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Dr Alexis Perry

Dr Alexis Perry

Lecturer in Organic Chemistry

 3450

 +44 (0) 1392 723450

 Geoffrey Pope 225

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

My research career has involved the both the development of novel synthetic methodologies and the application of organic synthesis in diverse and inspiring research fields – from molecular electronics and graphene derivatisation through to stem cell research and modulation of mitochondrial behaviour. My current research interests include the design and synthesis of novel hydrogen sulphide donors (in collaboration with Dr. Mark Wood (Biosciences, Exeter) and Dr. Matt Whiteman (Medical School, Exeter)) and the development of graphene-based sensors for biologically important targets (in collaboration with Dr. Dave Horsell and Dr. Steve Green (both Physics, Exeter).   

Qualifications

MSci Chemistry with Medicinal Chemistry (University of Glasgow, 2001),
PhD (University of Leeds, 2005)

Career

Post-doctoral research:

  • 2005-2006, University of Sydney;
  • 2007-2009, University of York;
  • 2009-2014, University of Exeter.

Research group links

Research

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Curnow A, Anayo L, Magnussen A, Perry A, Wood M (In Press). AN EXPERIMENTAL INVESTIGATION OF a NOVEL IRON CHELATING PROTOPORPHYRIN IX PRODRUG FOR THE ENHANCEMENT OF PHOTODYNAMIC THERAPY. Lasers in Surgery and Medicine Full text.
Gerő D, Torregrossa R, Perry A, Waters A, Le-Trionnaire S, Whatmore JL, Wood M, Whiteman M (In Press). The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro. Pharmacol Res, 113(Pt A), 186-198. Abstract.  Author URL.  Full text.
Wood ME, Alexander BE, Coles SJ, Fox BC, Khan TF, Maliszewski J, Perry A, Pitak MB, Whiteman M (In Press). investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137. MedChemComm
Moreman J, Takesono A, Trznadel M, Winter MJ, Perry A, Wood ME, Rogers NJ, Kudoh T, Tyler CR (2018). Estrogenic Mechanisms and Cardiac Responses Following Early Life Exposure to Bisphenol a (BPA) and its Metabolite 4-Methyl-2,4-bis( p-hydroxyphenyl)pent-1-ene (MBP) in Zebrafish. Environ Sci Technol, 52(11), 6656-6665. Abstract.  Author URL.
Perry A, Davis K, West L (2018). Synthesis of stereochemically-biased spiropyrans by microwave-promoted, one-pot alkylation-condensation. Org Biomol Chem, 16(39), 7245-7254. Abstract.  Author URL.
Perry A, Kousseff CJ (2017). Synthesis and metal binding properties of N-alkylcarboxyspiropyrans. Beilstein Journal of Organic Chemistry, 13, 1542-1550. Abstract.
Perry A, Miles D (2016). An off-the-shelf sensor for colourimetric detection of sulfide. Tetrahedron Letters, 57(51), 5788-5793. Abstract.
Perry A, Green SJ, Horsell DW, Hornett SM, Wood ME (2015). A pyrene-appended spiropyran for selective photo-switchable binding of Zn(II): UV-visible and fluorescence spectroscopy studies of binding and non-covalent attachment to graphene, graphene oxide and carbon nanotubes. Tetrahedron Abstract.
Perry A, Green SJ, Horsell DW, Homett SM, Wood ME (2015). A pyrene-appended spiropyran for selective photo-switchable binding of Zn(II): UV-visible and fluorescence spectroscopy studies of binding and non-covalent attachment to graphene, graphene oxide and carbon nanotubes. TETRAHEDRON, 71(38), 6776-6783. Author URL.  Full text.
Tomasova L, Pavlovicova M, Malekova L, Misak A, Kristek F, Grman M, Cacanyiova S, Tomasek M, Tomaskova Z, Perry A, et al (2015). Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Ca<inf>v</inf>3 and RyR2 channels. Nitric Oxide - Biology and Chemistry, 46, 131-144. Abstract.
Tomasova L, Pavlovicova M, Malekova L, Misak A, Kristek F, Grman M, Cacanyiova S, Tomasek M, Tomaskova Z, Perry A, et al (2015). Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels. Nitric Oxide, 46, 131-144. Abstract.  Author URL.  Full text.
Whiteman M, Perry A, Zhou Z, Bucci M, Papapetropoulos A, Cirino G, Wood ME (2015). Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors. Handb Exp Pharmacol, 230, 337-363. Abstract.  Author URL.
Hurst TE, Gorman RM, Drouhin P, Perry A, Taylor RJK (2014). A direct C-H/Ar-H coupling approach to oxindoles, thio-oxindoles, 3,4-dihydro-1 H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines. Chemistry (Weinheim an der Bergstrasse, Germany), 20(43), 14063-14073. Abstract.
