading to vaccines against infectious disease.

Previously lead research groups which have devised vaccines against plague and anthrax. These vaccines are currently in human clinical trials and should be licensed for use in humans within the next 2-3 years. Also devised vaccines against animal diseases caused by Clostridium perfringens; these vaccines are being developed by industry.

Previously been involved in projects to sequence the genomes of Yersinia pestis (causes plague), Burkholderia pseudomallei (causes melioidosis), Francisella tularensis (causes tularaemia) and Clostridium perfringens (causes gas-gangrene).

More recently I have been working on insects as infection models, and as sources of novel antimicrobial compounds.

Research Grants;

My research has been funded the Wellcome Trust, BBSRC, MRC, Cariplo Foundation, Dstl, US National institutes for Health, US Defence Threat Reduction Agency, EU, One Health Ventures, MS Sciences Ltd, Innovate UK and angel investor funding.

Total publications; 380, including works in Nature, Nature Genetics, Nature Communications, Science, Proceedings of the National Academy of Sciences USA.

h-index; 65 (Web of Science); 67 (Scopus)

Publications

Books

Oyston, P.C. Titball, R.W. (2003). DNA adenine methylation.

Karlyshev, A.V. Wren, B.W. Titball, R.W. (2003). Signature-tagged mutagenesis of Yersinia pestis.

Journal articles

Wagley S, Morcrette H, Kovacs-Simon A, Yang Z, Power A, Tennant R, Love J, Murray N, Titball R, Butler C, et al (In Press). Bacterial dormancy: a subpopulation of viable but non-culturable cells demonstrates better fitness for revival. PLoS Pathogens

Bokori-Brown M, Martin TG, Naylor CE, Basak AK, Titball RW, Savva CG (In Press). Cryo-EM Structure of Lysenin Pore Reveals Membrane Insertion by an Aerolysin family protein. Nature Communications

Titball RW, Bernstein DI, Fanget NVJ, Hall RA, Longet S, MacAry PA, Rupp RE, van Gils M, von Messling V, Walker DH, et al (2024). Progress with COVID vaccine development and implementation. npj Vaccines, 9(1).

Titball RW (2024). The Molecular Architecture and Mode of Action of Clostridium perfringens ε-Toxin. Toxins, 16(4), 180-180. Abstract.

Metters G, Hemsley C, Norville I, Titball R (2023). Identification of essential genes in Coxiella burnetii. Microbial Genomics, 9(2). Abstract.

Titball RW, Lewis N, Nicholas R (2023). Is Clostridium perfringens epsilon toxin associated with multiple sclerosis?. Mult Scler, 29(9), 1057-1063. Abstract. Author URL.

de Mello VVC, Placa AJV, Lee DAB, Franco EO, Lima L, Teixeira MMG, Hemsley C, Titball RW, Machado RZ, André MR, et al (2023). Molecular detection of blood-borne agents in vampire bats from Brazil, with the first molecular evidence of Neorickettsia sp. in Desmodus rotundus and Diphylla ecaudata. Acta Tropica, 244

Hemsley CM, Essex-Lopresti A, Chisnall T, Millar M, Neale S, Reichel R, Norville IH, Titball RW (2022). MLVA and com1 genotyping of Coxiella burnetii in farmed ruminants in Great Britain. Veterinary Microbiology, 277

Barrett ADT, Titball RW, MacAry PA, Rupp RE, von Messling V, Walker DH, Fanget NVJ (2022). The rapid progress in COVID vaccine development and implementation. NPJ Vaccines, 7(1). Author URL.

Hemsley CM, Essex-Lopresti A, Norville IH, Titball RW (2021). Correlating Genotyping Data of Coxiella burnetii with Genomic Groups. PATHOGENS, 10(5). Author URL.

Ikeda P, Torres JM, Placa AJV, de Mello VVC, Lourenço EC, Herrera HM, de Oliveira CE, Hemsley C, Titball RW, Machado RZ, et al (2021). Molecular Survey of Anaplasmataceae Agents and Coxiellaceae in Non-Hematophagous Bats and Associated Ectoparasites from Brazil. Parasitologia, 1(4), 197-209.

Harrison J, Nelson K, Morcrette H, Morcrette C, Preston J, Helmer L, Titball RW, Butler CS, Wagley S (2021). The increased prevalence of Vibrio species and the first reporting of Vibrio jasicida and Vibrio rotiferianus at UK shellfish sites. Water Research, 211

Kovacs-Simon A, Metters G, Norville I, Hemsley C, Titball RW (2020). Coxiella burnetii replicates in Galleria mellonella hemocytes and transcriptome mapping reveals in vivo regulated genes. Virulence, 11(1), 1268-1278.

Morcrette H, Kovacs-Simon A, Tennant RK, Love J, Wagley S, Yang ZR, Studholme DJ, Soyer OS, Champion OL, Butler CS, et al (2020). Campylobacter jejuni 11168H Exposed to Penicillin Forms Persister Cells and Cells with Altered Redox Protein Activity. Frontiers in Cellular and Infection Microbiology, 10 Abstract.

Srinon V, Withatanung P, Chaiwattanarungruengpaisan S, Thongdee M, Meethai C, Stevens JM, Titball RW, Korbsrisate S (2020). Functional redundancy of Burkholderia pseudomallei phospholipase C enzymes and their role in virulence. Scientific Reports, 10(1). Abstract.

Jitprasutwit S, Jitprasutwit N, Hemsley CM, Onlamoon N, Withatanung P, Muangsombut V, Vattanaviboon P, Stevens JM, Ong C, Stevens MP, et al (2020). Identification of Burkholderia pseudomallei Genes Induced During Infection of Macrophages by Differential Fluorescence Induction. Front Microbiol, 11 Abstract. Author URL.

Senior NJ, Titball RW (2020). Isolation and primary culture of Galleria mellonella hemocytes for infection studies. F1000Res, 9 Abstract. Author URL.

Vanaporn M, Titball RW (2020). Trehalose and bacterial virulence. Virulence, 11(1), 1192-1202. Abstract. Author URL.

Kovacs-Simon A, Hemsley CM, Scott AE, Prior JL, Titball RW (2019). Burkholderia thailandensis strain E555 is a surrogate for the investigation of Burkholderia pseudomallei replication and survival in macrophages. BMC Microbiol, 19(1). Abstract. Author URL.

Adler D, Linden JR, Shetty SV, Ma Y, Bokori-Brown M, Titball RW, Vartanian T (2019). Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model. iScience, 15, 39-54. Abstract. Author URL.

Morcrette H, Bokori-Brown M, Ong S, Bennett L, Wren BW, Lewis N, Titball RW (2019). Clostridium perfringens epsilon toxin vaccine candidate lacking toxicity to cells expressing myelin and lymphocyte protein. NPJ Vaccines, 4 Abstract. Author URL.

Wagley S, Bokori-Brown M, Morcrette H, Malaspina A, D'Arcy C, Gnanapavan S, Lewis N, Popoff MR, Raciborska D, Nicholas R, et al (2019). Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis. Mult Scler, 25(5), 653-660. Abstract. Author URL.

Hemsley CM, O'Neill PA, Essex-Lopresti A, Norville IH, Atkins TP, Titball RW (2019). Extensive genome analysis of Coxiella burnetii reveals limited evolution within genomic groups. BMC Genomics, 20(1). Abstract. Author URL.

Metters G, Norville IH, Titball RW, Hemsley CM (2019). From cell culture to cynomolgus macaque: infection models show lineage-specific virulence potential of Coxiella burnetii. J Med Microbiol, 68(10), 1419-1430. Abstract. Author URL.

Wagley S, Scott AE, Ireland PM, Prior JL, Atkins TP, Bancroft GJ, Studholme DJ, Titball RW (2019). Genome Resequencing of Laboratory Stocks of Burkholderia pseudomallei K96243. Microbiol Resour Announc, 8(9). Abstract. Author URL.

Ireland PM, Bullifent HL, Senior NJ, Southern SJ, Yang ZR, Ireland RE, Nelson M, Atkins HS, Titball RW, Scott AE, et al (2019). Global Analysis of Genes Essential for Francisella tularensis Schu S4 Growth in Vitro and for Fitness during Competitive Infection of Fischer 344 Rats. J Bacteriol, 201(7). Abstract. Author URL.

Morici L, Torres AG, Titball RW (2019). Novel multi-component vaccine approaches for Burkholderia pseudomallei. Clin Exp Immunol, 196(2), 178-188. Abstract. Author URL.

Withatanung P, Kurian D, Tangjittipokin W, Plengvidhya N, Titball RW, Korbsrisate S, Stevens JM (2019). Quantitative Proteomics Reveals Differences in the Response of Neutrophils Isolated from Healthy or Diabetic Subjects to Infection with Capsule-Variant Burkholderia thailandensis. Journal of Proteome Research, 18(7), 2848-2858. Abstract.

Luangasanatip N, Flasche S, Dance DAB, Limmathurotsakul D, Currie BJ, Mukhopadhyay C, Atkins T, Titball R, Jit M (2019). The global impact and cost-effectiveness of a melioidosis vaccine. BMC Medicine, 17(1). Abstract.

Savva CG, Clark AR, Naylor CE, Popoff MR, Moss DS, Basak AK, Titball RW, Bokori-Brown M (2019). The pore structure of Clostridium perfringens epsilon toxin. Nat Commun, 10(1). Abstract. Author URL.

Wagley S, Titball R, Butler C (2019). Uncovering the molecular basis of viable but non culturable (VBNC) cells. Access Microbiology, 1(1A).

Wagley S, Borne R, Harrison J, Baker-Austin C, Ottaviani D, Leoni F, Vuddhakul V, Titball RW (2018). Galleria mellonella as an infection model to investigate virulence of Vibrio parahaemolyticus. Virulence, 9(1), 197-207. Abstract. Author URL.

Allegra E, Titball RW, Carter J, Champion OL (2018). Galleria mellonella larvae allow the discrimination of toxic and non-toxic chemicals. Chemosphere, 198, 469-472. Abstract.

Morcrette H, Morgan MS, Farbos A, O'Neill P, Moore K, Titball RW, Studholme DJ (2018). Genome sequence of Staphylococcus aureus Ex1, isolated from a patient with spinal osteomyelitis. Genome Announcements, 6(26). Abstract.

Bokori-Brown M, Metz J, Petrov PG, Mussai F, De Santo C, Smart NJ, Saunders S, Knight B, Pastan I, Titball RW, et al (2018). Interactions Between Pseudomonas Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy. FRONTIERS IN ONCOLOGY, 8 Author URL.

Champion OL, Titball RW, Bates S (2018). Standardization of G. mellonella Larvae to Provide Reliable and Reproducible Results in the Study of Fungal Pathogens. J Fungi (Basel), 4(3). Abstract. Author URL.

Smith A, Kaczmar A, Bamford RA, Smith C, Frustaci S, Kovacs-Simon A, O'Neill P, Moore K, Paszkiewicz K, Titball RW, et al (2018). The Culture Environment Influences Both Gene Regulation and Phenotypic Heterogeneity in Escherichia coli. FRONTIERS IN MICROBIOLOGY, 9 Author URL.

Winter AJ, Williams C, Isupov MN, Crocker H, Gromova M, Marsh P, Wilkinson OJ, Dillingham MS, Harmer NJ, Titball RW, et al (2018). The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA. J Biol Chem, 293(50), 19429-19440. Abstract. Author URL.

Burton BR, Tennant RK, Love J, Titball RW, Wraith DC, White HN (2018). Variant proteins stimulate more IgM+ GC B-cells revealing a mechanism of cross-reactive recognition by antibody memory. eLife

Yang ZR, Bullifent HL, Moore K, Paszkiewicz K, Saint RJ, Southern SJ, Champion OL, Senior NJ, Sarkar-Tyson M, Oyston PCF, et al (2017). A Noise Trimming and Positional Significance of Transposon Insertion System to Identify Essential Genes in Yersinia pestis. Sci Rep, 7 Abstract. Author URL.

Wagley S, Vanaporn M, Rinchai D, Conejero L, Lertmemongkolchai G, Bancroft GJ, Titball RW (2017). A proteasome inhibitor produced by Burkholderia pseudomallei modulates intracellular growth. Microb Pathog, 107, 175-180. Abstract. Author URL.

Senior NJ, Sasidharan K, Saint RJ, Scott AE, Sarkar-Tyson M, Ireland PM, Bullifent HL, Rong Yang Z, Moore K, Oyston PCF, et al (2017). An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions. BMC Microbiology, 17(1). Abstract.

Titball RW, Burtnick MN, Bancroft GJ, Brett P (2017). Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?. Vaccine, 35(44), 5981-5989. Abstract.

Bamford RA, Smith A, Metz J, Glover G, Titball RW, Pagliara S (2017). Investigating the physiology of viable but non-culturable bacteria by microfluidics and time-lapse microscopy. BMC Biology, 15(1). Abstract.

Vanaporn M, Sarkar-Tyson M, Kovacs-Simon A, Ireland PM, Pumirat P, Korbsrisate S, Titball RW, Butt A (2017). Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts. Virulence, 8(1), 30-40. Abstract.

Muruato LA, Tapia D, Hatcher CL, Kalita M, Brett PJ, Gregory AE, Samuel JE, Titball RW, Torres AG (2017). Use of Reverse Vaccinology in the Design and Construction of Nanoglycoconjugate Vaccines against Burkholderia pseudomallei. CLINICAL AND VACCINE IMMUNOLOGY, 24(11). Author URL.

Muruato LA, Tapia D, Hatcher CL, Kalita M, Brett PJ, Gregory AE, Samuel JE, Titball RW, Torres AG (2017). Use of reverse vaccinology in the design and construction of nanoglycoconjugate vaccines against burkholderia pseudomallei. Journal fur Kardiologie, 24(11-12), 280-284. Abstract.

Hall CA, Flick-Smith HC, Harding SV, Atkins HS, Titball RW (2016). A bioluminescent Francisella tularensis SCHU S4 strain enables noninvasive tracking of bacterial dissemination and the evaluation of antibiotics in an inhalational mouse model of tularemia. Antimicrobial Agents and Chemotherapy, 60(12), 7206-7215. Abstract.

Butt A, Halliday N, Williams P, Atkins HS, Bancroft GJ, Titball RW (2016). Burkholderia pseudomallei kynB plays a role in AQ production, biofilm formation, bacterial swarming and persistence. Research in Microbiology, 167(3), 159-167. Abstract.

Butt AT, Titball RW (2016). Functional Analysis of the Role of Toxin-Antitoxin (TA) Loci in Bacterial Persistence. Methods Mol Biol, 1333, 121-129. Abstract. Author URL.

Champion OL, Wagley S, Titball RW (2016). Galleria mellonella as a model host for microbiological and toxin research. Virulence, 7(7), 840-845. Abstract. Author URL.

Champion OL, Gourlay LJ, Scott AE, Lassaux P, Conejero L, Perletti L, Hemsley C, Prior J, Bancroft G, Bolognesi M, et al (2016). Immunisation with proteins expressed during chronic murine melioidosis provides enhanced protection against disease. Vaccine, 34(14), 1665-1671. Abstract. Author URL.

Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW (2016). Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection. Sci Rep, 6 Abstract. Author URL.

Scott AE, Christ WJ, George AJ, Stokes MGM, Lohman GJS, Guo Y, Jones M, Titball RW, Atkins TP, Campbell AS, et al (2016). Protection against experimental melioidosis with a synthetic manno-heptopyranose hexasaccharide glycoconjugate. Bioconjugate Chemistry, 27(6), 1435-1446. Abstract.

Bokori-Brown M, Petrov PG, Khafaji MA, Mughal MK, Naylor CE, Shore AC, Gooding KM, Casanova F, Mitchell TJ, Titball RW, et al (2016). Red Blood Cell Susceptibility to Pneumolysin: CORRELATION WITH MEMBRANE BIOCHEMICAL AND PHYSICAL PROPERTIES. J Biol Chem, 291(19), 10210-10227. Abstract. Author URL.

