Description

Frontiers in Molecular Cell Biology

Description - summary of the module content

Module description

Science textbooks can sometimes give the impression that we know all there is to know. In Frontiers in Molecular Cell Biology, you will move away from this idea and examine how and why scientific research in molecular cell biology is carried out. You will study four fast-moving areas and ask such questions as: How do cells carry out fundamental processes such as cell motility and cell communication? What is their relevance to medicine, engineering or agriculture? How and why are discoveries linked to advances in scientific techniques? Other than introductory and summary lectures for each area, learning is based on student-led analysis of recently published papers in seminars of no more than ~36 students. You will use your presentation skills to present one research paper to the group for discussion. You will learn how to analyse and present a research paper in one of the first sessions, and you each have the opportunity for a tutorial on your paper where feedback can be given before you present to the group.

Module aims - intentions of the module

The module focuses on modern topics in molecular cell biology and aims to reinforce the analytical and presentation skills that you have learned earlier in your degree by applying them to real-world scientific problems. The module will make use of primary research papers and address the latest developments in this exciting field. One aim of the module is to understand the basic principles of cell function that overarch all life with examples drawn from kingdoms of eukaryotic life and bacteria. In addition, you will gain an understanding of the medical relevance of some cellular processes such as nuclear organisation, function and morphogenesis of cilia, pili and archaella, and bacterial environmental sensing and chemotaxis.

Intended Learning Outcomes (ILOs)

ILO: Module-specific skills

On successfully completing the module you will be able to...

• 1. Describe in detail and analyse the spatial organisation of cells
• 2. Critically evaluate the molecular basis of cell motility
• 3. Illustrate the complexity of molecular processes in living cells
• 4. Discuss the dynamic behaviour of living cells
• 5. Explain the molecular basis of some human disorders

ILO: Discipline-specific skills

On successfully completing the module you will be able to...

• 6. Evaluate in detail approaches to our understanding of molecular cell biology with reference to primary literature, reviews and research articles
• 7. Analyse in detail essential facts and theory in a subdiscipline of the biosciences
• 8. Analyse and evaluate independently a range of research-informed literature and synthesise research-informed examples from the literature into written work

ILO: Personal and key skills

On successfully completing the module you will be able to...

• 9. Communicate effectively arguments, evidence and conclusions using written and oral means in a manner appropriate to the intended audience
• 10. Devise and sustain, with little guidance, a logical and reasoned argument with sound, convincing conclusions
• 11. Analyse and evaluate appropriate data with very limited guidance

Syllabus plan

Syllabus plan

Overall, the module will provide insight into modern and competitive research areas in Molecular Cell Biology. The first lecture gives you an overview of the four subjects to be studied, and provides details of the research papers associated with each subject that will be analysed over the next few weeks. We then move on to each subject in turn: there will be a one hour introductory lecture, and then two student presentations per session followed by time for discussion. For the student-led journal clubs you will individually analyse, evaluate and present a primary publication journal article to the class. The presentation will be followed by questions and discussion involving the whole class. Articles will be chosen by the lecturers. You will have two weeks to research and prepare your journal club, during which time you will meet and receive guidance from one of the lecturers associated with the module. In the journal clubs you will be expected to contribute to discussion following the presentations. Your participation via asking relevant questions and contributing towards class understanding of issues raised by others will contribute up to 5% of the available marks for this module. You will also learn how to extract the most important pieces of information from a research article and summarise them in the form of a scientific abstract.

Learning and teaching

Learning activities and teaching methods (given in hours of study time)

Details of learning activities and teaching methods

Assessment

Formative assessment

Summative assessment (% of credit)

Details of summative assessment

Re-assessment

Details of re-assessment (where required by referral or deferral)

Re-assessment notes

Deferral – if you miss an assessment for certificated reasons judged acceptable by the Mitigation Committee, you will normally be either deferred in the assessment or an extension may be granted. The discussion assessment is not deferrable because of its practical nature. The mark given for a re-assessment taken as a result of deferral will not be capped and will be treated as it would be if it were your first attempt at the assessment.

Referral – if you have failed the module overall (i.e. a final overall module mark of less than 50%) you will be required to sit a further examination. The mark given for a re-assessment taken as a result of referral will count for 100% of the final mark and will be capped at 50%.

Resources

Indicative learning resources - Basic reading

• Selected chapters in: Alberts B, Johnson A, Lewis J, Raff M, Roberts K and Walter P (2007) Molecular Biology of the Cell (5th ed.) Garland Science

Module has an active ELE page

Indicative learning resources - Other resources

• Primary research publications and review articles.

Key words search

Biology, cell biology, microscopy, bacteria, cell polarity, cell signalling, cilia, transport