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Dr Lena Bayer-Wilfert

Dr Lena Bayer-Wilfert

Senior Lecturer in Molecular Evolution

 01326 370723

 Daphne du Maurier 3066

 

Daphne du Maurier Building, University of Exeter,  Penryn Campus, Penryn, Cornwall, TR10 9FE, UK

 Office hours:

My office hours are in DDM3066; this spring term, they are generally Mon 13:30-14:30 and Thursdays 14:15-15:15. These are likely to change though, please see below for any current changes.

Changed office hours:

  • week 10: Monday 1pm to 2pm, no office hour on Thursday the 22nd of March, instead Friday 23rd 9-10 am.
  • week 11: Monday 3 to 4pm, Thursday as normal

Overview

I am an evolutionary geneticist with particular interest in host-parasite interactions. To study the ecological and evolutionary risk factors that drive multi-host pathogens and emerging diseases, I use rapidly evolving viral pathogens that infect pollinating insects as an ecologically relevant model system. With a Royal Society Dorothy Hodgkin fellowship, I have recently shown that the globally distributed strain of DWV is a re-emerging man-made epidemic in honeybees and we have reviewed the biological and anthropogenic risk factors driving disease emergence in pollinators. We are currently following up this work by studying the effect of Varroa on disease prevalence and abundance as well as on viral diversity in wild pollinators. Visit our lab website to find out more.

During my PhD with Paul Schmid-Hempel at ETH Zurich, I studied the quantitative genetics of disease resistance and immunity in bumblebees. As a post-doc with Frank Jiggins, first at the University of Edinburgh and then at the University of Cambridge, I studied the coevolutionary dynamics of Drosophila melanogaster and the sigma virus, a vertically transmitted parasite.

Broad research specialisms:

My research focuses on the evolutionary ecology of fast-evolving viral parasites of pollinating insects such as bumblebees and hoverflies. With this natural system, I am asking fundamental questions such as identifying ecological and genetic risk factors that promote the emergence of novel diseases. As healthy pollinators are crucial for all flowering plants, my research is also motivated by the potential to improve conservation biology and agriculture.

Qualifications

Dr. sc (ETH Zurich, Switzerland; 2006)
Diploma in Biology (University Bayreuth, Germany; 2002)

Links

Research group links

Research

Research interests

Host-parasite coevolution is at the center of my research interests - find out more about our research on our lab webiste! In particular, I am interested in the ecology and evolution of emerging diseases. Using rapidly evolving RNA viruses that infect the community of pollinating insects, I study the ecological and genetic risk factors that may lead to disease emergence in this system. My work focuses on viral sequence evolution and the dynamics of pathogen adaptation. I am a member of the Evolution research group.

Research networks

Darren Obbard, Frank Jiggins, P. Schmid-Hempel, Ben Longdon.

Collaborating institutions include:

Genetic Diversity Centre, Eden Project, The Lost Gardens of Heligan, National Trust.

Research grants

  • 2012 Royal Society
    The Bumblebee Gut as an Infection Barrier: Does Pesticide Exposure Increase Vulnerability to Disease.
  • 2011 Royal Society Dorothy Hodgkin Fellowship
    Velux Foundation - Visiting Fellow Genomic Diversity Center ETH Zurich

Publications

Key publications | Publications by category | Publications by year

Key publications


Manley R, Boots M, Bayer-Wilfert L (In Press). Condition-dependent virulence of Slow Bee Paralysis Virus in Bombus terrestris: Are the impacts of honeybee viruses in wild pollinators underestimated?. Oecologia Full text.
Wilfert L, Long G, Leggett HC, Schmid-Hempel P, Butlin R, Martin SJM, Boots M (2016). Deformed wing virus is a recent global epidemic in honeybees driven by Varroa mites. Science, 351(6273), 594-597. Full text.
Manley R, Boots M, Wilfert L (2015). Emerging viral disease risk to pollinating insects: ecological, evolutionary and anthropogenic factors. J Appl Ecol, 52, 331-340. Author URL.  Full text.
Wilfert L, Jiggins FM (2014). Flies on the move: an inherited virus mirrors Drosophila melanogaster's elusive ecology and demography. Mol Ecol, 23(8), 2093-2104. Abstract.  Author URL.  Full text.
Wilfert L, Jiggins FM (2013). The dynamics of reciprocal selective sweeps of host resistance and a parasite counter-adaptation in drosophila. Evolution, 67(3), 761-773. Abstract.
Wilfert L, Jiggins FM (2012). The dynamics of reciprocal selective sweeps of host resistance and a parasite counter-adaptation in Drosophila. Evolution, in press