Anutrakunchai C, Hemsley CM, Sermswan RW, Titball RW, Chareonsudjai S, Taweechaisupapong S (2016). Role of RelA and SpoT in Burkholderia pseudomallei survival, biofilm formation and ceftazidime tolerance during nutritional stress. Tropical Biomedicine, 33(4), 786-798. Abstract.

Fernandes da Costa SP, Mot D, Geeraerts S, Bokori-Brown M, Van Immerseel F, Titball RW (2016). Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant. Avian Pathol, 45(3), 381-388. Abstract. Author URL.

Gregory AE, Judy BM, Qazi O, Blumentritt CA, Brown KA, Shaw AM, Torres AG, Titball RW (2015). A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei. Nanomedicine, 11(2), 447-456. Abstract. Author URL.

Nandi T, Holden MTG, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles. Genome Res, 25(4). Author URL.

Jewell SA, Titball RW, Huyet J, Naylor CE, Basak AK, Gologan P, Winlove CP, Petrov PG (2015). Clostridium perfringensα-toxin interaction with red cells and model membranes. Soft Matter, 11(39), 7748-7761. Abstract. Author URL.

Siddiqui FM, Ibrahim M, Noureen N, Noreen Z, Titball RW, Champion OL, Wren BW, Studholme D, Bokhari H (2015). Draft Genome Sequence of the Enteropathogenic Bacterium Campylobacter jejuni Strain cj255. Genome Announc, 3(5). Abstract. Author URL.

Nandi T, Holden MTG, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Errata: Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles (Genome Research (2015) 25 (129-141)). Genome Research, 25(4).

Benthall G, Touzel RE, Hind CK, Titball RW, Sutton JM, Thomas RJ, Wand ME (2015). Evaluation of antibiotic efficacy against infections caused by planktonic or biofilm cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae in Galleria mellonella. International Journal of Antimicrobial Agents, 46(5), 538-545. Abstract.

Gourlay LJ, Thomas RJ, Peri C, Conchillo-Solé O, Ferrer-Navarro M, Nithichanon A, Vila J, Daura X, Lertmemongkolchai G, Titball R, et al (2015). From crystal structure to in silico epitope discovery in the Burkholderia pseudomallei flagellar hook-associated protein FlgK. FEBS J, 282(7), 1319-1333. Abstract. Author URL.

Rinchai D, Riyapa D, Buddhisa S, Utispan K, Titball RW, Stevens MP, Stevens JM, Ogawa M, Tanida I, Koike M, et al (2015). Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils. Autophagy, 11(5), 748-755. Abstract. Author URL.

Siddiqui F, Champion O, Akram M, Studholme D, Eqani SAMAS, Wren BW, Titball R, Bokhari H (2015). Molecular detection identified a type six secretion system in Campylobacter jejuni from various sources but not from human cases. J Appl Microbiol, 118(5), 1191-1198. Abstract. Author URL.

Torres AG, Gregory AE, Hatcher CL, Vinet-Oliphant H, Morici LA, Titball RW, Roy CJ (2015). Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine. Vaccine, 33(5), 686-692. Abstract.

Gaudesi D, Peri C, Quilici G, Gori A, Ferrer-Navarro M, Conchillo-Solé O, Thomas R, Nithichanon A, Lertmemongkolchai G, Titball R, et al (2015). Structure-based design of a B cell antigen from B. pseudomallei. ACS Chem Biol, 10(3), 803-812. Abstract. Author URL.

Hemsley CM, Luo JX, Andreae CA, Butler CS, Soyer OS, Titball RW (2014). Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation but not anaerobic respiration. Antimicrob Agents Chemother, 58(10), 5775-5783. Abstract. Author URL.

Bokori-Brown M, Hall CA, Vance C, Fernandes da Costa SP, Savva CG, Naylor CE, Cole AR, Basak AK, Moss DS, Titball RW, et al (2014). Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia. Vaccine, 32(23), 2682-2687. Abstract.

Wagley S, Newcombe J, Laing E, Yusuf E, Sambles CM, Studholme DJ, La Ragione RM, Titball RW, Champion OL (2014). Differences in carbon source utilisation distinguish Campylobacter jejuni from Campylobacter coli. BMC Microbiol, 14 Abstract. Author URL.

Benthall G, Touzel RE, Hind CK, Titball RW, Sutton JM, Thomas RJ, Wand ME (2014). Evaluation of antibiotic efficacy against infections caused by planktonic or biofilm cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae in Galleria mellonella. International Journal of Antimicrobial Agents Abstract.

Moule MG, Hemsley CM, Seet Q, Guerra-Assunção JA, Lim J, Sarkar-Tyson M, Clark TG, Tan PBO, Titball RW, Cuccui J, et al (2014). Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development. mBio, 5(1). Abstract.

Fernandes da Costa SP, Savva CG, Bokori-Brown M, Naylor CE, Moss DS, Basak AK, Titball RW (2014). Identification of a key residue for oligomerisation and pore-formation of Clostridium perfringens NetB. Toxins (Basel), 6(3), 1049-1061. Abstract. Author URL.

Harrison JW, Dung TTN, Siddiqui F, Korbrisate S, Bukhari H, Tra MPV, Hoang NVM, Carrique-Mas J, Bryant J, Campbell JI, et al (2014). Identification of possible virulence marker from Campylobacter jejuni isolates. Emerg Infect Dis, 20(6), 1026-1029. Abstract. Author URL.

Andreae CA, Titball RW, Butler CS (2014). Influence of the molybdenum cofactor biosynthesis on anaerobic respiration, biofilm formation and motility in Burkholderia thailandensis. Research in Microbiology, 165(1), 41-49. Abstract.

Kovacs-Simon A, Leuzzi R, Kasendra M, Minton N, Titball RW, Michell SL (2014). Lipoprotein CD0873 is a novel adhesin of Clostridium difficile. J Infect Dis, 210(2), 274-284. Abstract. Author URL.

Scott AE, Ngugi SA, Laws TR, Corser D, Lonsdale CL, D'Elia RV, Titball RW, Williamson ED, Atkins TP, Prior JL, et al (2014). Protection against experimental melioidosis following immunisation with a lipopolysaccharide-protein conjugate. J Immunol Res, 2014 Abstract. Author URL.

Butt A, Higman VA, Williams C, Crump MP, Hemsley CM, Harmer N, Titball RW (2014). The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation. Biochem J, 459(2), 333-344. Abstract. Author URL.

Wagley S, Hemsley C, Thomas R, Moule MG, Vanaporn M, Andreae C, Robinson M, Goldman S, Wren BW, Butler CS, et al (2014). The twin arginine translocation system is essential for aerobic growth and full virulence of Burkholderia thailandensis. J Bacteriol, 196(2), 407-416. Abstract. Author URL.

Jitprasutwit S, Ong C, Juntawieng N, Ooi WF, Hemsley CM, Vattanaviboon P, Titball RW, Tan P, Korbsrisate S (2014). Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions. BMC Genomics, 15(1). Abstract.

Bokori-Brown M, Kokkinidou MC, Savva CG, Fernandes da Costa S, Naylor CE, Cole AR, Moss DS, Basak AK, Titball RW (2013). Clostridium perfringens epsilon toxin H149A mutant as a platform for receptor binding studies. Protein Sci, 22(5), 650-659. Abstract. Author URL.

Peacock SJ, Limmathurotsakul D, Lubell Y, Koh GC, White LJ, Day NP, Titball RW (2013). Correction: Melioidosis Vaccines: a Systematic Review and Appraisal of the Potential to Exploit Biodefense Vaccines for Public Health Purposes. PLoS Negl Trop Dis, 7(2). Abstract. Author URL.

Rees DGC, Phillpotts RJ, Griffin KF, Lukaszewski RA, Laws TR, Atkins HS, Krieg AM, Titball RW (2013). CpG oligonucleotides protect against Venezuelan equine encephalitis virus infection in a route-dependent manner. International Journal of Antimicrobial Agents, 42(6), 587-588.

Butt E, Foster JAH, Keedwell E, Bell JEA, Titball RW, Bhangu A, Michell SL, Sheridan R (2013). Derivation and validation of a simple, accurate and robust prediction rule for risk of mortality in patients with Clostridium difficile infection. BMC Infect Dis, 13 Abstract. Author URL.

Gourlay LJ, Peri C, Ferrer-Navarro M, Conchillo-Solé O, Gori A, Rinchai D, Thomas RJ, Champion OL, Michell SL, Kewcharoenwong C, et al (2013). Exploiting the Burkholderia pseudomallei acute phase antigen BPSL2765 for structure-based epitope discovery/design in structural vaccinology. Chem Biol, 20(9), 1147-1156. Abstract. Author URL.

Thomas RJ, Hamblin KA, Armstrong SJ, Müller CM, Bokori-Brown M, Goldman S, Atkins HS, Titball RW (2013). Galleria mellonella as a model system to test the pharmacokinetics and efficacy of antibiotics against Burkholderia pseudomallei. International Journal of Antimicrobial Agents, 41(4), 330-336. Abstract.

Thomas RJ, Hamblin KA, Armstrong SJ, Müller CM, Bokori-Brown M, Goldman S, Atkins HS, Titball RW (2013). Galleria mellonella as a model system to test the pharmacokinetics and efficacy of antibiotics against Burkholderia pseudomallei. Int J Antimicrob Agents, 41(4), 330-336. Abstract. Author URL.

Butt A, Müller C, Harmer N, Titball RW (2013). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiol Lett, 338(1), 86-94. Abstract. Author URL.

Savva CG, Fernandes da Costa SP, Bokori-Brown M, Naylor CE, Cole AR, Moss DS, Titball RW, Basak AK (2013). Molecular architecture and functional analysis of NetB, a pore-forming toxin from Clostridium perfringens. J Biol Chem, 288(5), 3512-3522. Abstract. Author URL.

Fernandes da Costa SP, Mot D, Bokori-Brown M, Savva CG, Basak AK, Van Immerseel F, Titball RW (2013). Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids. Vaccine, 31(37), 4003-4008. Abstract.

Van Immerseel F, Studholme DJ, Eeckhaut V, Heyndrickx M, Dewulf J, Dewaele I, Van Hoorebeke S, Haesebrouck F, Van Meirhaeghe H, Ducatelle R, et al (2013). Salmonella Gallinarum field isolates from laying hens are related to the vaccine strain SG9R. Vaccine, 31(43), 4940-4945. Abstract.

Rees DGC, Hartley MG, Green M, Lukaszewski RA, Griffin KF, Atkins HS, Lyons R, Krieg AM, Titball RW (2013). The ability of CpG oligonucleotides to protect mice against Francisella tularensis live vaccine strain but not fully virulent F. tularensis subspecies holarctica is reflected in cell-based assays. Microb Pathog, 63, 16-18. Abstract. Author URL.

Ooi WF, Ong C, Nandi T, Kreisberg JF, Chua HH, Sun G, Chen Y, Mueller C, Conejero L, Eshaghi M, et al (2013). The condition-dependent transcriptional landscape of Burkholderia pseudomallei. PLoS Genet, 9(9). Abstract. Author URL.

Gregory AE, Titball R, Williamson D (2013). Vaccine delivery using nanoparticles. Front Cell Infect Microbiol, 3 Abstract. Author URL.

Lau SK, Winlove P, Moger J, Champion OL, Titball RW, Yang ZH, Yang ZR (2012). A Bayesian Whittaker-Henderson smoother for general-purpose and sample-based spectral baseline estimation and peak extraction. JOURNAL OF RAMAN SPECTROSCOPY, 43(9), 1299-1305. Author URL.

Lau SK, Champion OL, Titball RW, Yang ZR, Winlove P, Moger J, Yang ZH (2012). A Bayesian Whittaker-Henderson smoother for general-purpose and sample-based spectral baseline estimation and peak extraction. Journal of Raman Spectroscopy Abstract.

Cuccui J, Milne TS, Harmer N, George AJ, Harding SV, Dean RE, Scott AE, Sarkar-Tyson M, Wren BW, Titball RW, et al (2012). Characterization of the Burkholderia pseudomallei K96243 capsular polysaccharide I coding region. Infect Immun, 80(3), 1209-1221. Abstract. Author URL.

Gregory AE, Shaw AM, Titball RW, Williamson ED, Prior JL, Butcher WA, Thompson IJ (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine Abstract.

Gregory AE, Williamson ED, Prior JL, Butcher WA, Thompson IJ, Shaw AM, Titball RW (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine, 30(48), 6777-6782. Abstract. Author URL.

Butt A, Müller C, Harmer N, Titball RW (2012). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiology Letters

Peacock SJ, Limmathurotsakul D, Lubell Y, Koh GCKW, White LJ, Day NPJ, Titball RW (2012). Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes. PLoS Negl Trop Dis, 6(1). Abstract. Author URL.

Monturiol-Gross L, Flores-Díaz M, Araya-Castillo C, Pineda-Padilla M-J, Clark GC, Titball RW, Alape-Girón A (2012). Reactive oxygen species and the MEK/ERK pathway are involved in the toxicity of clostridium perfringens α-toxin, a prototype bacterial phospholipase C. J Infect Dis, 206(8), 1218-1226. Abstract. Author URL.

Müller CM, Conejero L, Spink N, Wand ME, Bancroft GJ, Titball RW (2012). Role of RelA and SpoT in Burkholderia pseudomallei virulence and immunity. Infect Immun, 80(9), 3247-3255. Abstract. Author URL.

Cruz A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, et al (2011). A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A. Science, 334(6057), 821-824.

Norville IH, Harmer NJ, Harding SV, Fischer G, Keith KE, Brown KA, Sarkar-Tyson M, Titball RW (2011). A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence. Infect Immun, 79(11), 4299-4307. Abstract. Author URL.

Debieux CM, Dridge EJ, Mueller CM, Splatt P, Paszkiewicz K, Knight I, Florance H, Love J, Titball RW, Lewis RJ, et al (2011). A bacterial process for selenium nanosphere assembly. Proc Natl Acad Sci U S A, 108(33), 13480-13485. Abstract. Author URL.

Norville IH, Breitbach K, Eske-Pogodda K, Harmer NJ, Sarkar-Tyson M, Titball RW, Steinmetz I (2011). A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei. Microbiology (Reading), 157(Pt 9), 2629-2638. Abstract. Author URL.

Tippayawat P, Pinsiri M, Rinchai D, Riyapa D, Romphruk A, Gan Y-H, Houghton RL, Felgner PL, Titball RW, Stevens MP, et al (2011). Burkholderia pseudomallei proteins presented by monocyte-derived dendritic cells stimulate human memory T cells in vitro. Infect Immun, 79(1), 305-313. Abstract. Author URL.

Easton A, Haque A, Chu K, Patel N, Lukaszewski RA, Krieg AM, Titball RW, Bancroft GJ (2011). Combining vaccination and postexposure CpG therapy provides optimal protection against lethal sepsis in a biodefense model of human melioidosis. J Infect Dis, 204(4), 636-644. Abstract. Author URL.

Qazi O, Rani M, Gnanam AJ, Cullen TW, Stead CM, Kensing H, McCaul K, Ngugi S, Prior JL, Lipka A, et al (2011). Development of reagents and assays for the detection of pathogenic Burkholderia species. Faraday Discuss, 149, 23-36. Abstract. Author URL.

Patel N, Conejero L, De Reynal M, Easton A, Bancroft GJ, Titball RW (2011). Development of vaccines against burkholderia pseudomallei. Front Microbiol, 2 Abstract. Author URL.

Scott AE, Twine SM, Fulton KM, Titball RW, Essex-Lopresti AE, Atkins TP, Prior JL (2011). Flagellar glycosylation in Burkholderia pseudomallei and Burkholderia thailandensis. J Bacteriol, 193(14), 3577-3587. Abstract. Author URL.

Senior NJ, Bagnall MC, Champion OL, Reynolds SE, La Ragione RM, Woodward MJ, Salguero FJ, Titball RW (2011). Galleria mellonella as an infection model for Campylobacter jejuni virulence. J Med Microbiol, 60(Pt 5), 661-669. Abstract. Author URL.

Thomas RM, Twine SM, Fulton KM, Tessier L, Kilmury SLN, Ding W, Harmer N, Michell SL, Oyston PCF, Titball RW, et al (2011). Glycosylation of DsbA in Francisella tularensis subsp. tularensis. J Bacteriol, 193(19), 5498-5509. Abstract. Author URL.

