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Dr Frances Orton

Dr Frances Orton

Research Fellow

 4677

 01392 724677

 Geoffrey Pope 201

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

I am a postdoctoral fellow interested in reducing the impact of pollutants. A theme of my research has been on the protection of wildlife and humans from contaminant hazards. I have focused on the effects of environmentally relevant toxicants on reproductive health, applying both in vivo and in vitro approaches; and especially, the effects of pollutants on amphibians. Recently, I received funding for a project aimed at reducing the sacrificing of amphibians in research (DEFRA).

Broad research specialisms:

My work has been specialized in endocrine disruption and pollution, specifically the effects of pesticides on reproductive health.

Qualifications

PhD: Research in Aquatic Ecotoxicology
Institution: Institute for the Environment, Brunel University, UK   
Date: May 2004 – March 2008
Grade: Pass, minor corrections
Thesis: Investigation into the effects of pesticides on amphibians.
Supervisors: Dr. Daniel Pickford & Dr. Edwin Routledge   

Masters: MRes in Aquatic Ecotoxicology
Institutions: School of Biological Sciences, University of Plymouth, UK   
Department of Biological Sciences, Texas Tech University, USA
Date:  October 2002 – September 2003
Grade:  Pass with distinction
Thesis:  Effects of separate and combined exposure of atrazine and nitrate on larval development and sexual differentiation in Rana pipiens.
Supervisors:  Dr. Richard Handy (Plymouth) & Dr. James Carr (Texas)

B.Sc. (Hons):  Environmental Biology
Institution: School of Biological Sciences, University of Wales (Bangor), UK
Date: September 1997 – June 2000
Grade: Second class, division one
Thesis: Effects of silver on ionic regulation in the shore crab, Carcinus maenas.
Supervisor:  Dr. Nia Whiteley

Research

Research interests

One of the most critical conservation issues today is the on-going, global amphibian decline. An assessment by the IUCN (International Union for Conservation of Nature) reported that pollution is the second most important cause of species decline globally (other threats include habitat loss, climate change, disease, invasive species). When last assessed (2004), 32% of amphibian species were reported to be threatened with extinction and at least 43% were experiencing decline, which is faster than any other vertebrate group. The number of declining populations may be even higher as for 30% of species there was insufficient data to determine population status. In addition, since 1980 there have been 120 suspected, and 9 confirmed, amphibian species extinctions. Furthermore, areas harbouring the richest amphibian faunas are disproportionately affected by one or multiple threats.

Chemicals exposure is thought to be a major contributing factor to such declines, possibly through interfering with reproductive processes.

Research projects

“Predicting Reproductive Failure in Frogs using Non-destructive Biomarkers– A Pilot Study”

Estrogenic chemicals in the aquatic environment have long been known to cause feminisation, including intersex in fish and amphibians. More recently, a large number of chemicals that diminish the action of androgens (anti-androgenic) have been discovered and such chemicals have also been shown to cause reproductive dysfunction. Male secondary sex characters, such as the nuptial (“thumb”) pad and larynx (vocal organ), are controlled by androgens, and exposure to anti-androgenic chemicals have been shown to affect their development and maintenance.We will measure non-destructive biomarkers, and investigate the relationships of these markers to molecular and histological responses as well as reproductive success in the model amphibian species, Xenopus tropicalis.

It is anticipated that findings from this study will provide a crucial step towards the development of ethical alternatives to destructive sampling for chemicals regulatory testing in amphibians. Furthermore, these markers would also have the potential for application to vulnerable wild amphibian populations, thereby reducing the requirements for destructive sampling.

Grants/Funding:

2013: DEFRA Project Grant (Lead: Research, £63,865 + £36,806 “in kind”), with Prof. Tyler (Exeter, UK) and Prof. Berg (Uppsala, Sweden).
“Predicting Reproductive Failure in Frogs using Non-destructive Biomarkers– A Pilot Study”. This project is focused on mechanistic investigations.
2012: Open Collaboration bursary (Networking, £530)                   
2011: Chemtrust (Collaborator: Research, £600), with Prof. Jobling (Brunel, UK) “Identification of pollutants in amphibian breeding ponds”           
2009: Zoological Society of London Project Grant (Lead: Research, £3,000), with Dr. Garner (ZSL) “Non-destructive biomarkers of fertility in the common toad (Bufo bufo)”
2008: British Ecological Society (Travel, £300)                       
2008: Society of Experimental Biology (Travel, £500)                   
2003: Declining Amphibian Population Task Force Seed Grant (Lead: Research, £2,000), with Prof. Handy (Plymouth, UK) and Prof. Carr (Texas, USA) “Effects of nitrate and atrazine on the leopard frog, Rana pipiens”
2003: Society of Environmental Toxicology and Chemistry (Travel, £200)       
2003: Society of Experimental Biology (Travel, £200)                   
1999: Erasmus/Socrates Student Exchange Programme (Research, £350)

Key publications | Publications by category | Publications by year

Key publications


Orton F, Ermler S, Kugathas S, Rosivatz E, Scholze M, Kortenkamp A (2014). Mixture effects at very low doses with combinations of anti-androgenic pesticides, antioxidants, industrial pollutant and chemicals used in personal care products. Toxicol Appl Pharmacol, 278(3), 201-208. Abstract.  Author URL.
Gower DJ, Doherty-Bone T, Loader SP, Wilkinson M, Kouete MT, Tapley B, Orton F, Daniel OZ, Wynne F, Flach E, et al (2013). Batrachochytrium dendrobatidis infection and lethal chytridiomycosis in caecilian amphibians (Gymnophiona). Ecohealth, 10(2), 173-183. Abstract.  Author URL.
Orton F, Rosivatz E, Scholze M, Kortenkamp A (2012). Competitive androgen receptor antagonism as a factor determining the predictability of cumulative antiandrogenic effects of widely used pesticides. Environ Health Perspect, 120(11), 1578-1584. Abstract.  Author URL.
Kortenkamp A, Martin O, Evans R, Orton F, McKinlay R, Rosivatz E, Faust M (2012). Response to a critique of the European Commission Document, "State of the Art Assessment of Endocrine Disrupters" by Rhomberg and colleagues--letter to the editor. Crit Rev Toxicol, 42(9), 787-789. Author URL.
Orton F, Routledge E (2011). Agricultural intensity in ovo affects growth, metamorphic development and sexual differentiation in the common toad (Bufo bufo). Ecotoxicology, 20(4), 901-911. Abstract.  Author URL.
Hayes TB, Anderson LL, Beasley VR, de Solla SR, Iguchi T, Ingraham H, Kestemont P, Kniewald J, Kniewald Z, Langlois VS, et al (2011). Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes. J Steroid Biochem Mol Biol, 127(1-2), 64-73. Abstract.  Author URL.

Publications by category


Journal articles

Orton F, Baynes A, Clare F, Duffus ALJ, Larroze S, Scholze M, Garner TWJ (2014). Body size, nuptial pad size and hormone levels: potential non-destructive biomarkers of reproductive health in wild toads (Bufo bufo). Ecotoxicology, 23(7), 1359-1365. Abstract.  Author URL.
Orton F, Ermler S, Kugathas S, Rosivatz E, Scholze M, Kortenkamp A (2014). Mixture effects at very low doses with combinations of anti-androgenic pesticides, antioxidants, industrial pollutant and chemicals used in personal care products. Toxicol Appl Pharmacol, 278(3), 201-208. Abstract.  Author URL.
Gower DJ, Doherty-Bone T, Loader SP, Wilkinson M, Kouete MT, Tapley B, Orton F, Daniel OZ, Wynne F, Flach E, et al (2013). Batrachochytrium dendrobatidis infection and lethal chytridiomycosis in caecilian amphibians (Gymnophiona). Ecohealth, 10(2), 173-183. Abstract.  Author URL.
Orton F, Rosivatz E, Scholze M, Kortenkamp A (2012). Competitive androgen receptor antagonism as a factor determining the predictability of cumulative antiandrogenic effects of widely used pesticides. Environ Health Perspect, 120(11), 1578-1584. Abstract.  Author URL.
Kortenkamp A, Martin O, Evans R, Orton F, McKinlay R, Rosivatz E, Faust M (2012). Response to a critique of the European Commission Document, "State of the Art Assessment of Endocrine Disrupters" by Rhomberg and colleagues--letter to the editor. Crit Rev Toxicol, 42(9), 787-789. Author URL.
Orton F, Routledge E (2011). Agricultural intensity in ovo affects growth, metamorphic development and sexual differentiation in the common toad (Bufo bufo). Ecotoxicology, 20(4), 901-911. Abstract.  Author URL.
Hayes TB, Anderson LL, Beasley VR, de Solla SR, Iguchi T, Ingraham H, Kestemont P, Kniewald J, Kniewald Z, Langlois VS, et al (2011). Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes. J Steroid Biochem Mol Biol, 127(1-2), 64-73. Abstract.  Author URL.
Orton F, Rosivatz E, Scholze M, Kortenkamp A (2011). Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens. Environ Health Perspect, 119(6), 794-800. Abstract.  Author URL.
Orton F, Lutz I, Kloas W, Routledge EJ (2009). Endocrine disrupting effects of herbicides and pentachlorophenol: in vitro and in vivo evidence. Environ Sci Technol, 43(6), 2144-2150. Abstract.  Author URL.
Orton F, Carr JA, Handy RD (2006). Effects of nitrate and atrazine on larval development and sexual differentiation in the northern leopard frog Rana pipiens. Environ Toxicol Chem, 25(1), 65-71. Abstract.  Author URL.