Hurst TE, Gorman RM, Drouhin P, Perry A, Taylor RJK (2014). A direct C-H/Ar-H coupling approach to oxindoles, thio-oxindoles, 3,4-dihydro-1 H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines. Chemistry, 20(43), 14063-14073. Abstract.  Author URL.
Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C (2014). AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide - Biology and Chemistry, 41, 120-130. Abstract.
Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C (2014). AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide, 41, 120-130. Abstract.  Author URL.  Full text.
Le Trionnaire S, Perry A, Szczesny B, Szabo C, Winyard PG, Whatmore JL, Wood ME, Whiteman M (2014). The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl) triphenylphosphonium bromide (AP39). MedChemComm, 5(6), 728-736. Abstract.  Full text.
Yong QC, Cheong JL, Hua F, Deng LW, Khoo YM, Lee HS, Perry A, Wood M, Whiteman M, Bian JS, et al (2012). Erratum: Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide (Antioxidants and Redox Signaling (2011) 14 (2081-2091)). Antioxidants and Redox Signaling, 16(7).
Yong Q-C, Cheong JL, Hua F, Deng L-W, Khoo YM, Lee H-S, Perry A, Wood M, Whiteman M, Bian J-S, et al (2011). Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide. Antioxid Redox Signal, 14(11), 2081-2091. Abstract.  Author URL.
Klein JEMN, Perry A, Pugh DS, Taylor RJK (2010). First C-H activation route to oxindoles using copper catalysis. Org Lett, 12(15), 3446-3449. Abstract.  Author URL.
Pugh DS, Klein JEMN, Perry A, Taylor RJK (2010). Preparation of 3-alkyl-oxindoles by copper(II)-mediated C-H, Ar-H coupling followed by decarboxyalkylation. Synlett(6), 934-938. Abstract.
Lubkoll J, Millemaggi A, Perry A, Taylor RJK (2010). Tandem Horner-Wadsworth-Emmons/Heck procedures for the preparation of 3-alkenyl-oxindoles: the synthesis of Semaxanib and GW441756. Tetrahedron, 66(33), 6606-6612. Abstract.
Nelson A, Bone H, Damiano M, Welham M, Bartlett S, Perry A, Cordier CJ, Warriner S, Leach SG, Morton D, et al (2009). Exploring biologically-relevant chemical space with macrocyclic ligands. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 238 Author URL.
Bone HK, Damiano T, Bartlett S, Perry A, Letchford J, Ripoll YS, Nelson AS, Welham MJ (2009). Involvement of GSK-3 in Regulation of Murine Embryonic Stem Cell Self-Renewal Revealed by a Series of Bisindolylmaleimides. Chemistry and Biology, 16(1), 15-27. Abstract.
Perry A, Taylor RJK (2009). Oxindole synthesis by direct C-H, Ar-H coupling. Chem Commun (Camb)(22), 3249-3251. Abstract.  Author URL.
Millemaggi A, Perry A, Whitwood AC, Taylor RJK (2009). Telescoped enolate arylation/HWE procedure for the preparation of 3-alkenyl-oxindoles: the first synthesis of soulieotine. European Journal of Organic Chemistry(18), 2947-2952. Abstract.
Edwards MG, Kenworthy MN, Kitson RRA, Perry A, Scott MS, Whitwood AC, Taylor RJK (2008). The preparation of α-alkylidene-γ-butyrolactones using a telescoped intramolecular Michael/Olefination (TIMO) sequence: Synthesis of (+)-paeonilactone B. European Journal of Organic Chemistry(28), 4769-4783. Abstract.
Hodgson R, Kennedy A, Nelson A, Perry A (2007). Synthesis of 3-sulfonyloxypyridines: Oxidative ring expansion of alpha-furylsulfonamides and N -> O sulfonyl transfer. SYNLETT(7), 1043-1046. Author URL.
Kennedy A, Nelson A, Perry A (2005). A general, two-directional approach to aza-C-(1 → 1)-linked disaccharide mimetics. Chemical Communications(12), 1646-1648. Abstract.
Kennedy A, Nelson A, Perry A (2005). Methods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: Exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives. Beilstein Journal of Organic Chemistry, 1 Abstract.
Kennedy A, Nelson A, Perry A (2004). Highly diastereoselective addition of ketone enolates to N-sulfinyl imines: Asymmetric synthesis of syn- and anti-1,3-amino alcohol derivatives. Synlett(6), 967-970. Abstract.
Armstrong SK, Cross RJ, Farrugia LJ, Nichols DA, Perry A (2002). Semi-rigid bis-phosphane ligands for metallamacrocycle formation. European Journal of Inorganic Chemistry(1), 141-151. Abstract.