Publications by category


Journal articles

Boots M, wilfert, Bartlett L (In Press). A genotypic trade-off between constitutive resistance to viral infection and host growth rate. Evolution Full text.
Barons MJ, Hanea AM, Wright SK, Baldock KCR, Wilfert L, Chandler D, Datta S, Fannon J, Hartfield C, Lucas A, et al (In Press). Assessment of the response of pollinator abundance to environmental pressures using structured expert elicitation. Journal of Apicultural Research Full text.
Manley R, Boots M, Bayer-Wilfert L (In Press). Condition-dependent virulence of Slow Bee Paralysis Virus in Bombus terrestris: Are the impacts of honeybee viruses in wild pollinators underestimated?. Oecologia Full text.
Mordecai G, Bayer-Wilfert L, Martin S, Jones I, Schroeder D (In Press). Diversity in a honey bee pathogen: first report of a third master variant of the Deformed Wing Virus quasispecies. The ISME Journal: multidisciplinary journal of microbial ecology Abstract.  Full text.
Longdon B (In Press). Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts. Proceedings of the Royal Society B: Biological Sciences Full text.
Campbell LJ, Hammond SA, Price SJ, Sharma MD, Garner TWJ, Birol I, Helbing CC, Wilfert L, Griffiths AGF (2018). A novel approach to wildlife transcriptomics provides evidence of disease-mediated differential expression and changes to the microbiome of amphibian populations. Mol Ecol, 27(6), 1413-1427. Abstract.  Author URL.  Full text.
McMahon DP, Wilfert L, Paxton RJ, Brown MJF (2018). Emerging Viruses in Bees: from Molecules to Ecology. , 101, 251-291. Abstract.
Bayer-Wilfert L, Campbell LJ, Head ML, Griffiths A (2017). An ecological role for assortative mating under infection?. Conservation Genetics Full text.
Bonneaud C, Sepil I, Wilfert L, Calsbeek R (2017). Plasmodium Infections in Natural Populations of Anolis sagrei Reflect Tolerance Rather Than Susceptibility. Integrative and Comparative Biology, 57(2), 352-361. Full text.
Wilfert L, Long G, Leggett HC, Schmid-Hempel P, Butlin R, Martin SJM, Boots M (2016). Deformed wing virus is a recent global epidemic in honeybees driven by Varroa mites. Science, 351(6273), 594-597. Full text.
Manley R, Boots M, Wilfert L (2015). Emerging viral disease risk to pollinating insects: ecological, evolutionary and anthropogenic factors. J Appl Ecol, 52, 331-340. Author URL.  Full text.
Wilfert L, Jiggins FM (2014). Flies on the move: an inherited virus mirrors Drosophila melanogaster's elusive ecology and demography. Molecular Ecology, 23(8), 2093-2104. Abstract.
Wilfert L, Jiggins FM (2014). Flies on the move: an inherited virus mirrors Drosophila melanogaster's elusive ecology and demography. Mol Ecol, 23(8), 2093-2104. Abstract.  Author URL.  Full text.
Wilfert L, Jiggins FM (2013). The dynamics of reciprocal selective sweeps of host resistance and a parasite counter-adaptation in drosophila. Evolution, 67(3), 761-773. Abstract.
Wilfert L, Jiggins FM (2012). The dynamics of reciprocal selective sweeps of host resistance and a parasite counter-adaptation in Drosophila. Evolution, in press
Stolle E, Wilfert L, Schmid-Hempel R, Schmid-Hempel P, Kube M, Reinhardt R, Moritz RFA (2011). A second generation genetic map of the bumblebee Bombus terrestris (Linnaeus, 1758) reveals slow genome and chromosome evolution in the Apidae. BMC Genomics, 12 Abstract.  Author URL.  Full text.
Longdon B, Wilfert L, Osei-Poku J, Cagney H, Obbard DJ, Jiggins FM (2011). Host-switching by a vertically transmitted rhabdovirus in Drosophila. Biol Lett, 7(5), 747-750. Abstract.  Author URL.
Longdon B, Wilfert L, Obbard DJ, Jiggins FM (2011). Rhabdoviruses in two species of Drosophila: vertical transmission and a recent sweep. Genetics, 188(1), 141-150. Abstract.  Author URL.
Wilfert L, Longdon B, Ferreira AGA, Bayer F, Jiggins FM (2011). Trypanosomatids are common and diverse parasites of Drosophila. Parasitology, 138(7), 858-865. Abstract.  Author URL.
Wilfert L, Jiggins FM (2010). Disease association mapping in Drosophila can be replicated in the wild. Biol Lett, 6(5), 666-668. Abstract.  Author URL.
Wilfert L, Jiggins FM (2010). Host-parasite coevolution: genetic variation in a virus population and the interaction with a host gene. J Evol Biol, 23(7), 1447-1455. Abstract.  Author URL.
Wilfert L, Torres MM, Reber-Funk C, Schmid-Hempel R, Tomkins J, Gadau J, Schmid-Hempel P (2009). Construction and characterization of a BAC-library for a key pollinator, the bumblebee Bombus terrestris L. Insectes Sociaux, 56(1), 44-48. Abstract.
Carpenter JA, Keegan LP, Wilfert L, O'Connell MA, Jiggins FM (2009). Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae). BMC Genet, 10 Abstract.  Author URL.
Wilfert L, Schmid-Hempel P (2008). The genetic architecture of susceptibility to parasites. BMC Evol Biol, 8 Abstract.  Author URL.
Wilfert L, Gadau J, Baer B, Schmid-Hempel P (2007). Natural variation in the genetic architecture of a host-parasite interaction in the bumblebee Bombus terrestris. Mol Ecol, 16(6), 1327-1339. Abstract.  Author URL.
Wilfert L, Gadau J, Schmid-Hempel P (2007). The genetic architecture of immune defense and reproduction in male Bombus terrestris bumblebees. Evolution, 61(4), 804-815. Abstract.  Author URL.
Wilfert L, Gadau J, Schmid-Hempel P (2007). Variation in genomic recombination rates among animal taxa and the case of social insects. Heredity (Edinb), 98(4), 189-197. Abstract.  Author URL.
Wilfert L, Gadau J, Schmid-Hempel P (2006). A core linkage map of the bumblebee Bombus terrestris. Genome, 49(10), 1215-1226. Abstract.  Author URL.
Wilfert L, Kaib M, Durka W, Brandl R (2006). Differentiation between populations of a termite in eastern Africa: Implications for biogeography. Journal of Biogeography, 33(11), 1993-2000. Abstract.
Kaib M, Jmhasly P, Wilfert L, Durka W, Franke S, Francke W, Leuthold RH, Brandl R (2004). Cuticular hydrocarbons and aggression in the termite Macrotermes subhyalinus. J Chem Ecol, 30(2), 365-385. Abstract.  Author URL.
Clément JL, Bagnères AG, Uva P, Wilfert L, Quintana A, Reinhard J, Dronnet S (2001). Biosystematics of Reticulitermes termites in Europe: Morphological, chemical and molecular data. Insectes Sociaux, 48(3), 202-215. Abstract.

