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Professor Charles Tyler

Professor Charles Tyler

Professor of Environmental Biology/ Academic Lead

 4450

 Geoffrey Pope 314b

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Professor Charles Tyler observing fish in the aquarium

Professor Charles Tyler observing fish in the aquarium

Overview

I am a reproductive physiologist and environmental biologist. My research spans investigations into the mechanisms of endocrine disrupting chemicals and nanoparticle ecotoxicology to assessing population level effects of environmental contaminants in wildlife, principally fish. Much of my research includes applying genetic and genomic techniques to understand the basis of physiological processes and the mechanisms through which they are disrupted by environmental contaminants. I have a deep passion for wildlife and my research projects also include studies on the natural ecology of insects, fish, and birds.

I was Director of Research ( 2003-2009) and I now lead the Environmental Biology research theme and act as Deputy Head for Biosciences. I am also an Academic Lead for the College of Life and Environmental Sciences. I play roles also in leading various strategic research partnerships with external partners including AstraZeneca and cefas.

Qualifications

2003 DSc University of Lancaster
1984-1987 PhD University of Aston
1983-1984 MSc in Applied Fish Biology, University of Plymouth
1980-1983 BSc (Hons) Biological Sciences, University of Lancaster

Career

2010-2015 Chief Science Advisor for United Kingdom-Japan Research into Endocrine Disruption, Department of Food and Rural Affairs
2010-present
Deputy Head Biosciences, Academic Lead College of Life and Environmental Sciences
2005-2010 Director of Research for Biosciences, University of Exeter
2005-2010 UK Supervisor for United Kingdom-Japan Research into Endocrine Disruption, Department of Food and Rural Affairs
2005-2008 Honorary Research Fellow of the Institute of Zoology, London
2000-present Professor in Environmental and Molecular Fish Biology, University of Exeter
1999-2000 Reader in Biological Sciences, Brunel University
1996-1999 Senior Lecturer in Biological Sciences, Brunel University
1990-1996 Lecturer in Biological Sciences, Brunel University

Honours/Awards

2012 Elected Fellow for the Society of Biology
2012 The Fisheries Society of the British Isles Beverton Medal for ground breaking research in fish biology
2011 University of Exeter Impact Award for Outstanding contribution to Policy and Public Services
2008-to date Honorary Chair, Peninsular College for Medicine and Dentistry
2005-to date Honorary Research Fellow of the Institute of Zoology, London

Links

Research group links

Professor Charles Tyler in the aquarium

Professor Charles Tyler in the aquarium

Research

Research interests

Endocrine Disruption: A major focus of my research interest is endocrine disruption, the study of chemicals that alter hormone function which can lead to adverse impacts on health. Our work with colleagues at Brunel University was some of the very first research to show that effluents from wastewater treatment works causes feminisation of male fish. My teams work has subsequently proven that feminisation of wild roach living in UK rivers is caused by exposure to treated sewage effluents. Using a targeted biological screening of chemically fractionated bile from effluent exposed fish, with collaborators (University of Sussex), we have been able to identify the suite of feminising chemicals in effluent discharges, principally environmental oestrogens, and through laboratory exposures proven they contribute to the feminisation of wild fish in UK rivers. These chemicals include natural and synthetic steroid oestrogens, and alkylphenolic compounds. This original work has been very highly cited. Combining empirical studies with models including Concentration Addition/Joint Independent Action, my team has further established that oestrogenic chemicals can be additive in their effects and these findings have had a widespread and international influence.  More recently we discovered the widespread presence of anti-androgenic chemicals in wastewater effluent discharges and my team is now studying their possible contribution to the feminisation of fish living in UK rivers.

A major question we are now trying to establish is whether wild fish (roach, Rutilus rutilus) populations are impacted adversely by exposure to oestrogenic effluent discharges. Undertaking controlled breeding studies in the laboratory and applying DNA microsatellites to assess parentage with have proven that moderately to severely feminised males have a reduced capacity to compete with normal males to sire offspring. We have further shown that life long exposure to an oestrogenic effluent (at full strength) causes complete gonadal feminisation of males, some of which were able to breed as females. In some of our most current work we are applying DNA microsatellites to establish whether roach populations living in rivers heavily polluted with wastewater effluents have a reduced effective population breeding size. If so, this will show that exposure to wastewater effluents at these sites is fundamentally affecting population genetics.

The mechanisms of action and pathways of effects have been established for very few endocrine active chemicals and this has been another key focus of my teams work. Targeted single gene approaches, gene arrays and more recently sequencing technologies have been applied to unravel some of the molecular mechanisms of oestrogenic disruption (including for mixture effects) and other forms of chemical toxicity. Other ongoing projects include studying the metabolome and xenometabolome in fish in response to exposure to effluents and individual EDCs with Profs Hill (University of Susses) and Prof Viant (University of Birmingham).  Most recently, working with Dr Kudoh, also at Exeter, we have developed a ERE-GFP transgenic zebrafish that is exquisitely sensitive to oestrogens that allows us to identify – through the expression of a green fluorescent protein - where different oestrogens interact in the body and in real time. This is a very power tool that we are now using to investigate the potential for wider health impacts of exposure to environmental, oestrogens. We are currently attempting to develop a similar model for (anti-) androgens. Members of my team also work on other chemical contaminants of environmental and human health concern including pesticides and pharmaceuticals. 
   
I have an interest also in the development and application of in vitro systems for understanding mechanisms of action and reducing animal use. These systems include cell culture (especially hepatocytes), recombinant cell lines and receptor transactivation assays.

Almost all of our work on endocrine disruption is focused on fish, but we have also worked on birds (Dipper, Cinclus cinclus), mammals (Otter, Lutra lutra) and various invertebrates.