Suwannasaen D, Mahawantung J, Chaowagul W, Limmathurotsakul D, Felgner PL, Davies H, Bancroft GJ, Titball RW, Letmemongkolchai G (2011). Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis. JOURNAL OF IMMUNOLOGY, 186 Author URL.

Suwannasaen D, Mahawantung J, Chaowagul W, Limmathurotsakul D, Felgner PL, Davies H, Bancroft GJ, Titball RW, Lertmemongkolchai G (2011). Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis. J Infect Dis, 203(7), 1002-1011. Abstract. Author URL.

Kovacs-Simon A, Titball RW, Michell SL (2011). Lipoproteins of bacterial pathogens. Infect Immun, 79(2), 548-561. Abstract. Author URL.

Conejero L, Patel N, de Reynal M, Oberdorf S, Prior J, Felgner PL, Titball RW, Salguero FJ, Bancroft GJ (2011). Low-dose exposure of C57BL/6 mice to burkholderia pseudomallei mimics chronic human melioidosis. Am J Pathol, 179(1), 270-280. Abstract. Author URL.

Wand ME, Müller CM, Titball RW, Michell SL (2011). Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis. BMC Microbiol, 11(1). Abstract. Author URL.

Wang W, Hale C, Goulding D, Haslam SM, Tissot B, Lindsay C, Michell S, Titball R, Yu J, Toribio AL, et al (2011). Mannosidase 2, alpha 1 deficiency is associated with ricin resistance in embryonic stem (ES) cells. PLoS One, 6(8). Abstract. Author URL.

Bokori-Brown M, Savva CG, Fernandes da Costa SP, Naylor CE, Basak AK, Titball RW (2011). Molecular basis of toxicity of Clostridium perfringens epsilon toxin. FEBS J, 278(23), 4589-4601. Abstract. Author URL.

Titball RW (2011). More than an enzyme: the biochemical basis of bacterial disease revealed. Biochemical Journal, 2011(1), c2-c3.

Egge-Jacobsen W, Salomonsson EN, Aas FE, Forslund A-L, Winther-Larsen HC, Maier J, Macellaro A, Kuoppa K, Oyston PCF, Titball RW, et al (2011). O-linked glycosylation of the PilA pilin protein of Francisella tularensis: identification of the endogenous protein-targeting oligosaccharyltransferase and characterization of the native oligosaccharide. J Bacteriol, 193(19), 5487-5497. Abstract. Author URL.

Vanaporn M, Wand M, Michell SL, Sarkar-Tyson M, Ireland P, Goldman S, Kewcharoenwong C, Rinchai D, Lertmemongkolchai G, Titball RW, et al (2011). Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei. Microbiology (Reading), 157(Pt 8), 2392-2400. Abstract. Author URL.

Titball RW (2011). The biochemical basis of bacterial disease revealed More than an enzyme. Biochemist, 33(5), 26-28. Abstract.

Norville I, O'Shea K, Sarkar-Tyson M, Zheng S, Titball RW, Varani G, Harmer NJ (2011). The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. Biochemical Journal, 437, 413-422. Abstract.

Norville IH, O'Shea K, Sarkar-Tyson M, Zheng S, Titball RW, Varani G, Harmer NJ (2011). The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. Biochem J, 437(3), 413-422. Abstract. Author URL.

Laws TR, Davey MS, Green C, Cooper IAM, Titball RW, Lukaszewski RA (2011). Yersinia pseudotuberculosis is resistant to killing by human neutrophils. Microbes Infect, 13(6), 607-611. Abstract. Author URL.

Champion OL, Karlyshev A, Cooper IAM, Ford DC, Wren BW, Duffield M, Oyston PCF, Titball RW (2011). Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1. Microbiology (Reading), 157(Pt 4), 1115-1122. Abstract. Author URL.

Oyston PCF, Mellado-Sanchez G, Pasetti MF, Nataro JP, Titball RW, Atkins HS (2010). A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection. Microb Pathog, 48(5), 191-195. Abstract. Author URL.

Nandi T, Ong C, Singh AP, Boddey J, Atkins T, Sarkar-Tyson M, Essex-Lopresti AE, Chua HH, Pearson T, Kreisberg JF, et al (2010). A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence. PLoS pathogens, 6(4).

Vachieri SG, Clark GC, Alape-Girón A, Flores-Díaz M, Justin N, Naylor CE, Titball RW, Basak AK (2010). Comparison of a nontoxic variant of Clostridium perfringens α-toxin with the toxic wild-type strain. Acta Crystallogr D Biol Crystallogr, 66(Pt 10), 1067-1074. Abstract. Author URL.

Michell SL, Dean RE, Eyles JE, Hartley MG, Waters E, Prior JL, Titball RW, Oyston PCF (2010). Deletion of the Bacillus anthracis capB homologue in Francisella tularensis subspecies tularensis generates an attenuated strain that protects mice against virulent tularaemia. J Med Microbiol, 59(Pt 11), 1275-1284. Abstract. Author URL.

Dowling AJ, Wilkinson PA, Holden MTG, Quail MA, Bentley SD, Reger J, Waterfield NR, Titball RW, Ffrench-Constant RH (2010). Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen Burkholderia pseudomallei K96243. PLoS One, 5(12). Abstract. Author URL.

Champion OL, Karlyshev AV, Senior NJ, Woodward M, La Ragione R, Howard SL, Wren BW, Titball RW (2010). Insect infection model for Campylobacter jejuni reveals that O-methyl phosphoramidate has insecticidal activity. J Infect Dis, 201(5), 776-782. Abstract. Author URL.

Ngugi SA, Ventura VV, Qazi O, Harding SV, Kitto GB, Estes DM, Dell A, Titball RW, Atkins TP, Brown KA, et al (2010). Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis. Vaccine, 28(47), 7551-7555. Abstract. Author URL.

Laws TR, Davey MS, Titball RW, Lukaszewski R (2010). Neutrophils are important in early control of lung infection by Yersinia pestis. Microbes Infect, 12(4), 331-335. Abstract. Author URL.

Sarkar-Tyson M, Titball RW (2010). Progress toward development of vaccines against melioidosis: a review. Clin Ther, 32(8), 1437-1445. Abstract. Author URL.

Forslund A-L, Salomonsson EN, Golovliov I, Kuoppa K, Michell S, Titball R, Oyston P, Noppa L, Sjöstedt A, Forsberg A, et al (2010). The type IV pilin, PilA, is required for full virulence of Francisella tularensis subspecies tularensis. BMC Microbiol, 10 Abstract. Author URL.

Felgner PL, Kayala MA, Vigil A, Burk C, Nakajima-Sasaki R, Pablo J, Molina DM, Hirst S, Chew JSW, Wang D, et al (2009). A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens. Proc Natl Acad Sci U S A, 106(32), 13499-13504. Abstract. Author URL.

Yang ZR, Lertmemongkolchai G, Tan G, Felgner PL, Titball R (2009). A genetic programming approach for Burkholderia pseudomallei diagnostic pattern discovery. Bioinformatics, 25(17), 2256-2262. Abstract. Author URL.

Titball RW (2009). Bacterial Biothreat Agents. , 21-32.

Sarkar-Tyson M, Titball RW (2009). Burkholderia mallei and Burkholderia pseudomallei. , 831-843.

Titball RW (2009). Clostridium perfringens vaccines. Vaccine, 27 Suppl 4, D44-D47. Abstract. Author URL.

Champion MD, Zeng Q, Nix EB, Nano FE, Keim P, Kodira CD, Borowsky M, Young S, Koehrsen M, Engels R, et al (2009). Comparative genomic characterization of Francisella tularensis strains belonging to low and high virulence subspecies. PLoS Pathog, 5(5). Abstract. Author URL.

Thomas RJ, Webber D, Collinge A, Stagg AJ, Bailey SC, Nunez A, Gates A, Jayasekera PN, Taylor RR, Eley S, et al (2009). Different pathologies but equal levels of responsiveness to the recombinant F1 and V antigen vaccine and ciprofloxacin in a murine model of plague caused by small- and large-particle aerosols. Infect Immun, 77(4), 1315-1323. Abstract. Author URL.

Titball RW, Oyston PCF (2009). Francisella tularensis. , 1241-1253.

Champion OL, Cooper IAM, James SL, Ford D, Karlyshev A, Wren BW, Duffield M, Oyston PCF, Titball RW (2009). Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis. Microbiology (Reading), 155(Pt 5), 1516-1522. Abstract. Author URL.

Thomas RJ, Webber D, Sellors W, Collinge A, Frost A, Stagg AJ, Bailey SC, Jayasekera PN, Taylor RR, Eley S, et al (2009). Generation of large droplet aerosols within microbiological containment using a novel flow-focussing technique. Aerobiologia, 25(2), 75-84. Abstract.

Hill J, Leary S, Smither S, Best A, Pettersson J, Forsberg A, Lingard B, Lipka A, Brown KA, Williamson ED, et al (2009). N255 is a key residue for recognition by a monoclonal antibody which protects against Yersinia pestis infection. Vaccine, 27(50), 7073-7079. Abstract. Author URL.

Tippayawat P, Saenwongsa W, Mahawantung J, Suwannasaen D, Chetchotisakd P, Limmathurotsakul D, Peacock SJ, Felgner PL, Atkins HS, Titball RW, et al (2009). Phenotypic and functional characterization of human memory T cell responses to Burkholderia pseudomallei. PLoS Negl Trop Dis, 3(4). Abstract. Author URL.

Sarkar-Tyson M, Smither SJ, Harding SV, Atkins TP, Titball RW (2009). Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders. Vaccine, 27(33), 4447-4451. Abstract. Author URL.

Halling-Brown M, Shaban R, Frampton D, Sansom CE, Davies M, Flower D, Duffield M, Titball RW, Brusic V, Moss DS, et al (2009). Proteins accessible to immune surveillance show significant T-cell epitope depletion: Implications for vaccine design. Mol Immunol, 46(13), 2699-2705. Abstract. Author URL.

Dean RE, Ireland PM, Jordan JE, Titball RW, Oyston PCF (2009). RelA regulates virulence and intracellular survival of Francisella novicida. Microbiology (Reading), 155(Pt 12), 4104-4113. Abstract. Author URL.

Van Immerseel F, Rood JI, Moore RJ, Titball RW (2009). Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens. Trends Microbiol, 17(1), 32-36. Abstract. Author URL.

Stubben CJ, Duffield ML, Cooper IA, Ford DC, Gans JD, Karlyshev AV, Lingard B, Oyston PCF, de Rochefort A, Song J, et al (2009). Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens. BMC Genomics, 10 Abstract. Author URL.

Thwaite JE, Humphrey S, Fox MA, Savage VL, Laws TR, Ulaeto DO, Titball RW, Atkins HS (2009). The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains. J Med Microbiol, 58(Pt 7), 923-929. Abstract. Author URL.

Phan M-D, Kidgell C, Nair S, Holt KE, Turner AK, Hinds J, Butcher P, Cooke FJ, Thomson NR, Titball R, et al (2009). Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever. Antimicrob Agents Chemother, 53(2), 716-727. Abstract. Author URL.

Halling-Brown M, Sansom CE, Davies M, Titball RW, Moss DS (2008). Are bacterial vaccine antigens T-cell epitope depleted?. Trends Immunol, 29(8), 374-379. Abstract. Author URL.

Titball RW, Russell P, Cuccui J, Easton A, Haque A, Atkins T, Sarkar-Tyson M, Harley V, Wren B, Bancroft GJ, et al (2008). Burkholderia pseudomallei: animal models of infection. Trans R Soc Trop Med Hyg, 102 Suppl 1, S111-S116. Abstract. Author URL.

Thomas RJ, Webber D, Sellors W, Collinge A, Frost A, Stagg AJ, Bailey SC, Jayasekera PN, Taylor RR, Eley S, et al (2008). Characterization and deposition of respirable large- and small-particle bioaerosols. Appl Environ Microbiol, 74(20), 6437-6443. Abstract. Author URL.

Stabler RA, Dawson LF, Oyston PCF, Titball RW, Wade J, Hinds J, Witney AA, Wren BW (2008). Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux. BMC Microbiol, 8 Abstract. Author URL.

Gnanam AJ, Hall B, Shen X, Piasecki S, Vernados A, Galyov EE, Smither SJ, Kitto GB, Titball RW, Ellington AD, et al (2008). Development of aptamers specific for potential diagnostic targets in Burkholderia pseudomallei. Trans R Soc Trop Med Hyg, 102 Suppl 1(0 1), S55-S57. Abstract. Author URL.

Thompson DB, Crandall K, Harding SV, Smither SJ, Kitto GB, Titball RW, Brown KA (2008). In silico analysis of potential diagnostic targets from Burkholderia pseudomallei. Trans R Soc Trop Med Hyg, 102 Suppl 1, S61-S65. Abstract. Author URL.

Lukaszewski RA, Yates AM, Jackson MC, Swingler K, Scherer JM, Simpson AJ, Sadler P, McQuillan P, Titball RW, Brooks TJG, et al (2008). Presymptomatic prediction of sepsis in intensive care unit patients. Clin Vaccine Immunol, 15(7), 1089-1094. Abstract. Author URL.

Eyles JE, Hartley MG, Laws TR, Oyston PCF, Griffin KF, Titball RW (2008). Protection afforded against aerosol challenge by systemic immunisation with inactivated Francisella tularensis live vaccine strain (LVS). Microb Pathog, 44(2), 164-168. Abstract. Author URL.

Hoang TH, Hong HA, Clark GC, Titball RW, Cutting SM (2008). Recombinant Bacillus subtilis expressing the Clostridium perfringens alpha toxoid is a candidate orally delivered vaccine against necrotic enteritis. Infect Immun, 76(11), 5257-5265. Abstract. Author URL.

Titball RW (2008). Vaccines against intracellular bacterial pathogens. Drug Discov Today, 13(13-14), 596-600. Abstract. Author URL.

Michell, S.L. Diaper, H. Wikstrom, P. Titball, RW (2007). A 55 kDa hypothetical membrane protein is an iron-regulated virulence factor of Francisella tularensis subspecies novicida U112. Journal of Medical Microbiology, 56, 1268-1276.

Isherwood, K.E. Michell, S.L. Diaper, H. Titball, RW (2007). A Francisella tularensis subspecies novicida purF mutant, but not a purA mutant, induces protective immunity to tularemia in mice. Vaccine, 25, 2011-2018.

Oyston, P. Titball, RW (2007). A plague upon fibrin. Nature Medicine, 13, 253-254.

Harland DN, Dassa E, Titball RW, Brown KA, Atkins HS (2007). ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei. BMC Genomics, 8 Abstract. Author URL.

Nelson, M. Titball, R.W. Galloway, D.R. (2007). Analysis of Peptide Mimotopes of Burkholderia pseudomallei Exopolysaccharide. Vaccine, 25, 7796-7805.

Neeson BN, Clark GC, Atkins HS, Lingard B, Titball RW (2007). Analysis of protection afforded by a Clostridium perfringens alpha-toxoid against heterologous clostridial phospholipases C. Microb Pathog, 43(4), 161-165. Abstract. Author URL.

Kwaik YA, Metzger D, Nano F, Sjostedt A, Titball R (2007). Annals of the New York Academy: Preface. Annals of the New York Academy of Sciences, 1105

Sjostedt, A. Pevelka, M.S. Nano, F. (2007). Biosafety and Selectable Markers. Annals of the New York Academy of Sciences, 1105, 405-417.

Butcher, W.A. Titball, R.W. Hill, J. (2007). Concomitant administration of Yersinia pestis specific monoclonal antibodies with plague vaccine has a detrimental effect on vaccine mediated immunity. Vaccine, 25, 7301-7306.

Cuccui J, Easton A, Chu KK, Bancroft GJ, Oyston PCF, Titball RW, Wren BW (2007). Development of signature-tagged mutagenesis in Burkholderia pseudomallei to identify genes important in survival and pathogenesis. Infect Immun, 75(3), 1186-1195. Abstract. Author URL.

