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Dr Jonathan Ball

Dr Jonathan Ball

Research Fellow

 Not Known

 Hatherly 

 

Hatherly Building, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK

I joined Exeter University from AstraZeneca as part of the Zebrafish Research team which was relocated from the Brixham site in May 2014.

I have considerable experience of environmental toxicology from my Ph.D and post-doctoral research on the effects of Ethinyl oestradiol on gene expression and sexual development of the Zebrafish, and investigating the effects of environmental pollutants, respectively.

For the last 7 years I have been working in external commercial industry using the Zebrafish as a toxicity model. For the last 5 years I have been based at Brixham working for AstraZeneca.

At AstraZeneca I was the technical lead for non-mammalian alternatives for the assessment of Developmental Toxicology.  Recognised as an industry expert and the industry technical lead for an international consortium of five leading pharmaceutical companies (AZ, Pfizer, BMS, Amgen and Abbott), who joined forces to standardise the Zebrafish Developmental toxicity assay. 

Initiated and led the training of technical experts across the consortia.  Supporting a new research collaboration to identify novel complimentary techniques using the Zebrafish model, to extend its application and to encourage wider acceptance and usage within industry.  Use my knowledge and expertise to support research colleagues in the development of other novel zebrafish assays for the assessment of human safety.

Broad research specialisms:

  • Zebrafish
  • Developmental toxicity
  • Environmental safety
  • Human safety

Qualifications

1996-2000 B.Sc., Biochemistry, Cardiff University
2000-2004 Ph.D., Biology, Exeter University

Research

Research interests

  • Developmental biology
  • Zebrafish
  • Drug safety
  • Alternative models

Research projects

Supporting the research group which moved from AstraZeneca Brixham in early 2014 in maintaining the contact and research conducted by AstraZeneca at Exeter Univeristy

Grants/Funding:

Industrial support

Key publications | Publications by category | Publications by year

Key publications


Parker T, Libourel P-A, Hetheridge MJ, Cumming RI, Sutcliffe TP, Goonesinghe AC, Ball JS, Owen SF, Chomis Y, Winter MJ, et al (2014). A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function. J Pharmacol Toxicol Methods, 69(1), 30-38. Abstract.  Author URL.
Ball JS, Stedman DB, Hillegass JM, Zhang CX, Panzica-kelly J, Coburn A, Enright BP, Tornesi B, Amouzadeh HR, Hetheridge M, et al (2014). Fishing for teratogens: a consortium effort for a harmonized zebrafish developmental toxicology assay. Toxicological Sciences, 139(1), 210-219. Abstract.
Gustafson A-L, Stedman DB, Ball J, Hillegass JM, Flood A, Zhang CX, Panzica-Kelly J, Coburn A, Enright BP, Tornesi BM, et al (2012). Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay.  Author URL.
Gustafson A-L, Stedman DB, Ball J, Hillegass JM, Flood A, Zhang CX, Panzica-Kelly J, Cao J, Coburn A, Enright BP, et al (2012). Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay - progress report on phase I. Reprod Toxicol, 33(2), 155-164. Abstract.  Author URL.
Katsiadaki I, Williams TD, Ball JS, Bean TP, Sanders MB, Wu H, Santos EM, Brown MM, Baker P, Ortega F, et al (2010). Hepatic transcriptomic and metabolomic responses in the Stickleback (Gasterosteus aculeatus) exposed to ethinyl-estradiol. Aquat Toxicol, 97(3), 174-187. Abstract.  Author URL.
Santos EM, Ball JS, Williams TD, Wu H, Ortega F, van Aerle R, Katsiadaki I, Falciani F, Viant MR, Chipman JK, et al (2010). Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model. Environ Sci Technol, 44(2), 820-826. Abstract.  Author URL.