Chapters

McAllister GD, Perry A, Taylor RJK (2008). Diaziridines and diazirines. In  (Ed) Comprehensive Heterocyclic Chemistry III, 539-557.

Conferences

Waters A, Torregrossa R, Gero D, Perry A, Wood ME, Whiteman M (2017). RT01, a Novel Derivative of the Mitochondria-targeted Hydrogen Sulfide Donor AP39, Reversed Hyperglycaemia-induced Mitochondrial Dysfunction in Murine Brain Microvascular Endothelial Cells.  Author URL.
Alexander BE, Coles SJ, Khan TF, Maliszewsi J, Perry A, Pitak MP, Whiteman M, Wood ME (2015). Investigating the generation of hydrogen sulphide from the phosphinodithioate slow-release donor GYY4137: Novel products and experimental tools.  Author URL.
Tomasova L, Misak A, Kristek F, Perry A, Wood ME, Ondrias K, Whiteman M (2014). Effects of a Novel Triphenylphosphonium Derivatised Anethole Dithiolethione Hydrogen Sulfide (H2S) Donor, AP39, on Cardiac Ion Channels and on Haemodynamic Parameters in Normotensive and Hypertensive Rats in Vivo.  Author URL.
Whiteman M, Perry A, Wood ME (2014). H2S in inflammation: Time for resolution?.  Author URL.
Gero D, Szczesny B, Modis K, Yanagi K, Wood ME, Perry A, Szabo C, Whiteman M (2014). Mitochondira-targeted hydrogen sulfide donors AP39 and AP123 attenuate hyperglycaemia-induced oxidative stress and loss of bioenergetics in microvascular endothelial cells.  Author URL.
Gero D, Szczesny B, Perry A, Modis K, Wood ME, Szabo C, Whiteman M (2014). Novel Mitochondria-Targeted Hydrogen Sulfide (H2S) Donors AP39 and AP123 Attenuate Hyperglycaemia-Induced Oxidative Stress and Loss of Bioenergetics in Microvascular Endothelial Cells.  Author URL.
Ferguson D, Perry A, Wood ME, Winyard PG, Whiteman M (2014). Potentiation of Methyl Aminolevulinate (MAL)-Induced Photodynamic Therapy (PDT) Killing of Skin Cancer Cells by Mitochondria-Targeted Hydrogen Sulfide (H2S) Donors.  Author URL.
Le Trionnaire S, Perry A, Whatmore JL, Wood ME, Whiteman M (2013). Mitochondria-targeted hydrogen sulfide donors: a novel twist to an old "tail"?.  Author URL.
Whiteman M, Perry A, Le Trionnaire S, Whatmore JL, Ahmed T, Fox B, Kerr P, Haigh R, Winyard PG, Wood ME, et al (2013). Modulation of inflammatory and vascular signalling by novel slow release and mitochondria-targeted H2S donors.  Author URL.
Whatmore JL, Wolanska KI, Perry A, Wood ME, Whiteman M (2013). Slow release hydrogen sulfide (H2S) donors prevent hyperglycaemia-induced glycocalyx loss in retinal mirovascular endothelial cells.  Author URL.
Fox B, Perry A, Winyard P, Wood ME, Whiteman M (2012). Characterising the effect of novel slow-release H2S donors on pro-inflammatory enzyme activity in human cartilage cells.  Author URL.
Fox B, Holland T, Perry A, Wood ME, Whiteman M (2012). Characterising the effect of novel slow-release H2S donors on pro-inflammatory enzyme activity in human cartilage cells.  Author URL.
Fox B, Holland T, Perry A, Winyard PG, Wood ME, Whiteman M (2012). Defining the Effect of Novel Slow-Release H2S Donors on Pro-Inflammatory Mediators and Enzymes in Human Joint Cells.  Author URL.
Wolanska K, Perry A, Wood ME, Chibber R, Whatmore J, Whiteman M (2012). Hydrogen sulfide - a novel guardian of the endothelial glycocalyx?.  Author URL.
Le Trionnaire S, Perry A, Whatmore JL, Winyard PG, Wood ME, Whiteman M (2012). Mitochondria-Targeted Slow Release Hydrogen Donors: a Novel Link to an Old 'tail'?.  Author URL.
Le Trionnaire S, Whatmore J, Perry A, Wood ME, Matthew W (2012). Slow release H2S donors protect human microvascular endothelial cells from oxidative stress induced cell death: Markedly increased potency by mitochondria-targeting.  Author URL.
Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2012). Slow release H2S donors protect human microvascular endothelial cells from oxidative stress induced cell death: Markedly increased potency by mitochondria-targetting.  Author URL.
Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulfide (H2 S) and novel slow release H2S donors protect human endothelial cells from oxidative stress-induced cell death.  Author URL.
Le Trionnaire S, Whatmore J, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulphide (H2S) and novel slow release H2S donors protect human microvascular endothelial cells from oxidative stress-induced cell death.  Author URL.
Chopra M, Perry A, Hodgkinson A, Wood ME, Whiteman M (2010). Contrasting Effects of 'Fast' and 'Slow' Releasing H2S Donors on beta Cell Viability in the Diabetic Milieu.  Author URL.

