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Dr Alison Hill

Dr Alison Hill

Senior Lecturer

 4605

 Geoffrey Pope 416

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

  • Senior Tutor for Postgraduate Taught students
  • Flexible Combined Honours Tutor for Biosciences
  • Elected Senator for CLES
  • Exeter Education Incubator Fellow

Qualifications

1994 PhD Biological Chemistry, University of Cambridge
1989 BSc (Hons) Chemistry, Australian National University, Canberra, Australia

Career

2010-present Senior Lecturer
2005-2012 Teaching Fellow, School of Biosciences, University of Exeter
2001-2005 Research Fellow, School of Chemistry, University of Exeter
1995-2001 Lecturer, Department of Chemistry, King's College London
1994-1995 Postdoctoral Researcher, Department of Chemistry, Brown University, Rhode Island, USA

Research group links

Research

Research interests

I am currently reasearching addressing the Mathematics gap in Biosciences as part of my Exeter Education Incubator project.

https://uofeacademicpracticenetwork.wordpress.com/2018/04/20/addressing-the-mathematics-gap-in-biosciences-and-beyond/

Publications

Key publications | Publications by category | Publications by year

Key publications


Goodworth KJ, Herve AC, Stavropoulos E, Herve G, Casades I, Hill AM, Weingarten GG, Tascon RE, Colston MJ, Hailes HC, et al (2011). Synthesis and in vivo biological activity of large-ringed calixarenes against Mycobacterium tuberculosis. TETRAHEDRON, 67(2), 373-382. Abstract.
Hill AM, Staunton JS (2010). Modular Polyketide Synthases. In Mander L, Townsend C (Eds.) Comprehensive Natural Products II: Chemistry and Biology, Elsevier. Abstract.
Hill AM, Staunton, J (2010). Proposed Quaternary Structure of Type I (Modular) Polyketide Synthases. In Wrigley, SK, Thomas, R, Bedford, CT, Nicholson N (Eds.) Functional Molecules from Natural Sources, Cambridge: RSC, 195-208.
Hill AM (2009). Polyketide Biosynthesis, Polyethers. In Begley TP (Ed) Wiley Encycopedia of Chemical Biology, Wiley, 760-771.  Abstract.

Publications by category


Journal articles

Asakura M, Yoshino K, Hill AM, Kubo Y, Sakai Y, Takano Y (2012). Primary and secondary metabolism regulates lipolysis in appressoria of Colletotrichum orbiculare. FUNGAL GENETICS AND BIOLOGY, 49(11), 967-975. Author URL.
Goodworth KJ, Herve AC, Stavropoulos E, Herve G, Casades I, Hill AM, Weingarten GG, Tascon RE, Colston MJ, Hailes HC, et al (2011). Synthesis and in vivo biological activity of large-ringed calixarenes against Mycobacterium tuberculosis. TETRAHEDRON, 67(2), 373-382. Abstract.
Hii, K.K. Hill, A.M. (2007). Preparation of macrocyclon analogues: calix[8]arenes with extended polyethylene glycol chains. Tetrahedron, 63, 9947-9959.
Hill, A.M. (2006). The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites. Natural Product Reports, 23(2), 256-320.
Hailes, H.C. Hill, A.M. (2004). Antimycobacterial calixarenes enhance innate defense mechanisms in murine macrophages and induce control of Mycobacterium tuberculosis infection in mice. Infection and Immunity, 72(11), 6318-6323.
Louiseau, F.A. Hii, K.K. & Hill, A.M. (2004). Multigram synthesis of well-defined extended bifunctional polyethylene glycol (PEG) chains. Journal of Organic Chemistry, 69(3), 639-647.
Hill, A.M. (2003). A highly efficient synthesis of [1-C-13, O-18]- and [1-C-13, H-2(2)]-glycerol for the elucidation of biosynthetic pathways. Tetrahedron Letters, 44(4), 789-792.
Thompson, B.L. Harris, J.P. Siskos, A.P. (2003). Investigation of the early stages in soraphen a biosynthesis. Chemical Communications, 12, 1358-1359.
Thompson, B.L. (2003). Novel soraphens from precursor directed biosynthesis. Chemical Communications, 12, 1360-1361.
Hahn, D.U. Herve, A.C. Goodworth, K.J. (2003). The selective functionalisation and difunctionalisation of p-substituted calix[6]arene and calix[8]arenes using hydrophilic moieties. Organic and Biomolecular Chemistry, 1(2), 427-435.
Harris, J.P. Siskos, A.P. (1998). Investigation of glycerol incorporation into soraphen A. Chemical Communications, 21, 2361-2362.
Cane, D.E. JD, C. Mau, C.A. (1996). High level expression of Ricinus communis casbene synthase in Escherichia coli and characterization of the recombinant enzyme. Archives of Biochemistry & Biophysics, 336(2), 283-289.

Chapters

Hill AM, Staunton JS (2010). Modular Polyketide Synthases. In Mander L, Townsend C (Eds.) Comprehensive Natural Products II: Chemistry and Biology, Elsevier. Abstract.
Hill AM, Staunton, J (2010). Proposed Quaternary Structure of Type I (Modular) Polyketide Synthases. In Wrigley, SK, Thomas, R, Bedford, CT, Nicholson N (Eds.) Functional Molecules from Natural Sources, Cambridge: RSC, 195-208.
Hill AM (2009). Polyketide Biosynthesis, Polyethers. In Begley TP (Ed) Wiley Encycopedia of Chemical Biology, Wiley, 760-771.  Abstract.

