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Dr Tom Houslay

Dr Tom Houslay

Associate Research Fellow

 Daphne du Maurier 3052

 

Daphne du Maurier Building, University of Exeter,  Penryn Campus, Penryn, Cornwall, TR10 9FE, UK

Broadly, my research interests involve explaining individual variation in life histories: I am interested in how genetic, environmental and social factors affect allocation to competing traits. As a member of Dr Alastair Wilson’s group, my postdoctoral research focuses on the evolutionary genetics of the vertebrate stress response. Why do many animals exhibit damaging responses to chronic exposure to environmental stress? Using guppies (Poecilia reticulata) as a model system, I combine experimental manipulations with multivariate quantitative genetic methods to investigate whether constraints or conflicts enable the persistence of maladaptive responses.

My PhD research, under the supervision of Dr Luc Bussière at the University of Stirling, focused on the integration of life history theory and sexual selection. Such approaches are necessary in order to compare the relative costs and benefits of investing in energetically expensive, highly variable sexual traits. I am also interested in statistical methods and the visual display of quantitative data, and teach a workshop on statistical modeling using R.

See more details on my personal website.

Broad research specialisms:

  • Life history trade-offs
  • Sexual selection
  • Quantitative genetics
  • Phenotypic plasticity

Qualifications

2014 PhD Biology, University of Stirling.
2004 MSc Bioinformatics, University of Manchester.
2002 BSc (hons) Computer science, Lancaster University.

Research

Key publications | Publications by category | Publications by year

Key publications


Houslay TM, Wilson A (In Press). Avoiding the misuse of BLUP in behavioral ecology. Behavioral Ecology Full text.
Houslay T, Vierbuchen M, Grimmer AJ, Young AJ, Wilson A (2017). Testing the stability of behavioural coping style across stress contexts in the Trinidadian guppy. Functional Ecology Full text.
Houslay TM, Houslay KF, Hunt J, Rapkin J, Bussière LF (2016). Mating opportunities and energetic constraints drive variation in age-dependent sexual signalling. Functional Ecology Abstract.  Full text.
Houslay TM, Hunt J, Tinsley MC, Bussière LF (2015). Sex differences in the effects of juvenile and adult diet on age-dependent reproductive effort. J Evol Biol, 28(5), 1067-1079. Abstract.  Author URL.
Houslay TM, Bussière LF (2012). Sexual Selection and Life History Allocation. In  (Ed) eLS, Chichester: John Wiley & Sons, Ltd.  Abstract.

