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Dr Stineke Van Houte

Associate Research Fellow

 01326 259469

 Environment and Sustainability Institute desk 78, 2.03

 

Environment and Sustainability Institute, University of Exeter, Penryn Campus, Penryn, Cornwall, TR10 9FE, UK

I'm a BBSRC Future Leader Fellow in the Department of Biosciences. I have a broad interest in host-parasite interactions, and I have worked on various different model systems to tackle questions that are broadly related to how parasites manipulate their hosts (from behaviour to immune responses), and how  hosts counteracts these processes. For my PhD I have worked on behavioural manipulation of insects by baculoviruses, while for my postdoc I have shifted to bacteria and their viruses (phages) as a model system for host-parasite interactions. Among other things, I have studied if, how and when bacteria use an adaptive immune response (CRISPR-Cas) to defend themselves against phages. More recently I have studied how phages manage to counteract the CRISPR-Cas immune response in bacterial hosts. My lab currently focuses on how we can use CRISPR-Cas systems to alter microbial communities, with a particular focus on removing antimicrobial resistance genes from these communities, a project which is funded by the BBSRC. You can find more information about my research group at my personal website: https://vanhoutelab.wordpress.com. 

Qualifications

2014: PhD Wageningen University

2006: MSc Molecular Sciences Wageningen University

2004: BSc Molecular Sciences Wageningen University

 

Career

2018 - 2020: BBSRC Future Leader Fellow, Biosciences, University of Exeter

2016 - 2017: Marie Sklodowska Curie Research Fellow, Biosciences, University of Exeter

2014 - 2015: postdoctoral researcher, Biosciences, University of Exeter

2009 - 2013: PhD virology, defended on 21 January 2014, Wageningen University, the Netherlands 

2007 - 2008: junior researcher, University of Bologna, Italy

2001 - 2006: Bachelor and Master degree in Molecular Sciences, Wageningen University, the Netherlands

 

Research

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Han Y, van Houte S, van Oers MM, Ros VID (In Press). Baculovirus PTP2 Functions as a Pro-Apoptotic Protein. Viruses, 10(4). Abstract.  Author URL.
van Houte S, van Oers MM, Han Y, Vlak JM, Ros VID (In Press). Baculovirus infection triggers a positive phototactic response in caterpillars to induce 'tree-top' disease. Biol Lett, 10(12). Abstract.  Author URL.
van Houte S, Buckling A, Westra ER (In Press). Evolutionary Ecology of Prokaryotic Immune Mechanisms. Microbiol Mol Biol Rev, 80(3), 745-763. Abstract.  Author URL.  Full text.
Han Y, van Houte S, van Oers MM, Ros VID (2018). Timely trigger of caterpillar zombie behaviour: temporal requirements for light in baculovirus-induced tree-top disease. Parasitology, 145(6), 822-827. Abstract.  Author URL.
Morley D, Broniewski JM, Westra ER, Buckling A, van Houte S (2017). Host diversity limits the evolution of parasite local adaptation. Mol Ecol, 26(7), 1756-1763. Abstract.  Author URL.
Westra ER, Dowling AJ, Broniewski JM, Van Houte S (2016). Evolution and Ecology of CRISPR. Annual Review of Ecology, Evolution, and Systematics, 47, 307-331. Abstract.
Chabas H, van Houte S, Høyland-Kroghsbo NM, Buckling A, Westra ER (2016). Immigration of susceptible hosts triggers the evolution of alternative parasite defence strategies. Proc Biol Sci, 283(1837). Abstract.  Author URL.
van Houte S, Ekroth AKE, Broniewski JM, Chabas H, Ashby B, Bondy-Denomy J, Gandon S, Boots M, Paterson S, Buckling A, et al (2016). The diversity-generating benefits of a prokaryotic adaptive immune system. Nature, 532(7599), 385-388. Abstract.  Author URL.  Full text.
Van Houte S, Van Oers MM, Han Y, Vlak JM, Ros VID (2015). Baculovirus infection triggers a positive phototactic response in caterpillars: a response to Dobson et al. (2015). Biology Letters, 11(10).
Ros VID, van Houte S, Hemerik L, van Oers MM (2015). Baculovirus-induced tree-top disease: how extended is the role of egt as a gene for the extended phenotype?. Mol Ecol, 24(1), 249-258. Abstract.  Author URL.
Westra ER, Van houte S, Oyesiku-Blakemore S, Makin B, Broniewski JM, Best A, Bondy-Denomy J, Davidson A, Boots M, Buckling A, et al (2015). Parasite exposure drives selective evolution of constitutive versus inducible defense. Current Biology, 25(8), 1043-1049. Abstract.
Han Y, van Houte S, Drees GF, van Oers MM, Ros VID (2015). Parasitic manipulation of host behaviour: Baculovirus SeMNPV EGT facilitates tree-top disease in spodoptera exigua larvae by extending the time to death. Insects, 6(3), 716-731. Abstract.
van Houte S, Ros VID, van Oers MM (2014). Hyperactivity and tree-top disease induced by the baculovirus AcMNPV in Spodoptera exigua larvae are governed by independent mechanisms. Naturwissenschaften, 101(4), 347-350. Abstract.  Author URL.
Rispoli A, Cipollini E, Catania S, Di Giaimo R, Pulice G, van Houte S, Sparla F, Dal Piaz F, Roncarati D, Trost P, et al (2013). Insights in progressive myoclonus epilepsy: HSP70 promotes cystatin B polymerization. Biochim Biophys Acta, 1834(12), 2591-2599. Abstract.  Author URL.
van Houte S, Ros VID, van Oers MM (2013). Walking with insects: molecular mechanisms behind parasitic manipulation of host behaviour. Mol Ecol, 22(13), 3458-3475. Abstract.  Author URL.
van Houte S, Ros VID, Mastenbroek TG, Vendrig NJ, Hoover K, Spitzen J, van Oers MM (2012). Protein tyrosine phosphatase-induced hyperactivity is a conserved strategy of a subset of baculoviruses to manipulate lepidopteran host behavior. PLoS One, 7(10). Abstract.  Author URL.

