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 Isabelle Jourdain

Isabelle Jourdain

Lecturer in Cell Biology

 2713

 01392 722713

 Geoffrey Pope 324

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

I am a yeast cell biologist interested in the membrane trafficking events that govern organelles and cell morphology. My research currently focuses on the fundamental mechanisms by which the cell periphery and the cytoskeleton cross-talk to define cell polarity and shape. Because of its characteristic rod shape and technical ease of use, we employ the fission yeast Schizosaccharomyces pombe as a model organism. Our aim is to apply the conclusion drawn from this simple, single-celled system, to the understanding of cell surface remodelling in physiological and pathological situations in human cells. I am a member of the Cellular and Chemical Biology research group.

Qualifications

2000-2004: PhD, Molecular and Cellular Biology, René Descartes University, Paris V, France
1999-2000: MsC, Biology of Ageing, René Descartes University, Paris V, France
1995-1999: BsC, Biochemistry, Paul Sabatier University, Toulouse III, France

Career

2014 - : Cell Biology lecturer, University of Exeter
2012 - 2013: Researcher, The Biotechnology Centre of Oslo, Norway
2008 - 2013: Senior Postdoctoral Research Fellow, Cancer Research UK, London
2005 - 2008: Postdoctoral Research Fellow, Massey University, Palmerston North, New Zealand
1999 - 2004: PhD and Master Student, Institut du Fer à Moulin, INSERM, Paris, France

Research group links

Research

Research interests

Research in my laboratory is aimed at describing the fundamental mechanisms that govern cell polarity. Virtually all cell types from all kingdoms use the same set of factors to adopt a shape that is compatible with a specialised function, a need for migration, or a growth and division pattern. Some of these factors are involved in remodeling the plasma membrane, others control the organization of the cytoskeleton. We are investigating both aspects and their link, with an emphasis on the following themes:

  • How are the sequential steps of exocytosis coordinated? 
  • How does the cell periphery cross talk with the actin cytoskeleton?
  • Can cell surface compartments restrict the sites of plasma membrane remodeling?

To answer these questions, we routinely employ the yeast Schizosaccharomyces pombe as a model organism. S. pombe divides by fission and its characteristic shape makes it an ideal organism in which to study the morphological consequences of membrane trafficking alterations. Fission yeast also enables the use of a range of rapid, easy and ethical techniques from live cell imaging to genetics and biochemistry. By understanding how polarity is orchestrated in a simple organism such as fission yeast we will be able to assess the situation in more complex higher eukaryotes, notably in pathological conditions.

Publications

Key publications | Publications by category | Publications by year

Key publications


Martin-Urdiroz M, Deeks MJ, Horton CG, Dawe HR, Jourdain I (2016). The Exocyst Complex in Health and Disease. Frontiers in Cell and Developmental Biology, 4 Full text.
Jourdain I, Dooley HC, Toda T (2012). Fission yeast sec3 bridges the exocyst complex to the actin cytoskeleton. Traffic, 13(11), 1481-1495. Abstract.  Author URL.  Full text.
Ravelli RBG, Gigant B, Curmi PA, Jourdain I, Lachkar S, Sobel A, Knossow M (2004). Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature, 428(6979), 198-202. Abstract.  Author URL.

Publications by category


Books

Jourdain I (eds)(2014). Mécanismes de séquestration de la tubuline: Etudes biochimiques de l'interaction entre la tubuline et les protéines de la famille de la stathmine.  France, Presses Academiques Francophones. Abstract.  Full text.

Journal articles

Tang NH, Fong CS, Masuda H, Jourdain I, Toda T (In Press). Generation of temperature sensitive mutants for the genetic study of the fission yeast spindle pole body. Methods in Molecular Biology Full text.
Horton C, Heesom K, Jourdain I (In Press). Medium-throughput biochemical detection of fission yeast spindle pole body-interacting proteins. Methods in Molecular Biology Full text.
Kampmeyer C, Karakostova A, Schenstrøm SM, Abildgaard AB, Lauridsen A-M, Jourdain I, Hartmann-Petersen R (In Press). The exocyst subunit Sec3 is regulated by a protein quality control pathway. J Biol Chem, 292(37), 15240-15253. Abstract.  Author URL.
Martin-Urdiroz M, Deeks MJ, Horton CG, Dawe HR, Jourdain I (2016). The Exocyst Complex in Health and Disease. Frontiers in Cell and Developmental Biology, 4 Full text.
Jourdain I, Brzezińska EA, Toda T (2013). Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement. PLoS One, 8(1). Abstract.  Author URL.  Full text.
Jourdain I, Dooley HC, Toda T (2012). Fission yeast sec3 bridges the exocyst complex to the actin cytoskeleton. Traffic, 13(11), 1481-1495. Abstract.  Author URL.  Full text.
Jourdain I, Spielewoy N, Thompson J, Dhut S, Yates JR, Toda T (2009). Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast. Biochem J, 420(2), 169-177. Abstract.  Author URL.
Jourdain I, Gachet Y, Hyams JS (2009). The dynamin related protein Dnm1 fragments mitochondria in a microtubule-dependent manner during the fission yeast cell cycle. Cell Motil Cytoskeleton, 66(8), 509-523. Abstract.  Author URL.
Röthlisberger S, Jourdain I, Johnson C, Takegawa K, Hyams JS (2009). The dynamin-related protein Vps1 regulates vacuole fission, fusion and tubulation in the fission yeast, Schizosaccharomyces pombe. Fungal Genet Biol, 46(12), 927-935. Abstract.  Author URL.
Jourdain I, Sontam D, Johnson C, Dillies C, Hyams JS (2008). Dynamin-dependent biogenesis, cell cycle regulation and mitochondrial association of peroxisomes in fission yeast. Traffic, 9(3), 353-365. Abstract.  Author URL.
Eaton CJ, Jourdain I, Foster SJ, Hyams JS, Scott B (2008). Functional analysis of a fungal endophyte stress-activated MAP kinase. Curr Genet, 53(3), 163-174. Abstract.  Author URL.
Clément M-J, Jourdain I, Lachkar S, Savarin P, Gigant B, Knossow M, Toma F, Sobel A, Curmi PA (2005). N-terminal stathmin-like peptides bind tubulin and impede microtubule assembly. Biochemistry, 44(44), 14616-14625. Abstract.  Author URL.
Jourdain I, Lachkar S, Charbaut E, Gigant B, Knossow M, Sobel A, Curmi PA (2004). A synergistic relationship between three regions of stathmin family proteins is required for the formation of a stable complex with tubulin. Biochem J, 378(Pt 3), 877-888. Abstract.  Author URL.
Ravelli RBG, Gigant B, Curmi PA, Jourdain I, Lachkar S, Sobel A, Knossow M (2004). Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature, 428(6979), 198-202. Abstract.  Author URL.

