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Dr Karl Wotton

Dr Karl Wotton

Senior Lecturer in the Genetics of Migration and Royal Society University Research Fellow

 +44 (0)1326 25 4118

 Daphne du Maurier 3038

 

Daphne du Maurier Building, University of Exeter,  Penryn Campus, Penryn, Cornwall, TR10 9FE, UK

 Office hours:

My office hours are 14:00-15:00 on Mondays and Wednesdays.

My research identifies the origin, evolution and function of migratory characteristics, an approach that unites the fields of genetics, developmental biology, behaviour and ecology. 

 

Qualifications

2007 PhD Evolutionary Developmental Biology, University of Oxford
2002 BSc Molecular Genetics and Biotechnology, University of Sussex

Career

2008-2015 Postdoctoral researcher, EMBL/CRG Research Unit in Systems Biology, Spain
2010 Visiting Researcher, University of Chicago, USA
2007-2008 Postdoctoral researcher, King's College London

Research

Research interests

My research focuses on the spectacular long-distance migrations of hoverflies, an economically important group of insects that provide dual ecosystem services of pollination and biological control of crop pests. Understanding the movement of these insects offers major opportunities to improve agricultural practices and to deepen our understanding of the genetics of migration. Further information is available on the lab website: http://www.migratorygenomics.com

Key publications | Publications by category | Publications by year

Key publications


Crombach A, Wotton KR, Jiménez-Guri E, Jaeger J (In Press). Gap Gene Regulatory Dynamics Evolve along a Genotype Network. Mol Biol Evol, 33(5), 1293-1307. Abstract.  Author URL.
Verd B, Clark E, Wotton K, Janssens H, Jimenez-Guri E, Crombach A, Jaeger J (2018). A damped oscillator imposes temporal order on posterior gap gene expression in Drosophila. PLoS Biology Full text.
Wotton KR, Schubert FR, Dietrich S (2015). Hypaxial muscle: controversial classification and controversial data?. Results Probl Cell Differ, 56, 25-48. Abstract.  Author URL.
Wotton KR, Jiménez-Guri E, Jaeger J (2015). Maternal co-ordinate gene regulation and axis polarity in the scuttle fly Megaselia abdita. PLoS Genet, 11(3). Abstract.  Author URL.  Full text.
Wotton KR, Jiménez-Guri E, Crombach A, Janssens H, Alcaine-Colet A, Lemke S, Schmidt-Ott U, Jaeger J (2015). Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita. Elife, 4 Abstract.  Author URL.  Full text.
Cicin-Sain D, Pulido AH, Crombach A, Wotton KR, Jiménez-Guri E, Taly J-F, Roma G, Jaeger J (2015). SuperFly: a comparative database for quantified spatio-temporal gene expression patterns in early dipteran embryos. Nucleic Acids Res, 43(Database issue), D751-D755. Abstract.  Author URL.  Full text.