Publications by year


In Press

Han Y, van Houte S, van Oers MM, Ros VID (In Press). Baculovirus PTP2 Functions as a Pro-Apoptotic Protein. Viruses, 10(4). Abstract.  Author URL.
van Houte S, van Oers MM, Han Y, Vlak JM, Ros VID (In Press). Baculovirus infection triggers a positive phototactic response in caterpillars to induce 'tree-top' disease. Biol Lett, 10(12). Abstract.  Author URL.
van Houte S, Buckling A, Westra ER (In Press). Evolutionary Ecology of Prokaryotic Immune Mechanisms. Microbiol Mol Biol Rev, 80(3), 745-763. Abstract.  Author URL.  Full text.

2018

Han Y, van Houte S, van Oers MM, Ros VID (2018). Timely trigger of caterpillar zombie behaviour: temporal requirements for light in baculovirus-induced tree-top disease. Parasitology, 145(6), 822-827. Abstract.  Author URL.

2017

Morley D, Broniewski JM, Westra ER, Buckling A, van Houte S (2017). Host diversity limits the evolution of parasite local adaptation. Mol Ecol, 26(7), 1756-1763. Abstract.  Author URL.

2016

Westra ER, Dowling AJ, Broniewski JM, Van Houte S (2016). Evolution and Ecology of CRISPR. Annual Review of Ecology, Evolution, and Systematics, 47, 307-331. Abstract.
Chabas H, van Houte S, Høyland-Kroghsbo NM, Buckling A, Westra ER (2016). Immigration of susceptible hosts triggers the evolution of alternative parasite defence strategies. Proc Biol Sci, 283(1837). Abstract.  Author URL.
van Houte S, Ekroth AKE, Broniewski JM, Chabas H, Ashby B, Bondy-Denomy J, Gandon S, Boots M, Paterson S, Buckling A, et al (2016). The diversity-generating benefits of a prokaryotic adaptive immune system. Nature, 532(7599), 385-388. Abstract.  Author URL.  Full text.

2015

Van Houte S, Van Oers MM, Han Y, Vlak JM, Ros VID (2015). Baculovirus infection triggers a positive phototactic response in caterpillars: a response to Dobson et al. (2015). Biology Letters, 11(10).
Ros VID, van Houte S, Hemerik L, van Oers MM (2015). Baculovirus-induced tree-top disease: how extended is the role of egt as a gene for the extended phenotype?. Mol Ecol, 24(1), 249-258. Abstract.  Author URL.
Westra ER, Van houte S, Oyesiku-Blakemore S, Makin B, Broniewski JM, Best A, Bondy-Denomy J, Davidson A, Boots M, Buckling A, et al (2015). Parasite exposure drives selective evolution of constitutive versus inducible defense. Current Biology, 25(8), 1043-1049. Abstract.
Han Y, van Houte S, Drees GF, van Oers MM, Ros VID (2015). Parasitic manipulation of host behaviour: Baculovirus SeMNPV EGT facilitates tree-top disease in spodoptera exigua larvae by extending the time to death. Insects, 6(3), 716-731. Abstract.

2014

van Houte S, Ros VID, van Oers MM (2014). Hyperactivity and tree-top disease induced by the baculovirus AcMNPV in Spodoptera exigua larvae are governed by independent mechanisms. Naturwissenschaften, 101(4), 347-350. Abstract.  Author URL.

2013

Rispoli A, Cipollini E, Catania S, Di Giaimo R, Pulice G, van Houte S, Sparla F, Dal Piaz F, Roncarati D, Trost P, et al (2013). Insights in progressive myoclonus epilepsy: HSP70 promotes cystatin B polymerization. Biochim Biophys Acta, 1834(12), 2591-2599. Abstract.  Author URL.
van Houte S, Ros VID, van Oers MM (2013). Walking with insects: molecular mechanisms behind parasitic manipulation of host behaviour. Mol Ecol, 22(13), 3458-3475. Abstract.  Author URL.

2012

van Houte S, Ros VID, Mastenbroek TG, Vendrig NJ, Hoover K, Spitzen J, van Oers MM (2012). Protein tyrosine phosphatase-induced hyperactivity is a conserved strategy of a subset of baculoviruses to manipulate lepidopteran host behavior. PLoS One, 7(10). Abstract.  Author URL.

Christina_Van_Houte Details from cache as at 2018-11-18 00:47:42

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