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Dr Michael Deeks

Dr Michael Deeks

Senior Lecturer in Plant Biology

 5852

 Geoffrey Pope M02

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

I am a cell biologist with an interest in cell polarity; specifically the way plant cells respond to spatial information to guide their immune responses.

The cells of complex plants have an acute awareness of the events occurring immediately beyond their walls and make spatially precise responses to any perceived threat. Potentially pathogenic microbes cause plant defences to focus within a few square microns of the plant cell surface. This process can be summarised as 'pathogen-oriented cell polarisation'. The response is effective against most microbes but successful pathogens evade these counter-measures to establish infection.

My group aims to understand how multiple cell processes are co-ordinated as a system to achieve this important response that underpins the plant immune system.

Qualifications

1998 - 2001 University of Leeds. PhD Genetics.
1995 - 1998 University of Leeds. B.Sc. Hons. Genetics.

Career

7/98 - 9/98 Research Assistant, John Innes Institute, Norwich.
10/01 - 6/13 Senior Research Associate/Postdoctoral Fellow, School of Biological and Biomedical Sciences, Durham University.
7/13 - Present Lecturer in Plant Biology, Department of Biosciences, University of Exeter.

Research group links

Research

Research interests

Our research aims to understand the response of plant cells to localised pathogen assault. Changes in cell architecture support the plant immune system and an understanding of this response could potentially be exploited to protect key crops.

We are investigating the mechanisms co-ordinating this spatially focused phenomenon using advanced light microscopy combined with a broad range of molecular, genetic and biochemical techniques. We are particularly interested in how the plant-pathogen interface emerges from the co-ordination of several processes:

  • Microbe perception
  • Cytoskeletal re-arrangement
  • Long-range cargo transport
  • Exocytosis (cargo delivery)
  • Endocytosis (cargo recovery)

We are developing bioimage informatics and modelling approaches to better understand the relationships between these different players in both model plants and key cereals.

Research projects

  • Dynamics of vescile delivery to the plant-pathogen interface.
  • Live cell imaging of plant-pathogen interfaces in wheat using advanced light microscopy and recombinant fluorescent proteins.

Publications

Key publications | Publications by category | Publications by year

Key publications


Duckney P, Deeks MJ, Dixon MR, Kroon J, Hawkins TJ, Hussey PJ (2017). Actin-membrane interactions mediated by NETWORKED2 in Arabidopsis pollen tubes through associations with Pollen Receptor-Like Kinase 4 and 5. New Phytologist, 216(4), 1170-1180. Full text.
Hawkins TJ, Deeks MJ, Wang P, Hussey PJ (2014). The evolution of the actin binding NET superfamily. Front Plant Sci, 5 Abstract.  Author URL.  Full text.
Wang P, Hawkins TJ, Richardson C, Cummins I, Deeks MJ, Sparkes I, Hawes C, Hussey PJ (2014). The plant cytoskeleton, NET3C, and VAP27 mediate the link between the plasma membrane and endoplasmic reticulum. Curr Biol, 24(12), 1397-1405. Abstract.  Author URL.  Full text.
Deeks MJ, Calcutt JR, Ingle EKS, Hawkins TJ, Chapman S, Richardson AC, Mentlak DA, Dixon MR, Cartwright F, Smertenko AP, et al (2012). A superfamily of actin-binding proteins at the actin-membrane nexus of higher plants. Current Biology, 22(17), 1595-1600. Abstract.
Tõth R, Gerding-Reimers C, Deeks MJ, Menninger S, Gallegos RM, Tonaco IAN, Hübel K, Hussey PJ, Waldmann H, Coupland G, et al (2012). Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana. Plant Journal, 71(2), 338-352. Abstract.
Jiang K, Sorefan K, Deeks MJ, Bevan MW, Hussey PJ, Hetherington AM (2012). The ARP2/3 complex mediates guard cell actin reorganization and stomatal movement in Arabidopsis. Plant Cell, 24(5), 2031-2040. Abstract.

