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 Ross Brown

Ross Brown

Senior Research Fellow

 01392 72 4677

 Geoffrey Pope 202

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

I am a Senior Research Fellow in the Ecotoxicology and Aquatic Biology Research Group, based in Biosciences at the University of Exeter, UK. I previously gained 25 years of experience working in the chemical/pharmaceutical industry, in environmental risk and impact assessment. My former work spanned the prospective assessment of pharmaceutical effects on wild fish populations via laboratory exposure studies and computational population dynamics modelling - to retrospective ecological monitoring of chemical releases in aquatic ecosystems.  

My current research interests concern refining and improving the realism of environmental risk assessment via the use of molecular, ecotoxicological and ecological approaches to identify species, populations and assemblages which are most susceptible to chemical exposures and effects. Import aspects of this research include evaluating chemical impacts in the context of other environmental stressors and quantifying their potential interactions.

Broad research specialisms:

Aquatic (eco)toxicology including: assessing the impacts of chemical, physical and biological stressors on aquatic organisms (e.g. fish); extrapolating effects measured in model species in the laboratory to adverse effects on wildlife populations and communities.

Molecular, population and community ecology including: population dynamics and population genetics, focusing mainly on fish; application of computational and biological test systems for predicting environmental effects of chemicals based on ecological life-histories, environmental stressor and food web interactions.

Environmental and human health assessments including: the integrated design of risk assessments for ultimately protecting biodiversity and ecosystem services (which benefit human health) and the dual use of vertebrate models (e.g. zebrafish) as both environmental and human health assessment models.

Current Research:  

Understanding the effects of genetic and environmental factors on population fitness in fish

Prediction of fish species susceptibility to endocrine disrupting chemicals

Defining of “adverse outcome pathways” for chemicals with the aid of transgenic zebrafish models

Deriving specific protection goals for the environmental risk assessment of chemicals based on an ecosystem services framework

Qualifications

BSc. (hons); MSc.; PhD.

Research group links

Research

Research interests

Understanding the effects of genetic and environmental factors on population fitness in fish – Using laboratory to field studies and computer projections to study the interactive effects of inbreeding/ habitat loss, temperature elevation and chemical exposure on environmental sex determination and population viability of wild-caught zebrafish. 

Predicting the susceptibility of fish to endocrine disrupting chemicals (chronic reproductive toxicity) based on life-history traits - Population modelling studies focusing on pair-breeding stickleback and group-spawning roach.

Defining “adverse outcome pathways” for chemicals with the aid of transgenic (TG) zebrafish models:
e.g. Bisphenol A -Linking estrogen receptor activation and signalling with impaired cardio-vascular development and function in TG zebrafish
e.g Azole fungicides - Linking CYP26 and CYP51 enzyme inhibition with abnormal cranio-facial development using TG zebrafish as vertebrate models in human safety assessment.

Deriving specific protection goals for environmental risk assessment of chemicals based on an ecosystem services framework – Considering spatial (landscape) variation in habitat and functional redundancy in ecosystem service provision in order to highlight key service providing units and protection goals.

Research projects

Exploiting transgenic zebrafish embryos/larvae in (agro)chemical hazard assessment

Grants/Funding:

BBSRC/Syngenta Flexible Interchange Project (2 year Industrial Fellowship)