Duffield, M.L. Titball, R.W. Lindsay, C.D. (2007). Down-regulation of gene transcripts associated with ricin tolerance in human RPMI 2650 cells. Toxicology in vitro, 21, 509-520.

Titball RW, Petrosino JF (2007). Francisella tularensis genomics and proteomics. Ann N Y Acad Sci, 1105, 98-121. Abstract. Author URL.

Griffin KF, Oyston PCF, Titball RW (2007). Francisella tularensis vaccines. FEMS Immunol Med Microbiol, 49(3), 315-323. Abstract. Author URL.

Unal, B. Petersen, J.M. Hartley, G. (2007). From protein microarrays to diagnostic antigen discovery: a study of the pathogen F. tularensis. Bioinformatics, 23, 508-518.

Chaudhuri RR, Ren C-P, Desmond L, Vincent GA, Silman NJ, Brehm JK, Elmore MJ, Hudson MJ, Forsman M, Isherwood KE, et al (2007). Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4. PLoS One, 2(4). Abstract. Author URL.

Smither SJ, Hill J, van Baar BLM, Hulst AG, de Jong AL, & Titball RW (2007). Identification of Outer Membrane Proteins of Yersinia pestis through Biotinylation. Journal of Microbiological Methods, 68, 26-31.

Chu, K. Hawue, A. Nelson, M. (2007). Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis. Infection and Immunity, 75, 4173-4180.

Duc LH, Hong HA, Atkins HS, Flick-Smith HC, Durrani Z, Ripkema S, Titball RW & Cutting SM (2007). Immunisation against anthrax using Bacillus subtilis spores expressing the anthrax protective antigen. Vaccine, 25, 346-355.

Clark, G.C. Atkins, H.S. Lingard, B. (2007). Immunisation of mice with a Clostridium perfringens α-toxoid protects against heterologous Clostridial phospholipases C. Microbial Pathogen, 43, 161-165.

Atkins, H.S. Johnson, L. Titball, R.W. (2007). Immunization with Anthrolysin O or a genetic toxoid protects against challenge with the toxin but not against Bacillus anthracis. Vaccine, 25, 7197-7205.

Eyles JE, Unal B, Hartley MG, Newstead SL, Flick-Smith H, Prior JL, Oyston PCF, Randall A, Mu Y, Hirst S, et al (2007). Immunodominant Francisella tularensis antigens identified using proteome microarray. Proteomics, 7(13), 2172-2183. Abstract. Author URL.

Wood RJ, Maynard-Smith MD, Robinson VL, Oyston PCF, Titball RW, Roach PL (2007). Kinetic analysis of Yersinia pestis DNA adenine methyltransferase activity using a hemimethylated molecular break light oligonucleotide. PLoS One, 2(8). Abstract. Author URL.

Stagg, A.J. Eley, S.M. Taylor, R. (2007). Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague. Vaccine, 25, 1142-1148.

Stokes MGM, Titball RW, Neeson BN, Galen JE, Walker NJ, Stagg AJ, Jenner DC, Thwaite JE, Nataro JP, Baillie LWJ, Atkins HS (2007). Oral administration of a Salmonella-based vaccine espressing Bacillus anthracis protective antigen confers protection against aerosolized B. anthracis. Infection and Immunity, 75, 1827-1834.

Garbom S, Olofsson M, Bjornfot AC, Srivastava MK, Robinson VL, Oyston PCF, Titball RW, Wolf-Watz H (2007). Phenotypic characterizartion of a virulence-associated protein, VagH, of Yersinia pseudotuberculosis reveals a tight link between VagH and the type III secretion system. Microbiology, 153, 1464-1473.

Thwaite, J.E. Harding, S.V. Smither, S.J. (2007). Polysaccharides and virulence of Burkholderia pseudomallei. Journal of Medical Microbiology, 56, 1005-1010.

Tanabe M, Mirza O, Bertrand T, Atkins HS, Titball RW, Iwata S, Brown KA, Byrne B (2007). Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains. Acta Crystallogr D Biol Crystallogr, 63(Pt 11), 1185-1193. Abstract. Author URL.

Harding SV, Sarkar-Tyson M, Smither SJ, Atkins TP, Oyston PCF, Brown KA, Liu Y, Wait R, & Titball RW (2007). The identification of surface proteins of Burkholeria pseudomallei. Vaccine, 25, 2664-2672.

sm202, Grice ID, Griffin K, Hitchen PG (2007). The immunologically distinct O-antigens from Francisella tularensis subspecies tuarensis and Francisella novicida are both virulence determinants and protective antigens. Infection and Immunity, 75(1), 371-378.

Clark GC, Basak AK, Titball RW (2007). The rational design of bacterial toxin inhibitors. Current Computer-Aided Drug Design, 3(1), 1-12. Abstract.

Rodrigues F, Sarkar-Tyson M, Harding SV, Sim SH, Chua HH, Lin CH, Han X, Krishna R, Karuturi M, Sung K, et al (2006). A global map of growth regulated gene expression in Burkholderia pseudomallei, the Causative Agent of Melioidosis. Journal of Bacteriology, 188, 8178-8188.

Chu, K. Easton, A. Stevens, M. (2006). A live vaccine against Burkholderia pseudomallei elicits CD4+ T cell-mediated immunity, priming T cells specific for 2 Type III secretion system proteins. Journal of Infectious Diseases, 194, 1241-1248.

Eyles, J.E. Elvin, S.J. Healey, G.D. (2006). Administration of antibody to the lung protects mice against pneumonic plague. Infection and Immunity, 74, 3068-3070.

Bayer, C.R. Aldape, M.J. Wallace, R.J. (2006). Clostridium perfringens Phospholopase C-induced platelet/leukocyte interactions impede neutrophil diapedesis. Journal of Medical Microbiology, 55, 495-504.

sm202, Bystrom A, Forslund AL, Johansson A (2006). Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis. Molecular Microbiology, 59(6), 1818-1830.

Taylor, R. Prior, J. Newstead, S. (2006). Grey variants of the live vaccine strain of Francisella tularensis lack lipopolysaccharide O-antigen, show reduced ability to survive in macrophages and do not induce protective immunity in mice. Vaccine, 24, 989-996.

Atkins, H.S. Harland, D.N. Elvin, S.J. (2006). Identification and evaluation of ABC transporter components that protect against Yersinia pestis. Infection and Immunity, 74, 3687-3691.

Hibbs, S. Titball, R.W. Atkins, T.P. (2006). Proteolytic degradation of the human antimicrobial peptide LL-37 by Bacillus anthracis may contribute to virulence. Antimicrobial Agents and Chemotherapy, 50, 2316-2322.

Morton, M. Griffin, K.F. Stockes, M. (2006). Recombinant Salmonella vaccines for biodefence. Vaccine, 24, 2710-2717.

Rasko, D.A. Cheung, J.K. Ravel, J. (2006). Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Research, 16, 1031-1040.

Tanabe M, Atkins HS, Harland DN, Elvin SJ, Stagg AJ, Mirza O, Titball RW, Byrne B, Brown KA (2006). The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection. Infect Immun, 74(6), 3687-3691. Abstract. Author URL.

Dassa, E. Walker, N.J. Griffin, K.F. (2006). The identification and evaluation of ATP-binding cassette systems in the intracellular bacterium Francisella tularensis. Research in Microbiology, 157, 593-604.

Laws TR, Atkins HS, Atkins TP, Titball RW (2006). The pathogen Pseudomonas aeruginosa negatively affects the attraction response of the nematode Caenorhabditis elegans to bacteria. Microb Pathog, 40(6), 293-297. Abstract. Author URL.

Easton, A. Smith, D. O'Garra, A. (2006). The role of T-cells in innate and adptive immunity against murine Burkholderia pseudomallei infection. Journal of Infectious Diseases, 193, 370-379.

Oyston, P.C.F. Titball, R.W. (2005). A dam mutant of Yersinia pestis is attenuated and induces protection against plague. FEMS Microbiology Letters, 252, 251-256.

Boddey, J.A. Thomas, R. Smith, M.P. (2005). A type IV pilin, pilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo. Infection and Immunity, 73, 1260-1264.

Garmory, H.S. Brown, K.A. Titball, R.W. (2005). An association between ATP binding cassette systems, genome sizes and lifestyles of bacteria. Research in Microbiology, 156, 434-442.

Alape-Giron, A. Clark, G. Catimel, B. (2005). Cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C. Journal of Biological Chemistry, 280, 26680-26689.

Gates, A.J. Green, M. Eastaugh, L. (2005). CpG-DNA protects against a lethal orthopoxvirus infection in a murine model. Antiviral Research, 65, 87-95.

Perkins, S.D. Phillpotts, R.J. Titball, R.W. (2005). DNA vaccines for biodefence. Advanced Drug Delivery Reviews, 57, 1343-1361.

Choules, G. Rogers, D. Titball, R.W. (2005). Efficacy of the live attenuated Francisella tularensis vaccine (LVS) in a murine model of disease. Vaccine, 23, 2680-2686.

Oyston, P.C. Crossett, B. Fairweather, N.F. (2005). Functional characterization of OXA-57, a Class D β-lactamase from Burkholderia pseudomallei. Antimicrobial Agents and Chemotherapy, 49, 1639-1641.

Titball, R.W. (2005). Gas gangrene: an open and closed case. Microbiology, 151, 2821-2828.

Harrison B, Raju D, Garmory HS, Brett MM, Titball RW, Sarker MR (2005). Molecular characterization of Clostridium perfringens isolates from humans with sporadic diarrhea: evidence for transcriptional regulation of the beta2-toxin-encoding gene. Appl Environ Microbiol, 71(12), 8362-8370. Abstract. Author URL.

Taylor VL, Titball RW, Oyston PCF (2005). Oral immunization with a dam mutant of Yersinia pseudotuberculosis protects against plague. Microbiology, 151(6), 1919-1926. Abstract.

Taylor VL, Titball RW, Oyston PCF (2005). Oral immunization with a dam mutant of Yersinia pseudotuberculosis protects against plague. Microbiology (Reading), 151(Pt 6), 1919-1926. Abstract. Author URL.

Bedford, R. Townson, K. Phillpotts, R. (2005). Protective efficacy of a recombinant plague vaccine when co-administered with another sub-unit or live attenuated vaccine. FEMS Immunology and Medical Microbiology, 43, 425-430.

RT101, Andersson SGE, Chain P, Chu MC (2005). The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nature Genetics, 37(2), 153-159.

Laws TR, Smith SA, Smith MP, Harding SV, Atkins TP, Titball RW (2005). The nematode Panagrellus redivivus is susceptible to killing by human pathogens at 37 degrees C. FEMS Microbiol Lett, 250(1), 77-83. Abstract. Author URL.

Isherwood KE, Titball RW, Davies DH, Felgner PL, Morrow WJW (2005). Vaccination strategies for Francisella tularensis. Adv Drug Deliv Rev, 57(9), 1403-1414. Abstract. Author URL.

Garmory, H.S. Perkins, S.D. O'Dowd, A.M. (2004). A Salmonella enterica serovar Typhi vaccine expressing Yersinia pestis F1 antigen on its surface provides protection against plague in mice. Vaccine, 22, 2524-2532.

Titball, R.W. (2004). ATP-Binding Cassette Transporters Are Targets for the Development of Antibacterial Vaccines and Therapies. Infection and Immunity, 72, 6757-6763.

TP, J. Cuccui, W. White, N. (2004). Absence of Yersinia pestis-specific DNA in human teeth from five European excavations of putative plague victims. Microbiology, 150, 341-354.

Laws TR, Harding SV, Smith MP, Atkins TP, Titball RW (2004). Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria. FEMS Microbiol Lett, 234(2), 281-287. Abstract. Author URL.

Harding, S.V. Smith, M.P. Atkins, T.P. (2004). Aging and bacterial disease in the nematode Caenorhabditis elegans. FEMS Microbiology Letters, 234, 281-287.

Titball, R.W. (2004). An elusive serial killer. Nature, 430, 145-146.

Haque, A. Atkins, T. Hill, J. (2004). Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in a murine model of melioidosis. Microbiology, 150, 2669-2676.

Cole AR, Gilbert M, Popoff M, Moss DS, Titball RW, Basak A (2004). Clostridium perfringens epsilon toxin shows structural similarity with the pore forming toxin aerolysin. Nature Structural Biology, 11, 797-798.

Thelestam, T. Clark, G. Titball, R.W. (2004). Effects of Clostridium perfringens phospholipase C in mammalian cells. Anaerobe, 10, 115-123.

Prior, J.L. Lever, M.S. Jones, H.E. (2004). Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis. Journal of Medical Microbiology, 53, 1177-1182.

Rijnbrand, R.C. Wang, H. Ryman, K.D. (2004). Genetic Relationships and Evolution of Genotypes of Yellow Fever Virus and Other Members of the Yellow Fever Virus Group within the Flavivirus Genus Based on the 3' Noncoding Region. Journal of Virology, 78, 9652-9665.

RT101, Atkins T, Bason N, Beacham IR (2004). Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proceedings of the National Academy of Sciences, 101(39), 14240-14245.

Titball, R.W. Jepson, M. Bayer, C. (2004). Immunization with C-domain of alpha-toxin prevents lethal infection, localises tissue injury and promotes host response to challenge with viable Clostridium perfringens. Journal of Infectious Diseases, 190, 767-773.

Drancourt M, Raoult D, Gilbert MTP, Cuccui J, White W, Lynnerup N, Titball RW, Cooper A, Prentice MB (2004). Molecular detection of Yersinia pestis in dental pulp. Microbiology, 150(2), 263-265.

Titball RW (2004). Plague: a natural history of Yersinia pestis. The Biochemist, 26(2), 11-14.

Titball RW (2004). Plague: the mysterious past and terrifying future of the world's most dangerous disease. NATURE, 430(6996), 145-146. Author URL.

Green, M. Choules, G.R. Ogers, D. (2004). Protection afforded by heat shock protein 60 from Francisella tularensis is due to co-purified lipopolysaccharide. Infection and Immunity, 72, 4109-4113.

Freeman, D. Brown, K.A. Titball, R.W. (2004). Protection against plague afforded by immunisation with DNA vaccines optimised for expression of the Yersinia pestis V antigen. Vaccine, 22, 947-957.

Gilbert MTP, Cuccui J, White W, Lynnerup N, Titball RW, Cooper A, Prentice MB (2004). Response to Drancourt and Raoult. MICROBIOLOGY-SGM, 150, 264-265. Author URL.

Titball RW (2004). Return of the black death: the world's greatest serial killer. NATURE, 430(6996), 145-146. Author URL.

Titball RW, Basak AK (2004). The bacterial zinc-metallophospholipases C. Journal of Toxicology - Toxin Reviews, 23(4), 509-554. Abstract.

Basak, A.K. (2004). The bacterial zinc-metallophospholipases C. Journal of Toxicology - Toxin Reviews, 23, 509-554.

Titball, R.W. Lindsay, C.D. (2004). The interaction of Pseudomonas aeruginosa PAK with human and animal respiratory tract cell lines. FEMS Microbiology Letters, 238, 49-55.

Leary, S. EC, K.F. Griffin, E.D. (2004). The use of live attenuated bacteria as a delivery system for heterologous antigens. Journal of Drug Targeting, 11, 471-479.

Sjostedt, A. Titball, R.W. (2004). Tularemia: bioterrorism defence renews interest in Francisella tularensis. Nature Reviews Microbiology, 2, 967-978.

Titball RW, Williamson ED (2004). Yersinia pestis (plague) vaccines. Expert Opin Biol Ther, 4(6), 965-973. Abstract. Author URL.

Titball, R.W. (2004). Yersinia pestis. The Biochemist, 26, 11-14.

WP, A. Karleyshev, M. Smith, K. (2003). A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface. Microbiology, 149, 3221-3229.

Titball RW, Oyston PCF (2003). A vaccine for tularaemia. Expert Opin Biol Ther, 3(4), 645-653. Abstract. Author URL.

Mayers C, Duffield M, Rowe S, Miller J, Lingard B, Hayward S, Titball RW (2003). Analysis of known bacterial protein vaccine antigens reveals biased physical properties and amino acid composition. Comp Funct Genomics, 4(5), 468-478. Abstract. Author URL.