Chapters

Longdon B, Wilfert L, Jiggins FM (2012). The Sigma Viruses of Drosophila. In Dietzgen RG (Ed) Rhabdoviruses: Molecular Taxonomy, Evolution, Genomics, Ecology, Cytopathology and Control, Horizon Scientific Press.
Wilfert L, Schmid-Hempel P, Gadau J (2007). Bumblebees. In Kole C, Hunter W (Eds.) Genome Mapping and Genomics in Animals, Berlin, Heidelberg, New York: Springer.

Publications by year


In Press

Boots M, wilfert, Bartlett L (In Press). A genotypic trade-off between constitutive resistance to viral infection and host growth rate. Evolution Full text.
Barons MJ, Hanea AM, Wright SK, Baldock KCR, Wilfert L, Chandler D, Datta S, Fannon J, Hartfield C, Lucas A, et al (In Press). Assessment of the response of pollinator abundance to environmental pressures using structured expert elicitation. Journal of Apicultural Research Full text.
Manley R, Boots M, Bayer-Wilfert L (In Press). Condition-dependent virulence of Slow Bee Paralysis Virus in Bombus terrestris: Are the impacts of honeybee viruses in wild pollinators underestimated?. Oecologia Full text.
Mordecai G, Bayer-Wilfert L, Martin S, Jones I, Schroeder D (In Press). Diversity in a honey bee pathogen: first report of a third master variant of the Deformed Wing Virus quasispecies. The ISME Journal: multidisciplinary journal of microbial ecology Abstract.  Full text.
Longdon B (In Press). Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts. Proceedings of the Royal Society B: Biological Sciences Full text.