Nanotoxicology: Nanotechnology is an emerging field of science that deals with engineered molecules of an extremely small size (1-100 nanometres). Because of size – related changes in physico – chemical properties, substances at the nanoscale display optical, magnetic and chemical properties that can differ greatly from the standard material enabling diverse commercial applications. Nanoparticles are currently used in products such as suntan lotion, cosmetics, clothing, cleaning materials, medicines and food and assessing the potential health risks associated with exposure to nanoparticles is now recognised as being a major international research priority. Working with other members of the Envrionment and Evolution theme (Prof Galloway) my team is researching into the effects of metal and metal oxide nanoparticles, principally in fish, but also some invertebrates.

Most of  our  research on nanomaterials has been focused on understanding their bioavailability, including for exposures in natural waters and in effluents. This work is being complemented by in vitro studies with various fish cell types including hepatocytes, gut and gill cells to investigate how nanoparticles cross cell membranes and their fate within cells. Further methods applied in this work include whole mount in situ hybridisation to investigate specific gene responses in the bodies of whole embryos. Various analytical techniques and state of the art imaging techniques are being employed to monitor particle fate and behaviour in the water and fish, including RAMAN scattering. In our work to date we have found that many metal nanomaterials ( ceria, zinc, titania) show little toxicity to fish. In contrast silver nanoparticles are toxic, albeit that this toxicity may result from dissolution and free silver, rather than an innate function of the particles themselves. In our current work we are applying whole genome sequencing on exposed zebrafish embryos and the target tissues for specific nanomaterials in larger fish to further establish the effect mechanisms of metal/metal oxide nanoparticles in the body and thus help unravel some of the possible health concerns linked with these materials. This work is funded by very diverse sources including Research Councils, DEFRA, and various industries reflecting the multi-stakeholder interest.

Disease: I have  a growing interest in the effects of combined environmental stressors on wildlife, including features of climate change. A project that has recently been initiated with the Centre for Environment, Fisheries and Aquaculture Science is the application of sequencing technologies to understand the pathogenic process of white spot virus, a major disease organism for cultures and wild crustaceans.

Basic Biology: Underpinning all of my teams ecotoxicology work is my interest in the basic biology of fish and other wildlife species. Here primary interests include  understanding the mechanisms controlling sexual development and reproduction. To be able to assess what is abnormal for exposure to an environmental stressor, it is important to understand the normal basic processes and variation.

Major research activities and findings from my team include the following:

Sexual differentiation: My team has established the timing and mapped histologically the process of sexual differentiation in the roach, Rutilus rutilus, a sentinel species for studies on chemical effects in wild fish in UK freshwaters, and in the fathead minnow and zebrafish, both key laboratory species. They have further identified some of the molecular mechanisms controlling sexual differentiation in these fish.

Oogenesis (egg development) and Spermatogenesis: We have mapped histologically the process of oogenesis and spermatogenesis in roach, fathead minnow and zebrafish. In this work we have especially focused on the process of vitellogenesis (provision and uptake of yolk into oocytes) and established some of the endocrine and molecular mechanisms controlling yolk uptake and processing. Our work has included the cloning and sequencing of the first cDNA for a fish vitellogenin receptor, establishing the developmental expression and cellular localisation of the vitellogenin receptor mRNA in fish oocytes, and the cloning and sequencing of some of the first yolk processing enzymes (cathepsins) in oocytes. My team has  also developed some of the first assays to quantify vitellogenins in fish, which have been vital for  work on endocrine disruption.

Endocrine control of fecundity: Very little is known about the determinants of fecundity in any animal. Fish, because they are highly fecund, provide excellent model systems for investigating the endocrine control of oocyte recruitment and growth - the associated titres of plasma hormones are considerably higher than for most other animals. Applying the technique of unilateral ovariectomy (to manipulate oocyte recruitment) we have identified some of the hormones controlling ovarian development.

Puberty: We have cloned the KiSS I receptor in various fish species, identified and cloned some of the KiSS peptin ligands (the first to do so in fish) and mapped them to their chromosomes. We have established the ontogeny and localization of expression of KiSS 1 receptor in the brain in both male and female fathead minnow during sexual development and shown how this expression aligns with the expression of an extensive suite if other genes involved in mediating sexual development (e.g. the GnRHs). The ability to control puberty in fish would be of great significance in the aquaculture of many fish species.

Sexual behaviour: The zebrafish is one of the major models for studies in ecotoxicology, yet very little is known about its basic biology. My lab team has contributed to filling this knowledge gap through extensive studies on its reproductive biology. In this work we have projects studying the behaviour of the zebrafish in breeding colonies. This work is principally focused on understanding the interactions and hierarchies that develop in zebrafish colonies to advance our understanding on their breeding dynamics in natural populations. In this work, detailed studies on male-male, male-female and female-female interactions are being established for different sized colonies and the reproductive success of individuals in those colonies are determined through genotyping of the offspring produced (through the use of DNA microsatellites). Our work on zebrafish is principally laboratory based, but we also have some ongoing studies on natural colonies in Bangladesh. This work also includes the development and application of population models.

New Models: I am always interested in exploring new models for understanding basic reproductive processes and/or exploiting them for better understanding possible health effects of environmental contaminants. A model we are currently working on is a Xenotoca spp, that gives birth to live young. Currently we are studying the basic reproductive biology, but our longer term plan is to use this model to investigate maternal transfer of EDCs, pharmaceuticals and nanomaterials and their health effects on developing embryos.

Wildlife Biology. My passion in life is wildlife and I have a series of projects with various external partners including the UK Environment Agency, defra, cefas, RSPB, BTO, Dartmoor National Park studying the ecology of various insects and birds(most notably the Cuckoo).