RT101, Hinchcliffe SJ, Hinds J, Isherwood KE (2003). Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis . Genome Research, 13(9), 2018-2029.

Prior JL, Prior RG, Hitchen PG, Diaper H, Griffin KF, Morris HR, Dell A, Titball RW (2003). Characterization of the O antigen gene cluster and structural analysis of the O antigen of Francisella tularensis subsp. tularensis. J Med Microbiol, 52(Pt 10), 845-851. Abstract. Author URL.

Briggs, D.C. Karasawa, T. Wang, X. (2003). Clostridium absonum alpha-toxin: new insights into Clostridial alpha-toxin substrate binding and specificity. Journal of Molecular Biology, 333, 759-769.

Garmory HS, Titball RW, Brown KA, Bennett AM (2003). Construction and evaluation of a eukaryotic expression plasmid for stable delivery using attenuated Salmonella. Microb Pathog, 34(3), 115-119. Abstract. Author URL.

Hinds, J. Witney, A.A. Isherwood, K. (2003). Construction of a Yersinia pestis microarray. Advances in Experimental Medicine and Biology, 529, 47-49.

Garmory HS, Brown KA, Titball RW (2003). DNA vaccines: improving expression of antigens. Genet Vaccines Ther, 1(1). Abstract. Author URL.

Thomas R, Johansson A, Neeson B, Isherwood K, Sjöstedt A, Ellis J, Titball RW (2003). Discrimination of human pathogenic subspecies of Francisella tularensis by using restriction fragment length polymorphism. J Clin Microbiol, 41(1), 50-57. Abstract. Author URL.

Donelli G, Fiorentini C, Matarrese P, Falzano L, Cardines R, Mastrantonio P, Payne DW, Titball RW (2003). Evidence for cytoskeletal changes secondary to plasma membrane functional alterations in the in vitro cell response to Clostridium perfringens epsilon-toxin. Comp Immunol Microbiol Infect Dis, 26(3), 145-156. Abstract. Author URL.

Lever MS, Nelson M, Ireland PI, Stagg AJ, Beedham RJ, Hall GA, Knight G, Titball RW (2003). Experimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouse. J Med Microbiol, 52(Pt 12), 1109-1115. Abstract. Author URL.

Oyston PCF, Prior JL, Kiljunen S, Skurnik M, Hill J, Titball RW (2003). Expression of heterologous O-antigen in Yersinia pestis KIM does not affect virulence by the intravenous route. J Med Microbiol, 52(Pt 4), 289-294. Abstract. Author URL.

Titball RW, Sjöstedt A (2003). Francisella tularensis:: an overview. ASM NEWS, 69(11), 558-+. Author URL.

Broekhuijsen M, Larsson P, Johansson A, Byström M, Eriksson U, Larsson E, Prior RG, Sjöstedt A, Titball RW, Forsman M, et al (2003). Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis. J Clin Microbiol, 41(7), 2924-2931. Abstract. Author URL.

Waters M, Savoie A, Garmory HS, Bueschel D, Popoff MR, Songer JG, Titball RW, McClane BA, Sarker MR (2003). Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets. J Clin Microbiol, 41(8), 3584-3591. Abstract. Author URL.

Underwood, C.D. Sundberg, L. Astrom, H. (2003). Immunological characterisation of sub-units of the Yersinia type III secretion apparatus. Advances in Experimental Medicine and Biology, 529, 415-417.

Garmory HS, Griffin KF, Brown KA, Titball RW (2003). Oral immunisation with live aroA attenuated Salmonella enterica serovar Typhimurium expressing the Yersinia pestis V antigen protects mice against plague. Vaccine, 21(21-22), 3051-3057. Abstract. Author URL.

Garmory HS, Titball RW, Griffin KF, Hahn U, Böhm R, Beyer W (2003). Salmonella enterica serovar typhimurium expressing a chromosomally integrated copy of the Bacillus anthracis protective antigen gene protects mice against an anthrax spore challenge. Infect Immun, 71(7), 3831-3836. Abstract. Author URL.

Williamson, E.D. (2003). Second and third generation plague vaccines. Advances in Experimental Medicine and Biology, 529, 397-406.

Hill J, Copse C, Leary S, Stagg AJ, Williamson ED, Titball RW (2003). Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis. Infect Immun, 71(4), 2234-2238. Abstract. Author URL.

Titball, R.W. Lindsay, C.D. (2003). The development of tolderance to Clostridium perfringens type D ε-toxin in MDCK and G402 cells. Human & Experimental Toxicology, 22, 593-605.

Foynes S, Holley JL, Garmory HS, Titball RW, Fairweather NF (2003). Vaccination against type F botulinum toxin using attenuated Salmonella enterica var Typhimurium strains expressing the BoNT/F H(C) fragment. Vaccine, 21(11-12), 1052-1059. Abstract. Author URL.

Titball RW, Williamson ED (2003). Vaccine development for potential bioterrorism agents. Curr Drug Targets Infect Disord, 3(3), 255-262. Abstract. Author URL.

Titball RW, Johansson A, Forsman M (2003). Will the enigma of Francisella tularensis virulence soon be solved?. Trends Microbiol, 11(3), 118-123. Abstract. Author URL.

Smith MP, Laws TR, Atkins TP, Oyston PCF, de Pomerai DI, Titball RW (2002). A liquid-based method for the assessment of bacterial pathogenicity using the nematode Caenorhabditis elegans. FEMS Microbiol Lett, 210(2), 181-185. Abstract. Author URL.

Atkins T, Prior RG, Mack K, Russell P, Nelson M, Oyston PCF, Dougan G, Titball RW (2002). A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis. Infect Immun, 70(9), 5290-5294. Abstract. Author URL.

Flick-Smith HC, Walker NJ, Gibson P, Bullifent H, Hayward S, Miller J, Titball RW, Williamson ED (2002). A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection. Infect Immun, 70(3), 1653-1656. Abstract. Author URL.

Atkins T, Prior R, Mack K, Russell P, Nelson M, Prior J, Ellis J, Oyston PCF, Dougan G, Titball RW, et al (2002). Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis. J Med Microbiol, 51(7), 539-553. Abstract. Author URL.

Eaton JT, Naylor CE, Howells AM, Moss DS, Titball RW, Basak AK (2002). Crystal structure of the C. perfringens alpha-toxin with the active site closed by a flexible loop region. J Mol Biol, 319(2), 275-281. Abstract. Author URL.

Lawton DG, Longstaff C, Wallace BA, Hill J, Leary SEC, Titball RW, Brown KA (2002). Interactions of the type III secretion pathway proteins LcrV and LcrG from Yersinia pestis are mediated by coiled-coil domains. J Biol Chem, 277(41), 38714-38722. Abstract. Author URL.

Prior JL, Titball RW (2002). Monoclonal antibodies against Yersinia pestis lipopolysaccharide detect bacteria cultured at 28 degrees C or 37 degrees C. Mol Cell Probes, 16(4), 251-256. Abstract. Author URL.

Howells AM, Bullifent HL, Dhaliwal K, Griffin K, García de Castro A, Frith G, Tunnacliffe A, Titball RW (2002). Role of trehalose biosynthesis in environmental survival and virulence of Salmonella enterica serovar typhimurium. Res Microbiol, 153(5), 281-287. Abstract. Author URL.

Garmory HS, Brown KA, Titball RW (2002). Salmonella vaccines for use in humans: present and future perspectives. FEMS Microbiol Rev, 26(4), 339-353. Abstract. Author URL.

Baker MD, Papageorgiou AC, Titball RW, Miller J, White S, Lingard B, Lee JJ, Cavanagh D, Kehoe MA, Robinson JH, et al (2002). Structural and functional role of threonine 112 in a superantigen Staphylococcus aureus enterotoxin B. J Biol Chem, 277(4), 2756-2762. Abstract. Author URL.

Hitchen PG, Prior JL, Oyston PCF, Panico M, Wren BW, Titball RW, Morris HR, Dell A (2002). Structural characterization of lipo-oligosaccharide (LOS) from Yersinia pestis: regulation of LOS structure by the PhoPQ system. Mol Microbiol, 44(6), 1637-1650. Abstract. Author URL.

Garmory HS, Griffin KF, Leary SEC, Perkins SD, Brown KA, Titball RW (2002). The effect of recombinant plasmids on in vivo colonisation of Salmonella enterica serovar Typhimurium strains is not reflected by in vitro cellular invasion assays. Vaccine, 20(27-28), 3239-3243. Abstract. Author URL.

Justin N, Walker N, Bullifent HL, Songer G, Bueschel DM, Jost H, Naylor C, Miller J, Moss DS, Titball RW, et al (2002). The first strain of Clostridium perfringens isolated from an avian source has an alpha-toxin with divergent structural and kinetic properties. Biochemistry, 41(20), 6253-6262. Abstract. Author URL.

Ellis J, Oyston PCF, Green M, Titball RW (2002). Tularemia. CLINICAL MICROBIOLOGY REVIEWS, 15(4), 631-+. Author URL.

Ellis J, Oyston PCF, Green M, Titball RW (2002). Tularemia. Clin Microbiol Rev, 15(4), 631-646. Abstract. Author URL.

Williamson ED, Titball RW (2002). Vaccines against dangerous pathogens. Br Med Bull, 62, 163-173. Abstract. Author URL.

Karlyshev AV, Oyston PC, Williams K, Clark GC, Titball RW, Winzeler EA, Wren BW (2001). Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes. Infect Immun, 69(12), 7810-7819. Abstract. Author URL.

Prior JL, Hitchen PG, Williamson DE, Reason AJ, Morris HR, Dell A, Wren BW, Titball RW (2001). Characterization of the lipopolysaccharide of Yersinia pestis. Microb Pathog, 30(2), 49-57. Abstract. Author URL.

RT101, Cerdeno-Tarraga AM, Chillingworth T, Churcher C (2001). Genome sequence of Yersinia pestis, the causative agent of plague. Nature, 413(6855), 523-527.

Tito MA, Miller J, Griffin KF, Williamson ED, Titball RW, Robinson CV (2001). Macromolecular organization of the Yersinia pestis capsular F1 antigen: insights from time-of-flight mass spectrometry. Protein Sci, 10(11), 2408-2413. Abstract. Author URL.

Tito MA, Miller J, Walker N, Griffin KF, Williamson ED, Despeyroux-Hill D, Titball RW, Robinson CV (2001). Probing molecular interactions in intact antibody: antigen complexes, an electrospray time-of-flight mass spectrometry approach. Biophys J, 81(6), 3503-3509. Abstract. Author URL.

Fulop M, Mastroeni P, Green M, Titball RW (2001). Role of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensis. Vaccine, 19(31), 4465-4472. Abstract. Author URL.

Prior JL, Parkhill J, Hitchen PG, Mungall KL, Stevens K, Morris HR, Reason AJ, Oyston PC, Dell A, Wren BW, et al (2001). The failure of different strains of Yersinia pestis to produce lipopolysaccharide O-antigen under different growth conditions is due to mutations in the O-antigen gene cluster. FEMS Microbiol Lett, 197(2), 229-233. Abstract. Author URL.

Jepson M, Bullifent HL, Crane D, Flores-Diaz M, Alape-Giron A, Jayasekeera P, Lingard B, Moss D, Titball RW (2001). Tyrosine 331 and phenylalanine 334 in Clostridium perfringens alpha-toxin are essential for cytotoxic activity. FEBS Lett, 495(3), 172-177. Abstract. Author URL.

Titball RW, Williamson ED (2001). Vaccination against bubonic and pneumonic plague. Vaccine, 19(30), 4175-4184. Abstract. Author URL.

Prentice MB, James KD, Parkhill J, Baker SG, Stevens K, Simmonds MN, Mungall KL, Churcher C, Oyston PC, Titball RW, et al (2001). Yersinia pestis pFra shows biovar-specific differences and recent common ancestry with a Salmonella enterica serovar Typhi plasmid. J Bacteriol, 183(8), 2586-2594. Abstract. Author URL.

Titball RW (2001). Yersinia pestis: a case of mistaken identity? SusanScottChristopher JDuncanBiology of Plagues2001Cambridge University PressCambridgePp 434. £65.00. ISBN 0521801508. The Lancet, 357(9273).

Williamson ED, Eley SM, Stagg AJ, Green M, Russell P, Titball RW (2000). A single dose sub-unit vaccine protects against pneumonic plague. Vaccine, 19(4-5), 566-571. Abstract. Author URL.

Shortt SJ, Titball RW, Lindsay CD (2000). An assessment of the in vitro toxicology of Clostridium perfringens type D epsilon-toxin in human and animal cells. Hum Exp Toxicol, 19(2), 108-116. Abstract. Author URL.

Bullifent HL, Griffin KF, Jones SM, Yates A, Harrington L, Titball RW (2000). Antibody responses to Yersinia pestis F1-antigen expressed in Salmonella typhimurium aroA from in vivo-inducible promoters. Vaccine, 18(24), 2668-2676. Abstract. Author URL.

Holley JL, Elmore M, Mauchline M, Minton N, Titball RW (2000). Cloning, expression and evaluation of a recombinant sub-unit vaccine against Clostridium botulinum type F toxin. Vaccine, 19(2-3), 288-297. Abstract. Author URL.

Karlyshev AV, Oyston PC, Williams K, Titball RW, Davis R, Winzeler EA, Wren BW (2000). Development of high-density DNA array based signature-tagged mutagenesis and its application for the discovery of novel Y. pseudotuberculosis virulence-associated genes. Biochemical Society Transactions, 28(5), a232-a232.

Byrne MP, Titball RW, Holley J, Smith LA (2000). Fermentation, purification, and efficacy of a recombinant vaccine candidate against botulinum neurotoxin type F from Pichia pastoris. Protein Expr Purif, 18(3), 327-337. Abstract. Author URL.

Walker C, Goodyear C, Anderson D, Titball RW (2000). Identification of arsenic-resistant bacteria in the soil of a former munitions factory at Locknitz, Germany. Land Contamination and Reclamation, 8(1), 13-18. Abstract.

Alape-Girón A, Flores-Díaz M, Guillouard I, Naylor CE, Titball RW, Rucavado A, Lomonte B, Basak AK, Gutiérrez JM, Cole ST, et al (2000). Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene. Eur J Biochem, 267(16), 5191-5197. Abstract. Author URL.

Walker N, Holley J, Naylor CE, Flores-Díaz M, Alape-Girón A, Carter G, Carr FJ, Thelestam M, Keyte M, Moss DS, et al (2000). Identification of residues in the carboxy-terminal domain of Clostridium perfringens alpha-toxin (phospholipase C) which are required for its biological activities. Arch Biochem Biophys, 384(1), 24-30. Abstract. Author URL.

Wright A, Andrews PL, Titball RW (2000). Induction of emetic, pyrexic, and behavioral effects of Staphylococcus aureus enterotoxin B in the ferret. Infect Immun, 68(4), 2386-2389. Abstract. Author URL.

Williams K, Oyston PC, Dorrell N, Li S, Titball RW, Wren BW (2000). Investigation into the role of the serine protease HtrA in Yersinia pestis pathogenesis. FEMS Microbiol Lett, 186(2), 281-286. Abstract. Author URL.

Garmory HS, Chanter N, French NP, Bueschel D, Songer JG, Titball RM (2000). Occurrence of Clostridium perfringens β2-toxin amongst animals, determined using genotyping and subtyping PCR assays (vol 124, pg 61, 2000). EPIDEMIOLOGY AND INFECTION, 125(1), 227-227. Author URL.

Garmory HS, Chanter N, French NP, Bueschel D, Songer JG, Titball RW (2000). Occurrence of Clostridium perfringens beta2-toxin amongst animals, determined using genotyping and subtyping PCR assays. Epidemiol Infect, 124(1), 61-67. Abstract. Author URL.

Skinner MA, Titball RW, Oyston PCF, Brown KA (2000). STRUCTURE-BASED VACCINE DESIGN. Biochemical Society Transactions, 28(5), a332-a332.