Links


Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Green JM, Metz J, Lee O, Trznadel M, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR (In Press). High-Content and Semi-Automated Quantification of Responses to Estrogenic Chemicals Using a Novel Translucent Transgenic Zebrafish. Environ Sci Technol, 50(12), 6536-6545. Abstract.  Author URL.
Brown AR (In Press). Predicting the effects of endocrine disruptors on fish populations. Human and ecological risk assessment, 9, 761-788.
Brown AR, Whale G, Jackson M, Marshall S, Hamer M, Solga A, Kabouw P, Galay-Burgos M, Woods R, Nadzialek S, et al (2017). Toward the definition of specific protection goals for the environmental risk assessment of chemicals: a perspective on environmental regulation in Europe. Integr Environ Assess Manag, 13(1), 17-37. Abstract.  Author URL.  Full text.
Wolf JC, Dietrich DR, Friederich U, Caunter J, Brown AR (2016). Qualitative and Quantitative Histomorphologic Assessment of Fathead Minnow Pimephales promelas Gonads as an Endpoint for Evaluating Endocrine-Active Compounds: a Pilot Methodology Study. Toxicologic Pathology, 32(5), 600-612.
Brown AR, Owen SF, Peters J, Zhang Y, Soffker M, Paull GC, Hosken DJ, Wahab MA, Tyler CR (2015). Climate change and pollution speed declines in zebrafish populations. Proc Natl Acad Sci U S A, 112(11), E1237-E1246. Abstract.  Author URL.  Full text.
Brown AR, Gunnarsson L, Kristiansson E, Tyler CR (2014). Assessing variation in the potential susceptibility of fish to pharmaceuticals, considering evolutionary differences in their physiology and ecology. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1656). Abstract.  Full text.
Arnold KE, Brown AR, Ankley GT, Sumpter JP (2014). Medicating the environment: assessing risks of pharmaceuticals to wildlife and ecosystems. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 369(1656). Author URL.  Full text.
Sumpter JP (2014). The challenge : Do pharmaceuticals present a risk to the environment, and what needs to be done to answer the question?. Environmental Toxicology and Chemistry, 33(9), 1915-1915.
Bickley LK, Brown AR, Hosken DJ, Hamilton PB, Le Page G, Paull GC, Owen SF, Tyler CR (2013). Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish. Evolutionary Applications, 6(2), 279-289. Abstract.  Full text.
Brown AR, Bickley LK, Ryan TA, Paull GC, Hamilton PB, Owen SF, Sharpe AD, Tyler CR (2012). Differences in sexual development in inbred and outbred zebrafish (Danio rerio) and implications for chemical testing. Aquat Toxicol, 112-113, 27-38. Abstract.  Author URL.
Brown AR, Bickley LK, Le Page G, Hosken DJ, Paull GC, Hamilton PB, Owen SF, Robinson J, Sharpe AD, Tyler CR, et al (2011). Are toxicological responses in laboratory (inbred) zebrafish representative of those in outbred (wild) populations? - a case study with an endocrine disrupting chemical. Environ Sci Technol, 45(9), 4166-4172. Abstract.  Author URL.
Langston WJ, Pope ND, Jonas PJC, Nikitic C, Field MDR, Dowell B, Shillabeer N, Swarbrick RH, Brown AR (2010). Contaminants in fine sediments and their consequences for biota of the Severn Estuary. MARINE POLLUTION BULLETIN, 61(1-3), 68-82. Author URL.
Crane M, Gross M, Matthiessen P, Ankley GT, Axford S, Bjerregaard P, Brown R, Chapman P, Dorgeloh M, Galay-Burgos M, et al (2010). Multi-criteria decision analysis of test endpoints for detecting the effects of endocrine active substances in fish full life cycle tests. Integrated Environmental Assessment and Management, 6(3), 378-389.
Brown AR, Hosken DJ, Balloux F, Bickley LK, LePage G, Owen SF, Hetheridge MJ, Tyler CR (2009). Genetic variation, inbreeding and chemical exposure--combined effects in wildlife and critical considerations for ecotoxicology. Philos Trans R Soc Lond B Biol Sci, 364(1534), 3377-3390. Abstract.  Author URL.
Brown A, Riddle A, Winfield I, Fletcher J, James J (2005). Predicting the effects of endocrine disrupting chemicals on healthy and disease impacted populations of perch (perca fluviatilis). Ecological Modelling, 189(3-4), 377-395.
Cape J, Leith I, Binnie J, Content J, Donkin M, Skewes M, Price D, Brown A, Sharpe A (2003). Effects of VOCs on herbaceous plants in an open-top chamber experiment. Environmental Pollution, 124(2), 341-353.
Warwick R, Ashman C, Brown A, Clarke K, Dowell B, Hart B, Lewis Re Shillabeer N, Somerfield P, Tapp J (2002). Inter-annual changes in the biodiversity and community structure of the macrobenthos in Tees Bay and the Tees estuary, UK, associated with local and regional environmental events. Marine Ecology Progress Series, 234, 1-13.
Brown AR, Shillabeer N (1996). Development of a biologically based environmental quality standard from a long-term benthic monitoring programme in the North Sea. Oceanologica Acta, 20, 275-282.