Publications by year


In Press

Curnow A, Anayo L, Magnussen A, Perry A, Wood M (In Press). AN EXPERIMENTAL INVESTIGATION OF a NOVEL IRON CHELATING PROTOPORPHYRIN IX PRODRUG FOR THE ENHANCEMENT OF PHOTODYNAMIC THERAPY. Lasers in Surgery and Medicine Full text.
Gerő D, Torregrossa R, Perry A, Waters A, Le-Trionnaire S, Whatmore JL, Wood M, Whiteman M (In Press). The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro. Pharmacol Res, 113(Pt A), 186-198. Abstract.  Author URL.  Full text.
Wood ME, Alexander BE, Coles SJ, Fox BC, Khan TF, Maliszewski J, Perry A, Pitak MB, Whiteman M (In Press). investigating the generation of hydrogen sulfide from the phosphonamidodithioate slow-release donor GYY4137. MedChemComm

2018

Moreman J, Takesono A, Trznadel M, Winter MJ, Perry A, Wood ME, Rogers NJ, Kudoh T, Tyler CR (2018). Estrogenic Mechanisms and Cardiac Responses Following Early Life Exposure to Bisphenol a (BPA) and its Metabolite 4-Methyl-2,4-bis( p-hydroxyphenyl)pent-1-ene (MBP) in Zebrafish. Environ Sci Technol, 52(11), 6656-6665. Abstract.  Author URL.
Perry A, Davis K, West L (2018). Synthesis of stereochemically-biased spiropyrans by microwave-promoted, one-pot alkylation-condensation. Org Biomol Chem, 16(39), 7245-7254. Abstract.  Author URL.

2017

Waters A, Torregrossa R, Gero D, Perry A, Wood ME, Whiteman M (2017). RT01, a Novel Derivative of the Mitochondria-targeted Hydrogen Sulfide Donor AP39, Reversed Hyperglycaemia-induced Mitochondrial Dysfunction in Murine Brain Microvascular Endothelial Cells.  Author URL.
Perry A, Kousseff CJ (2017). Synthesis and metal binding properties of N-alkylcarboxyspiropyrans. Beilstein Journal of Organic Chemistry, 13, 1542-1550. Abstract.