Publications by category


Journal articles

Crombach A, Wotton KR, Jiménez-Guri E, Jaeger J (In Press). Gap Gene Regulatory Dynamics Evolve along a Genotype Network. Mol Biol Evol, 33(5), 1293-1307. Abstract.  Author URL.
Verd B, Clark E, Wotton K, Janssens H, Jimenez-Guri E, Crombach A, Jaeger J (2018). A damped oscillator imposes temporal order on posterior gap gene expression in Drosophila. PLoS Biology Full text.
Jimenez-Guri E, Wotton KR, Jaeger J (2018). tarsal-less is expressed as a gap gene but has no gap gene phenotype in the moth midge Clogmia albipunctata. Royal Society Open Science Full text.
Wotton KR, Alcaine-Colet A, Jaeger J, Jiménez-Guri E (2017). Non-canonical dorsoventral patterning in the moth midge Clogmia albipunctata. EvoDevo, 20178:20 Full text.
Wotton KR, Jiménez-Guri E, Crombach A, Cicin-Sain D, Jaeger J (2015). High-resolution gene expression data from blastoderm embryos of the scuttle fly Megaselia abdita. Sci Data, 2 Abstract.  Author URL.  Full text.
Wotton KR, Schubert FR, Dietrich S (2015). Hypaxial muscle: controversial classification and controversial data?. Results Probl Cell Differ, 56, 25-48. Abstract.  Author URL.
Wotton KR, Jiménez-Guri E, Jaeger J (2015). Maternal co-ordinate gene regulation and axis polarity in the scuttle fly Megaselia abdita. PLoS Genet, 11(3). Abstract.  Author URL.  Full text.
Wotton KR, Jiménez-Guri E, Crombach A, Janssens H, Alcaine-Colet A, Lemke S, Schmidt-Ott U, Jaeger J (2015). Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita. Elife, 4 Abstract.  Author URL.  Full text.
Alcaine-Colet A, Wotton KR, Jimenez-Guri E (2015). Rearing the scuttle fly Megaselia scalaris (Diptera: Phoridae) on industrial compounds: implications on size and lifespan. PeerJ, 3 Abstract.  Author URL.  Full text.
Cicin-Sain D, Pulido AH, Crombach A, Wotton KR, Jiménez-Guri E, Taly J-F, Roma G, Jaeger J (2015). SuperFly: a comparative database for quantified spatio-temporal gene expression patterns in early dipteran embryos. Nucleic Acids Res, 43(Database issue), D751-D755. Abstract.  Author URL.  Full text.
Jiménez-Guri E, Wotton KR, Gavilán B, Jaeger J (2014). A staging scheme for the development of the moth midge Clogmia albipunctata. PLoS One, 9(1). Abstract.  Author URL.  Full text.
Wotton KR, Jiménez-Guri E, García Matheu B, Jaeger J (2014). A staging scheme for the development of the scuttle fly Megaselia abdita. PLoS One, 9(1). Abstract.  Author URL.  Full text.
Lours-Calet C, Alvares LE, El-Hanfy AS, Gandesha S, Walters EH, Sobreira DR, Wotton KR, Jorge EC, Lawson JA, Kelsey Lewis A, et al (2014). Evolutionarily conserved morphogenetic movements at the vertebrate head-trunk interface coordinate the transport and assembly of hypopharyngeal structures. Dev Biol, 390(2), 231-246. Abstract.  Author URL.
Wotton KR (2014). Heterochronic shifts in germband movements contribute to the rapid embryonic development of the coffin fly Megaselia scalaris. Arthropod Struct Dev, 43(6), 589-594. Abstract.  Author URL.
Fernández-Jaén A, Suela J, Fernández-Mayoralas DM, Fernández-Perrone AL, Wotton KR, Dietrich S, Castellanos MDC, Cigudosa JC, Calleja-Pérez B, López-Martín S, et al (2014). Microduplication 10q24.31 in a Spanish girl with scoliosis and myopathy: the critical role of LBX. Am J Med Genet A, 164A(8), 2074-2078. Abstract.  Author URL.
Jiménez-Guri E, Huerta-Cepas J, Cozzuto L, Wotton KR, Kang H, Himmelbauer H, Roma G, Gabaldón T, Jaeger J (2013). Comparative transcriptomics of early dipteran development. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Wotton KR, Alcaine Colet A, Jaeger J, Jimenez-Guri E (2013). Evolution and expression of BMP genes in flies. Dev Genes Evol, 223(5), 335-340. Abstract.  Author URL.  Full text.
Janssens H, Crombach A, Wotton KR, Cicin-Sain D, Surkova S, Lim CL, Samsonova M, Akam M, Jaeger J (2013). Lack of tailless leads to an increase in expression variability in Drosophila embryos. Dev Biol, 377(1), 305-317. Abstract.  Author URL.
Crombach A, Wotton KR, Cicin-Sain D, Ashyraliyev M, Jaeger J (2012). Efficient reverse-engineering of a developmental gene regulatory network. PLoS Comput Biol, 8(7). Abstract.  Author URL.  Full text.
Crombach A, Cicin-Sain D, Wotton KR, Jaeger J (2012). Medium-throughput processing of whole mount in situ hybridisation experiments into gene expression domains. PLoS One, 7(9). Abstract.  Author URL.  Full text.
Wotton KR, Shimeld SM (2011). Analysis of lamprey clustered Fox genes: insight into Fox gene evolution and expression in vertebrates. Gene, 489(1), 30-40. Abstract.  Author URL.
Wotton KR, Weierud FK, Juárez-Morales JL, Alvares LE, Dietrich S, Lewis KE (2009). Conservation of gene linkage in dispersed vertebrate NK homeobox clusters. Dev Genes Evol, 219(9-10), 481-496. Abstract.  Author URL.
Wotton KR, Weierud FK, Dietrich S, Lewis KE (2008). Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. BMC Evol Biol, 8 Abstract.  Author URL.  Full text.
Wotton KR, Mazet F, Shimeld SM (2008). Expression of FoxC, FoxF, FoxL1, and FoxQ1 genes in the dogfish Scyliorhinus canicula defines ancient and derived roles for Fox genes in vertebrate development. Dev Dyn, 237(6), 1590-1603. Abstract.  Author URL.
Wotton KR, French KEM, Shimeld SM (2007). The developmental expression of foxl2 in the dogfish Scyliorhinus canicula. Gene Expr Patterns, 7(7), 793-797. Abstract.  Author URL.  Full text.
Wotton KR, Shimeld SM (2006). Comparative genomics of vertebrate Fox cluster loci. BMC Genomics, 7 Abstract.  Author URL.  Full text.