Karlsson J, Prior RG, Williams K, Lindler L, Brown KA, Chatwell N, Hjalmarsson K, Loman N, Mack KA, Pallen M, et al (2000). Sequencing of the Francisella tularensis strain Schu 4 genome reveals the shikimate and purine metabolic pathways, targets for the construction of a rationally attenuated auxotrophic vaccine. Microb Comp Genomics, 5(1), 25-39. Abstract. Author URL.

Bullifent HL, Dhaliwal K, Howells AM, Goan K, Griffin K, Lindsay CD, Tunnacliffe A, Titball RW (2000). Stabilisation of Salmonella vaccine vectors by the induction of trehalose biosynthesis. Vaccine, 19(9-10), 1239-1245. Abstract. Author URL.

Jepson M, Titball R (2000). Structure and function of clostridial phospholipases C. Microbes Infect, 2(10), 1277-1284. Abstract. Author URL.

Oyston PC, Dorrell N, Williams K, Li SR, Green M, Titball RW, Wren BW (2000). The response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in Yersinia pestis. Infect Immun, 68(6), 3419-3425. Abstract. Author URL.

Williamson ED, Vesey PM, Gillhespy KJ, Eley SM, Green M, Titball RW (1999). An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse model. Clin Exp Immunol, 116(1), 107-114. Abstract. Author URL.

Naylor CE, Jepson M, Crane DT, Titball RW, Miller J, Basak AK, Bolgiano B (1999). Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin. J Mol Biol, 294(3), 757-770. Abstract. Author URL.

Manoj N, Srinivas VR, Surolia A, Vijayan M, Suguna K, Ravishankar R, Suguna K, Surolia A, Vijayan M, Schwarzenbacher R, et al (1999). Contributory presentations/posters. Journal of Biosciences, 24(Suppl 1).

Jepson M, Howells A, Bullifent HL, Bolgiano B, Crane D, Miller J, Holley J, Jayasekera P, Titball RW (1999). Differences in the carboxy-terminal (Putative phospholipid binding) domains of Clostridium perfringens and Clostridium bifermentans phospholipases C influence the hemolytic and lethal properties of these enzymes. Infect Immun, 67(7), 3297-3301. Abstract. Author URL.

Kenny DJ, Russell P, Rogers D, Eley SM, Titball RW (1999). In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp. Antimicrob Agents Chemother, 43(11), 2773-2775. Abstract. Author URL.

Bennett AM, Lescott T, Phillpotts RJ, Mackett M, Titball RW (1999). Recombinant vaccinia viruses protect against Clostridium perfringens alpha-toxin. Viral Immunol, 12(2), 97-105. Abstract. Author URL.

Justin N, Eaton J, Naylor C, Howells A, Moss D, Titball R, Basak A (1999). Structure Function Studies of Clostridium perfringens Alpha-Toxin; a Gas Gangrene Causing Protein. Journal of Chemical Society of Pakistan, 21(3), 239-247.

Titball RW, Naylor CE, Basak AK (1999). The Clostridium perfringens alpha-toxin. Anaerobe, 5(2), 51-64. Abstract. Author URL.

Green M, Rogers D, Russell P, Stagg AJ, Bell DL, Eley SM, Titball RW, Williamson ED (1999). The SCID/Beige mouse as a model to investigate protection against Yersinia pestis. FEMS Immunol Med Microbiol, 23(2), 107-113. Abstract. Author URL.

Pettersson J, Holmström A, Hill J, Leary S, Frithz-Lindsten E, von Euler-Matell A, Carlsson E, Titball R, Forsberg A, Wolf-Watz H, et al (1999). The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation. Mol Microbiol, 32(5), 961-976. Abstract. Author URL.

Leary SE, Griffin KF, Galyov EE, Hewer J, Williamson ED, Holmström A, Forsberg A, Titball RW (1999). Yersinia outer proteins (YOPS) E, K and N are antigenic but non-protective compared to V antigen, in a murine model of bubonic plague. Microb Pathog, 26(3), 159-169. Abstract. Author URL.

Titball RW (1998). Bacterial phospholipases. Journal of Applied Microbiology, 84(S1), 127s-137s.

Titball RW (1998). Bacterial phospholipases. Journal of Applied Microbiology Symposium Supplement, 84(27). Abstract.

Titball RW (1998). Bacterial phospholipases. Symp Ser Soc Appl Microbiol, 27, 127S-137S. Abstract. Author URL.

Basak AK, Howells A, Eaton JT, Moss DS, Naylor CE, Miller J, Titball RW (1998). Crystallization and preliminary X-ray diffraction studies of alpha-toxin from two different strains (NCTC8237 and CER89L43) of Clostridium perfringens. Acta Crystallogr D Biol Crystallogr, 54(Pt 6 Pt 2), 1425-1428. Abstract. Author URL.

Russell P, Eley SM, Green M, Stagg AJ, Taylor RR, Nelson M, Beedham RJ, Bell DL, Rogers D, Whittington D, et al (1998). Efficacy of doxycycline and ciprofloxacin against experimental Yersinia pestis infection. J Antimicrob Chemother, 41(2), 301-305. Abstract. Author URL.

Carter G, White P, Fernie M, King S, McLean G, Titball R, Carr FJ (1998). Enhanced antitumour effect of liposomal daunorubicin using antibody-phospholipase C conjugates or fusion protein. Int J Oncol, 13(4), 819-825. Abstract. Author URL.

Miller J, Williamson ED, Lakey JH, Pearce MJ, Jones SM, Titball RW (1998). Macromolecular organisation of recombinant Yersinia pestis F1 antigen and the effect of structure on immunogenicity. FEMS Immunol Med Microbiol, 21(3), 213-221. Abstract. Author URL.

Oyston PCF, Payne DW, Havard HL, Williamson ED, Titball RW (1998). Production of a non-toxic site-directed mutant of Clostridium perfringens epsilon-toxin which induces protective immunity in mice. Microbiology (Reading), 144 ( Pt 2), 333-341. Abstract. Author URL.

Basak AK, Eaton TJ, Howells A, Justin N, Miller J, Moss DS, Naylor CE, Titball RW (1998). Structure and function of clostridial A-toxin and its role in gas-gangrene. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 216, U66-U66. Author URL.

Naylor CE, Eaton JT, Howells A, Justin N, Moss DS, Titball RW, Basak AK (1998). Structure of the key toxin in gas gangrene. Nat Struct Biol, 5(8), 738-746. Abstract. Author URL.

Mack K, Titball RW (1998). The detection of insertion sequences within the human pathogen Burkholderia pseudomallei which have been identified previously in Burkholderia cepacia. FEMS Microbiol Lett, 162(1), 69-74. Abstract. Author URL.

Russell P, Eley SM, Fulop MJ, Bell DL, Titball RW (1998). The efficacy of ciprofloxacin and doxycycline against experimental tularaemia. J Antimicrob Chemother, 41(4), 461-465. Abstract. Author URL.

Payne D, Tatham D, Williamson ED, Titball RW (1998). The pH 6 antigen of Yersinia pestis binds to beta1-linked galactosyl residues in glycosphingolipids. Infect Immun, 66(9), 4545-4548. Abstract. Author URL.

Flores-Díaz M, Alape-Girón A, Titball RW, Moos M, Guillouard I, Cole S, Howells AM, von Eichel-Streiber C, Florin I, Thelestam M, et al (1998). UDP-glucose deficiency causes hypersensitivity to the cytotoxic effect of Clostridium perfringens phospholipase C. J Biol Chem, 273(38), 24433-24438. Abstract. Author URL.

Williamson ED, Eley SM, Stagg AJ, Green M, Russell P, Titball RW (1997). A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunized animals against pneumonic plague. Vaccine, 15(10), 1079-1084. Abstract. Author URL.

Titball RW (1997). Bacterial phospholipases. Trends Microbiol, 5(7). Author URL.

Leary SE, Griffin KF, Garmory HS, Williamson ED, Titball RW (1997). Expression of an F1/V fusion protein in attenuated Salmonella typhimurium and protection of mice against plague. Microb Pathog, 23(3), 167-179. Abstract. Author URL.

Titball RW, Howells AM, Oyston PC, Williamson ED (1997). Expression of the Yersinia pestis capsular antigen (F1 antigen) on the surface of an aroA mutant of Salmonella typhimurium induces high levels of protection against plague. Infect Immun, 65(5), 1926-1930. Abstract. Author URL.

Russell P, Nelson M, Whittington D, Green M, Eley SM, Titball RW (1997). Laboratory diagnosis of plague. Br J Biomed Sci, 54(4), 231-236. Abstract. Author URL.

Hill J, Leary SE, Griffin KF, Williamson ED, Titball RW (1997). Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunization. Infect Immun, 65(11), 4476-4482. Abstract. Author URL.

Fulop M, Leslie D, Titball R (1996). A rapid, highly sensitive method for the detection of Francisella tularensis in clinical samples using the polymerase chain reaction. Am J Trop Med Hyg, 54(4), 364-366. Abstract. Author URL.

Oyston PC, Russell P, Williamson ED, Titball RW (1996). An aroA mutant of Yersinia pestis is attenuated in guinea-pigs, but virulent in mice. Microbiology (Reading), 142 ( Pt 7), 1847-1853. Abstract. Author URL.

Ivanov A, Titball RW, Kostadinova S (1996). Characterisation of a phospholipase C produced by Pseudomonas fluorescens. New Microbiol, 19(2), 113-121. Abstract. Author URL.

Russell P, Eley SM, Bell DL, Manchee RJ, Titball RW (1996). Doxycycline or ciprofloxacin prophylaxis and therapy against experimental Yersinia pestis infection in mice. J Antimicrob Chemother, 37(4), 769-774. Abstract. Author URL.

Williamson ED, Sharp GJ, Eley SM, Vesey PM, Pepper TC, Titball RW, Alpar HO (1996). Local and systemic immune response to a microencapsulated sub-unit vaccine for plague. Vaccine, 14(17-18), 1613-1619. Abstract. Author URL.

Ginter A, Williamson ED, Dessy F, Coppe P, Bullifent H, Howells A, Titball RW (1996). Molecular variation between the alpha-toxins from the type strain (NCTC 8237) and clinical isolates of Clostridium perfringens associated with disease in man and animals. Microbiology (Reading), 142 ( Pt 1), 191-198. Abstract. Author URL.

Anderson GW, Leary SE, Williamson ED, Titball RW, Welkos SL, Worsham PL, Friedlander AM (1996). Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis. Infect Immun, 64(11), 4580-4585. Abstract. Author URL.

McGregor DP, Forster S, Steven J, Adair J, Leary SE, Leslie DL, Harris WJ, Titball RW (1996). Simultaneous detection of microorganisms in soil suspension based on PCR amplification of bacterial 16S rRNA fragments. Biotechniques, 21(3), 463-471. Abstract. Author URL.

Bullifent HL, Moir A, Awad MM, Scott PT, Rood JI, Titball RW (1996). The level of expression of α-toxin by different strains of Clostridium perfringens is dependent on differences in promoter structure and genetic background. Anaerobe, 2(6), 365-371. Abstract.

Mack K, Titball RW (1996). Transformation of Burkholderia pseudomallei by electroporation. Anal Biochem, 242(1), 73-76. Abstract. Author URL.

Russell P, Eley SM, Hibbs SE, Manchee RJ, Stagg AJ, Titball RW (1995). A comparison of Plague vaccine, USP and EV76 vaccine induced protection against Yersinia pestis in a murine model. Vaccine, 13(16), 1551-1556. Abstract. Author URL.

Diane Williamson E, Eley SM, Griffin KF, Green M, Russell P, Leary SEC, Oyston PCF, Easterbrook T, Reddin KM, Robinson A, et al (1995). A new improved sub-unit vaccine for plague: the basis of protection. FEMS Immunology and Medical Microbiology, 12(3-4), 223-230. Abstract.

Leary SE, Williamson ED, Griffin KF, Russell P, Eley SM, Titball RW (1995). Active immunization with recombinant V antigen from Yersinia pestis protects mice against plague. Infect Immun, 63(8), 2854-2858. Abstract. Author URL.

Oyston PC, Williamson ED, Leary SE, Eley SM, Griffin KF, Titball RW (1995). Immunization with live recombinant Salmonella typhimurium aroA producing F1 antigen protects against plague. Infect Immun, 63(2), 563-568. Abstract. Author URL.

Fulop LD, Barrett AD, Titball RW (1995). Nucleotide sequence of the NS5 gene of Banzi virus: comparison with other flaviviruses. J Gen Virol, 76 ( Pt 9), 2317-2321. Abstract. Author URL.

Fulop M, Manchee R, Titball R (1995). Role of lipopolysaccharide and a major outer membrane protein from Francisella tularensis in the induction of immunity against tularemia. Vaccine, 13(13), 1220-1225. Abstract. Author URL.

Bullifent HL, Moir A, Titball RW (1995). The construction of a reporter system and use for the investigation of Clostridium perfringens gene expression. FEMS Microbiol Lett, 131(1), 99-105. Abstract. Author URL.

Coulson NM, Fulop M, Titball RW (1994). Bacillus anthracis protective antigen, expressed in Salmonella typhimurium SL 3261, affords protection against anthrax spore challenge. Vaccine, 12(15), 1395-1401. Abstract. Author URL.

Coulson NM, Fulop M, Titball RW (1994). Effect of different plasmids on colonization of mouse tissues by the aromatic amino acid dependent Salmonella typhimurium SL 3261. Microb Pathog, 16(4), 305-311. Abstract. Author URL.

Tempest PR, White P, Williamson ED, Titball RW, Kelly DC, Kemp GJ, Gray PM, Forster SJ, Carr FJ, Harris WJ, et al (1994). Efficient generation of a reshaped human mAb specific for the alpha toxin of Clostridium perfringens. Protein Eng, 7(12), 1501-1507. Abstract. Author URL.

Johns M, Harrington L, Titball RW, Leslie DL (1994). Improved methods for the detection of Bacillus anthracis spores by the polymerase chain reaction. Letters in Applied Microbiology, 18(4), 236-238. Abstract.

Basak AK, Stuart DI, Nikura T, Bishop DH, Kelly DC, Fearn A, Titball RW (1994). Purification, crystallization and preliminary X-ray diffraction studies of alpha-toxin of Clostridium perfringens. J Mol Biol, 244(5), 648-650. Abstract. Author URL.

Williamson ED, Titball RW (1993). A genetically engineered vaccine against the alpha-toxin of Clostridium perfringens protects mice against experimental gas gangrene. Vaccine, 11(12), 1253-1258. Abstract. Author URL.

Leslie DL, Cox J, Lee M, Titball RW (1993). Analysis of a cloned Francisella tularensis outer membrane protein gene and expression in attenuated Salmonella typhimurium. FEMS Microbiol Lett, 111(2-3), 331-335. Abstract. Author URL.

TITBALL RW, PEARSON GS (1993). BWC VERIFICATION MEASURES - TECHNOLOGIES FOR THE IDENTIFICATION OF BIOLOGICAL WARFARE AGENTS. POLITICS AND THE LIFE SCIENCES, 12(2), 255-263. Author URL.

Titball RW (1993). Bacterial phospholipases C. Microbiol Rev, 57(2), 347-366. Abstract. Author URL.

Titball RW, Fearn AM, Williamson ED (1993). Biochemical and immunological properties of the C-terminal domain of the alpha-toxin of Clostridium perfringens. FEMS Microbiol Lett, 110(1), 45-50. Abstract. Author URL.

Hunter SE, Brown JE, Oyston PC, Sakurai J, Titball RW (1993). Molecular genetic analysis of beta-toxin of Clostridium perfringens reveals sequence homology with alpha-toxin, gamma-toxin, and leukocidin of Staphylococcus aureus. Infect Immun, 61(9), 3958-3965. Abstract. Author URL.

Fulop L, Barrett AD, Phillpotts R, Martin K, Leslie D, Titball RW (1993). Rapid identification of flaviviruses based on conserved NS5 gene sequences. J Virol Methods, 44(2-3), 179-188. Abstract. Author URL.

Hunter SE, Clarke IN, Kelly DC, Titball RW (1992). Cloning and nucleotide sequencing of the Clostridium perfringens epsilon-toxin gene and its expression in Escherichia coli. Infect Immun, 60(1), 102-110. Abstract. Author URL.