2016

Perry A, Miles D (2016). An off-the-shelf sensor for colourimetric detection of sulfide. Tetrahedron Letters, 57(51), 5788-5793. Abstract.

2015

Perry A, Green SJ, Horsell DW, Hornett SM, Wood ME (2015). A pyrene-appended spiropyran for selective photo-switchable binding of Zn(II): UV-visible and fluorescence spectroscopy studies of binding and non-covalent attachment to graphene, graphene oxide and carbon nanotubes. Tetrahedron Abstract.
Perry A, Green SJ, Horsell DW, Homett SM, Wood ME (2015). A pyrene-appended spiropyran for selective photo-switchable binding of Zn(II): UV-visible and fluorescence spectroscopy studies of binding and non-covalent attachment to graphene, graphene oxide and carbon nanotubes. TETRAHEDRON, 71(38), 6776-6783. Author URL.  Full text.
Tomasova L, Pavlovicova M, Malekova L, Misak A, Kristek F, Grman M, Cacanyiova S, Tomasek M, Tomaskova Z, Perry A, et al (2015). Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Ca<inf>v</inf>3 and RyR2 channels. Nitric Oxide - Biology and Chemistry, 46, 131-144. Abstract.
Tomasova L, Pavlovicova M, Malekova L, Misak A, Kristek F, Grman M, Cacanyiova S, Tomasek M, Tomaskova Z, Perry A, et al (2015). Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels. Nitric Oxide, 46, 131-144. Abstract.  Author URL.  Full text.
Alexander BE, Coles SJ, Khan TF, Maliszewsi J, Perry A, Pitak MP, Whiteman M, Wood ME (2015). Investigating the generation of hydrogen sulphide from the phosphinodithioate slow-release donor GYY4137: Novel products and experimental tools.  Author URL.
Whiteman M, Perry A, Zhou Z, Bucci M, Papapetropoulos A, Cirino G, Wood ME (2015). Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors. Handb Exp Pharmacol, 230, 337-363. Abstract.  Author URL.

2014

Hurst TE, Gorman RM, Drouhin P, Perry A, Taylor RJK (2014). A direct C-H/Ar-H coupling approach to oxindoles, thio-oxindoles, 3,4-dihydro-1 H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines. Chemistry (Weinheim an der Bergstrasse, Germany), 20(43), 14063-14073. Abstract.
Hurst TE, Gorman RM, Drouhin P, Perry A, Taylor RJK (2014). A direct C-H/Ar-H coupling approach to oxindoles, thio-oxindoles, 3,4-dihydro-1 H-quinolin-2-ones, and 1,2,3,4-tetrahydroquinolines. Chemistry, 20(43), 14063-14073. Abstract.  Author URL.
Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C (2014). AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide - Biology and Chemistry, 41, 120-130. Abstract.
Szczesny B, Módis K, Yanagi K, Coletta C, Le Trionnaire S, Perry A, Wood ME, Whiteman M, Szabo C (2014). AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide, 41, 120-130. Abstract.  Author URL.  Full text.
Tomasova L, Misak A, Kristek F, Perry A, Wood ME, Ondrias K, Whiteman M (2014). Effects of a Novel Triphenylphosphonium Derivatised Anethole Dithiolethione Hydrogen Sulfide (H2S) Donor, AP39, on Cardiac Ion Channels and on Haemodynamic Parameters in Normotensive and Hypertensive Rats in Vivo.  Author URL.
Whiteman M, Perry A, Wood ME (2014). H2S in inflammation: Time for resolution?.  Author URL.
Gero D, Szczesny B, Modis K, Yanagi K, Wood ME, Perry A, Szabo C, Whiteman M (2014). Mitochondira-targeted hydrogen sulfide donors AP39 and AP123 attenuate hyperglycaemia-induced oxidative stress and loss of bioenergetics in microvascular endothelial cells.  Author URL.
Gero D, Szczesny B, Perry A, Modis K, Wood ME, Szabo C, Whiteman M (2014). Novel Mitochondria-Targeted Hydrogen Sulfide (H2S) Donors AP39 and AP123 Attenuate Hyperglycaemia-Induced Oxidative Stress and Loss of Bioenergetics in Microvascular Endothelial Cells.  Author URL.
Ferguson D, Perry A, Wood ME, Winyard PG, Whiteman M (2014). Potentiation of Methyl Aminolevulinate (MAL)-Induced Photodynamic Therapy (PDT) Killing of Skin Cancer Cells by Mitochondria-Targeted Hydrogen Sulfide (H2S) Donors.  Author URL.
Le Trionnaire S, Perry A, Szczesny B, Szabo C, Winyard PG, Whatmore JL, Wood ME, Whiteman M (2014). The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl) triphenylphosphonium bromide (AP39). MedChemComm, 5(6), 728-736. Abstract.  Full text.

