Overview
Dr Seána Duggan is an independent Early Career Fellow at the MRC Centre for Medical Mycology. Her research investigates fungal - bacterial co-infections.
Qualifications
Dr. rer. nat. Microbiology Hans-Knöll Institute for Infection Biology and Natural Product Research and Friedrich Schiller University Jena, Germany
MSc (Res), TU Dublin, Ireland
BSc (Hons) Bioanalytical Science, TU Dublin, Ireland
Career
Post-doctoral Research Associate, University of Bristol
Links
Research group links
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Research
Research interests
Co-infections caused by Candida albicans and Staphylococcus aureus result in worse disease compared to mono-infections due to the synergistic interaction between C. albicans and S. aureus. Seána’s fellowship aims to define drivers of this synergy with a view to mitigation. She interrogates fungal-bacterial-human cell cultures with omics coupled with phenotypic and infection assays.
Research projects
- Fungal - Bacterial Biofilms
- Co-infection Biology
- Candida albicans - Staphylococcus aureus interactions
- Candida parapsilosis - Staphylococcus aureus interactions
- Social Justice of Infections
Research networks
GW4 AMR Alliance
Microbes & Society
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Publications
Journal articles
Duggan S, Usher J (2023). Candida glabrata: a powerhouse of resistance.
PLoS Pathog,
19(10).
Author URL.
Douglas EJA, Marshall B, Alghamadi A, Joseph EA, Duggan S, Vittorio S, De Luca L, Serpi M, Laabei M (2023). Improved Antibacterial Activity of 1,3,4-Oxadiazole-Based Compounds That Restrict Staphylococcus aureus Growth Independent of LtaS Function.
ACS Infect Dis,
9(11), 2141-2159.
Abstract.
Author URL.
Laabei M, Duggan S (2022). CidA and LrgA: a "Hole" Lot More than Programmed Cell Death.
mBio,
13(3).
Abstract.
Author URL.
Stevens EJ, Morse DJ, Bonini D, Duggan S, Brignoli T, Recker M, Lees JA, Croucher NJ, Bentley S, Wilson DJ, et al (2022). Targeted control of pneumolysin production by a mobile genetic element in Streptococcus pneumoniae.
Microb Genom,
8(4).
Abstract.
Author URL.
Brignoli T, Douglas E, Duggan S, Fagunloye OG, Adhikari R, Aman MJ, Massey RC (2022). Wall Teichoic Acids Facilitate the Release of Toxins from the Surface of Staphylococcus aureus.
Microbiology Spectrum,
10(4).
Abstract.
Douglas EJA, Duggan S, Brignoli T, Massey RC (2021). The MpsB protein contributes to both the toxicity and immune evasion capacity of <i>Staphylococcus aureus</i>.
MICROBIOLOGY-SGM,
167(10).
Author URL.
Duggan S, Laabei M, Alnahari AA, O'Brien EC, Lacey KA, Bacon L, Heesom K, Fu C-L, Otto M, Skaar E, et al (2020). A Small Membrane Stabilizing Protein Critical to the Pathogenicity of <i>Staphylococcus aureus</i>.
INFECTION AND IMMUNITY,
88(9).
Author URL.
Linde J, Duggan S, Weber M, Horn F, Sieber P, Hellwig D, Riege K, Marz M, Martin R, Guthke R, et al (2015). Defining the transcriptomic landscape of <i>Candida glabrata</i> by RNA-Seq.
NUCLEIC ACIDS RESEARCH,
43(3), 1392-1406.
Author URL.
Duggan S, Leonhardt I, Huenniger K, Kurzai O (2015). Host response to <i>Candida albicans</i> bloodstream infection and sepsis.
VIRULENCE,
6(4), 316-326.
Author URL.
Duggan S, Essig F, Huenniger K, Mokhtari Z, Bauer L, Lehnert T, Brandes S, Haeder A, Jacobsen ID, Martin R, et al (2015). Neutrophil activation by <i>Candida glabrata</i> but not <i>Candida albicans</i> promotes fungal uptake by monocytes.
CELLULAR MICROBIOLOGY,
17(9), 1259-1276.
Author URL.
Conferences
Herzog S, Aly M, Duggan S, Linde J, Martin R, Kurzai O (2015). A network of heat shock-associated genes is up-regulated during the interaction of <i>Candida glabrata</i> with human neutrophils.
Author URL.
Huenniger K, Essig F, Duggan S, Mokhtari Z, Brandes S, Figge MT, Kurzai O (2015). Human neutrophils act differentially on the human fungal pathogens <i>Candida albicans</i> and <i>Candida glabrata</i>.
Author URL.
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Supervision / Group
Postgraduate researchers
- Grace Paul :"Delineating how Candida albicans worsens Staphylococcus aureus lung epithelium infection"
Alumni
- Maitry Gheewala
- Daniel Pain
- Orlando Ross
- Jess Swan
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