Geoffrey Pope Lab 201
Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK
In the summer of 2016, between the 2nd and 3rd year of BSc Zoology degree, I conducted a summer studentship here at the University of Exeter. The aim was to determine if a population of zebrafish carried resistance to the pesticide Pictroxoxin, and if so, begin preliminary molecular analysis to see if this mutation was caused by a mutation on a GABA receptor, as is exhibited in invertebrates. Having loved this project, this led me to pursue a PhD in this area of research.
Broad research specialisms
The effects of environmental contaminants on aquatic species.
Project Title: Integrated health effects analysis of antidepressants inhibiting serotonin and/or norepinephrine reuptake using zebrafish models
Supervisors: Professor Charles Tyler, Dr Matthew Winter, Dr Lina Gunnarsson and Dr Malcolm Hetheridge
Funding Body: MSD and University of Exeter
My PhD has three key parts; first, I will assess the bioavailability of a range of widely prescribed antidepressants that are detected in the environment. Secondly, using a transgenic zebrafish model, I will use light sheet microscopy to identify the neural circuits affected by exposure to these drugs. Finally, based on the results I generate from the first two studies, I will design an assay that will enable me to target specific larval fish behaviours, such as measuring anxiety via altered explanatory behaviour.
Poster presentation at the Autumn iPiE meeting.