Havard HL, Hunter SE, Titball RW (1992). Comparison of the nucleotide sequence and development of a PCR test for the epsilon toxin gene of Clostridium perfringens type B and type D. FEMS Microbiol Lett, 76(1-2), 77-81. Abstract. Author URL.

Carl M, Hawkins R, Coulson N, Lowe J, Robertson DL, Nelson WM, Titball RW, Woody JN (1992). Detection of spores of Bacillus anthracis using the polymerase chain reaction. J Infect Dis, 165(6), 1145-1148. Abstract. Author URL.

Logan AJ, Williamson ED, Titball RW, Percival DA, Shuttleworth AD, Conlan JW, Kelly DC (1991). Epitope mapping of the alpha-toxin of Clostridium perfringens. Infect Immun, 59(12), 4338-4342. Abstract. Author URL.

Titball RW, Leslie DL, Harvey S, Kelly D (1991). Hemolytic and sphingomyelinase activities of Clostridium perfringens alpha-toxin are dependent on a domain homologous to that of an enzyme from the human arachidonic acid pathway. Infect Immun, 59(5), 1872-1874. Abstract. Author URL.

Titball RW, Turnbull PCB, Hutson RA (1991). The monitoring and detection of Bacillus anthracis in the environment. Journal of Applied Bacteriology Symposium Supplement(20).

Titball RW, Turnbull PC, Hutson RA (1991). The monitoring and detection of Bacillus anthracis in the environment. Soc Appl Bacteriol Symp Ser, 20, 9S-18S. Author URL.

Titball RW, Rubidge T (1990). The role of histidine residues in the alpha toxin of Clostridium perfringens. FEMS Microbiol Lett, 56(3), 261-265. Abstract. Author URL.

Titball RW, Hunter SE, Martin KL, Morris BC, Shuttleworth AD, Rubidge T, Anderson DW, Kelly DC (1989). Molecular cloning and nucleotide sequence of the alpha-toxin (phospholipase C) of Clostridium perfringens. Infect Immun, 57(2), 367-376. Abstract. Author URL.

Titball RW, Manchee RJ (1987). Factors affecting the germination of spores of Bacillus anthracis. J Appl Bacteriol, 62(3), 269-273. Abstract. Author URL.

TITBALL RW (1986). PATHOGENIC BACTERIA IN THE SOIL. JOURNAL OF APPLIED BACTERIOLOGY, 61(6), R6-R6. Author URL.

TITBALL RW, MANCHEE RJ (1985). FACTORS AFFECTING THE GERMINATION OF SPORES OF BACILLUS-ANTHRACIS. JOURNAL OF APPLIED BACTERIOLOGY, 59(6), R18-R18. Author URL.

Titball RW, Bell A, Munn CB (1985). Role of caseinase from Aeromonas salmonicida in activation of hemolysin. Infect Immun, 49(3), 756-759. Abstract. Author URL.

Titball RW, Munn CB (1985). The purification and some properties of H-lysin from Aeromonas salmonicida. J Gen Microbiol, 131(7), 1603-1609. Abstract. Author URL.

Titball RW, Munn CB (1983). Partial purification and properties of a haemolytic activity (T-lysin) from Aeromonas salmonicida. FEMS Microbiology Letters, 20(2), 207-210. Abstract.

TITBALL RW (1981). CORRECTION. FEMS MICROBIOLOGY LETTERS, 12(4), 428-428. Author URL.

Titball RW, Munn CB (1981). Evidence for two haemolytic activities from Aeromonas salmonicida. FEMS Microbiology Letters, 12(1), 27-30.

Chapters

Basak AK, Naylor CE, Huyet J, Savva C, Popoff MR, Titball R (2015). 27 Structural relationships between small β-pore-forming toxins from Clostridium perfringens. In (Ed) The Comprehensive Sourcebook of Bacterial Protein Toxins, Elsevier, 794-814.

Basak AK, Naylor CE, Huyet J, Savva C, Popoff MR, Titball R (2015). Structural relationships between small β-pore-forming toxins from Clostridium perfringens. In (Ed) The Comprehensive Sourcebook of Bacterial Protein Toxins, 794-814. Abstract.

Titball RW, Atkins HS (2012). Attenuated Bacterial Vaccines. In (Ed) Vaccinology: Principles and Practice, 179-195.

Titball RW (2009). Chapter 2 Bacterial Biothreat Agents. In (Ed) Vaccines for Biodefense and Emerging and Neglected Diseases, Elsevier, 21-32.

Sarkar-Tyson M, Titball RW (2009). Chapter 43 Burkholderia mallei and Burkholderia pseudomallei. In (Ed) Vaccines for Biodefense and Emerging and Neglected Diseases, Elsevier, 831-843.

Titball RW, Oyston PCF (2009). Chapter 61 Francisella tularensis. In (Ed) Vaccines for Biodefense and Emerging and Neglected Diseases, Elsevier, 1241-1253.

Williamson ED, Simpson AJ, Titball RW (2008). Chapter 22 Plague vaccines. In (Ed) Vaccines, Elsevier, 519-529.

Oyston PCF, Titball RW (2008). Plague. In (Ed) Beyond Anthrax, Springer Nature, 55-76.

Atkins, H.S. (2006). Bacillus. In Greenwood D, Slack R, Peutherer J, Barer M (Eds.) Medical Microbiology, 17th edition, Elsevier.

Titball RW, Basak AK (2006). Chapter 27 Membrane-damaging and cytotoxic phospholipases. In (Ed) The Comprehensive Sourcebook of Bacterial Protein Toxins, Elsevier, 516-534.

Basak AK, Popoff M, Titball RW, Cole A (2006). Chapter 35 Clostridium perfringens ɛ-toxin. In (Ed) The Comprehensive Sourcebook of Bacterial Protein Toxins, Elsevier, 631-642.

Popoff, M. Titball, R.W. Cole, A. (2006). Clostridium perfringens ε-toxin. In Joseph JE, Michel M, Popoff (Eds.) The Comprehensive Sourcebook of Bacterial Protein Toxins, London: , 631-642.

Duffield, M. (2006). Comparative genomics – what do such studies tell us about the emergence and spread of. key pathogens. In Logan NA, Lappin-Scott HM, Oyston PCF (Eds.) Prokaryotic diversity: mechanisms and significance, Cambridge University Press, 175-186.

Basak, A.K. (2006). Membrane damaging and cytotoxic phospholipases. In Joseph JE, Michel M, Popopoff (Eds.) The Comprehensive Sourcebook of Bacterial Protein Toxins, London: Academic Press, 516-534.

Simpson, A.J. Titball, R.W. (2006). Plague. In Plotkin SA, Orenstein WA (Eds.) Vaccines 5th edn, Philadelphia: , 999-1010.

Michell SL, Griffin, K.F. Titball, R.W. (2006). Tularemia Pathogenesis and Immunity. In Friedman H, Anderson B (Eds.) Microbial Infection and Bioterrorism, Kluwer Academic Publishers, 121-138.

Forsman, M. Oyston, P. Titball, R. (2005). Genomics for Biodefence: Exploiting the Francisella tularensis genome sequence. In Lindler L, Lebeda F, Korch GW (Eds.) Biological Weapons Defense. Infectious Diseases and Counterbioterrorism, Totowa, USA: Humana Press Inc, 435-452.

Andersson SGE, Forsman M, Oyston PCF, Titball RW (2005). Genomics for Biodefense. In (Ed) Biological Weapons Defense, Springer Nature, 435-452.

Titball, R.W. (2005). Membrane active toxins. In Duerre P (Ed) Handbook on Clostridia, Boca Raton: Taylor & Francis, 451-490.

Krieg, A. Titball, R.W. (2005). Non-specific Immunomodulator Therapy; CpG. In Lindler L, Lebeda F, Korch GW (Eds.) Biological Weapons Defense. Infectious Diseases and Counterbioterrorism, Totowa, USA: Humana Press Inc, 317-331.

Oyston, P.C.F. (2005). Plague. In Lutwick LI, Lutwick SM (Eds.) Bioterror: the Weaponization of Infectious Diseases, New Jersey:.

Titball RW, Rood JI (2002). 89 Clostridium perfringens Wound Infections. In (Ed) Molecular Medical Microbiology, Elsevier, 1875-xii.

Titball RW (1997). Chapter 14 Clostridial Phospholipases. In (Ed) The Clostridia, Elsevier, 223-242.

Leary SEC, Titball RW (1997). Chapter 15 the Clostridium perfringens β-toxin. In (Ed) The Clostridia, Elsevier, 243-250.

Rood JI, McClane BA, Songer JG, Titball RW (1997). Preface. In (Ed) The Clostridia, Elsevier, xvii-xviii.

Titball RW, Yeoman H, Hunter SEC (1993). Gene Cloning and Organization of the Alpha-Toxin of Clostridium perfringens. In (Ed) Genetics and Molecular Biology of Anaerobic Bacteria, Springer Nature, 211-226.

RUBIDGE T, TITBALL RW, MARTIN KL (1989). THE CLONING OF TOXIN AND OTHER CLOSTRIDIAL GENES. In (Ed) Natural Toxins, Elsevier, 110-120.

Conferences

Morcrette H, Lewis N, Popoff M, Everett R, Palace J, Titball R (2020). Evidence of clostridium perfringens epsilon toxin involvement in neuromyelitis optica. Author URL.

Savva CG, Clark AR, Naylor CE, Popoff MR, Moss DS, Basak AK, Titball RW, Bokori-Brown M (2019). The pore structure of Clostridium perfringens epsilon toxin. European Workshop on Bacterial Protein Toxin – ETOX19. 22nd - 26th Jun 2019. Abstract.

Adler D, Linden J, Ma Y, Shetty S, Bokori-Brown M, Titball R, Fetcho J, Vartanian T (2018). Clostridium perfringens induced blood-brain barrier permeability: specificity and temporal dynamics in a humanized zebrafish model. Author URL.

Raciborska D, Turner B, Titball R, Bokori-Brown M, Wagley S, Gnanapavan S, Lewis N (2017). Epsilon toxin as a causative agent in MS. Author URL.

Gourlay LJ, Lassaux P, Thomas RJ, Peri C, Conchillo-Sole O, Nithichanon A, Ferrer-Navarro M, Vila J, Daura X, Lertmemongkolchai G, et al (2015). Flagellar subunits as targets for structure-based epitope discovery approaches and melioidosis vaccine development. Author URL.

Campbell AS, Christ WJ, Lohmanb G, Guo Y, Jones M, Scott AE, George AJ, Titball RW, Atkins TP, Prior JL, et al (2014). De novo synthesis, conjugation, and immnunogenicity of the Burkholderia pseudomallei manno-heptose capsule. Author URL.

Sundaresh S, Randall A, Unal B, Petersen JM, Belisle JT, Hartley MG, Duffield M, Titball RW, Davies DH, Felgner PL, et al (2007). From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis. Abstract. Author URL.

Vachieri S, Clarke G, Moss DS, Titball RW, Basak A (2005). Structures of C.perfringens α-toxin mutant, T74I, that Affects its Activity. Author URL.

Stabler RA, Hinds J, Witney AA, Isherwood K, Oyston P, Titball R, Wren B, Hinchliffe S, Prentice M, Mangan JA, et al (2003). Construction of a Yersinia pestis microarray. Author URL.

Oyston PCF, Karlyshev AV, Wren BW, Titball RW (2003). Signature-tagged mutagenesis of Yersinia pestis. Author URL.

Titball RW, Hill J, Lawton DG, Brown KA (2003). Yersinia pestis and plague. Abstract. Author URL.

Briggs DC, Clark G, Nakamura S, Titball RW, Basak AK (2002). STRUCTURE OF CLOSTRIDIUM ABSONUM PHOSPHOLIPASE C AT 2.5Å. Author URL.

Hinchliffe SJ, Isherwood KE, Stabler RA, Oyston PCF, Hinds J, Titbal RW, Wren BW (2002). Separated at birth? Microarray analysis of two strikingly similar yersinia species. Author URL.

Prior RG, Klasson L, Larsson P, Williams K, Lindler L, Sjöstedt A, Svensson T, Tamas I, Wren BW, Oyston PC, et al (2001). Preliminary analysis and annotation of the partial genome sequence of Francisella tularensis strain Schu 4. Author URL.

Russell P, Eley SM, Ellis J, Green M, Bell DL, Kenny DJ, Titball RW (2000). Comparison of efficacy of ciprofloxacin and doxycycline against experimental melioidosis and glanders. Abstract. Author URL.

Titball RW, Naylor CE, Miller J, Moss DS, Basak AK (2000). Opening of the active site of Clostridium perfringens alpha-toxin may be triggered by membrane binding. Abstract. Author URL.

Naylor CE, Eaton JT, Justin N, Moss D, Basak AK, Howells A, Titball R (1999). THE STRUCTURE OF CLOSTRIDIUM PERFRINGENS ALPHA-TOXIN: a GANGRENEOUS TALE. Author URL.

Payne D, Diane Williamson E, Titball RW (1997). The clostridium perfringens epsilon-toxin. Abstract.

Basa AK, Eaton JT, Moss DS, Titball RW (1996). CRYSTALLOGRAPHIC STUDIES OF ALPHA-TOXIN (PHOSPHOLIPASE C) FROM CLOSTRIDIUM PERFRINGENS. Author URL.

Fulop M, Manchee R, Titball R (1996). Role of two outer membrane antigens in the induction of protective immunity against Francisella tularensis strains of different virulence. Abstract. Author URL.

Leary SE, Eley SM, Williamson ED, Titball RW (1995). Expression of Yersinia pestis V antigen in attenuated salmonella typhimurium: development of a novel vaccine for plague. Author URL.

YEOMAN HL, MOIR A, TITBALL RW (1994). ANALYSIS OF GENE-EXPRESSION IN HIGH AND LOW ALPHA-TOXIN PRODUCING STRAINS OF CLOSTRIDIUM-PERFRINGENS. Author URL.

TITBALL RW, NIKURAKANEKO T, STUART DI, KELLY DC, BISHOP DL, BASAK A (1994). CRYSTALLIZATION AND STRUCTURAL-ANALYSIS OF THE ALPHA-TOXIN (PHOSPHOLIPASE-C) FROM CLOSTRIDIUM-PERFRINGENS. Author URL.

HUNTER SEC, SAKURAI J, BROWN JE, TITBALL RW (1994). GENETIC-ANALYSIS OF THE BETA-TOXIN OF CLOSTRIDIUM-PERFRINGENS REVEALS HOMOLOGY WITH THE ALPHA-TOXIN, GAMMA-TOXIN AND LEUKOCIDIN OF STAPHYLOCOCCUS-AUREUS. Author URL.

COULSON NM, TITBALL RW (1993). EXPRESSION OF BACILLUS-ANTHRACIS PROTECTIVE ANTIGEN IN SALMONELLA-TYPHIMURIUM. Author URL.

HUNTER SEC, TITBALL RW (1993). MOLECULAR-CLONING OF CLOSTRIDIUM-PERFRINGENS EPSILON-TOXIN. Author URL.

TITBALL RW (1992). MOLECULAR ASPECTS OF CLOSTRIDIUM-PERFRINGENS TOXIN. Author URL.