Publications by category


Journal articles

Houslay TM, Wilson A (In Press). Avoiding the misuse of BLUP in behavioral ecology. Behavioral Ecology Full text.
White S, Houslay T, Wilson A (In Press). Evolutionary genetics of personality in the Trinidadian guppy II: Sexual dimorphism and genotype-by-sex interactions. Heredity Full text.
Styga J, Houslay T, Wilson A, Earley R (In Press). Ontogeny of the morphology-performance axis in an amphibious fish (Kryptolebias marmoratus). Journal of Experimental Zoology Part A: Comparative Experimental Biology Full text.
Longdon B (In Press). Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts. Proceedings of the Royal Society B: Biological Sciences Full text.
Maskrey D, White S, Wilson A, Houslay T (In Press). Who dares doesn’t always win: risk-averse rockpool prawns are better at controlling a limited food resource. Animal Behaviour Full text.
Duffield KR, Hampton KJ, Houslay TM, Hunt J, Rapkin J, Sakaluk SK, Sadd BM (2018). Age-dependent variation in the terminal investment threshold in male crickets. Evolution, 72(3), 578-589. Abstract.  Author URL.  Full text.
Longdon B, Day JP, Alves JM, Smith SCL, Houslay TM, McGonigle JE, Tagliaferri L, Jiggins FM (2018). Host shifts result in parallel genetic changes when viruses evolve in closely related species. PLoS Pathogens Full text.
Jarrett BJM, Schrader M, Rebar D, Houslay TM, Kilner RM (2017). Cooperative interactions within the family enhance the capacity for evolutionary change in body size. Nature Ecology and Evolution Abstract.  Full text.
Duarte A, Cotter SC, De Gasperin O, Houslay TM, Boncoraglio G, Welch M, Kilner RM (2017). No evidence of a cleaning mutualism between burying beetles and their phoretic mites. Sci Rep, 7(1). Abstract.  Author URL.
Houslay T, Vierbuchen M, Grimmer AJ, Young AJ, Wilson A (2017). Testing the stability of behavioural coping style across stress contexts in the Trinidadian guppy. Functional Ecology Full text.
Houslay TM, Houslay KF, Hunt J, Rapkin J, Bussière LF (2016). Mating opportunities and energetic constraints drive variation in age-dependent sexual signalling. Functional Ecology Abstract.  Full text.
Houslay TM, Hunt J, Tinsley MC, Bussière LF (2015). Sex differences in the effects of juvenile and adult diet on age-dependent reproductive effort. J Evol Biol, 28(5), 1067-1079. Abstract.  Author URL.
Isherwood BJ, Walls RE, Roberts ME, Houslay TM, Brave SR, Barry ST, Carragher NO (2013). High-content analysis to leverage a robust phenotypic profiling approach to vascular modulation. Journal of Biomolecular Screening, 18(10), 1246-1259. Abstract.
Caie PD, Walls RE, Ingleston-Orme A, Daya S, Houslay T, Eagle R, Roberts ME, Carragher NO (2010). High-content phenotypic profiling of drug response signatures across distinct cancer cells. Mol Cancer Ther, 9(6), 1913-1926. Abstract.  Author URL.
Xu T-R, Baillie GS, Bhari N, Houslay TM, Pitt AM, Adams DR, Kolch W, Houslay MD, Milligan G (2008). Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs. Biochem J, 413(1), 51-60. Abstract.  Author URL.
Smith KJ, Baillie GS, Hyde EI, Li X, Houslay TM, McCahill A, Dunlop AJ, Bolger GB, Klussmann E, Adams DR, et al (2007). <sup>1</sup>H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, βarrestin and RACK1. Cellular Signalling, 19(12), 2612-2624. Abstract.
Baillie GS, Adams DR, Bhari N, Houslay TM, Vadrevu S, Meng D, Li X, Dunlop A, Milligan G, Bolger GB, et al (2007). Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays. Biochem J, 404(1), 71-80. Abstract.  Author URL.
Huston E, Gall I, Houslay TM, Houslay MD (2006). Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+. Journal of Cell Science, 119(18), 3799-3810. Abstract.
Huston E, Gall I, Houslay TM, Houslay MD (2006). Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+. J Cell Sci, 119(Pt 18), 3799-3810. Abstract.  Author URL.
Huston E, Houslay TM, Baillie GS, Houslay MD (2006). cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling. Biochemical Society Transactions, 34(4), 504-509. Abstract.
Huston E, Houslay TM, Baillie GS, Houslay MD (2006). cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling. Biochem Soc Trans, 34(Pt 4), 504-509. Abstract.  Author URL.
Wallace DA, Johnston LA, Huston E, MacMaster D, Houslay TM, Cheung Y-F, Campbell L, Millen JE, Smith RA, Gall I, et al (2005). Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene. Mol Pharmacol, 67(6), 1920-1934. Abstract.  Author URL.

Chapters

Houslay TM, Bussière LF (2012). Sexual Selection and Life History Allocation. In  (Ed) eLS, Chichester: John Wiley & Sons, Ltd.  Abstract.

Publications by year


In Press

Houslay TM, Wilson A (In Press). Avoiding the misuse of BLUP in behavioral ecology. Behavioral Ecology Full text.
White S, Houslay T, Wilson A (In Press). Evolutionary genetics of personality in the Trinidadian guppy II: Sexual dimorphism and genotype-by-sex interactions. Heredity Full text.
Styga J, Houslay T, Wilson A, Earley R (In Press). Ontogeny of the morphology-performance axis in an amphibious fish (Kryptolebias marmoratus). Journal of Experimental Zoology Part A: Comparative Experimental Biology Full text.
Longdon B (In Press). Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts. Proceedings of the Royal Society B: Biological Sciences Full text.
Maskrey D, White S, Wilson A, Houslay T (In Press). Who dares doesn’t always win: risk-averse rockpool prawns are better at controlling a limited food resource. Animal Behaviour Full text.

