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Dr Penelope Anne Lynch

Associate Research Fellow

 

Overview

Having stupidly dropped out of the first year of a biology degree back in 1980, I have had a long career in finance before finally returning to science via a part-time maths degree and a PhD modelling evolution in disease-causing organisms. I’m now modelling the effects of public health interventions on malaria vectors, with a partcular interest in their potential evolutionary consequences and I’m endlessly surprised and grateful to find myself working on something I’m so passionately engaged by.

Qualifications

Batchelor of Science (Honours) in Mathematical Sciences, 2003, Open University

PhD, Mathematical modelling of the effects of health interventions on the evolution of life history in disease causing organisms, 2013, Open University

co-supervised by;

Professor Uwe Grimm, Department of Mathematics & Statistics at The Open University

and

Professor Andrew Fraser Read, FRS, Center for Infectious Disease Dynamics (CIDD) at Pennsylvania State University

Career

1981-present

Specialist spreadsheet modelling for project finance

2013 - present

Associate research fellow CLES

2013 - present

Working collaboratively with researchers at Penn State University

Links

Research group links

Research

Research interests

During my PhD I was fortunate enough to be able to model a novel concept in malaria control, the potential for insecticides targetting only older mosquitoes to provide good malaria control without generating strong selection for insecticide resistance. This involved modelling age-structured vector survival probabilities alongside the number of infectious bites expected per vector lifetime. This modelling then fed into a population genetics model which tracked and compared the spread of resistance, and consequent changes in infectious bites per unit of time, for vector populations subject to a range of conventional and late-life-acting interventions. I maintain my interest in this area, with my current research comprising the development and application of mathematical models which consider vector ecology and life history to explore the potential benefits of novel vector control methods. I am also still exploring ways to manage and even exploit the evolutionary effects of human interventions on vector populations.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Waite JL, Lynch PA, Thomas MB (In Press). Eave tubes for malaria control in Africa: a modelling assessment of potential impact on transmission. Malar J, 15(1). Abstract.  Author URL.  Full text.
Lynch PA, Boots M (In Press). Using evolution to generate sustainable malaria control with spatial repellents. Elife, 5 Abstract.  Author URL.  Full text.
Glunt KD, Coetzee M, Huijben S, Koffi AA, Lynch PA, N'Guessan R, Oumbouke WA, Sternberg ED, Thomas MB (2018). Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets. Evolutionary Applications, 11(4), 431-441. Abstract.
Ohm JR, Baldini F, Barreaux P, Lefevre T, Lynch PA, Suh E, Whitehead SA, Thomas MB (2018). Rethinking the extrinsic incubation period of malaria parasites. Parasites and Vectors, 11(1). Abstract.
Waite JL, Swain S, Lynch PA, Sharma SK, Haque MA, Montgomery J, Thomas MB (2017). Increasing the potential for malaria elimination by targeting zoophilic vectors. Scientific Reports, 7 Abstract.
Cator LJ, Lynch PA, Thomas MB, Read AF (2014). Alterations in mosquito behaviour by malaria parasites: potential impact on force of infection. Malaria Journal, 13(1), 164-164. Full text.
Cator LJ, Lynch PA, Read AF, Thomas MB (2012). Do malaria parasites manipulate mosquitoes?. Trends in Parasitology, 28(11), 466-470.
Lynch PA, Grimm U, Thomas MB, Read AF (2012). Prospective malaria control using entomopathogenic fungi: comparative evaluation of impact on transmission and selection for resistance. Malaria Journal(1), 383-383. Abstract.  Full text.
Read AF, Lynch PA, Thomas MB (2009). How to Make Evolution-Proof Insecticides for Malaria Control. PLoS Biology, 7, e58-e58. Abstract.  Full text.
Koella JC, Lynch PA, Thomas MB, Read AF (2009). Towards evolution-proof malaria control with insecticides. Evolutionary Applications, 2(4), 469-480.
Lynch PA, Grimm UWE, Read AF (2008). How will public and animal health interventions drive life-history evolution in parasitic nematodes?. Parasitology, 135 (Special Issue 13), 1599-1611.((Special Issue 13),), 1599-1611.  Abstract.

Publications by year


In Press

Waite JL, Lynch PA, Thomas MB (In Press). Eave tubes for malaria control in Africa: a modelling assessment of potential impact on transmission. Malar J, 15(1). Abstract.  Author URL.  Full text.
Lynch PA, Boots M (In Press). Using evolution to generate sustainable malaria control with spatial repellents. Elife, 5 Abstract.  Author URL.  Full text.

2018

Glunt KD, Coetzee M, Huijben S, Koffi AA, Lynch PA, N'Guessan R, Oumbouke WA, Sternberg ED, Thomas MB (2018). Empirical and theoretical investigation into the potential impacts of insecticide resistance on the effectiveness of insecticide-treated bed nets. Evolutionary Applications, 11(4), 431-441. Abstract.
Ohm JR, Baldini F, Barreaux P, Lefevre T, Lynch PA, Suh E, Whitehead SA, Thomas MB (2018). Rethinking the extrinsic incubation period of malaria parasites. Parasites and Vectors, 11(1). Abstract.

2017

Waite JL, Swain S, Lynch PA, Sharma SK, Haque MA, Montgomery J, Thomas MB (2017). Increasing the potential for malaria elimination by targeting zoophilic vectors. Scientific Reports, 7 Abstract.

2014

Cator LJ, Lynch PA, Thomas MB, Read AF (2014). Alterations in mosquito behaviour by malaria parasites: potential impact on force of infection. Malaria Journal, 13(1), 164-164. Full text.

2012

Cator LJ, Lynch PA, Read AF, Thomas MB (2012). Do malaria parasites manipulate mosquitoes?. Trends in Parasitology, 28(11), 466-470.
Lynch PA, Grimm U, Thomas MB, Read AF (2012). Prospective malaria control using entomopathogenic fungi: comparative evaluation of impact on transmission and selection for resistance. Malaria Journal(1), 383-383. Abstract.  Full text.

2009

Read AF, Lynch PA, Thomas MB (2009). How to Make Evolution-Proof Insecticides for Malaria Control. PLoS Biology, 7, e58-e58. Abstract.  Full text.
Koella JC, Lynch PA, Thomas MB, Read AF (2009). Towards evolution-proof malaria control with insecticides. Evolutionary Applications, 2(4), 469-480.

2008

Lynch PA, Grimm UWE, Read AF (2008). How will public and animal health interventions drive life-history evolution in parasitic nematodes?. Parasitology, 135 (Special Issue 13), 1599-1611.((Special Issue 13),), 1599-1611.  Abstract.

Penny_Lynch Details from cache as at 2018-12-11 09:20:23

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