Current Funding

  • 2010 -2013 Joint US-UK (NERC) Research Program: Environmental Behaviour, Bioavailability and Effects of Manufactured Nanomaterials (EPA-G2008-STAR-R1)  - (£203 000 PI to Exeter, PI., total grant £3M). Consortium for Manufactured Nanomaterial Bioavailability & Environmental Exposure (nanoBEE).
  • 2010 -2013  EU - Qnano. Infrastructure and toxicology assessment unit. (Euros 285 991, Co-I)
  • 2010 Wolfson. Zebrafish Developmental Biology Imaging Unit (infrastructure and microscopes) (£400k  PI).
  • 2011-2013 DEFRA (£160 000 - PI). Emerging endocrine disrupting chemicals. UK/Japan partnership Grant. Pending
  • 2011-2014 NERC(£420 000 - Development and Application of Transgenic Biosensor Zebrafish
    for Assessing the Environmental Health Impacts of Anti-Androgens.
  • 2011 CEFAS (£17 000 –co PI). Investigating the potential molecular mechanisms associated with white spot virus resistance in Carcinus maenas
  • 2011-2014 CEFAS (£37 500 - co I). The Implications of Ocean Acidification in Combination with Chemical Stressors for Juvenile Fish (50% PhD studentship  support)
  • 2011-2014 Leverhulme (£143 800 - co I). The Evolution of Cooperation in Structured Animal Societies
  • 2011-2014 Interegg European Neurosciences Project (Euros140 00 –PI).
  • 2012 DEFRA/ Open Innovation Fund. (£60 000 - co I) CB0456 - Global NanoMaPPP - Ecotoxicology of
    Metal Oxide Nanomaterials in the Aquatic Environment
  • 2012-2015 Cefas- (£300k, drawing down further support from the UoE Open Innovation platform - value of total grant £532 000, PI). Building a Molecular Platform for Understanding the Host-Pathogen Interface in Invertebrates.
  • 2012-15 EU (£300k, co-I).  ( CLEANSEAS) . Microplastics in the Marine Environment
  • 2012 British Ecological Survey (£1,860 - PI): Niche partitioning and factors determining success of ground nesting birds, including Cuckoo parasitism, on Dartmoor
  • 2012-15 EU. (540k Euros, PI). NanoMILE (10 million Euro Consortium grant). Nanoparticles in the Environment.
  • 2013 Cefas. (£28,854 PI). Exposure effects of natural plants extracts on fish
  • 2013-15 BASF (£144 000, co-I with Prof Galloway). Ecotoxicology of nanopolymer dispersions. A case study of aqueous acrylic ester copolymers.
  • 2013-14 Spanish Government (£30 000 co-I)Molecular identification of sex, reproductive stage and fecundity in fish of commercial interest: mechanisms, aplications and exploitation. SEXOVUM.
  • 2013-14 NERC (FENAC/2012/11/002; £24 000 co-I). Transfer of Bulk and Nanoparticulate Cerium between a Mussel and a Crab
  • 2013-14 NERC (FENAC/2012/11/001; £24 000 P.I). Biological uptake and effects of metal oxide nanomaterials in early life stages of fish and for exposure to a complex mixture
  • 2013-16 NERC (£578 000 P.I., £399 000 to Exeter). Can roach, Rutilus rutilus, adapt to the harmful effects of oestrogen exposure from waste water treatment work effluents?
  • 2013-16 German Gov. (40 000 Euros P.I). Consultant for the German National programme on Nanomaterials
  • 2013-15 BBSRC (£149,724, PI) Exploiting Transgenic Zebrafish Embryos/Larvae for Systems- Wide Analysis of Endocrine Disrupting Chemicals
  • 2013-14 Defra ((£64 000)Predicting Reproductive Failure in Frogs using Non-destructive Biomarkers – A Pilot Study
  • 2013-15 NERC/TSB/KTP –Develop and Validate Numerical Modelling Capability for HR Wallingford - (£247 870 co-I)
  • 2013-16 EU (€139,600 Co-I, total consortium €6million) GuideNano: Assessment and mitigation of nano-enabled product risks on human and environmental health

Research networks

Universities/Academic Institutes

  • National: Cardiff University (Dr. Kille), Brunel University (Prof. Sumpter/Dr. Jobling), University of Liverpool (Prof.Cossins), University of Lancaster (Prof Wit, Dr Thomas), University of Birmingham (Prof. Chipman, Dr. Viant, Dr Lead), University of East Anglia (Dr. Gage), University of Plymouth (Dr. Handy), University of Sussex (Dr Hill), Imperial University (Dr Ebbles, Prof Nicholson), University College, London (Dr Lorenzi), Kings College, London (Prof Hogstrand, Dr Bury).
    International: University of Ancona, Italy (Dr. Carnevali), University of Frankfurt, Germany (Prof. J and Dr. U Oehlmann), University of Anantapur, India (Dr. Gundala), University of Heidelberg, Germany (Prof. Braunbeck), Centre for Integrative Biosciences, Okazaki, Japan (Prof. Iguchi, Dr. Katsu), University of Victoria, Canada (Dr. Helbing), University of Florida, USA (Prof Lou Guillette, Prof. Denslow), University of Pretoria, South Africa (Prof. Boreman), University of Bergen, Norway (Prof Ian Mayer), University of Utrecht, The Netherlands (Prof R. Schulz).
  • Actively involved with the ERASMUS and SOCRATES programme for the exchange of research students to undertake projects in research laboratories throughout Europe. Through this programme I have supervised 11 students from The Netherlands, Italy and Portugal.