2018

Duffield KR, Hampton KJ, Houslay TM, Hunt J, Rapkin J, Sakaluk SK, Sadd BM (2018). Age-dependent variation in the terminal investment threshold in male crickets. Evolution, 72(3), 578-589. Abstract.  Author URL.  Full text.
Longdon B, Day JP, Alves JM, Smith SCL, Houslay TM, McGonigle JE, Tagliaferri L, Jiggins FM (2018). Host shifts result in parallel genetic changes when viruses evolve in closely related species. PLoS Pathogens Full text.

2017

Jarrett BJM, Schrader M, Rebar D, Houslay TM, Kilner RM (2017). Cooperative interactions within the family enhance the capacity for evolutionary change in body size. Nature Ecology and Evolution Abstract.  Full text.
Duarte A, Cotter SC, De Gasperin O, Houslay TM, Boncoraglio G, Welch M, Kilner RM (2017). No evidence of a cleaning mutualism between burying beetles and their phoretic mites. Sci Rep, 7(1). Abstract.  Author URL.
Houslay T, Vierbuchen M, Grimmer AJ, Young AJ, Wilson A (2017). Testing the stability of behavioural coping style across stress contexts in the Trinidadian guppy. Functional Ecology Full text.

2016

Houslay TM, Houslay KF, Hunt J, Rapkin J, Bussière LF (2016). Mating opportunities and energetic constraints drive variation in age-dependent sexual signalling. Functional Ecology Abstract.  Full text.

2015

Houslay TM, Hunt J, Tinsley MC, Bussière LF (2015). Sex differences in the effects of juvenile and adult diet on age-dependent reproductive effort. J Evol Biol, 28(5), 1067-1079. Abstract.  Author URL.

2013

Isherwood BJ, Walls RE, Roberts ME, Houslay TM, Brave SR, Barry ST, Carragher NO (2013). High-content analysis to leverage a robust phenotypic profiling approach to vascular modulation. Journal of Biomolecular Screening, 18(10), 1246-1259. Abstract.

2012

Houslay TM, Bussière LF (2012). Sexual Selection and Life History Allocation. In  (Ed) eLS, Chichester: John Wiley & Sons, Ltd.  Abstract.

2010

Caie PD, Walls RE, Ingleston-Orme A, Daya S, Houslay T, Eagle R, Roberts ME, Carragher NO (2010). High-content phenotypic profiling of drug response signatures across distinct cancer cells. Mol Cancer Ther, 9(6), 1913-1926. Abstract.  Author URL.

2008

Xu T-R, Baillie GS, Bhari N, Houslay TM, Pitt AM, Adams DR, Kolch W, Houslay MD, Milligan G (2008). Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs. Biochem J, 413(1), 51-60. Abstract.  Author URL.

2007

Smith KJ, Baillie GS, Hyde EI, Li X, Houslay TM, McCahill A, Dunlop AJ, Bolger GB, Klussmann E, Adams DR, et al (2007). <sup>1</sup>H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, βarrestin and RACK1. Cellular Signalling, 19(12), 2612-2624. Abstract.
Baillie GS, Adams DR, Bhari N, Houslay TM, Vadrevu S, Meng D, Li X, Dunlop A, Milligan G, Bolger GB, et al (2007). Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays. Biochem J, 404(1), 71-80. Abstract.  Author URL.

2006

Huston E, Gall I, Houslay TM, Houslay MD (2006). Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+. Journal of Cell Science, 119(18), 3799-3810. Abstract.
Huston E, Gall I, Houslay TM, Houslay MD (2006). Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+. J Cell Sci, 119(Pt 18), 3799-3810. Abstract.  Author URL.
Huston E, Houslay TM, Baillie GS, Houslay MD (2006). cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling. Biochemical Society Transactions, 34(4), 504-509. Abstract.
Huston E, Houslay TM, Baillie GS, Houslay MD (2006). cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling. Biochem Soc Trans, 34(Pt 4), 504-509. Abstract.  Author URL.

2005

Wallace DA, Johnston LA, Huston E, MacMaster D, Houslay TM, Cheung Y-F, Campbell L, Millen JE, Smith RA, Gall I, et al (2005). Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene. Mol Pharmacol, 67(6), 1920-1934. Abstract.  Author URL.

Tom_Houslay Details from cache as at 2018-06-24 18:58:26

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