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Dr Steffen Scholpp

Dr Steffen Scholpp

Associate Professor, Cell and Developmental Biology

 7451

 Living Systems Institute 

 

Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD

Tissue development is a key process for life starting from the earliest embryonic stages during which cells differentiate into later organs composing an entire body. An essential component for these developmental processes but also for tissue regeneration and stem cell regulation is the communication of cells by chemical signalling. The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration dependent manner. We identified a novel way of spreading of Wnt proteins in vertebrates: Wnt molecules are mobilized on specific cell protrusions so-called cytonemes. These specialized signalling filopodia transmit signal proteins between communicating cells and allow a high degree of control of propagation speed, direction and concentration of the transmitted ligand. The signalling molecules are delivered directly to the receiving cells by a direct-contact model and parameters such as cytoneme length or speed of filopodia formation dictate local Wnt concentration. At the Living Systems Institute, we collaborate with biophysicists using super-resolution microscopy to describe these signalling processes in a quantitative way on a molecular level. As it is very difficult to determine the specific impact of individual parameters in a complex biological system by a purely experimental approach, we interact with mathematicians using computational modelling. Together, we develop a robust mathematical model for the distribution of signal molecules on the basis of signalling filopodia. Due to the conserved nature of vertebrate cell behaviour our results will be relevant to Wnt signalling during human embryonic development and could suggest novel vulnerabilities to Wnt-dependent diseases – a prerequisite for the development of novel therapeutics.

Living Systems Institute Profile

Qualifications

2003 PhD Neurobiology (Hons., summa cum laude), University of Heidelberg, Germany

Career

2017-present Associate Professor of Cell and Developmental Biology, Biosciences, University of Exeter, UK

2009-2016 Emmy-Noether group leader (Assistant Professor) at the Karlsruhe Institute of Technology (KIT), Germany

2004-2009 Postdoctoral Research Fellow with Andrew Lumsden, MRC Centre for Developmental Neurobiology, King’s College London, UK

2003-2004 Postdoctoral Research Associate with M. Brand, Max Planck-Institute of Cell Biology and Genetics (MPI-CBG), Dresden, Germany

1999-2003 PhD in Neurobiology (Laboratory of M. Brand), University of Heidelberg, Germany and Max Planck-Institute of Cell Biology and Genetics (MPI-CBG), Dresden, Germany

Wnt protein (red) on cytoneme tips in vivo

Research

Research interests

After secretion, developmental signals known as morphogens must travel relatively long distances to form a concentration gradient that the responding tissue uses to acquire positional information. The role of morphogen transport and endocytic trafficking in this process is the subject of intense debate. Wnt proteins regulate developmental processes, tissue regeneration and stem cell maintenance. It has been postulated that Wnt/β-catenin signalling form concentration gradients across responsive tissues and act as morphogens. However, little is known about the transport mechanism for these lipid-modified signalling proteins in vertebrates.

Recently, we showed that Wnt8a is transported on short, actin-based filopodia to contact responding cells and activate signalling during neural plate formation in zebrafish (1). Cdc42/N-Wasp regulates the formation of these Wnt-positive filopodia. Enhanced formation of filopodia increases the effective signalling range of Wnt by facilitating spreading. Consistently, reduction in filopodia leads to a restricted distribution of the ligand and a limited signalling range. Using a numerical simulation, we provide evidence that such a short-range transport system for Wnt has long-range signalling function.

After contact by Wnt/β-catenin positive filopodia, a multi-protein complex at the plasma membrane assembles clustering membrane-bound receptors and intracellular signal transducers into the so-called Lrp6-signalosome. Our imaging studies in live zebrafish embryos showed that the signalosome is a highly dynamic structure, which is continuously assembled and disassembled by a Dvl2-mediated endocytic process (2). We showed that this endocytic process is not only essential for ligand-receptor internalization but also for signaling.

We conclude that a cytoneme-based transport system for Wnt and subsequent endocytosis is important for Wnt/β-catenin signaling and controls anteroposterior patterning of the neural plate during vertebrate gastrulation (3,4).