Publications by year


In Press

Tang NH, Fong CS, Masuda H, Jourdain I, Toda T (In Press). Generation of temperature sensitive mutants for the genetic study of the fission yeast spindle pole body. Methods in Molecular Biology Full text.
Horton C, Heesom K, Jourdain I (In Press). Medium-throughput biochemical detection of fission yeast spindle pole body-interacting proteins. Methods in Molecular Biology Full text.
Kampmeyer C, Karakostova A, Schenstrøm SM, Abildgaard AB, Lauridsen A-M, Jourdain I, Hartmann-Petersen R (In Press). The exocyst subunit Sec3 is regulated by a protein quality control pathway. J Biol Chem, 292(37), 15240-15253. Abstract.  Author URL.

2016

Martin-Urdiroz M, Deeks MJ, Horton CG, Dawe HR, Jourdain I (2016). The Exocyst Complex in Health and Disease. Frontiers in Cell and Developmental Biology, 4 Full text.

2014

Jourdain I (eds)(2014). Mécanismes de séquestration de la tubuline: Etudes biochimiques de l'interaction entre la tubuline et les protéines de la famille de la stathmine.  France, Presses Academiques Francophones. Abstract.  Full text.

2013

Jourdain I, Brzezińska EA, Toda T (2013). Fission yeast Nod1 is a component of cortical nodes involved in cell size control and division site placement. PLoS One, 8(1). Abstract.  Author URL.  Full text.

2012

Jourdain I, Dooley HC, Toda T (2012). Fission yeast sec3 bridges the exocyst complex to the actin cytoskeleton. Traffic, 13(11), 1481-1495. Abstract.  Author URL.  Full text.

2009

Jourdain I, Spielewoy N, Thompson J, Dhut S, Yates JR, Toda T (2009). Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast. Biochem J, 420(2), 169-177. Abstract.  Author URL.
Jourdain I, Gachet Y, Hyams JS (2009). The dynamin related protein Dnm1 fragments mitochondria in a microtubule-dependent manner during the fission yeast cell cycle. Cell Motil Cytoskeleton, 66(8), 509-523. Abstract.  Author URL.
Röthlisberger S, Jourdain I, Johnson C, Takegawa K, Hyams JS (2009). The dynamin-related protein Vps1 regulates vacuole fission, fusion and tubulation in the fission yeast, Schizosaccharomyces pombe. Fungal Genet Biol, 46(12), 927-935. Abstract.  Author URL.

2008

Jourdain I, Sontam D, Johnson C, Dillies C, Hyams JS (2008). Dynamin-dependent biogenesis, cell cycle regulation and mitochondrial association of peroxisomes in fission yeast. Traffic, 9(3), 353-365. Abstract.  Author URL.
Eaton CJ, Jourdain I, Foster SJ, Hyams JS, Scott B (2008). Functional analysis of a fungal endophyte stress-activated MAP kinase. Curr Genet, 53(3), 163-174. Abstract.  Author URL.

2005

Clément M-J, Jourdain I, Lachkar S, Savarin P, Gigant B, Knossow M, Toma F, Sobel A, Curmi PA (2005). N-terminal stathmin-like peptides bind tubulin and impede microtubule assembly. Biochemistry, 44(44), 14616-14625. Abstract.  Author URL.

2004

Jourdain I, Lachkar S, Charbaut E, Gigant B, Knossow M, Sobel A, Curmi PA (2004). A synergistic relationship between three regions of stathmin family proteins is required for the formation of a stable complex with tubulin. Biochem J, 378(Pt 3), 877-888. Abstract.  Author URL.
Ravelli RBG, Gigant B, Curmi PA, Jourdain I, Lachkar S, Sobel A, Knossow M (2004). Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature, 428(6979), 198-202. Abstract.  Author URL.

Isabelle_Jourdain Details from cache as at 2018-12-13 01:23:45

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2018/19

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