Government Agencies and Industry

  • Government Agencies: Environment Agency, UK (Dr. A. Henshaw, Dr. Benstead, Nick Cartwright), The Centre for Environment, Fisheries and Aquaculture Sciences, UK (Dr. Katsiakdaki, Dr Stentiford), CEH, Wallingford (Dr Johnston), Plymouth Marine Laboratory, Plymouth, UK (Prof. Readman), DEFRA (Dr Mike Roberts) Cedex, France (Dr. Procher and Dr. Flammaron), National Institute of Fisheries, Seattle USA (Prof. Swanson), US Environment Protection Agency, Duluth, USA (Prof. Ankley), Gulf Breeze (Prof Benson).
  • Industry: Astra-Zeneca, Brixham Environmental Laboratory, Brixham, UK (Dr. Brown, Dr. Owen, Dr. Winter, Dr Hetheridge, Dr. Ball), Essex and Suffolk Water plc, UK (A. Jambakhsh & D.Walker), Biosense Laboratories AS, Bergen, Norway. (Prof. Goksoyr), Schering AG Experimental Toxicology, Germany (Dr. Laenge), Syngenta (Dr Thornbeck), Anglian Water plc UK (Dr.Rostron), UK Water Institute for Research, Water Research Council-NSF, UK (Dr. Johnson).
  • These are collaborations that have provided funding for my research and/or from which joint research papers have resulted. I presently have 7 Research Council-CASE studentships. I am also involved with the EUREKA programme that promotes an exchange of scientific research between academic institutes and industry.

Research Council Knowledge Transfer Schemes

  • I have been a partner in 6 (NERC/TSB –funded) knowledge transfer schemes

Links


Publications

Key publications | Publications by category | Publications by year

Key publications


Green JM, Metz J, Lee O, Trznadel M, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR (In Press). High-Content and Semi-Automated Quantification of Responses to Estrogenic Chemicals Using a Novel Translucent Transgenic Zebrafish. Environ Sci Technol, 50(12), 6536-6545. Abstract.  Author URL.
Le Page G, Gunnarsson L, Snape J, Tyler CR (In Press). Integrating human and environmental health in antibiotic risk assessment: a critical analysis of protection goals, species sensitivity and antimicrobial resistance. Environ Int, 109, 155-169. Abstract.  Author URL.
Osborne OJ, Mukaigasa K, Nakajima H, Stolpe B, Romer I, Philips U, Lynch I, Mourabit S, Hirose S, Lead JR, et al (In Press). Sensory systems and ionocytes are targets for silver nanoparticle effects in fish. Nanotoxicology, 10(9), 1276-1286. Abstract.  Author URL.
Verbruggen B, Gunnarsson L, Kristiansson E, Österlund T, Owen SF, Snape JR, Tyler CR (2018). ECOdrug: a database connecting drugs and conservation of their targets across species. Nucleic Acids Res, 46(D1), D930-D936. Abstract.  Author URL.
Brown AR, Owen SF, Peters J, Zhang Y, Soffker M, Paull GC, Hosken DJ, Wahab MA, Tyler CR (2015). Climate change and pollution speed declines in zebrafish populations. Proc Natl Acad Sci U S A, 112(11), E1237-E1246. Abstract.  Author URL.  Full text.
Hamilton PB, Lange A, Nicol E, Bickley LK, De-Bastos ESR, Jobling S, Tyler CR (2015). Effects of Exposure to WwTW Effluents over Two Generations on Sexual Development and Breeding in Roach Rutilus rutilus. Environ Sci Technol, 49(21), 12994-13002. Abstract.  Author URL.