(1) Stanganello et al., Nature Comms., 2015; (2) Hagemann, et al., J.Cell Sci., 2014; (3) Stanganello and Scholpp, J.Cell Sci., 2016; (4) Brunt and Scholpp, CMLS, 2017

Key publications | Publications by category | Publications by year

Key publications


Stanganello E, Hagemann AIH, Mattes B, Sinner C, Meyen D, Weber S, Schug A, Raz E, Scholpp S (2015). Filopodia-based Wnt transport during vertebrate tissue patterning. Nat Commun, 6 Abstract.  Author URL.

Publications by category


Journal articles

Gardilla AC, Sanchez D, Brunt L, Scholpp S (In Press). From top to bottom: Cell polarity in Hedgehog and Wnt trafficking. BMC Biology Full text.
Liu T-L, Upadhyayula S, Milkie D, Singh V, Wang K, Swineburn I, Scholpp S, Megason S, Kirchhausen T, Betzig E, et al (In Press). Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science
Brunt L, Scholpp S (2018). The function of endocytosis in Wnt signaling. Cellular and Molecular Life Sciences, 75(5), 785-795. Abstract.  Full text.
Stanganello E, Scholpp S (2016). Role of cytonemes in Wnt transport. J Cell Sci, 129(4), 665-672. Abstract.  Author URL.
Brinkmann E-M, Mattes B, Kumar R, Hagemann AIH, Gradl D, Scholpp S, Steinbeisser H, Kaufmann LT, Özbek S (2016). Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation. J Biol Chem, 291(26), 13730-13742. Abstract.  Author URL.  Full text.
Stanganello E, Hagemann AIH, Mattes B, Sinner C, Meyen D, Weber S, Schug A, Raz E, Scholpp S (2015). Filopodia-based Wnt transport during vertebrate tissue patterning. Nat Commun, 6 Abstract.  Author URL.
Hirschbiel AF, Geyer S, Yameen B, Welle A, Nikolov P, Giselbrecht S, Scholpp S, Delaittre G, Barner-Kowollik C (2015). Photolithographic patterning of 3D-formed polycarbonate films for targeted cell guiding. Adv Mater, 27(16), 2621-2626. Abstract.  Author URL.
Hagemann AIH, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S, et al (2014). Correction to in vivo analysis of formation and endocytosis of the Wnt/β-Catenin signaling complex in zebrafish embryos [J. Cell Sci. 127, (2014) 3970-3982]. Journal of Cell Science, 127(24).
Rengarajan C, Matzke A, Reiner L, Orian-Rousseau V, Scholpp S (2014). Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling. PLoS One, 9(1). Abstract.  Author URL.
Hagemann AIH, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S, et al (2014). In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryos. J Cell Sci, 127(Pt 18), 3970-3982. Abstract.  Author URL.
Chatterjee M, Guo Q, Weber S, Scholpp S, Li JY (2014). Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates. BMC Biol, 12 Abstract.  Author URL.
Chen Q, Su Y, Wesslowski J, Hagemann AI, Ramialison M, Wittbrodt J, Scholpp S, Davidson G (2014). Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signalling. EMBO Rep, 15(12), 1254-1267. Abstract.  Author URL.
Scholpp S, Poggi L, Zigman M (2013). Brain on the stage - spotlight on nervous system development in zebrafish: EMBO practical course, KIT, Sept. 2013. Neural Dev, 8 Abstract.  Author URL.
Scholpp S, Shimogori T (2013). Building the gateway to consciousness-about the development of the thalamus. Front Neurosci, 7 Author URL.
Efremov AN, Stanganello E, Welle A, Scholpp S, Levkin PA (2013). Micropatterned superhydrophobic structures for the simultaneous culture of multiple cell types and the study of cell-cell communication. Biomaterials, 34(7), 1757-1763. Abstract.  Author URL.
Schmidt R, Strähle U, Scholpp S (2013). Neurogenesis in zebrafish - from embryo to adult. Neural Dev, 8 Abstract.  Author URL.
Hagemann AIH, Scholpp S (2012). The Tale of the Three Brothers - Shh, Wnt, and Fgf during Development of the Thalamus. Front Neurosci, 6 Abstract.  Author URL.