Conferences

Hill AM, Staunton JS (2010). ÝProposed Quaternary Structure of Type I (Modular) Polyketide Synthases. Functional Molecules from Natural Sources. 6th - 8th Jul 2009.

Publications by year


2012

Asakura M, Yoshino K, Hill AM, Kubo Y, Sakai Y, Takano Y (2012). Primary and secondary metabolism regulates lipolysis in appressoria of Colletotrichum orbiculare. FUNGAL GENETICS AND BIOLOGY, 49(11), 967-975. Author URL.

2011

Goodworth KJ, Herve AC, Stavropoulos E, Herve G, Casades I, Hill AM, Weingarten GG, Tascon RE, Colston MJ, Hailes HC, et al (2011). Synthesis and in vivo biological activity of large-ringed calixarenes against Mycobacterium tuberculosis. TETRAHEDRON, 67(2), 373-382. Abstract.

2010

Hill AM, Staunton JS (2010). Modular Polyketide Synthases. In Mander L, Townsend C (Eds.) Comprehensive Natural Products II: Chemistry and Biology, Elsevier. Abstract.
Hill AM, Staunton, J (2010). Proposed Quaternary Structure of Type I (Modular) Polyketide Synthases. In Wrigley, SK, Thomas, R, Bedford, CT, Nicholson N (Eds.) Functional Molecules from Natural Sources, Cambridge: RSC, 195-208.
Hill AM, Staunton JS (2010). ÝProposed Quaternary Structure of Type I (Modular) Polyketide Synthases. Functional Molecules from Natural Sources. 6th - 8th Jul 2009.

2009

Hill AM (2009). Polyketide Biosynthesis, Polyethers. In Begley TP (Ed) Wiley Encycopedia of Chemical Biology, Wiley, 760-771.  Abstract.
Hill AM (2009). Polyketide Biosynthesis, Polyethers. , 3, 760-771. Abstract.

2008

Hill, A.M. (2008). Polyketide Biosynthesis, Polyethers.

2007

Hii, K.K. Hill, A.M. (2007). Preparation of macrocyclon analogues: calix[8]arenes with extended polyethylene glycol chains. Tetrahedron, 63, 9947-9959.

2006

Hill, A.M. (2006). The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites. Natural Product Reports, 23(2), 256-320.

2004

Hailes, H.C. Hill, A.M. (2004). Antimycobacterial calixarenes enhance innate defense mechanisms in murine macrophages and induce control of Mycobacterium tuberculosis infection in mice. Infection and Immunity, 72(11), 6318-6323.
Louiseau, F.A. Hii, K.K. & Hill, A.M. (2004). Multigram synthesis of well-defined extended bifunctional polyethylene glycol (PEG) chains. Journal of Organic Chemistry, 69(3), 639-647.

2003

Hill, A.M. (2003). A highly efficient synthesis of [1-C-13, O-18]- and [1-C-13, H-2(2)]-glycerol for the elucidation of biosynthetic pathways. Tetrahedron Letters, 44(4), 789-792.
Thompson, B.L. Harris, J.P. Siskos, A.P. (2003). Investigation of the early stages in soraphen a biosynthesis. Chemical Communications, 12, 1358-1359.
Thompson, B.L. (2003). Novel soraphens from precursor directed biosynthesis. Chemical Communications, 12, 1360-1361.
Hahn, D.U. Herve, A.C. Goodworth, K.J. (2003). The selective functionalisation and difunctionalisation of p-substituted calix[6]arene and calix[8]arenes using hydrophilic moieties. Organic and Biomolecular Chemistry, 1(2), 427-435.

1998

Harris, J.P. Siskos, A.P. (1998). Investigation of glycerol incorporation into soraphen A. Chemical Communications, 21, 2361-2362.

1996

Cane, D.E. JD, C. Mau, C.A. (1996). High level expression of Ricinus communis casbene synthase in Escherichia coli and characterization of the recombinant enzyme. Archives of Biochemistry & Biophysics, 336(2), 283-289.

alison_hill Details from cache as at 2018-12-10 10:21:08

Refresh publications

External Engagment and Impact

Awards/Honorary fellowships

Most Supportive Member of Staff Bioscience 2012; shortlisted for Exeter Teaching Awards 2012 in this category


Editorial responsibilities

I review papers for ChemBioChem

Review Article: A.M. Hill, Natural Product Reports, 2006, 23(2), 256-320

Review Article: A. M. Hill, Wiley Encylopedia of Chemical Biology, 2007, DOI: 10.1002/9780470048672


Invited lectures

Delivery of a research-led programme on polyketides and isotopic labelling methods  to PGT and PGR students at the Swedish University of Agricultural Sciences, Uppsala (2010).

University of Gothenburg 2004

University of Uppsala 2002

University of St Andrews, 2001

Find out more as.exeter.ac.uk/aspire

Teaching

  • Senior Fellow of the Higher Education Academy
  • Senior Tutor, Postgraduate Taught Students
  • Flexible Combined Honours Tutor for Bioscience, Biochemistry and Chemistry

Module Coordinator:

  • BIO2090 Analytical Techniques in Biochemistry
  • BIO3041 Pharmacology and Medicinal Chemistry
  • BIO3090 Secondary Metabolism and Metabolites
  • BIOM509 Professional Skills

Module Contributor:

  • BIO2085 Structure and Reactivity of Organic Compounds 2
  • BIO2086 Metabolism
  • BIO3085 Horizons of Biochemical Research
  • BIO3089 Organic Synthesis

Modules

2018/19


Supervision / Group

Postgraduate researchers

  • Carine Masson (EPSRC)

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