Publications by category


Journal articles

Parker T, Libourel P-A, Hetheridge MJ, Cumming RI, Sutcliffe TP, Goonesinghe AC, Ball JS, Owen SF, Chomis Y, Winter MJ, et al (2014). A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function. J Pharmacol Toxicol Methods, 69(1), 30-38. Abstract.  Author URL.
Corcoran J, Lange A, Cumming RI, Owen SF, Ball JS, Tyler CR, Winter MJ (2014). Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio). Aquat Toxicol, 152, 57-65. Abstract.  Author URL.
Ball JS, Stedman DB, Hillegass JM, Zhang CX, Panzica-kelly J, Coburn A, Enright BP, Tornesi B, Amouzadeh HR, Hetheridge M, et al (2014). Fishing for teratogens: a consortium effort for a harmonized zebrafish developmental toxicology assay. Toxicological Sciences, 139(1), 210-219. Abstract.
Santos EM, Hamilton PB, Coe TS, Ball JS, Cook AC, Katsiadaki I, Tyler CR (2013). Population bottlenecks, genetic diversity and breeding ability of the three-spined stickleback (Gasterosteus aculeatus) from three polluted English Rivers. Aquatic Toxicology, 142-143, 264-271. Abstract.
Gustafson A-L, Stedman DB, Ball J, Hillegass JM, Flood A, Zhang CX, Panzica-Kelly J, Cao J, Coburn A, Enright BP, et al (2012). Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay - progress report on phase I. Reprod Toxicol, 33(2), 155-164. Abstract.  Author URL.
Gustafson A-L, Stedman DB, Ball J, Hillegass JM, Zhang CX, Panzica-Kelly J, Coburn A, Enright BP, Amouzadeh HR, Tornesi MB, et al (2012). Zebrafish As a Model for Predicting Developmental Toxicity. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 94(5), 309-309. Author URL.
Katsiadaki I, Williams TD, Ball JS, Bean TP, Sanders MB, Wu H, Santos EM, Brown MM, Baker P, Ortega F, et al (2010). Hepatic transcriptomic and metabolomic responses in the Stickleback (Gasterosteus aculeatus) exposed to ethinyl-estradiol. Aquat Toxicol, 97(3), 174-187. Abstract.  Author URL.
Santos EM, Ball JS, Williams TD, Wu H, Ortega F, van Aerle R, Katsiadaki I, Falciani F, Viant MR, Chipman JK, et al (2010). Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model. Environ Sci Technol, 44(2), 820-826. Abstract.  Author URL.
Williams TD, Wu H, Santos EM, Ball J, Katsiadaki I, Brown MM, Baker P, Ortega F, Falciani F, Craft JA, et al (2009). Hepatic transcriptomic and metabolomic responses in the stickleback (Gasterosteus aculeatus) exposed to environmentally relevant concentrations of dibenzanthracene. Environ Sci Technol, 43(16), 6341-6348. Abstract.  Author URL.
Williams TD, Brown M, Chipman JK, Falciani F, Ortega F, Geoghegan F, Craft JA, Katsiadaki I, Ball J, Tyler CR, et al (2008). Development of a stickleback (Gasterosteus aculeatus) cDNA microarray and gene expression responses to dibenzanthracene, ethinyl-estradiol and copper. MARINE ENVIRONMENTAL RESEARCH, 66(1), 140-140. Author URL.
Schulz RW, Bogerd J, Male R, Ball J, Fenske M, Olsen LC, Tyler CR (2007). Estrogen-induced alterations in amh and dmrt1 expression signal for disruption in male sexual development in the zebrafish. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 41(17), 6305-6310. Author URL.
Booth T, Gilbert J, Neufeld JD, Ball J, Thurston M, Chipman K, Joint I, Field D (2007). Handlebar: a flexible, web-based inventory manager for handling barcoded samples. BioTechniques, 42(3), 300-302.

Conferences

Winter MJ, Ball J, Goonesinghe A, Hetheridge M (2013). The utility of the zebrafish for drug safety assessment: an industry perspective.  Author URL.
Gustafson A-L, Stedman DB, Ball J, Hillegass JM, Flood A, Zhang CX, Panzica-Kelly J, Coburn A, Enright BP, Tornesi BM, et al (2012). Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay.  Author URL.
Tyler CR, Ball J, Maack G, Paull G, Santos EM (2002). Endocrine disruption in vertebrate wildlife - Today's story.  Author URL.