Mattes B, Weber S, Peres J, Chen Q, Davidson G, Houart C, Scholpp S (2012). Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain. Neural Dev, 7 Abstract.  Author URL.
Peukert D, Weber S, Lumsden A, Scholpp S (2011). Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling. PLoS Biol, 9(12). Abstract.  Author URL.
Scholpp S, Lumsden A (2010). Building a bridal chamber: development of the thalamus. Trends Neurosci, 33(8), 373-380. Abstract.  Author URL.
Blackshaw S, Scholpp S, Placzek M, Ingraham H, Simerly R, Shimogori T (2010). Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation. J Neurosci, 30(45), 14925-14930. Abstract.  Author URL.
Peukert D, Scholpp S (2010). Ontogenesis of the brain: the development of the thalamus - the gateway to consciousness. BioSpektrum, 16(6), 639-643. Abstract.
Fassier C, Hutt JA, Scholpp S, Lumsden A, Giros B, Nothias F, Schneider-Maunoury S, Houart C, Hazan J (2010). Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway. Nat Neurosci, 13(11), 1380-1387. Abstract.  Author URL.
Yu SR, Burkhardt M, Nowak M, Ries J, Petrásek Z, Scholpp S, Schwille P, Brand M (2009). Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature, 461(7263), 533-536. Abstract.  Author URL.
Scholpp S, Delogu A, Gilthorpe J, Peukert D, Schindler S, Lumsden A (2009). Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus. Proc Natl Acad Sci U S A, 106(47), 19895-19900. Abstract.  Author URL.
Wendl T, Adzic D, Schoenebeck JJ, Scholpp S, Brand M, Yelon D, Rohr KB (2007). Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development, 134(15), 2871-2879. Abstract.  Author URL.
Scholpp S, Foucher I, Staudt N, Peukert D, Lumsden A, Houart C (2007). Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon. Development, 134(17), 3167-3176. Abstract.  Author URL.
Erickson T, Scholpp S, Brand M, Moens CB, Waskiewicz AJ (2007). Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries. Dev Biol, 301(2), 504-517. Abstract.  Author URL.
Scholpp S, Wolf O, Brand M, Lumsden A (2006). Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon. Development, 133(5), 855-864. Abstract.  Author URL.
Scholpp S, Brand M (2004). Endocytosis controls spreading and effective signaling range of Fgf8 protein. Curr Biol, 14(20), 1834-1841. Abstract.  Author URL.
Scholpp S, Groth C, Lohs C, Lardelli M, Brand M (2004). Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Dev Genes Evol, 214(6), 285-295. Abstract.  Author URL.
Scholpp S, Lohs C, Brand M (2003). Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon (vol 130, pg 4881, 2003). DEVELOPMENT, 130(21), 5293-5293. Author URL.
Scholpp S, Lohs C, Brand M (2003). Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon. Development, 130(20), 4881-4893. Abstract.  Author URL.
Scholpp S, Lohs C, Brand M (2003). Erratum: Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon (Development vol. 130 (4881-4893)). Development, 130(21).
Scholpp S, Brand M (2003). Integrity of the midbrain region is required to maintain the diencephalic-mesencephalic boundary in zebrafish no isthmus/pax2.1 mutants. Dev Dyn, 228(3), 313-322. Abstract.  Author URL.
Picker A, Scholpp S, Böhli H, Takeda H, Brand M (2002). A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines. Development, 129(13), 3227-3239. Abstract.  Author URL.
Scholpp S, Brand M (2001). Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique functions in midbrain--hindbrain boundary development. Genesis, 30(3), 129-133. Author URL.

Chapters

Scholpp S, Brand M (2010). Neural Patterning: Midbrain-Hindbrain Boundary. In  (Ed) Encyclopedia of Neuroscience, 205-211.  Abstract.