Publications by year


2014

Orton F, Baynes A, Clare F, Duffus ALJ, Larroze S, Scholze M, Garner TWJ (2014). Body size, nuptial pad size and hormone levels: potential non-destructive biomarkers of reproductive health in wild toads (Bufo bufo). Ecotoxicology, 23(7), 1359-1365. Abstract.  Author URL.
Orton F, Ermler S, Kugathas S, Rosivatz E, Scholze M, Kortenkamp A (2014). Mixture effects at very low doses with combinations of anti-androgenic pesticides, antioxidants, industrial pollutant and chemicals used in personal care products. Toxicol Appl Pharmacol, 278(3), 201-208. Abstract.  Author URL.

2013

Gower DJ, Doherty-Bone T, Loader SP, Wilkinson M, Kouete MT, Tapley B, Orton F, Daniel OZ, Wynne F, Flach E, et al (2013). Batrachochytrium dendrobatidis infection and lethal chytridiomycosis in caecilian amphibians (Gymnophiona). Ecohealth, 10(2), 173-183. Abstract.  Author URL.

2012

Orton F, Rosivatz E, Scholze M, Kortenkamp A (2012). Competitive androgen receptor antagonism as a factor determining the predictability of cumulative antiandrogenic effects of widely used pesticides. Environ Health Perspect, 120(11), 1578-1584. Abstract.  Author URL.
Kortenkamp A, Martin O, Evans R, Orton F, McKinlay R, Rosivatz E, Faust M (2012). Response to a critique of the European Commission Document, "State of the Art Assessment of Endocrine Disrupters" by Rhomberg and colleagues--letter to the editor. Crit Rev Toxicol, 42(9), 787-789. Author URL.

2011

Orton F, Routledge E (2011). Agricultural intensity in ovo affects growth, metamorphic development and sexual differentiation in the common toad (Bufo bufo). Ecotoxicology, 20(4), 901-911. Abstract.  Author URL.
Hayes TB, Anderson LL, Beasley VR, de Solla SR, Iguchi T, Ingraham H, Kestemont P, Kniewald J, Kniewald Z, Langlois VS, et al (2011). Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes. J Steroid Biochem Mol Biol, 127(1-2), 64-73. Abstract.  Author URL.
Orton F, Rosivatz E, Scholze M, Kortenkamp A (2011). Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens. Environ Health Perspect, 119(6), 794-800. Abstract.  Author URL.

2009

Orton F, Lutz I, Kloas W, Routledge EJ (2009). Endocrine disrupting effects of herbicides and pentachlorophenol: in vitro and in vivo evidence. Environ Sci Technol, 43(6), 2144-2150. Abstract.  Author URL.

2006

Orton F, Carr JA, Handy RD (2006). Effects of nitrate and atrazine on larval development and sexual differentiation in the northern leopard frog Rana pipiens. Environ Toxicol Chem, 25(1), 65-71. Abstract.  Author URL.

Frances_Orton Details from cache as at 2018-10-15 20:41:25

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