Publications by category


Journal articles

Hamilton PB, Rolshausen G, Uren Webster TM, Tyler CR (In Press). Adaptive capabilities and fitness consequences associated with pollution exposure in fish. Philos Trans R Soc Lond B Biol Sci, 372(1712). Abstract.  Author URL.
Le Page G, Gunnarsson L, Snape J, Tyler CR (In Press). Antibiotic risk assessment needs to protect both environmental and human health. Environ Int, 115, 397-399. Author URL.
Bickley LK, van Aerle R, Brown AR, Hargreaves A, Huby R, Cammack V, Jackson R, Santos EM, Tyler CR (In Press). Bioavailability and Kidney Responses to Diclofenac in the Fathead Minnow (Pimephales promelas). Environ Sci Technol, 51(3), 1764-1774. Abstract.  Author URL.  Full text.
David A, Lange A, Abdul-Sada A, Tyler CR, Hill EM (In Press). Disruption of the Prostaglandin Metabolome and Characterization of the Pharmaceutical Exposome in Fish Exposed to Wastewater Treatment Works Effluent As Revealed by Nanoflow-Nanospray Mass Spectrometry-Based Metabolomics. Environ Sci Technol, 51(1), 616-624. Abstract.  Author URL.
Windsor FM, Ormerod SJ, Tyler CR (In Press). Endocrine disruption in aquatic systems: up-scaling research to address ecological consequences. Biol Rev Camb Philos Soc, 93(1), 626-641. Abstract.  Author URL.
Green JM, Metz J, Lee O, Trznadel M, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR (In Press). High-Content and Semi-Automated Quantification of Responses to Estrogenic Chemicals Using a Novel Translucent Transgenic Zebrafish. Environ Sci Technol, 50(12), 6536-6545. Abstract.  Author URL.
Le Page G, Gunnarsson L, Snape J, Tyler CR (In Press). Integrating human and environmental health in antibiotic risk assessment: a critical analysis of protection goals, species sensitivity and antimicrobial resistance. Environ Int, 109, 155-169. Abstract.  Author URL.
Osborne OJ, Mukaigasa K, Nakajima H, Stolpe B, Romer I, Philips U, Lynch I, Mourabit S, Hirose S, Lead JR, et al (In Press). Sensory systems and ionocytes are targets for silver nanoparticle effects in fish. Nanotoxicology, 10(9), 1276-1286. Abstract.  Author URL.
Stevens CH, Croft DP, Paull, Tyler (In Press). Stress and welfare in ornamental fishes: what can be learned from aquaculture?. Jounral of Fish Biology Full text.
Edenbrow M, Bleakley BH, Darden SK, Tyler CR, Ramnarine IW, Croft DP (In Press). The evolution of cooperation: Interacting phenotypes among social partners. The American Naturalist Full text.
Johnston HJ, Verdon R, Gillies S, Brown DM, Fernandes TF, Henry TB, Rossi AG, Tran L, Tucker C, Tyler CR, et al (2018). Adoption of in vitro systems and zebrafish embryos as alternative models for reducing rodent use in assessments of immunological and oxidative stress responses to nanomaterials. Crit Rev Toxicol, 48(3), 252-271. Abstract.  Author URL.
Lee CJ, Tyler CR, Paull GC (2018). Can simple tank changes benefit the welfare of laboratory zebrafish Danio rerio?. J Fish Biol, 92(3), 653-659. Abstract.  Author URL.
Mintram KS, Brown AR, Maynard SK, Thorbek P, Tyler CR (2018). Capturing ecology in modeling approaches applied to environmental risk assessment of endocrine active chemicals in fish. Crit Rev Toxicol, 48(2), 109-120. Abstract.  Author URL.
David A, Lange A, Tyler CR, Hill EM (2018). Concentrating mixtures of neuroactive pharmaceuticals and altered neurotransmitter levels in the brain of fish exposed to a wastewater effluent. Science of the Total Environment, 621, 782-790. Abstract.
Verbruggen B, Gunnarsson L, Kristiansson E, Österlund T, Owen SF, Snape JR, Tyler CR (2018). ECOdrug: a database connecting drugs and conservation of their targets across species. Nucleic Acids Res, 46(D1), D930-D936. Abstract.  Author URL.
Green JM, Lange A, Scott A, Trznadel M, Wai HA, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR, et al (2018). Early life exposure to ethinylestradiol enhances subsequent responses to environmental estrogens measured in a novel transgenic zebrafish. Sci Rep, 8(1). Abstract.  Author URL.  Full text.
Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, et al (2017). 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain. Sci Rep, 7(1). Abstract.  Author URL.  Full text.
Moreman J, Lee O, Trznadel M, David A, Kudoh T, Tyler CR (2017). Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol a and its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae. Environ Sci Technol, 51(21), 12796-12805. Abstract.  Author URL.
Bickley LK, van Aerle R, Brown AR, Hargreaves A, Huby R, Cammack V, Jackson R, Santos EM, Tyler CR (2017). Bioavailability and Kidney Responses to Diclofenac in the Fathead Minnow (Pimephales promelas). ENVIRONMENTAL SCIENCE & TECHNOLOGY, 51(3), 1764-1774. Author URL.
Lange A, Corcoran J, Miyagawa S, Iguchi T, Winter MJ, Tyler CR (2017). Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals. Toxicol in Vitro, 41, 114-122. Abstract.  Author URL.  Full text.
Galloway TS, Dogra Y, Garrett N, Rowe D, Tyler CR, Moger J, Lammer E, Landsiedel R, Sauer UG, Scherer G, et al (2017). Ecotoxicological assessment of nanoparticle-containing acrylic copolymer dispersions in fairy shrimp and zebrafish embryos. Environmental Science: Nano, 4(10), 1981-1997. Abstract.
Tohyama S, Ogino Y, Lange A, Myosho T, Kobayashi T, Hirano Y, Yamada G, Sato T, Tatarazako N, Tyler CR, et al (2017). Establishment of estrogen receptor 1 (ESR1)-knockout medaka: ESR1 is dispensable for sexual development and reproduction in medaka, Oryzias latipes. Dev Growth Differ, 59(6), 552-561. Abstract.  Author URL.