Publications by category


Journal articles

Moger JJ, Littlejohn GL, Deeks MD (In Press). Making microscopy count: quantitative light microscopy of dynamic processes in living plants. Journal of Microscopy Abstract.  Full text.
Deeks M, Sánchez-Rodríguez C (In Press). Seeing is believing: cell biology at the plant-microbe interface. New Phytol, 211(1), 16-19. Author URL.  Full text.
Sassmann S, Rodrigues C, Milne SW, Nenninger A, Allwood E, Littlejohn GR, Talbot NJ, Soeller C, Davies B, Hussey PJ, et al (2018). An Immune-Responsive Cytoskeletal-Plasma Membrane Feedback Loop in Plants. Current Biology, 28(13), 2136-2144.e7. Abstract.  Full text.
Isner JC, Xu Z, Costa JM, Monnet F, Batstone T, Ou X, Deeks MJ, Genty B, Jiang K, Hetherington AM, et al (2017). Actin filament reorganisation controlled by the SCAR/WAVE complex mediates stomatal response to darkness. New Phytologist, 215(3), 1059-1067. Abstract.  Full text.
Duckney P, Deeks MJ, Dixon MR, Kroon J, Hawkins TJ, Hussey PJ (2017). Actin-membrane interactions mediated by NETWORKED2 in Arabidopsis pollen tubes through associations with Pollen Receptor-Like Kinase 4 and 5. New Phytologist, 216(4), 1170-1180. Full text.
Tolmie F, Poulet A, McKenna J, Sassmann S, Graumann K, Deeks M, Runions J (2017). The cell wall of Arabidopsis thaliana influences actin network dynamics. Journal of Experimental Botany, 68(16), 4517-4527.
Martin-Urdiroz M, Deeks MJ, Horton CG, Dawe HR, Jourdain I (2016). The Exocyst Complex in Health and Disease. Frontiers in Cell and Developmental Biology, 4 Full text.
Nelson CJ, Duckney P, Hawkins TJ, Deeks MJ, Laissue PP, Hussey PJ, Obara B (2014). Blobs and curves: object-based colocalisation for plant cells. Functional Plant Biology Abstract.  Author URL.  Full text.
Hawkins TJ, Deeks MJ, Wang P, Hussey PJ (2014). The evolution of the actin binding NET superfamily. Front Plant Sci, 5 Abstract.  Author URL.  Full text.
Wang P, Hawkins TJ, Richardson C, Cummins I, Deeks MJ, Sparkes I, Hawes C, Hussey PJ (2014). The plant cytoskeleton, NET3C, and VAP27 mediate the link between the plasma membrane and endoplasmic reticulum. Curr Biol, 24(12), 1397-1405. Abstract.  Author URL.  Full text.
Deeks MJ, Calcutt JR, Ingle EKS, Hawkins TJ, Chapman S, Richardson AC, Mentlak DA, Dixon MR, Cartwright F, Smertenko AP, et al (2012). A superfamily of actin-binding proteins at the actin-membrane nexus of higher plants. Current Biology, 22(17), 1595-1600. Abstract.
Tõth R, Gerding-Reimers C, Deeks MJ, Menninger S, Gallegos RM, Tonaco IAN, Hübel K, Hussey PJ, Waldmann H, Coupland G, et al (2012). Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana. Plant Journal, 71(2), 338-352. Abstract.
Jiang K, Sorefan K, Deeks MJ, Bevan MW, Hussey PJ, Hetherington AM (2012). The ARP2/3 complex mediates guard cell actin reorganization and stomatal movement in Arabidopsis. Plant Cell, 24(5), 2031-2040. Abstract.
Liu J, Piette BMAG, Deeks MJ, Franklin-Tong VE, Hussey PJ (2010). A compartmental model analysis of integrative and self- regulatory ion dynamics in pollen tube growth. PLoS ONE, 5(10). Abstract.  Full text.
Smertenko AP, Deeks MJ, Hussey PJ (2010). Strategies of actin reorganisation in plant cells. J Cell Sci, 123(Pt 17), 3019-3028. Abstract.  Author URL.
Deeks MJ, Fendrych M, Smertenko A, Bell KS, Oparka K, Cvrcková F, Zársky V, Hussey PJ (2010). The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain. J Cell Sci, 123(Pt 8), 1209-1215. Abstract.  Author URL.
Piette BMAG, Liu J, Peeters K, Smertenko A, Hawkins T, Deeks M, Quinlan R, Zakrzewski WJ, Hussey PJ (2009). A thermodynamic model of microtubule assembly and disassembly. PLoS One, 4(8). Abstract.  Author URL.  Full text.
Deeks MJ, Rodrigues C, Dimmock S, Ketelaar T, Maciver SK, Malhó R, Hussey PJ (2007). Arabidopsis CAP1 - a key regulator of actin organisation and development. J Cell Sci, 120(Pt 15), 2609-2618. Abstract.  Author URL.
Uhrig JF, Mutondo M, Zimmermann I, Deeks MJ, Machesky LM, Thomas P, Uhrig S, Rambke C, Hussey PJ, Hülskamp M, et al (2007). The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis. Development, 134(5), 967-977. Abstract.
Hussey PJ, Ketelaar T, Deeks MJ (2006). Control of the actin cytoskeleton in plant cell growth. Annual Review of Plant Biology, 57, 109-125. Abstract.
Deeks MJ, Cvrcková F, Machesky LM, Mikitová V, Ketelaar T, Zársky V, Davies B, Hussey PJ (2005). Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression. New Phytologist, 168(3), 529-540. Abstract.
Deeks MJ, Hussey PJ (2005). Arp2/3 and SCAR: Plants move to the fore. Nature Reviews Molecular Cell Biology, 6(12), 954-964. Abstract.
Deeks MJ, Kaloriti D, Davies B, Malhó R, Hussey PJ (2004). Arabidopsis NAP1 is essential for Arp2/3-dependent trichome morphogenesis. Current Biology, 14(15), 1410-1414. Abstract.
Deeks MJ, Hussey PJ (2003). Arp2/3 and 'The Shape of things to come'. Current Opinion in Plant Biology, 6(6), 561-567. Abstract.
Deeks MJ, Hussey PJ, Davies B (2002). Formins: Intermediates in signal-transduction cascades that affect cytoskeletal reorganization. Trends in Plant Science, 7(11), 492-498. Abstract.