Publications by year


2014

Parker T, Libourel P-A, Hetheridge MJ, Cumming RI, Sutcliffe TP, Goonesinghe AC, Ball JS, Owen SF, Chomis Y, Winter MJ, et al (2014). A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function. J Pharmacol Toxicol Methods, 69(1), 30-38. Abstract.  Author URL.
Corcoran J, Lange A, Cumming RI, Owen SF, Ball JS, Tyler CR, Winter MJ (2014). Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio). Aquat Toxicol, 152, 57-65. Abstract.  Author URL.
Ball JS, Stedman DB, Hillegass JM, Zhang CX, Panzica-kelly J, Coburn A, Enright BP, Tornesi B, Amouzadeh HR, Hetheridge M, et al (2014). Fishing for teratogens: a consortium effort for a harmonized zebrafish developmental toxicology assay. Toxicological Sciences, 139(1), 210-219. Abstract.

2013

Santos EM, Hamilton PB, Coe TS, Ball JS, Cook AC, Katsiadaki I, Tyler CR (2013). Population bottlenecks, genetic diversity and breeding ability of the three-spined stickleback (Gasterosteus aculeatus) from three polluted English Rivers. Aquatic Toxicology, 142-143, 264-271. Abstract.
Winter MJ, Ball J, Goonesinghe A, Hetheridge M (2013). The utility of the zebrafish for drug safety assessment: an industry perspective.  Author URL.

2012

Gustafson A-L, Stedman DB, Ball J, Hillegass JM, Flood A, Zhang CX, Panzica-Kelly J, Coburn A, Enright BP, Tornesi BM, et al (2012). Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay.  Author URL.
Gustafson A-L, Stedman DB, Ball J, Hillegass JM, Flood A, Zhang CX, Panzica-Kelly J, Cao J, Coburn A, Enright BP, et al (2012). Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay - progress report on phase I. Reprod Toxicol, 33(2), 155-164. Abstract.  Author URL.
Gustafson A-L, Stedman DB, Ball J, Hillegass JM, Zhang CX, Panzica-Kelly J, Coburn A, Enright BP, Amouzadeh HR, Tornesi MB, et al (2012). Zebrafish As a Model for Predicting Developmental Toxicity. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 94(5), 309-309. Author URL.

2010

Katsiadaki I, Williams TD, Ball JS, Bean TP, Sanders MB, Wu H, Santos EM, Brown MM, Baker P, Ortega F, et al (2010). Hepatic transcriptomic and metabolomic responses in the Stickleback (Gasterosteus aculeatus) exposed to ethinyl-estradiol. Aquat Toxicol, 97(3), 174-187. Abstract.  Author URL.
Santos EM, Ball JS, Williams TD, Wu H, Ortega F, van Aerle R, Katsiadaki I, Falciani F, Viant MR, Chipman JK, et al (2010). Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model. Environ Sci Technol, 44(2), 820-826. Abstract.  Author URL.

2009

Williams TD, Wu H, Santos EM, Ball J, Katsiadaki I, Brown MM, Baker P, Ortega F, Falciani F, Craft JA, et al (2009). Hepatic transcriptomic and metabolomic responses in the stickleback (Gasterosteus aculeatus) exposed to environmentally relevant concentrations of dibenzanthracene. Environ Sci Technol, 43(16), 6341-6348. Abstract.  Author URL.

2008

Williams TD, Brown M, Chipman JK, Falciani F, Ortega F, Geoghegan F, Craft JA, Katsiadaki I, Ball J, Tyler CR, et al (2008). Development of a stickleback (Gasterosteus aculeatus) cDNA microarray and gene expression responses to dibenzanthracene, ethinyl-estradiol and copper. MARINE ENVIRONMENTAL RESEARCH, 66(1), 140-140. Author URL.

2007

Schulz RW, Bogerd J, Male R, Ball J, Fenske M, Olsen LC, Tyler CR (2007). Estrogen-induced alterations in amh and dmrt1 expression signal for disruption in male sexual development in the zebrafish. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 41(17), 6305-6310. Author URL.
Booth T, Gilbert J, Neufeld JD, Ball J, Thurston M, Chipman K, Joint I, Field D (2007). Handlebar: a flexible, web-based inventory manager for handling barcoded samples. BioTechniques, 42(3), 300-302.

2002

Tyler CR, Ball J, Maack G, Paull G, Santos EM (2002). Endocrine disruption in vertebrate wildlife - Today's story.  Author URL.

Jonathan_Ball Details from cache as at 2018-09-19 00:38:14

Refresh publications

Invited lectures

British Teratogenic Society 2013

European Teratogenic Society 2013

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