Conferences

Wotton KR, Mazet F, Shimeld SM (2005). Fox gene duplication in vertebrate evolution.  Author URL.

Publications by year


In Press

Crombach A, Wotton KR, Jiménez-Guri E, Jaeger J (In Press). Gap Gene Regulatory Dynamics Evolve along a Genotype Network. Mol Biol Evol, 33(5), 1293-1307. Abstract.  Author URL.

2018

Verd B, Clark E, Wotton K, Janssens H, Jimenez-Guri E, Crombach A, Jaeger J (2018). A damped oscillator imposes temporal order on posterior gap gene expression in Drosophila. PLoS Biology Full text.
Clark E, Verd B, Wotton KR, Crombach A, Janssens H, Jimenez-Guri E, Jaeger J (2018). Supplementary Data for a Damped Oscillator Imposes Temporal Order on Posterior Gap Gene Expression in Drosophila.  Abstract.  Author URL.
Jimenez-Guri E, Wotton KR, Jaeger J (2018). tarsal-less is expressed as a gap gene but has no gap gene phenotype in the moth midge Clogmia albipunctata. Royal Society Open Science Full text.

2017

Wotton KR, Alcaine-Colet A, Jaeger J, Jiménez-Guri E (2017). Non-canonical dorsoventral patterning in the moth midge Clogmia albipunctata. EvoDevo, 20178:20 Full text.

2015

Wotton KR, Jiménez-Guri E, Crombach A, Cicin-Sain D, Jaeger J (2015). High-resolution gene expression data from blastoderm embryos of the scuttle fly Megaselia abdita. Sci Data, 2 Abstract.  Author URL.  Full text.
Wotton KR, Schubert FR, Dietrich S (2015). Hypaxial muscle: controversial classification and controversial data?. Results Probl Cell Differ, 56, 25-48. Abstract.  Author URL.
Wotton KR, Jiménez-Guri E, Jaeger J (2015). Maternal co-ordinate gene regulation and axis polarity in the scuttle fly Megaselia abdita. PLoS Genet, 11(3). Abstract.  Author URL.  Full text.
Wotton KR, Jiménez-Guri E, Crombach A, Janssens H, Alcaine-Colet A, Lemke S, Schmidt-Ott U, Jaeger J (2015). Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita. Elife, 4 Abstract.  Author URL.  Full text.
Alcaine-Colet A, Wotton KR, Jimenez-Guri E (2015). Rearing the scuttle fly Megaselia scalaris (Diptera: Phoridae) on industrial compounds: implications on size and lifespan. PeerJ, 3 Abstract.  Author URL.  Full text.
Cicin-Sain D, Pulido AH, Crombach A, Wotton KR, Jiménez-Guri E, Taly J-F, Roma G, Jaeger J (2015). SuperFly: a comparative database for quantified spatio-temporal gene expression patterns in early dipteran embryos. Nucleic Acids Res, 43(Database issue), D751-D755. Abstract.  Author URL.  Full text.