Conferences

Mattes B, Scholpp S (2017). Towards deciphering the molecular mechanism regulating Wnt ligand trafficking.  Author URL.
Reinartz I, Sinner C, Stanganello E, Mattes B, Scholpp S, Schug A (2016). 3D Simulations of Morphogen Transport in an Early Fish Embryo.  Author URL.
Sinner C, Reinartz I, Boesze B, Scholpp S, Schug A (2016). Dynamic Simulations of Cell Migration with Applications to Brain Development.  Author URL.
Heeren-Hagemann A, Kurz J, Kauffeld S, Chen Q, Reeves P, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S, et al (2016). In vivo analysis of formation and endocytosis of the Wnt/beta-Catenin signaling complex in zebrafish embryos.  Author URL.
Sinner C, Stanganello E, Hagemann AIH, Mattes B, Meyen D, Weber S, Raz E, Scholpp S, Schug A (2015). Monte Carlo Simulation of Wnt Propagation by a Novel Transport Mechanism Complementing a Joint Experimental Study.  Author URL.
Hagemann A, Kurz J, Kauffeld S, Chen Q, Reeves P, Davidson G, Kirchhausen T, Scholpp S (2014). In-vivo analysis of formation and endocytosis of the Wnt/beta-catenin signaling complex in zebrafish embryos.  Author URL.
Hagemann AI, Schindler S, Scholpp S (2010). The clathrin adaptor-protein subunit ap2m1 regulates canonical Wnt signalling in early neural development of the zebrafish.  Author URL.
Heinze KG, Schlopp S, Brand M, Schwille P (2004). Probing intercellular pathways and propagation of Fgf8 signalling protein during embryogenesis by FCS.  Author URL.
Scholpp S, Brand M (2003). Endocytosis controls propagation of Fgf8 during zebrafish embryogenesis.  Author URL.

Publications by year


In Press

Gardilla AC, Sanchez D, Brunt L, Scholpp S (In Press). From top to bottom: Cell polarity in Hedgehog and Wnt trafficking. BMC Biology Full text.
Liu T-L, Upadhyayula S, Milkie D, Singh V, Wang K, Swineburn I, Scholpp S, Megason S, Kirchhausen T, Betzig E, et al (In Press). Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science

2018

Brunt L, Scholpp S (2018). The function of endocytosis in Wnt signaling. Cellular and Molecular Life Sciences, 75(5), 785-795. Abstract.  Full text.

2017

Mattes B, Scholpp S (2017). Towards deciphering the molecular mechanism regulating Wnt ligand trafficking.  Author URL.

2016

Reinartz I, Sinner C, Stanganello E, Mattes B, Scholpp S, Schug A (2016). 3D Simulations of Morphogen Transport in an Early Fish Embryo.  Author URL.
Sinner C, Reinartz I, Boesze B, Scholpp S, Schug A (2016). Dynamic Simulations of Cell Migration with Applications to Brain Development.  Author URL.
Heeren-Hagemann A, Kurz J, Kauffeld S, Chen Q, Reeves P, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S, et al (2016). In vivo analysis of formation and endocytosis of the Wnt/beta-Catenin signaling complex in zebrafish embryos.  Author URL.
Stanganello E, Scholpp S (2016). Role of cytonemes in Wnt transport. J Cell Sci, 129(4), 665-672. Abstract.  Author URL.
Brinkmann E-M, Mattes B, Kumar R, Hagemann AIH, Gradl D, Scholpp S, Steinbeisser H, Kaufmann LT, Özbek S (2016). Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation. J Biol Chem, 291(26), 13730-13742. Abstract.  Author URL.  Full text.

2015

Stanganello E, Hagemann AIH, Mattes B, Sinner C, Meyen D, Weber S, Schug A, Raz E, Scholpp S (2015). Filopodia-based Wnt transport during vertebrate tissue patterning. Nat Commun, 6 Abstract.  Author URL.
Sinner C, Stanganello E, Hagemann AIH, Mattes B, Meyen D, Weber S, Raz E, Scholpp S, Schug A (2015). Monte Carlo Simulation of Wnt Propagation by a Novel Transport Mechanism Complementing a Joint Experimental Study.  Author URL.
Hirschbiel AF, Geyer S, Yameen B, Welle A, Nikolov P, Giselbrecht S, Scholpp S, Delaittre G, Barner-Kowollik C (2015). Photolithographic patterning of 3D-formed polycarbonate films for targeted cell guiding. Adv Mater, 27(16), 2621-2626. Abstract.  Author URL.