External Engagement and Impact

Awards/Honorary fellowships

1979 University of Plymouth Biological Sciences prize.

2005 Society for General Microbiology Colworth Prize Lectureship

2005-2009 Faculty of 1000 Medicine

Committee/panel activities

1994 Defence Scientific Advisory Council ( DSAC ) working group on Genetic Weapons
1996 Defence Scientific Advisory Council ( DSAC ) working group on the threat potential of genetic engineering technologies
1997 Defence Scientific Advisory Council ( DSAC ) working group on Biotechnology
1998 Defence Scientific Advisory Council ( DSAC ) working group on Vaccines
2000 NIH Grant Review Committee for research proposals on bioterrorism defence. Jan 2000.
2001 Steering Committee of the EU concerted action QLK2-CT2001-01267 on genus Clostridium.
2002 NIH Grant Review Committee for research proposals on bioterrorism defence. Jun 12-14th 2002.
2002 Defence Scientific Advisory Council (DSAC) working group on alternatives to vaccines as medical countermeasures and military protection
2002 Chairperson, National Institute of Allergy and Infectious Disease, Special Emphasis panel, Chairperson, Dec 2nd 2002.
2000 NIH Grant Review Committee for research proposals on bioterrorism defence. May 13th 2002.
2003 NiH Grant Review Committee for research proposals on bioterrorism defence. Jul 21st 2003.
2003 World Health Organisation Improving Public Health preparedness for and response to the threat of epidemics;tularaemia network. 14-15th September 2003, Bath UK.
2004 NiH Grant Review Committee for research proposals on bioterrorism defence. Feb 12th 2004.
2004 Chairperson, NiH Grant Review Committee for research proposals on bioterrorism defence. Feb 12th 2004.
2004 NiH Grant Review Committee for research proposals for ethnic minorities. June 29th 2004.
2007 Chairperson, NiH Grant Review Committee for research proposals on bioterrorism defence. Apr 4h 2007.
2007 Organiser of the European Science Foundation / European Medical Research Councils Exploratory Workshop on Clostridium perfringens induced disease in domestic animals: learning from human medical science and biotechnology for understanding animal disease, Ghent, Belgium, 23-24th October 2007.
2007 UK Clinical Research Collaboration Strategic Planning Group on Microbiology and Infectious Diseases Research.
2008 Chairperson, NiH Special Emphasis Panel Grant Review Committee. Apr 9th 2008.
2008 Member of the Society for General Microbiology Review of DEFRA Bovine Tuberculosis Research in the United Kingdom.
2009 Member of the Government Office of Science, Chemical, Biological, Radiological and Nuclear Research and Development Expert Review Panel.
2010 US Department of Homeland Security, Science and Technology Directorate (DHS S&T) Stakeholder Panel for Agent Detection Assays (SPADA), Burkholderia Working Group.
2010 Academic Expert at Dstl Chemical and Biological (CB) attribution workshop. Royal School of Artillery, Larkhill, 21st Oct 2010.
2011 Panel member; NiH Special Emphasis Panel for “Host-pathogen” interactions. 24th March 2011.
2012 BBSRC-DSTL-EPSRC-MRC Joint Synthetic Biology Initiative Panel meeting. 8-9th Feb 2012
2013 Panel member; National Institute of Allergy and Infectious Disease. Special Emphasis Panel "OMICS" Technologies for Predictive Modeling of Infectious Diseases (U19)" 25th – 27th Feb 2012. Washington, USA
2015 Panel Member. Wellcome Trust Pathogen Biology and Disease Transmission Expert Review Group. 20th Jan 2015.
2015 Medical Research Council. Cross council Antimicrobial Resistance Theme 2 expert panel; Accelerating therapeutic and diagnostics development. Sep 8th-9th 2015.
2017 Panel member; National Institute of Allergy and Infectious Disease. "Systems Biology: The Next Generation for Infections Diseases (U19)" 19th – 20th July 2017. Washington, USA.

Editorial responsibilities

Editorial Board, Animal Health Research Reviews; 1999 to present
Senior Editor, Journal of Medical Microbiology, 2007 to 2014
Council of 100, Vaccine; 2010 to 2014
Associate Editor, Vaccine; 2015 to 2017
Editorial Board, npj Vaccines; 2016 -
Associate Editor, npj Vaccines. 2018 to 2021
Deputy Editor in Chief, npj Vaccines. 2021 –

Invited lectures

Invited conference presentations

1990 Summer Symposium of the Society for Applied Bacteriology, Leeds, UK.

1991 7th Biennial International Symposium of the Society for Anaerobic Microbiology, 18-20th, July 1991, Cambridge, UK.

1994 94th General Meeting of the American Society for Microbiology, Las Vegas, USA. 23-27th May 1994.

1995 1st ASM International meeting on the Molecular Genetics and Pathogenesis of the Clostridia, Jan 11-14th 1995, Rio Rico, Arizona,USA.

1995 5th Parma Annual Meeting of Microbiology, Parma, Italy, October 9th 1995,

1997 Crystal structure of C. perfringens alpha-toxin. 2nd International meeting on the Molecular Genetics and Pathogenesis of the Clostridia, Seillac, France, 22nd-25th June, 1997.

1997 10th International Symposium of the Society for Anaerobic Microbiology, Cambridge, UK, 9th-11th July 1997.

1997 Summer Conference of the Society for Applied Microbiology, Norwich UK, 14th-17th July 1997.

1998 Molecular architecture of C. perfringens alpha-toxin. Presented at 2nd International Congress on Anaerobic Bacteria, Nice, France, 3rd-6th October, 1998.

1998 6th Annual Congress of the British Society for Immunology, Harrogate UK, 1st-4th Dec 1998.

1999 9th European Workshop on Bacterial Protein Toxins, Nice France, 27th June-2nd July 1999.

1999 179th Meeting of the Pathological Society of Great Britain and Ireland, Dundee UK, 7-9th July 1999.

2000 Yakult International Conference, Microbial Characterisation, Diversity and Function through Genome and Proteome Analysis. CPHL London 17th-18th April 2000.

2000 3rd International meeting on the Molecular Genetics and Pathogenesis of the Clostridia, 8th-11th June, Tokyo, Japan.

2000 Tularemia vaccines. 3rd International Conference on Tularemia. 27-30th August 2000, Umea, Sweden

2001 Recombinant plague vaccine. 7th International Symposium on Protection against CBW agents, 15th-19th June 2001, Stockholm, Sweden.

2002 25th January 2002. Genus Clostridium: an introduction. Molecular Genetics, classification, pathology and ecology of the genus Clostridium. First meeting of the EU concerted action on genus Clostridium, 25th – 26th January 2002, Liege, Belgium.

2002 27th June 2002. Overview of the pathogenesis of plague. Mathematics in Medicine Initiative workshop on bubonic plague. University of Warwick, 27th June 2002.

2002 5th Sep 2002. Yersinia pestis and plague. Signalling the Future. University of Liverpool 4th-6th Sep 2002.

2002 7th Sep 2002. 2nd and 3rd Generation Plague Vaccines. 8th International meeting on the Yersinia. Turku, Finland, 5th-8th Sep 2002.

2003 4th April 2003. Specific Biological Agents (categories A &B). Bioterrorism; the current threat. Joint New York Academy of Sciences and The Royal Society of Medicine meeting. London 3rd - 4th April 2003.

2003 5th December 2003. Prediction of vaccine antigens from genome sequences. British Society for Immunology, Annual Congress. Harrogate, UK. 2nd 5th December

2004 2nd December 2004. Francisella tularensis. 6th European Congress of Chemotherapy and Infection. Dec 1-3rd 2004, Paris, France.

2005 27th May 2004. Membrane binding may trigger the opening of the active site of the Clostridium perfringens phospholipase C α-toxin. Presented at the 104th meeting of the American Society for Microbiology, New Orleans, May 23rd-27th 2004 New Orleans, USA.

2005 Gas gangrene and open and closed case. Presented at 156th Meeting of the Society for General Microbiology. 4-7th April, Edinburgh, UK.

2006 Bioterrorism Vaccines. Presented at the 2006 Winter Meeting of the Society for Applied Microbiology. 6th January, London, UK.

2006 Comparative genomics - what do such studies tell us about the emergence and spread of key pathogens ? 158th meeting of the Society for General Microbiology, University of Warwick, 3-6th April 2006.

2006 Titball,R.W. Vaccines against Clostridium perfringens α-toxin. Presented at the 5th International Meeting on the Molecular Biology and Pathogenesis of the Clostridia. Nottingham, 21st-25th June 2006.

2006 Identification of immunogenic proteins of F. tularensis using a proteome chip. presented at the 5th International Conference on Tularemia, Woods Hole, USA. Nov 1-4th 2006

2007 Clostridium perfringens toxins and virulence factors. Presented at the European Science Foundation / European Medical Research Councils Exploratory Workshop on Clostridium perfringens induced disease in domestic animals: learning from human medical science and biotechnology for understanding animal disease, Ghent, Belgium, 23-24th October 2007.

2007 Animal models of melioidosis. Presented at the 5th World Melioidosis Congress, Khon Kaen, Thailand, 21st-23rd Nov 2007.

2008 Vaccines against intracellular pathogens. Presented at The Society for Medicines Research meeting on Biotherapeutics. 6th March 2008, NHLI, London

2008 Burkholderia pseudomallei. Presented at the Bristol Microbiology Forum on Host-Pathogen Interactions. 16th Sep 2008, Bristol

2009 Gas gangrene. Presented at the Society for General Microbiology, spring meeting, 30th March - 2nd April 2009. Harrogate.

2009 Bacterial-mediated civilian and military threats. 3rd Annual Plymouth CBRN symposium 2009. 27th November 2009, Derriford Hospital Plymouth.

2009 Signalling pathways activated by Clostridium perfringens alpha-toxin. Presented at the 17th meeting of the French Society of Toxinology. Paris, 2nd-3rd Dec 2009.

2010 Zoonotic pathogens and biological weapons. Presented at the Royal Society of Medicine meeting “Zoonoses from Wildlife to Warfare”. London, 2nd Feb 2010.

2010 A vaccine for melioidosis. Presented at “Controlling Infectious Disease in the 21st Century”. Galveston, USA 26th-28th Feb 2010.

2010 “A vaccine for Melioidosis”. Presented at ”An integrated approach to research in infectious diseases” University of Birmingham, 15th April 2010.

2010 “Melioidosis vaccines; will they work and who will use them ?” Presented at ”VIth World Melioidosis Congress”. Townsville, Australia 30th Nov- 3rd Dec 2010.

2010 “Persister Cells and Persistent Melioidosis”. Presented at ”CMDL Symposium: High Throughput Approaches in Infection and Immunity. Hua Hin, Thailand, 7-8th Dec 2010.

2010 “Old and new toxins from Clostridium perfringens” Presented at ClostNet, The Conference. Nottingham 15th-16th Dec 2010.

2011 “Clostridium perfringens: new toxins from an old pathogen”. Presented at the Society for General Microbiology Autumn Conference, York 5-7th Sep 2011.

2011 “Bug manipulation –getting the worst out of your work”. 5th Annual Plymouth CBRN symposium 2011. 25th November 2011, Derriford Hospital Plymouth.

2012 Titball, RW. "An update on vaccine options”. Presented at the European Melioidosis Network meeting, 24 February 2012, Amsterdam.

2012 “Old and New Toxins from Clostridium perfringens”. Presented at the All Wales and South West Microbiology forum, 13th-14th Sep 2012, Swansea.

2012 “Multicomponent Melioidosis Vaccines”. Centre for Research and Development of Medical Diagnostic Laboratories 2012 Conference: From Genomics to Vaccine Development Research. 25-27th October 2012 Khon Kaen, Thailand.

2012 “Vaccines against chronic melioidosis”. Presented at the US FDA Public Workshop on Burkholderia 29th-30th Nov 2012, Washington, USA.

2013 “Nanoparticle vaccines for melioidosis and glanders”. Presented at the 11th American Society for Microbiology Biodefense and Emerging Disease Research Meeting. 25th – 27th Feb 2013, Washington, USA.

2013 “A Burkholderia pseudomallei toxin deamidates eIF4A”. Presented at the Society for General Microbiology Autumn Conference, Brighton, 2-4th Sep 2013.

2014 “Alternative models for the assessment of virulence”. Presented at the Society for Applied Microbiology / Med-Vet-Net Association Summer Conference. Brighton. 30th June-3rd July 2014.

2014 “Non-inherited antibiotic resistance” Presented at the Microbiology and Infectious Disease Congress. London 29-30th September 2014.

2015 “Vaccines against melioidosis" Presented at the Learning from each other- improving the clinical management and prevention of melioidosis and tuberculosis in the UK and South East Asia. Khon Kaen. 6th -9th January 2015.

2016 “Melioidosis Vaccine: how far are we?” Presented at the Melioidosis Research Coordination Network. Bangkok, 23rd- 25th February 2016.

2016 “Update on Melioidosis Vaccines”. Presented at the Newton Fund Institutional links Meeting, Sidmouth 5-7th October 2016.

2016 “Galleria mellonella as a model for antimicrobial drug screening”. Presented at the 2nd World Congress and Exhibition on Antibiotiocs and Antibiotic Resistance. 13-15th October 2016, Manchester, UK.

2017 “Melioidosis Vaccines” Presented at Learning from each other: Updating the clinical management and prevention of melioidosis and tuberculosis in the UK and Thailand 20-21 February 2017, Bangkok, Thailand.

2018 “Galleria mellonella; a model host for infection studies, toxicity testing and drug development. Presented at NC3Rs 2019 Funding Highlight Notice Launch. 4th Sep 2018, London, UK

2019 “Livestock Vaccines. Leading or Lagging” Presented at BactiVac Network, 2nd Annual Network Meeting. 20-21st March 2019, Birmingham, UK

2019 “Epsilon Toxin”. Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. 16th May 2019

2019 “Alternative Infection Models”. Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. 17th Sep 2019

2019 “Q is for query, V is for vaccine”. Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. 18th Sep 2019

2019 “Epsilon Toxin, Mal and multiple sclerosis”. Faculty of Science, Mahidol University, Bangkok, Thailand. 19th Sep 2019

2019 “Q is for query, V is for vaccine”. Marshall Centre, University of Western Australia, Australia. 26th Sep 2019

2019 “Epsilon toxin, Mal and multiple sclerosis”. BacPath 15. Sep 30th - 3rd Oct 2019. Perth, Australia

2021 “Omics based study of Coxiella burnetii infection”. Galleria mellonella WORKSHOP on-line. 16-27th July 2021.

Media Coverage

UK Science Media Centre Expert

Workshops/Conferences organised

1994 Organising Committee of the 1st ASM International meeting on the Molecular Genetics and Pathogenesis of the Clostridia, Rio Rico, Arizona,USA, 1995.
1996 Organising Committee of the 2nd International meeting on the Molecular Genetics and Pathogenesis of the Clostridia, Seillac, France, 1997.
1998 Organising Committee of the 3rd International meeting on the Molecular Genetics and Pathogenesis of the Clostridia, Tokyo, Japan, 8th-11th June 2000.
1998 Organising Committee of the 1st European Conference on Dangerous Pathogens, Winchester, UK, 1999.
1999 Organising committee of the Third International Conference on Tularemia, Umea, Sweden, August 28th-30th 2000.
2000 Scientific Advisory Board – 8th International Congress on Yersinia, Finland September 4th–8th, 2002.
2001 Organising Committee of the 4th International meeting on the Molecular Genetics and Pathogenesis of the Clostridia, USA, 2003.
2001 Organising Committee for the 4th International Meeting on Tularemia, Bath, Sep 2003.
2004 Organising Committee of the 5th International meeting on the Molecular Genetics and Pathogenesis of the Clostridia, UK, 21st-25th June 2006.
2006 Organising Committee for the 5th International Meeting on Tularemia, Woods Hole, Nov 1-4th 2006.
2008 Organising Committee of the 6th International meeting on the Molecular Genetics and Pathogenesis of the Clostridia, Rome, Oct 19th-22nd, 2009.
2008 Organiser of Clostridium perfringens Epidemiology, Diagnosis, Control and Prevention, 1-4th December 2008, The Grand Hotel, Devon, UK.
2009 International Advisory Committee of the VIth World Melioidosis Congress,Townsville, Australia in 2010.
2009 Chairperson of the Organising Committee for the 2nd South West and South Wales Regional Microbiology Forum, Exeter, 24th Sep 2009.
2010 Organising Committee of “Controlling Infectious Disease in the 21st Century”. Galveston, USA 26th-28th Feb 2010.
2010 Organizing committee, 7th International meeting on the Molecular Genetics and Pathogenesis of the Clostridia, Ames, IA October 25-29, 2011
2013 Scientific Committee and International Advisory Committe of the VIIth World Melioidosis Congress, Bangkok, Thailand, 2013.
2015 Scientific Committee 1st International Conference on Necrotic Enteritis in Poultry, Copenhagen, Denmark, 10-12th June 2015
2015 European Melioidosis Congress Committee. 26-27th March 2015, Cambridge UK
2017 Organising Committee 11th Vaccine Congress, 17th-20th Sep 2017. San Diego USA.