2014

Jiménez-Guri E, Wotton KR, Gavilán B, Jaeger J (2014). A staging scheme for the development of the moth midge Clogmia albipunctata. PLoS One, 9(1). Abstract.  Author URL.  Full text.
Wotton KR, Jiménez-Guri E, García Matheu B, Jaeger J (2014). A staging scheme for the development of the scuttle fly Megaselia abdita. PLoS One, 9(1). Abstract.  Author URL.  Full text.
Lours-Calet C, Alvares LE, El-Hanfy AS, Gandesha S, Walters EH, Sobreira DR, Wotton KR, Jorge EC, Lawson JA, Kelsey Lewis A, et al (2014). Evolutionarily conserved morphogenetic movements at the vertebrate head-trunk interface coordinate the transport and assembly of hypopharyngeal structures. Dev Biol, 390(2), 231-246. Abstract.  Author URL.
Wotton KR (2014). Heterochronic shifts in germband movements contribute to the rapid embryonic development of the coffin fly Megaselia scalaris. Arthropod Struct Dev, 43(6), 589-594. Abstract.  Author URL.
Fernández-Jaén A, Suela J, Fernández-Mayoralas DM, Fernández-Perrone AL, Wotton KR, Dietrich S, Castellanos MDC, Cigudosa JC, Calleja-Pérez B, López-Martín S, et al (2014). Microduplication 10q24.31 in a Spanish girl with scoliosis and myopathy: the critical role of LBX. Am J Med Genet A, 164A(8), 2074-2078. Abstract.  Author URL.

2013

Jiménez-Guri E, Huerta-Cepas J, Cozzuto L, Wotton KR, Kang H, Himmelbauer H, Roma G, Gabaldón T, Jaeger J (2013). Comparative transcriptomics of early dipteran development. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Wotton KR, Alcaine Colet A, Jaeger J, Jimenez-Guri E (2013). Evolution and expression of BMP genes in flies. Dev Genes Evol, 223(5), 335-340. Abstract.  Author URL.  Full text.
Janssens H, Crombach A, Wotton KR, Cicin-Sain D, Surkova S, Lim CL, Samsonova M, Akam M, Jaeger J (2013). Lack of tailless leads to an increase in expression variability in Drosophila embryos. Dev Biol, 377(1), 305-317. Abstract.  Author URL.

2012

Crombach A, Wotton KR, Cicin-Sain D, Ashyraliyev M, Jaeger J (2012). Efficient reverse-engineering of a developmental gene regulatory network. PLoS Comput Biol, 8(7). Abstract.  Author URL.  Full text.
Crombach A, Cicin-Sain D, Wotton KR, Jaeger J (2012). Medium-throughput processing of whole mount in situ hybridisation experiments into gene expression domains. PLoS One, 7(9). Abstract.  Author URL.  Full text.

2011

Wotton KR, Shimeld SM (2011). Analysis of lamprey clustered Fox genes: insight into Fox gene evolution and expression in vertebrates. Gene, 489(1), 30-40. Abstract.  Author URL.

2009

Wotton KR, Weierud FK, Juárez-Morales JL, Alvares LE, Dietrich S, Lewis KE (2009). Conservation of gene linkage in dispersed vertebrate NK homeobox clusters. Dev Genes Evol, 219(9-10), 481-496. Abstract.  Author URL.

2008

Wotton KR, Weierud FK, Dietrich S, Lewis KE (2008). Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. BMC Evol Biol, 8 Abstract.  Author URL.  Full text.
Wotton KR, Mazet F, Shimeld SM (2008). Expression of FoxC, FoxF, FoxL1, and FoxQ1 genes in the dogfish Scyliorhinus canicula defines ancient and derived roles for Fox genes in vertebrate development. Dev Dyn, 237(6), 1590-1603. Abstract.  Author URL.

2007

Wotton KR, French KEM, Shimeld SM (2007). The developmental expression of foxl2 in the dogfish Scyliorhinus canicula. Gene Expr Patterns, 7(7), 793-797. Abstract.  Author URL.  Full text.

2006

Wotton KR, Shimeld SM (2006). Comparative genomics of vertebrate Fox cluster loci. BMC Genomics, 7 Abstract.  Author URL.  Full text.

2005

Wotton KR, Mazet F, Shimeld SM (2005). Fox gene duplication in vertebrate evolution.  Author URL.

Karl_Wotton Details from cache as at 2018-10-15 14:51:50

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I co-lead the Pyrenees Field Course (BIO2449) where students can visit my fieldsite and migration hotspot on the Spanish/French border. I also teach the genetics and physiology of migrants and circular statistics on the Animal Migration module (BIO3421). 

Postgraduate researchers

  • William Hawkes
  • Richard Massy

Research Technicians

  • Toby Doyle

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