Uren Webster TM, Williams TD, Katsiadaki I, Lange A, Lewis C, Shears JA, Tyler CR, Santos EM (2017). Hepatic transcriptional responses to copper in the three-spined stickleback are affected by their pollution exposure history. Aquat Toxicol, 184, 26-36. Abstract.  Author URL.  Full text.
Sherman KD, King RA, Dahlgren CP, Simpson SD, Stevens JR, Tyler CR (2017). Historical processes and contemporary anthropogenic activities influence genetic population dynamics of Nassau grouper (Epinephelus striatus) within the Bahamas. Frontiers in Marine Science, 4(DEC). Abstract.  Full text.
Bruintjes R, Harding HR, Bunce T, Birch F, Lister J, Spiga I, Benson T, Rossington K, Jones D, Tyler CR, et al (2017). Shipbuilding Docks as Experimental Systems for Realistic Assessments of Anthropogenic Stressors on Marine Organisms. BIOSCIENCE, 67(9), 853-859. Author URL.  Full text.
Lillicrap A, Springer T, Tyler CR (2016). A tiered assessment strategy for more effective evaluation of bioaccumulation of chemicals in fish. Regul Toxicol Pharmacol, 75, 20-26. Abstract.  Author URL.
Dogra Y, Arkill KP, Elgy C, Stolpe B, Lead J, Valsami-Jones E, Tyler CR, Galloway TS (2016). Cerium oxide nanoparticles induce oxidative stress in the sediment-dwelling amphipod Corophium volutator. Nanotoxicology, 10(4), 480-487. Abstract.  Author URL.  Full text.
Tohyama S, Miyagawa S, Lange A, Ogino Y, Mizutani T, Ihara M, Tanaka H, Tatarazako N, Kobayashi T, Tyler CR, et al (2016). Evolution of estrogen receptors in ray-finned fish and their comparative responses to estrogenic substances. J Steroid Biochem Mol Biol, 158, 189-197. Abstract.  Author URL.
Sherman KD, Dahlgren CP, Stevens JR, Tyler CR (2016). Integrating population biology into conservation management for endangered Nassau grouper Epinephelus striatus. Marine Ecology Progress Series, 554, 263-280. Abstract.  Full text.
Collison E, Hird H, Cresswell J, Tyler C (2016). Interactive effects of pesticide exposure and pathogen infection on bee health – a critical analysis. Biological Reviews, 91(4), 1006-1019. Abstract.
Verbruggen B, Bickley LK, van Aerle R, Bateman KS, Stentiford GD, Santos EM, Tyler CR (2016). Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments. Viruses, 8(1). Abstract.  Author URL.  Full text.
Hamilton PB, Cowx IG, Oleksiak MF, Griffiths AM, Grahn M, Stevens JR, Carvalho GR, Nicol E, Tyler CR (2016). Population-level consequences for wild fish exposed to sublethal concentrations of chemicals – a critical review. Fish and Fisheries, 17(3), 545-566. Abstract.
Song L, Vijver MG, Peijnenburg WJGM, Galloway TS, Tyler CR (2015). A comparative analysis on the in vivo toxicity of copper nanoparticles in three species of freshwater fish. Chemosphere, 139, 181-189. Abstract.  Author URL.
Miyagawa S, Lange A, Tohyama S, Ogino Y, Mizutani T, Kobayashi T, Tatarazako N, Tyler CR, Iguchi T (2015). Characterization of Oryzias latipes glucocorticoid receptors and their unique response to progestins. Journal of Applied Toxicology, 35(3), 302-309. Abstract.
Brown AR, Owen SF, Peters J, Zhang Y, Soffker M, Paull GC, Hosken DJ, Wahab MA, Tyler CR (2015). Climate change and pollution speed declines in zebrafish populations. Proc Natl Acad Sci U S A, 112(11), E1237-E1246. Abstract.  Author URL.  Full text.
Verbruggen B, Bickley LK, Santos EM, Tyler CR, Stentiford GD, Bateman KS, van Aerle R (2015). De novo assembly of the Carcinus maenas transcriptome and characterization of innate immune system pathways. BMC Genomics, 16 Abstract.  Author URL.  Full text.
Orton F, Tyler CR (2015). Do hormone-modulating chemicals impact on reproduction and development of wild amphibians?. Biol Rev Camb Philos Soc, 90(4), 1100-1117. Abstract.  Author URL.
Rolshausen G, Phillip DAT, Beckles DM, Akbari A, Ghoshal S, Hamilton PB, Tyler CR, Scarlett AG, Ramnarine I, Bentzen P, et al (2015). Do stressful conditions make adaptation difficult? Guppies in the oil-polluted environments of southern Trinidad. Evol Appl, 8(9), 854-870. Abstract.  Author URL.
Jennings V, Goodhead R, Tyler CR (2015). Ecotoxicology of Nanomaterials in Aquatic Systems. Frontiers of Nanoscience, 8, 3-45. Abstract.
Hamilton PB, Lange A, Nicol E, Bickley LK, De-Bastos ESR, Jobling S, Tyler CR (2015). Effects of Exposure to WwTW Effluents over Two Generations on Sexual Development and Breeding in Roach Rutilus rutilus. Environ Sci Technol, 49(21), 12994-13002. Abstract.  Author URL.
Corcoran J, Winter MJ, Lange A, Cumming R, Owen SF, Tyler CR (2015). Effects of the lipid regulating drug clofibric acid on PPARα-regulated gene transcript levels in common carp (Cyprinus carpio) at pharmacological and environmental exposure levels. Aquat Toxicol, 161, 127-137. Abstract.  Author URL.
Lange A, Sebire M, Rostkowski P, Mizutani T, Miyagawa S, Iguchi T, Hill EM, Tyler CR (2015). Environmental chemicals active as human antiandrogens do not activate a stickleback androgen receptor but enhance a feminising effect of oestrogen in roach. Aquat Toxicol, 168, 48-59. Abstract.  Author URL.
Pountney A, Filby AL, Thomas GO, Simpson VR, Chadwick EA, Stevens JR, Tyler CR (2015). High liver content of polybrominated diphenyl ether (PBDE) in otters (Lutra lutra) from England and Wales. Chemosphere, 118, 81-86. Abstract.  Author URL.
Heindel JJ, Newbold RR, Williams CJ, Iguchi T, Tyler CR (2015). Lou Guillette--in memorandum. Mol Reprod Dev, 82(10), Fmi-v. Author URL.
Goodhead RM, Moger J, Galloway TS, Tyler CR (2015). Tracing engineered nanomaterials in biological tissues using coherent anti-Stokes Raman scattering (CARS) microscopy - a critical review. Nanotoxicology, 9(7), 928-939. Abstract.  Author URL.