2014

Hagemann AIH, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S, et al (2014). Correction to in vivo analysis of formation and endocytosis of the Wnt/β-Catenin signaling complex in zebrafish embryos [J. Cell Sci. 127, (2014) 3970-3982]. Journal of Cell Science, 127(24).
Rengarajan C, Matzke A, Reiner L, Orian-Rousseau V, Scholpp S (2014). Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling. PLoS One, 9(1). Abstract.  Author URL.
Hagemann AIH, Kurz J, Kauffeld S, Chen Q, Reeves PM, Weber S, Schindler S, Davidson G, Kirchhausen T, Scholpp S, et al (2014). In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryos. J Cell Sci, 127(Pt 18), 3970-3982. Abstract.  Author URL.
Hagemann A, Kurz J, Kauffeld S, Chen Q, Reeves P, Davidson G, Kirchhausen T, Scholpp S (2014). In-vivo analysis of formation and endocytosis of the Wnt/beta-catenin signaling complex in zebrafish embryos.  Author URL.
Chatterjee M, Guo Q, Weber S, Scholpp S, Li JY (2014). Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates. BMC Biol, 12 Abstract.  Author URL.
Chen Q, Su Y, Wesslowski J, Hagemann AI, Ramialison M, Wittbrodt J, Scholpp S, Davidson G (2014). Tyrosine phosphorylation of LRP6 by Src and Fer inhibits Wnt/β-catenin signalling. EMBO Rep, 15(12), 1254-1267. Abstract.  Author URL.

2013

Scholpp S, Poggi L, Zigman M (2013). Brain on the stage - spotlight on nervous system development in zebrafish: EMBO practical course, KIT, Sept. 2013. Neural Dev, 8 Abstract.  Author URL.
Scholpp S, Shimogori T (2013). Building the gateway to consciousness-about the development of the thalamus. Front Neurosci, 7 Author URL.
Efremov AN, Stanganello E, Welle A, Scholpp S, Levkin PA (2013). Micropatterned superhydrophobic structures for the simultaneous culture of multiple cell types and the study of cell-cell communication. Biomaterials, 34(7), 1757-1763. Abstract.  Author URL.
Schmidt R, Strähle U, Scholpp S (2013). Neurogenesis in zebrafish - from embryo to adult. Neural Dev, 8 Abstract.  Author URL.

2012

Hagemann AIH, Scholpp S (2012). The Tale of the Three Brothers - Shh, Wnt, and Fgf during Development of the Thalamus. Front Neurosci, 6 Abstract.  Author URL.
Mattes B, Weber S, Peres J, Chen Q, Davidson G, Houart C, Scholpp S (2012). Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain. Neural Dev, 7 Abstract.  Author URL.

2011

Peukert D, Weber S, Lumsden A, Scholpp S (2011). Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling. PLoS Biol, 9(12). Abstract.  Author URL.

2010

Scholpp S, Lumsden A (2010). Building a bridal chamber: development of the thalamus. Trends Neurosci, 33(8), 373-380. Abstract.  Author URL.
Blackshaw S, Scholpp S, Placzek M, Ingraham H, Simerly R, Shimogori T (2010). Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation. J Neurosci, 30(45), 14925-14930. Abstract.  Author URL.
Scholpp S, Brand M (2010). Neural Patterning: Midbrain-Hindbrain Boundary. In  (Ed) Encyclopedia of Neuroscience, 205-211.  Abstract.
Peukert D, Scholpp S (2010). Ontogenesis of the brain: the development of the thalamus - the gateway to consciousness. BioSpektrum, 16(6), 639-643. Abstract.
Hagemann AI, Schindler S, Scholpp S (2010). The clathrin adaptor-protein subunit ap2m1 regulates canonical Wnt signalling in early neural development of the zebrafish.  Author URL.
Fassier C, Hutt JA, Scholpp S, Lumsden A, Giros B, Nothias F, Schneider-Maunoury S, Houart C, Hazan J (2010). Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway. Nat Neurosci, 13(11), 1380-1387. Abstract.  Author URL.