2018

Campbell LJ, Hammond SA, Price SJ, Sharma MD, Garner TWJ, Birol I, Helbing CC, Wilfert L, Griffiths AGF (2018). A novel approach to wildlife transcriptomics provides evidence of disease-mediated differential expression and changes to the microbiome of amphibian populations. Mol Ecol, 27(6), 1413-1427. Abstract.  Author URL.  Full text.
McMahon DP, Wilfert L, Paxton RJ, Brown MJF (2018). Emerging Viruses in Bees: from Molecules to Ecology. , 101, 251-291. Abstract.

2017

Bayer-Wilfert L, Campbell LJ, Head ML, Griffiths A (2017). An ecological role for assortative mating under infection?. Conservation Genetics Full text.
Bonneaud C, Sepil I, Wilfert L, Calsbeek R (2017). Plasmodium Infections in Natural Populations of Anolis sagrei Reflect Tolerance Rather Than Susceptibility. Integrative and Comparative Biology, 57(2), 352-361. Full text.

2016

Wilfert L, Long G, Leggett HC, Schmid-Hempel P, Butlin R, Martin SJM, Boots M (2016). Deformed wing virus is a recent global epidemic in honeybees driven by Varroa mites. Science, 351(6273), 594-597. Full text.

2015

Manley R, Boots M, Wilfert L (2015). Emerging viral disease risk to pollinating insects: ecological, evolutionary and anthropogenic factors. J Appl Ecol, 52, 331-340. Author URL.  Full text.

2014

Wilfert L, Jiggins FM (2014). Flies on the move: an inherited virus mirrors Drosophila melanogaster's elusive ecology and demography. Molecular Ecology, 23(8), 2093-2104. Abstract.
Wilfert L, Jiggins FM (2014). Flies on the move: an inherited virus mirrors Drosophila melanogaster's elusive ecology and demography. Mol Ecol, 23(8), 2093-2104. Abstract.  Author URL.  Full text.

2013

Wilfert L, Jiggins FM (2013). The dynamics of reciprocal selective sweeps of host resistance and a parasite counter-adaptation in drosophila. Evolution, 67(3), 761-773. Abstract.

2012

Longdon B, Wilfert L, Jiggins FM (2012). The Sigma Viruses of Drosophila. In Dietzgen RG (Ed) Rhabdoviruses: Molecular Taxonomy, Evolution, Genomics, Ecology, Cytopathology and Control, Horizon Scientific Press.
Wilfert L, Jiggins FM (2012). The dynamics of reciprocal selective sweeps of host resistance and a parasite counter-adaptation in Drosophila. Evolution, in press

2011

Stolle E, Wilfert L, Schmid-Hempel R, Schmid-Hempel P, Kube M, Reinhardt R, Moritz RFA (2011). A second generation genetic map of the bumblebee Bombus terrestris (Linnaeus, 1758) reveals slow genome and chromosome evolution in the Apidae. BMC Genomics, 12 Abstract.  Author URL.  Full text.
Longdon B, Wilfert L, Osei-Poku J, Cagney H, Obbard DJ, Jiggins FM (2011). Host-switching by a vertically transmitted rhabdovirus in Drosophila. Biol Lett, 7(5), 747-750. Abstract.  Author URL.
Longdon B, Wilfert L, Obbard DJ, Jiggins FM (2011). Rhabdoviruses in two species of Drosophila: vertical transmission and a recent sweep. Genetics, 188(1), 141-150. Abstract.  Author URL.
Wilfert L, Longdon B, Ferreira AGA, Bayer F, Jiggins FM (2011). Trypanosomatids are common and diverse parasites of Drosophila. Parasitology, 138(7), 858-865. Abstract.  Author URL.

2010

Wilfert L, Jiggins FM (2010). Disease association mapping in Drosophila can be replicated in the wild. Biol Lett, 6(5), 666-668. Abstract.  Author URL.
Wilfert L, Jiggins FM (2010). Host-parasite coevolution: genetic variation in a virus population and the interaction with a host gene. J Evol Biol, 23(7), 1447-1455. Abstract.  Author URL.