Lee O, Green JM, Tyler CR (2015). Transgenic fish systems and their application in ecotoxicology. Crit Rev Toxicol, 45(2), 124-141. Abstract.  Author URL.
Tohyama S, Miyagawa S, Lange A, Ogino Y, Mizutani T, Tatarazako N, Katsu Y, Ihara M, Tanaka H, Ishibashi H, et al (2015). Understanding the Molecular Basis for Differences in Responses of Fish Estrogen Receptor Subtypes to Environmental Estrogens. Environmental Science and Technology, 49(12), 7439-7447. Abstract.
David A, Abdul-Sada A, Lange A, Tyler CR, Hill EM (2014). A new approach for plasma (xeno)metabolomics based on solid-phase extraction and nanoflow liquid chromatography-nanoelectrospray ionisation mass spectrometry. J Chromatogr A, 1365, 72-85. Abstract.  Author URL.
Brown AR, Gunnarsson L, Kristiansson E, Tyler CR (2014). Assessing variation in the potential susceptibility of fish to pharmaceuticals, considering evolutionary differences in their physiology and ecology. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1656). Abstract.  Full text.
Corcoran J, Lange A, Cumming RI, Owen SF, Ball JS, Tyler CR, Winter MJ (2014). Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio). Aquat Toxicol, 152, 57-65. Abstract.  Author URL.
Miyagawa S, Lange A, Tohyama S, Ogino Y, Mizutani T, Kobayashi T, Tatarazako N, Tyler CR, Iguchi T (2014). Characterization of Oryzias latipes glucocorticoid receptors and their unique response to progestins. Journal of Applied Toxicology
Morrissey CA, Stanton DW, Tyler CR, Pereira MG, Newton J, Durance I, Ormerod SJ (2014). Developmental impairment in eurasian dipper nestlings exposed to urban stream pollutants. Environmental Toxicology and Chemistry
Morrissey CA, Stanton DWG, Tyler CR, Pereira MG, Newton J, Durance I, Ormerod SJ (2014). Developmental impairment in eurasian dipper nestlings exposed to urban stream pollutants. Environmental Toxicology and Chemistry, 33(6), 1315-1323. Abstract.
Miyagawa S, Lange A, Hirakawa I, Tohyama S, Ogino Y, Mizutani T, Kagami Y, Kusano T, Ihara M, Tanaka H, et al (2014). Differing species responsiveness of estrogenic contaminants in fish is conferred by the ligand binding domain of the estrogen receptor. Environmental Science and Technology, 48(9), 5254-5263. Abstract.
Southam AD, Lange A, Al-Salhi R, Hill EM, Tyler CR, Viant MR (2014). Distinguishing between the metabolome and xenobiotic exposome in environmental field samples analysed by direct-infusion mass spectrometry based metabolomics and lipidomics. Metabolomics, 10(6), 1050-1058. Abstract.  Author URL.
Kermorgant M, Lancien F, Mimassi N, Tyler CR, Le Mével J-C (2014). Effects of intracerebroventricular administered fluoxetine on cardio-ventilatory functions in rainbow trout (Oncorhynchus mykiss). Gen Comp Endocrinol, 205, 176-184. Abstract.  Author URL.
Baker TJ, Tyler CR, Galloway TS (2014). Impacts of metal and metal oxide nanoparticles on marine organisms. Environmental Pollution, 186, 257-271. Abstract.
Baker TJ, Tyler CR, Galloway TS (2014). Impacts of metal and metal oxide nanoparticles on marine organisms. Environ Pollut, 186, 257-271. Abstract.  Author URL.
Hazlerigg CRE, Tyler CR, Lorenzen K, Wheeler JR, Thorbek P (2014). Population relevance of toxicant mediated changes in sex ratio in fish: an assessment using an individual-based zebrafish (Danio rerio) model. Ecological Modelling
Hazlerigg CRE, Tyler CR, Lorenzen K, Wheeler JR, Thorbek P (2014). Population relevance of toxicant mediated changes in sex ratio in fish: an assessment using an individual-based zebrafish (Danio rerio) model. Ecological Modelling, 280, 76-88. Abstract.
Hamilton PB, Nicol E, De-Bastos ESR, Williams RJ, Sumpter JP, Jobling S, Stevens JR, Tyler CR (2014). Populations of a cyprinid fish are self-sustaining despite widespread feminization of males. BMC Biol, 12 Abstract.  Author URL.  Full text.
Filby AL, Ortiz-Zarragoitia M, Tyler CR (2014). The vas:: Egfp transgenic zebrafish: a practical model for studies on the molecular mechanisms by which environmental estrogens affect gonadal sex differentiation. Environmental Toxicology and Chemistry, 33(3), 602-605. Abstract.
Filby AL, Ortiz-Zarragoitia M, Tyler CR (2014). The vas::egfp transgenic zebrafish: a practical model for studies on the molecular mechanisms by which environmental estrogens affect gonadal sex differentiation. Environ Toxicol Chem, 33(3), 602-605. Abstract.  Author URL.
Watts AJR, Lewis C, Goodhead RM, Beckett SJ, Moger J, Tyler CR, Galloway TS (2014). Uptake and retention of microplastics by the shore crab Carcinus maenas. Environ Sci Technol, 48(15), 8823-8830. Abstract.  Author URL.
Katsu Y, Lange A, Miyagawa S, Urushitani H, Tatarazako N, Kawashima Y, Tyler CR, Iguchi T (2013). Cloning, expression and functional characterization of carp, cyprinus carpio, estrogen receptors and their differential activations by estrogens. Journal of Applied Toxicology, 33(1), 41-49. Abstract.
Ankley GT, Tyler CR (2013). Development of methods to detect occurrence and effects of endocrine-disrupting chemicals: Fueling a fundamental shift in regulatory ecotoxicology. Environmental Toxicology and Chemistry, 32(12), 2661-2662.
Osborne OJ, Johnston BD, Moger J, Balousha M, Lead JR, Kudoh T, Tyler CR (2013). Effects of particle size and coating on nanoscale Ag and TiO₂ exposure in zebrafish (Danio rerio) embryos. Nanotoxicology, 7(8), 1315-1324. Abstract.  Author URL.