2009

Yu SR, Burkhardt M, Nowak M, Ries J, Petrásek Z, Scholpp S, Schwille P, Brand M (2009). Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature, 461(7263), 533-536. Abstract.  Author URL.
Scholpp S, Delogu A, Gilthorpe J, Peukert D, Schindler S, Lumsden A (2009). Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus. Proc Natl Acad Sci U S A, 106(47), 19895-19900. Abstract.  Author URL.

2007

Wendl T, Adzic D, Schoenebeck JJ, Scholpp S, Brand M, Yelon D, Rohr KB (2007). Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development, 134(15), 2871-2879. Abstract.  Author URL.
Scholpp S, Foucher I, Staudt N, Peukert D, Lumsden A, Houart C (2007). Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon. Development, 134(17), 3167-3176. Abstract.  Author URL.
Erickson T, Scholpp S, Brand M, Moens CB, Waskiewicz AJ (2007). Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries. Dev Biol, 301(2), 504-517. Abstract.  Author URL.

2006

Scholpp S, Wolf O, Brand M, Lumsden A (2006). Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon. Development, 133(5), 855-864. Abstract.  Author URL.

2004

Scholpp S, Brand M (2004). Endocytosis controls spreading and effective signaling range of Fgf8 protein. Curr Biol, 14(20), 1834-1841. Abstract.  Author URL.
Heinze KG, Schlopp S, Brand M, Schwille P (2004). Probing intercellular pathways and propagation of Fgf8 signalling protein during embryogenesis by FCS.  Author URL.
Scholpp S, Groth C, Lohs C, Lardelli M, Brand M (2004). Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Dev Genes Evol, 214(6), 285-295. Abstract.  Author URL.

2003

Scholpp S, Brand M (2003). Endocytosis controls propagation of Fgf8 during zebrafish embryogenesis.  Author URL.
Scholpp S, Lohs C, Brand M (2003). Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon (vol 130, pg 4881, 2003). DEVELOPMENT, 130(21), 5293-5293. Author URL.
Scholpp S, Lohs C, Brand M (2003). Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon. Development, 130(20), 4881-4893. Abstract.  Author URL.
Scholpp S, Lohs C, Brand M (2003). Erratum: Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon (Development vol. 130 (4881-4893)). Development, 130(21).
Scholpp S, Brand M (2003). Integrity of the midbrain region is required to maintain the diencephalic-mesencephalic boundary in zebrafish no isthmus/pax2.1 mutants. Dev Dyn, 228(3), 313-322. Abstract.  Author URL.

2002

Picker A, Scholpp S, Böhli H, Takeda H, Brand M (2002). A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines. Development, 129(13), 3227-3239. Abstract.  Author URL.

2001

Scholpp S, Brand M (2001). Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique functions in midbrain--hindbrain boundary development. Genesis, 30(3), 129-133. Author URL.

Steffen_Scholpp Details from cache as at 2018-05-28 00:30:32

Refresh publications

Administrative responsibilities

Exeter

since 2017       Deputy Director of Postgraduate Research (D-DPGR)

KIT

2016                elected member of the KIT convent

2013 - 2014     Coordinator of the research cluster “Neural development and neural stem cells” of the Helmholtz Research Program “BioInterfaces”

2012 - 2013     Spokesman of the Young Investigator Network (YIN); assembly of junior faculties at

2010 - 2016    Member of the PhD Selection Committee for the BioInterfaces Graduate School, KIT

since 2010     Graduate Student Advisor, KIT

2009 - 2011     Organizer of the Internal Seminar Series “On Fish and Technologies”, ITG, KIT

2009 - 2016     Member of the Faculty of Chemistry and Life Science, KIT, Germany