2009

Wilfert L, Torres MM, Reber-Funk C, Schmid-Hempel R, Tomkins J, Gadau J, Schmid-Hempel P (2009). Construction and characterization of a BAC-library for a key pollinator, the bumblebee Bombus terrestris L. Insectes Sociaux, 56(1), 44-48. Abstract.
Carpenter JA, Keegan LP, Wilfert L, O'Connell MA, Jiggins FM (2009). Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae). BMC Genet, 10 Abstract.  Author URL.

2008

Wilfert L, Schmid-Hempel P (2008). The genetic architecture of susceptibility to parasites. BMC Evol Biol, 8 Abstract.  Author URL.

2007

Wilfert L, Schmid-Hempel P, Gadau J (2007). Bumblebees. In Kole C, Hunter W (Eds.) Genome Mapping and Genomics in Animals, Berlin, Heidelberg, New York: Springer.
Wilfert L, Gadau J, Baer B, Schmid-Hempel P (2007). Natural variation in the genetic architecture of a host-parasite interaction in the bumblebee Bombus terrestris. Mol Ecol, 16(6), 1327-1339. Abstract.  Author URL.
Wilfert L, Gadau J, Schmid-Hempel P (2007). The genetic architecture of immune defense and reproduction in male Bombus terrestris bumblebees. Evolution, 61(4), 804-815. Abstract.  Author URL.
Wilfert L, Gadau J, Schmid-Hempel P (2007). Variation in genomic recombination rates among animal taxa and the case of social insects. Heredity (Edinb), 98(4), 189-197. Abstract.  Author URL.

2006

Wilfert L, Gadau J, Schmid-Hempel P (2006). A core linkage map of the bumblebee Bombus terrestris. Genome, 49(10), 1215-1226. Abstract.  Author URL.
Wilfert L, Kaib M, Durka W, Brandl R (2006). Differentiation between populations of a termite in eastern Africa: Implications for biogeography. Journal of Biogeography, 33(11), 1993-2000. Abstract.

2004

Kaib M, Jmhasly P, Wilfert L, Durka W, Franke S, Francke W, Leuthold RH, Brandl R (2004). Cuticular hydrocarbons and aggression in the termite Macrotermes subhyalinus. J Chem Ecol, 30(2), 365-385. Abstract.  Author URL.

2001

Clément JL, Bagnères AG, Uva P, Wilfert L, Quintana A, Reinhard J, Dronnet S (2001). Biosystematics of Reticulitermes termites in Europe: Morphological, chemical and molecular data. Insectes Sociaux, 48(3), 202-215. Abstract.

Lena_Wilfert Details from cache as at 2018-12-09 09:53:07

Refresh publications

External Engagment and Impact

Awards/Honorary fellowships

For her PhD, Lena received the Chorafas Foundation Award and the ETH Medal for outstanding dissertations in 2007. She was a visiting fellow at the Genetic Diversity Center at ETH Zurich in 2011/2012.


Committee/panel activities

Lena is a member of the Biosciences Cornwall Research comittee.


Editorial responsibilities

Lena is an associate editor for BMC Evolutionary Biology.


Invited lectures

She has given invited talks at several UK and international Universities. She was an invited expert at the EMPSEB European PhD meeting in 2011.


Workshops/Conferences organised

Lena was involved in setting up the Cambridge Evolutionary Genetics network at the University of Cambridge. She initiated the annual Cambridge Evolutionary Genetics Symposia, organising them between 2009 and 2011.

Teaching

I coordinate the year 2 module ‘Critical Thinking and Scientific Reasoning’ and teach on the Cyprus field course and Coevolutionary Interactions in year 3. I also supervise undergraduate, Mres and Msc research projects and we often host lab experience students in our labs.

 

Office hourshttp://biosciences.exeter.ac.uk/cec/staff/index.php?web_id=Lena_Wilfert&refresh

 

Modules

2018/19


Supervision / Group

Postdoctoral researchers

Postgraduate researchers

Research Technicians

Alumni

  • Frances Bensley (Undergraduate)
  • Toby Doyle (MSc)
  • Krisztina Gyarmati (MSc)
  • Lindsey Leyden (Undergraduate)
  • Tom Robinson (Undergraduate)
  • Nicole Sykes (Undergraduate)
  • Laura Telford (Undergraduate)
  • Felix Vaux (Undergraduate)

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