Chapters

Brown AR, Robinson PF, Riddle AM, Panter GH (2009). Population dynamics modelling: a tool for environmental risk assessment of endocrine disrupting chemicals. In Devillers J (Ed) Endocrine disruption modelling, Boca Raton, FL, USA: CRC Press.
Cape N, Leith ID, Binnie J, Dopnkin M, Price DN, Brown AR, Schroder P (2004). Techniques for measuring the response of plants to VOC exposure. In Klump A, Ansel W, Klump G (Eds.) Urban air pollution, bioindication and environmental awareness, Göttingen: Cuvillier Verlag.

Conferences

Arnold KE, Boxall ABA, Brown AR, Cuthbert RJ, Gaw S, Hutchinson TH, Jobling S, Madden JC, Metcalfe CD, Naidoo V, et al (2013). Assessing the exposure risk and impacts of pharmaceuticals in the environment on individuals and ecosystems.  Abstract.

Publications by year


In Press

Green JM, Metz J, Lee O, Trznadel M, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR (In Press). High-Content and Semi-Automated Quantification of Responses to Estrogenic Chemicals Using a Novel Translucent Transgenic Zebrafish. Environ Sci Technol, 50(12), 6536-6545. Abstract.  Author URL.
Brown AR (In Press). Predicting the effects of endocrine disruptors on fish populations. Human and ecological risk assessment, 9, 761-788.

2017

Brown AR, Whale G, Jackson M, Marshall S, Hamer M, Solga A, Kabouw P, Galay-Burgos M, Woods R, Nadzialek S, et al (2017). Toward the definition of specific protection goals for the environmental risk assessment of chemicals: a perspective on environmental regulation in Europe. Integr Environ Assess Manag, 13(1), 17-37. Abstract.  Author URL.  Full text.

2016

Wolf JC, Dietrich DR, Friederich U, Caunter J, Brown AR (2016). Qualitative and Quantitative Histomorphologic Assessment of Fathead Minnow Pimephales promelas Gonads as an Endpoint for Evaluating Endocrine-Active Compounds: a Pilot Methodology Study. Toxicologic Pathology, 32(5), 600-612.

2015

Brown AR, Owen SF, Peters J, Zhang Y, Soffker M, Paull GC, Hosken DJ, Wahab MA, Tyler CR (2015). Climate change and pollution speed declines in zebrafish populations. Proc Natl Acad Sci U S A, 112(11), E1237-E1246. Abstract.  Author URL.  Full text.

2014

Brown AR, Gunnarsson L, Kristiansson E, Tyler CR (2014). Assessing variation in the potential susceptibility of fish to pharmaceuticals, considering evolutionary differences in their physiology and ecology. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1656). Abstract.  Full text.
Arnold KE, Brown AR, Ankley GT, Sumpter JP (2014). Medicating the environment: assessing risks of pharmaceuticals to wildlife and ecosystems. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 369(1656). Author URL.  Full text.
Sumpter JP (2014). The challenge : Do pharmaceuticals present a risk to the environment, and what needs to be done to answer the question?. Environmental Toxicology and Chemistry, 33(9), 1915-1915.

2013

Arnold KE, Boxall ABA, Brown AR, Cuthbert RJ, Gaw S, Hutchinson TH, Jobling S, Madden JC, Metcalfe CD, Naidoo V, et al (2013). Assessing the exposure risk and impacts of pharmaceuticals in the environment on individuals and ecosystems.  Abstract.
Bickley LK, Brown AR, Hosken DJ, Hamilton PB, Le Page G, Paull GC, Owen SF, Tyler CR (2013). Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish. Evolutionary Applications, 6(2), 279-289. Abstract.  Full text.

2012

Brown AR, Bickley LK, Ryan TA, Paull GC, Hamilton PB, Owen SF, Sharpe AD, Tyler CR (2012). Differences in sexual development in inbred and outbred zebrafish (Danio rerio) and implications for chemical testing. Aquat Toxicol, 112-113, 27-38. Abstract.  Author URL.