2013

Le Trionnaire S, Perry A, Whatmore JL, Wood ME, Whiteman M (2013). Mitochondria-targeted hydrogen sulfide donors: a novel twist to an old "tail"?.  Author URL.
Whiteman M, Perry A, Le Trionnaire S, Whatmore JL, Ahmed T, Fox B, Kerr P, Haigh R, Winyard PG, Wood ME, et al (2013). Modulation of inflammatory and vascular signalling by novel slow release and mitochondria-targeted H2S donors.  Author URL.
Whatmore JL, Wolanska KI, Perry A, Wood ME, Whiteman M (2013). Slow release hydrogen sulfide (H2S) donors prevent hyperglycaemia-induced glycocalyx loss in retinal mirovascular endothelial cells.  Author URL.

2012

Fox B, Perry A, Winyard P, Wood ME, Whiteman M (2012). Characterising the effect of novel slow-release H2S donors on pro-inflammatory enzyme activity in human cartilage cells.  Author URL.
Fox B, Holland T, Perry A, Wood ME, Whiteman M (2012). Characterising the effect of novel slow-release H2S donors on pro-inflammatory enzyme activity in human cartilage cells.  Author URL.
Whiteman ML, Wood ME, Perry A (2012). Compounds for use in the treatment of plants.  Abstract.  Author URL.
Fox B, Holland T, Perry A, Winyard PG, Wood ME, Whiteman M (2012). Defining the Effect of Novel Slow-Release H2S Donors on Pro-Inflammatory Mediators and Enzymes in Human Joint Cells.  Author URL.
Yong QC, Cheong JL, Hua F, Deng LW, Khoo YM, Lee HS, Perry A, Wood M, Whiteman M, Bian JS, et al (2012). Erratum: Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide (Antioxidants and Redox Signaling (2011) 14 (2081-2091)). Antioxidants and Redox Signaling, 16(7).
Wolanska K, Perry A, Wood ME, Chibber R, Whatmore J, Whiteman M (2012). Hydrogen sulfide - a novel guardian of the endothelial glycocalyx?.  Author URL.
Le Trionnaire S, Perry A, Whatmore JL, Winyard PG, Wood ME, Whiteman M (2012). Mitochondria-Targeted Slow Release Hydrogen Donors: a Novel Link to an Old 'tail'?.  Author URL.
Le Trionnaire S, Whatmore J, Perry A, Wood ME, Matthew W (2012). Slow release H2S donors protect human microvascular endothelial cells from oxidative stress induced cell death: Markedly increased potency by mitochondria-targeting.  Author URL.
Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2012). Slow release H2S donors protect human microvascular endothelial cells from oxidative stress induced cell death: Markedly increased potency by mitochondria-targetting.  Author URL.

2011

Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulfide (H2 S) and novel slow release H2S donors protect human endothelial cells from oxidative stress-induced cell death.  Author URL.
Le Trionnaire S, Whatmore J, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulphide (H2S) and novel slow release H2S donors protect human microvascular endothelial cells from oxidative stress-induced cell death.  Author URL.
Yong Q-C, Cheong JL, Hua F, Deng L-W, Khoo YM, Lee H-S, Perry A, Wood M, Whiteman M, Bian J-S, et al (2011). Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide. Antioxid Redox Signal, 14(11), 2081-2091. Abstract.  Author URL.