Publications by year


In Press

Moger JJ, Littlejohn GL, Deeks MD (In Press). Making microscopy count: quantitative light microscopy of dynamic processes in living plants. Journal of Microscopy Abstract.  Full text.
Deeks M, Sánchez-Rodríguez C (In Press). Seeing is believing: cell biology at the plant-microbe interface. New Phytol, 211(1), 16-19. Author URL.  Full text.

2018

Sassmann S, Rodrigues C, Milne SW, Nenninger A, Allwood E, Littlejohn GR, Talbot NJ, Soeller C, Davies B, Hussey PJ, et al (2018). An Immune-Responsive Cytoskeletal-Plasma Membrane Feedback Loop in Plants. Current Biology, 28(13), 2136-2144.e7. Abstract.  Full text.

2017

Isner JC, Xu Z, Costa JM, Monnet F, Batstone T, Ou X, Deeks MJ, Genty B, Jiang K, Hetherington AM, et al (2017). Actin filament reorganisation controlled by the SCAR/WAVE complex mediates stomatal response to darkness. New Phytologist, 215(3), 1059-1067. Abstract.  Full text.
Duckney P, Deeks MJ, Dixon MR, Kroon J, Hawkins TJ, Hussey PJ (2017). Actin-membrane interactions mediated by NETWORKED2 in Arabidopsis pollen tubes through associations with Pollen Receptor-Like Kinase 4 and 5. New Phytologist, 216(4), 1170-1180. Full text.
Tolmie F, Poulet A, McKenna J, Sassmann S, Graumann K, Deeks M, Runions J (2017). The cell wall of Arabidopsis thaliana influences actin network dynamics. Journal of Experimental Botany, 68(16), 4517-4527.

2016

Martin-Urdiroz M, Deeks MJ, Horton CG, Dawe HR, Jourdain I (2016). The Exocyst Complex in Health and Disease. Frontiers in Cell and Developmental Biology, 4 Full text.

2014

Nelson CJ, Duckney P, Hawkins TJ, Deeks MJ, Laissue PP, Hussey PJ, Obara B (2014). Blobs and curves: object-based colocalisation for plant cells. Functional Plant Biology Abstract.  Author URL.  Full text.
Hawkins TJ, Deeks MJ, Wang P, Hussey PJ (2014). The evolution of the actin binding NET superfamily. Front Plant Sci, 5 Abstract.  Author URL.  Full text.
Wang P, Hawkins TJ, Richardson C, Cummins I, Deeks MJ, Sparkes I, Hawes C, Hussey PJ (2014). The plant cytoskeleton, NET3C, and VAP27 mediate the link between the plasma membrane and endoplasmic reticulum. Curr Biol, 24(12), 1397-1405. Abstract.  Author URL.  Full text.

2012

Deeks MJ, Calcutt JR, Ingle EKS, Hawkins TJ, Chapman S, Richardson AC, Mentlak DA, Dixon MR, Cartwright F, Smertenko AP, et al (2012). A superfamily of actin-binding proteins at the actin-membrane nexus of higher plants. Current Biology, 22(17), 1595-1600. Abstract.
Tõth R, Gerding-Reimers C, Deeks MJ, Menninger S, Gallegos RM, Tonaco IAN, Hübel K, Hussey PJ, Waldmann H, Coupland G, et al (2012). Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana. Plant Journal, 71(2), 338-352. Abstract.
Jiang K, Sorefan K, Deeks MJ, Bevan MW, Hussey PJ, Hetherington AM (2012). The ARP2/3 complex mediates guard cell actin reorganization and stomatal movement in Arabidopsis. Plant Cell, 24(5), 2031-2040. Abstract.