Committee/panel activities

since 2016       Reviewer for BBSRC

since 2014       Scientific reviewer for Research grants of the National Science Centre, NSC Poland

since 2010       Reviewer for Research grants of the German Research Council (DFG)

2010                Scientific reviewer for DFG-Center for Regenerative Therapies, Dresden (CRTD)


Editorial responsibilities

since 2016 Scientific editor of Mechanisms of Development (MOD)

since 2015 Scientific editor of Genesis, John Wiley and Sons, Inc

since 2014 Scientific editor of Molecular Science, AIMS Press

since 2011 Associated editor of Frontiers in Neuroscience


External positions

Selected activities as referee for scientific journals

Nature Communications; PLoS Biology; PNAS; EMBO reports; J Cell Sci; Development; Stem Cell Reports; Scientific Reports; Developmental Biology; Brain Structure & Function; Neurobiology of Disease; Neural Development; PLoS One; Differentiation; J of Medical Genetics; Cell & Tissue Research; Genesis; Cellular and Molecular Life Science; Development, Genes & Evolution


Invited lectures

Number of invited lectures in total

International lectures

National lectures

43

29

14

Recently invited lectures

2017 Duke-NUS, Singapore; University of Calgary, Canada; ARUK Oxford,; University of Madrid, Spain, Wnt meeting and PhD summer school, Kobe Japan.

2016 University of Exeter UK, University of Bath, UK, EZPM Lisbon, Portugal, EMBO Wnt meeting, Brno

2015 UCSF, San Francisco, USA; Uni Jena, Germany; Dev. Biol. Soc. Meeting, Nuremberg, Germany; ETH Zürich Switzerland; EMBO workshop, Madrid, Spain; Gordon Research Conference on Developmental Biology, Mount Holyoke College, USA; DanStem Center, Copenhagen; Instituto de Neurociencias, Alicante, Spain.


Research networks

2011 – 2015    Member of the DFG Research Network 1036: “Mechanism, functions and evolution of Wnt signalling pathways”

2007                Honorary Member of the Royal Microscopical Society (RMS)

 


Workshops/Conferences organised

2017                Lecturer, Summer School, Jap Soc Dev Biol, Kobe, Japan.

2015                Session Chair, EMBO workshop „Signaling synapsis“, Madrid, Spain.

2014                Session Chair, European Zebrafish PI Meeting, Ein Gedi, Israel.

2013                Organizer, EMBO practical course „Imaging of Neural Development“, KIT, Germany.

                        Lecturer, Summer School, Jap Soc Dev Biol, Tokyo, Japan.

2012                Lecturer, GfE Summer School, Schloss Reissenburg, Ulm, Germany.

                        Session Chair, SURF Meeting Biozentrum Basel, Switzerland.

2011                Session Chair, Regional Meeting on Fish Genetics and Development, Landeck, Germany.

2002                Instructor, EMBO Developmental Biology Practical Course, MPI Tübingen, Germany.

Happy Lab Citizen

Teaching

Lectures

  • BIO2088 Advanced Cell Biology

UG Projects

  • Lab projects on molecular and cell biological topics

Former Teaching Responsibilities

2010-2016 Lecturer and supervisor in BSc and MSc program “Life Science” at the Faculty of Chemistry and Life Science; 1 lecture series per semester, supervision for 2 practical courses per semester at KIT, Germany.
2010-2016 Lecturer of Biointerface International Graduate School (BIF-IGS) at KIT, Germany.
2013-2016 Lecturer of the International Zebrafish and Medaka course (IZMC) at the EZRC.

       

The Scholpp lab in 2017

Postdoctoral researchers

  • Lucy Brunt
  • Joana Viales

Postgraduate researchers

  • Benjamin Mattes
  • Lucy Porter

Research Technicians

  • Simone Schindler

Alumni

  • Bernadett Boesze PhD student (2012-2016)
  • Simone Geyer PhD student(2012-2015)
  • Anja Hagemann PostDoc (2009-2014)
  • Daniela Peukert PhD student(2008-2011)
  • Charanya Rengarajan PhD student (2009-2013)
  • Eliana Stanganello PhD student, summa cum laude (2011-2015)

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