2010

Chopra M, Perry A, Hodgkinson A, Wood ME, Whiteman M (2010). Contrasting Effects of 'Fast' and 'Slow' Releasing H2S Donors on beta Cell Viability in the Diabetic Milieu.  Author URL.
Klein JEMN, Perry A, Pugh DS, Taylor RJK (2010). First C-H activation route to oxindoles using copper catalysis. Org Lett, 12(15), 3446-3449. Abstract.  Author URL.
Pugh DS, Klein JEMN, Perry A, Taylor RJK (2010). Preparation of 3-alkyl-oxindoles by copper(II)-mediated C-H, Ar-H coupling followed by decarboxyalkylation. Synlett(6), 934-938. Abstract.
Lubkoll J, Millemaggi A, Perry A, Taylor RJK (2010). Tandem Horner-Wadsworth-Emmons/Heck procedures for the preparation of 3-alkenyl-oxindoles: the synthesis of Semaxanib and GW441756. Tetrahedron, 66(33), 6606-6612. Abstract.

2009

Nelson A, Bone H, Damiano M, Welham M, Bartlett S, Perry A, Cordier CJ, Warriner S, Leach SG, Morton D, et al (2009). Exploring biologically-relevant chemical space with macrocyclic ligands. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 238 Author URL.
Bone HK, Damiano T, Bartlett S, Perry A, Letchford J, Ripoll YS, Nelson AS, Welham MJ (2009). Involvement of GSK-3 in Regulation of Murine Embryonic Stem Cell Self-Renewal Revealed by a Series of Bisindolylmaleimides. Chemistry and Biology, 16(1), 15-27. Abstract.
Perry A, Taylor RJK (2009). Oxindole synthesis by direct C-H, Ar-H coupling. Chem Commun (Camb)(22), 3249-3251. Abstract.  Author URL.
Millemaggi A, Perry A, Whitwood AC, Taylor RJK (2009). Telescoped enolate arylation/HWE procedure for the preparation of 3-alkenyl-oxindoles: the first synthesis of soulieotine. European Journal of Organic Chemistry(18), 2947-2952. Abstract.

2008

McAllister GD, Perry A, Taylor RJK (2008). Diaziridines and diazirines. In  (Ed) Comprehensive Heterocyclic Chemistry III, 539-557.
Edwards MG, Kenworthy MN, Kitson RRA, Perry A, Scott MS, Whitwood AC, Taylor RJK (2008). The preparation of α-alkylidene-γ-butyrolactones using a telescoped intramolecular Michael/Olefination (TIMO) sequence: Synthesis of (+)-paeonilactone B. European Journal of Organic Chemistry(28), 4769-4783. Abstract.

2007

Hodgson R, Kennedy A, Nelson A, Perry A (2007). Synthesis of 3-sulfonyloxypyridines: Oxidative ring expansion of alpha-furylsulfonamides and N -> O sulfonyl transfer. SYNLETT(7), 1043-1046. Author URL.

2005

Kennedy A, Nelson A, Perry A (2005). A general, two-directional approach to aza-C-(1 → 1)-linked disaccharide mimetics. Chemical Communications(12), 1646-1648. Abstract.
Kennedy A, Nelson A, Perry A (2005). Methods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: Exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives. Beilstein Journal of Organic Chemistry, 1 Abstract.

2004

Kennedy A, Nelson A, Perry A (2004). Highly diastereoselective addition of ketone enolates to N-sulfinyl imines: Asymmetric synthesis of syn- and anti-1,3-amino alcohol derivatives. Synlett(6), 967-970. Abstract.

2002

Armstrong SK, Cross RJ, Farrugia LJ, Nichols DA, Perry A (2002). Semi-rigid bis-phosphane ligands for metallamacrocycle formation. European Journal of Inorganic Chemistry(1), 141-151. Abstract.

Alexis_Perry Details from cache as at 2018-12-10 02:03:55

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Teaching

  • Undergraduate lectures,
  • tutorials,
  • lab demonstration
  • supervision of research project students.

My teaching activities are primarily concerned with fundamental organic chemistry, from basic molecules through to complex synthesis and spectroscopy.

Modules

2018/19


Supervision / Group

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