2010

Liu J, Piette BMAG, Deeks MJ, Franklin-Tong VE, Hussey PJ (2010). A compartmental model analysis of integrative and self- regulatory ion dynamics in pollen tube growth. PLoS ONE, 5(10). Abstract.  Full text.
Smertenko AP, Deeks MJ, Hussey PJ (2010). Strategies of actin reorganisation in plant cells. J Cell Sci, 123(Pt 17), 3019-3028. Abstract.  Author URL.
Deeks MJ, Fendrych M, Smertenko A, Bell KS, Oparka K, Cvrcková F, Zársky V, Hussey PJ (2010). The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain. J Cell Sci, 123(Pt 8), 1209-1215. Abstract.  Author URL.

2009

Piette BMAG, Liu J, Peeters K, Smertenko A, Hawkins T, Deeks M, Quinlan R, Zakrzewski WJ, Hussey PJ (2009). A thermodynamic model of microtubule assembly and disassembly. PLoS One, 4(8). Abstract.  Author URL.  Full text.

2007

Deeks MJ, Rodrigues C, Dimmock S, Ketelaar T, Maciver SK, Malhó R, Hussey PJ (2007). Arabidopsis CAP1 - a key regulator of actin organisation and development. J Cell Sci, 120(Pt 15), 2609-2618. Abstract.  Author URL.
Uhrig JF, Mutondo M, Zimmermann I, Deeks MJ, Machesky LM, Thomas P, Uhrig S, Rambke C, Hussey PJ, Hülskamp M, et al (2007). The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis. Development, 134(5), 967-977. Abstract.

2006

Hussey PJ, Ketelaar T, Deeks MJ (2006). Control of the actin cytoskeleton in plant cell growth. Annual Review of Plant Biology, 57, 109-125. Abstract.

2005

Deeks MJ, Cvrcková F, Machesky LM, Mikitová V, Ketelaar T, Zársky V, Davies B, Hussey PJ (2005). Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression. New Phytologist, 168(3), 529-540. Abstract.
Deeks MJ, Hussey PJ (2005). Arp2/3 and SCAR: Plants move to the fore. Nature Reviews Molecular Cell Biology, 6(12), 954-964. Abstract.

2004

Deeks MJ, Kaloriti D, Davies B, Malhó R, Hussey PJ (2004). Arabidopsis NAP1 is essential for Arp2/3-dependent trichome morphogenesis. Current Biology, 14(15), 1410-1414. Abstract.

2003

Deeks MJ, Hussey PJ (2003). Arp2/3 and 'The Shape of things to come'. Current Opinion in Plant Biology, 6(6), 561-567. Abstract.

2002

Deeks MJ, Hussey PJ, Davies B (2002). Formins: Intermediates in signal-transduction cascades that affect cytoskeletal reorganization. Trends in Plant Science, 7(11), 492-498. Abstract.

Michael_Deeks Details from cache as at 2018-12-10 00:57:47

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External Engagment and Impact

Committee/panel activities

Vice-chair UK Biochemical Society ‘Cells’ theme panel.

Primary PI for the GW4-wide Imaging Network (funded by the GW4 communities
programme; http://projects.exeter.ac.uk/ein/).


Invited lectures

Invited guest lecturer, University of Leeds, Level 3 undergraduate plant development, May 2012.

Invited speaker – ‘Untangling Plant Actin’ SEB Annual Meeting, July 2008, Marseille.

Invited seminar speaker, Department of Plant Sciences, University of Oxford, ‘Analysing Actin Remodeling Proteins in Plants Using Reverse Genetics’. February 2007.

Invited speaker – ‘Actin Nucleating Proteins in Plants’ Bioscience 2005, September 2005, Glasgow.


Workshops/Conferences organised

Co-organiser for ‘Imaging Pathogenesis’, SEB Annual Meeting (Sweden 2017).

Co-organiser for Royal Microscopical Society Botanical Meeting (Exeter 2015).

Co-organiser 'Imaging to Mathematical Modelling' (Exeter 2013).

Local coordinator (Durham) for EPSO 'Fascination of Plants Day 2012'.

Teaching

Level 1:

  • NSC1003 - Foundations in Natural Science (lecturer)

Level 2:

  • BIO2099 - Molecular Plant Science (coordinator)
  • NSC2001 - Frontiers in Science 2 (co-coordinator)

Level 3:

  • BIO3096 - Biosciences Research Project
  • NSC3001 - Natural Sciences BSc Research Project

Level 4:

  • NSC3002 - Natural Sciences MSc Research Project

 

I am a tutor for Natural Sciences and Biosciences undergraduate students.

Modules

2018/19


Supervision / Group

Postdoctoral researchers

  • Dominique Arnaud (PI Prof. Nick Smirnoff)
  • Anja Nenninger
  • Stefan Sassmann (Co-I Christian Soeller, Physics)
  • Graham Thomas (PI Prof. Ken Haynes)

Postgraduate researchers

Alumni

  • Kathryn Grant
  • Dr. Stephen Milne
  • Dr. Cecilia Rodrigues (visiting researcher)

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