2011

Brown AR, Bickley LK, Le Page G, Hosken DJ, Paull GC, Hamilton PB, Owen SF, Robinson J, Sharpe AD, Tyler CR, et al (2011). Are toxicological responses in laboratory (inbred) zebrafish representative of those in outbred (wild) populations? - a case study with an endocrine disrupting chemical. Environ Sci Technol, 45(9), 4166-4172. Abstract.  Author URL.

2010

Langston WJ, Pope ND, Jonas PJC, Nikitic C, Field MDR, Dowell B, Shillabeer N, Swarbrick RH, Brown AR (2010). Contaminants in fine sediments and their consequences for biota of the Severn Estuary. MARINE POLLUTION BULLETIN, 61(1-3), 68-82. Author URL.
Crane M, Gross M, Matthiessen P, Ankley GT, Axford S, Bjerregaard P, Brown R, Chapman P, Dorgeloh M, Galay-Burgos M, et al (2010). Multi-criteria decision analysis of test endpoints for detecting the effects of endocrine active substances in fish full life cycle tests. Integrated Environmental Assessment and Management, 6(3), 378-389.

2009

Brown AR, Hosken DJ, Balloux F, Bickley LK, LePage G, Owen SF, Hetheridge MJ, Tyler CR (2009). Genetic variation, inbreeding and chemical exposure--combined effects in wildlife and critical considerations for ecotoxicology. Philos Trans R Soc Lond B Biol Sci, 364(1534), 3377-3390. Abstract.  Author URL.
Brown AR, Robinson PF, Riddle AM, Panter GH (2009). Population dynamics modelling: a tool for environmental risk assessment of endocrine disrupting chemicals. In Devillers J (Ed) Endocrine disruption modelling, Boca Raton, FL, USA: CRC Press.

2005

Brown A, Riddle A, Winfield I, Fletcher J, James J (2005). Predicting the effects of endocrine disrupting chemicals on healthy and disease impacted populations of perch (perca fluviatilis). Ecological Modelling, 189(3-4), 377-395.

2004

Cape N, Leith ID, Binnie J, Dopnkin M, Price DN, Brown AR, Schroder P (2004). Techniques for measuring the response of plants to VOC exposure. In Klump A, Ansel W, Klump G (Eds.) Urban air pollution, bioindication and environmental awareness, Göttingen: Cuvillier Verlag.

2003

Cape J, Leith I, Binnie J, Content J, Donkin M, Skewes M, Price D, Brown A, Sharpe A (2003). Effects of VOCs on herbaceous plants in an open-top chamber experiment. Environmental Pollution, 124(2), 341-353.

2002

Warwick R, Ashman C, Brown A, Clarke K, Dowell B, Hart B, Lewis Re Shillabeer N, Somerfield P, Tapp J (2002). Inter-annual changes in the biodiversity and community structure of the macrobenthos in Tees Bay and the Tees estuary, UK, associated with local and regional environmental events. Marine Ecology Progress Series, 234, 1-13.

1996

Brown AR, Shillabeer N (1996). Development of a biologically based environmental quality standard from a long-term benthic monitoring programme in the North Sea. Oceanologica Acta, 20, 275-282.

Ross_Brown Details from cache as at 2018-12-09 15:02:19

Refresh publications

External Engagment and Impact

Committee/panel activities

Society for Environmental Toxicology and Chemistry (SETAC): Personal Member 2003-date; Scientific Committee Member 2012-2013

Estuarine and Coastal Sciences Assoc. (ESCA): Council Member 2003-date; Publicity Officer 2014-date

European Centre for Ecotoxicology Of Chemicals (ECETOC): Task Force on Ecosystem Services in Environmental Risk Assessment 2013-15


Editorial responsibilities

Guest editor for Philosophical Transactions of the Royal Society B. Issue: “Assessing risks and impacts of pharmaceuticals in the environment” (Oct. 2014) Regular

Reviewer for: Science of the Total Environment; Environmental Toxicology and Chemistry; Aquatic Toxicology


Invited lectures

European Federation of Pharmaceutical Sciences (EUFEPS) Annual Meeting System Approaches for Better Medicines and Health 15-17 June 2015 Geneva.


Media Coverage

“Scientists warn that fish are changing SEX due to warmer climate”
The Express 3 Mar 2015

Teaching

Supervision / Group

Postgraduate researchers

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