Hawkes LA, McGowan A, Godley BJ, Gore S, Lange A, Tyler CR, Wheatley D, White J, Witt MJ, Broderick AC, et al (2013). Estimating sex ratios in Caribbean hawksbill turtles: Testosterone levels and climate effects. Aquatic Biology, 18(1), 9-19. Abstract.
Morrissey CA, Stanton DWG, Pereira MG, Newton J, Durance I, Tyler CR, Ormerod SJ (2013). Eurasian dipper eggs indicate elevated organohalogenated contaminants in urban rivers. Environmental Science and Technology, 47(15), 8931-8939. Abstract.
Segner H, Casanova-Nakayama A, Kase R, Tyler CR (2013). Impact of environmental estrogens on Yfish considering the diversity of estrogen signaling. General and Comparative Endocrinology, 191, 190-201. Abstract.
Bickley LK, Brown AR, Hosken DJ, Hamilton PB, Le Page G, Paull GC, Owen SF, Tyler CR (2013). Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish. Evolutionary Applications, 6(2), 279-289. Abstract.  Full text.
van Aerle R, Lange A, Moorhouse A, Paszkiewicz K, Ball K, Johnston BD, de-Bastos E, Booth T, Tyler CR, Santos EM, et al (2013). Molecular mechanisms of toxicity of silver nanoparticles in zebrafish embryos. Environ Sci Technol, 47(14), 8005-8014. Abstract.  Author URL.  Full text.
Santos EM, Hamilton PB, Coe TS, Ball JS, Cook AC, Katsiadaki I, Tyler CR (2013). Population bottlenecks, genetic diversity and breeding ability of the three-spined stickleback (Gasterosteus aculeatus) from three polluted English Rivers. Aquatic Toxicology, 142-143, 264-271. Abstract.
Bergman A, Andersson AM, Becher G, Van Den Berg M, Blumberg B, Bjerregaard P, Bornehag CG, Bornman R, Brandt I, Brian JV, et al (2013). Science and policy on endocrine disrupters must not be mixed: a reply to a "common sense" intervention by toxicology journal editors. Environmental Health: a Global Access Science Source, 12(1). Abstract.
Lee OH, Takesono A, Tada M, Tyler CR, Kudoh T (2012). Biosensor zebrafish provide new insights into potential health effects of environmental estrogens. Environ Health Perspect, 120, 990-996. Full text.
Baalousha M, Ju-Nam Y, Cole PA, Gaiser B, Fernandes TF, Hriljac JA, Jepson MA, Stone V, Tyler CR, Lead JR, et al (2012). Characterization of cerium oxide nanoparticles-Part 1: Size measurements. Environmental Toxicology and Chemistry, 31(5), 983-993. Abstract.
Baalousha M, Ju-Nam Y, Cole PA, Hriljac JA, Jones IP, Tyler CR, Stone V, Fernandes TF, Jepson MA, Lead JR, et al (2012). Characterization of cerium oxide nanoparticles-Part 2: Nonsize measurements. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 31(5), 994-1003. Author URL.
Baalousha M, Ju-Nam Y, Cole PA, Hriljac JA, Jones IP, Tyler CR, Stone V, Fernandes TF, Jepson MA, Lead JR, et al (2012). Characterization of cerium oxide nanoparticles-Part 2: Nonsize measurements. Environmental Toxicology and Chemistry, 31(5), 994-1003. Abstract.
Baalousha M, Ju-Nam Y, Cole PA, Gaiser B, Fernandes TF, Hriljac JA, Jepson MA, Stone V, Tyler CR, Lead JR, et al (2012). Characterization of cerium oxide nanoparticles-part 1: Size measurements. Environmental Toxicology and Chemistry
Baalousha M, Ju-Nam Y, Cole PA, Hriljac JA, Jones IP, Tyler CR, Stone V, Fernandes TF, Jepson MA, Lead JR, et al (2012). Characterization of cerium oxide nanoparticles-part 2: Nonsize measurements. Environmental Toxicology and Chemistry
Katsu Y, Lange A, Miyagawa S, Urushitani H, Tatarazako N, Kawashima CR, Iguchi T (2012). Cloning, expression and functional characterization of carp, Cyprinus carpio, estrogen receptors and their differential activations by estrogens. Journal of Applied Toxicology Abstract.
Söffker M, Stevens JR, Tyler CR (2012). Comparative breeding and behavioral responses to ethinylestradiol exposure in wild and laboratory maintained zebrafish (Danio rerio) populations. Environ Sci Technol, 46(20), 11377-11383. Abstract.  Author URL.
Lange A, Katsu Y, Miyagawa S, Ogino Y, Urushitani H, Kobayashi T, Hirai T, Shears JA, Nagae M, Yamamoto J, et al (2012). Comparative responsiveness to natural and synthetic estrogens of fish species commonly used in the laboratory and field monitoring. Aquat Toxicol, 109, 250-258. Abstract.  Author URL.
Hazlerigg CRE, Lorenzen K, Thorbek P, Wheeler JR, Tyler CR (2012). Density-dependent processes in the life history of fishes: Evidence from laboratory populations of zebrafish Danio rerio. PLoS ONE, 7(5). Abstract.
Lee O, Tyler CR, Kudoh T (2012). Development of a transient expression assay for detecting environmental oestrogens in zebrafish and medaka embryos. BMC Biotechnol, 12 Abstract.  Author URL.  Full text.
Brown AR, Bickley LK, Ryan TA, Paull GC, Hamilton PB, Owen SF, Sharpe AD, Tyler CR (2012). Differences in sexual development in inbred and outbred zebrafish (Danio rerio) and implications for chemical testing. Aquat Toxicol, 112-113, 27-38. Abstract.  Author URL.
Cresswell JE, Page CJ, Uygun MB, Holmbergh M, Li Y, Wheeler JG, Laycock I, Pook CJ, de Ibarra NH, Smirnoff N, et al (2012). Differential sensitivity of honey bees and bumble bees to a dietary insecticide (imidacloprid). Zoology
Cresswell JE, Page CJ, Uygun MB, Holmbergh M, Li Y, Wheeler JG, Laycock I, Pook CJ, de Ibarra NH, Smirnoff N, et al (2012). Differential sensitivity of honey bees and bumble bees to a dietary insecticide (imidacloprid). Zoology, 115(6), 365-371. Abstract.
Corcoran J, Lange A, Winter MJ, Tyler CR (2012). Effects of Pharmaceuticals on the Expression of Genes Involved in Detoxification in a Carp Primary Hepatocyte Model. Environmental Science and Technology, 46(11), 6306-6314. Abstract.
Söffker M, Tyler CR (2012). Endocrine disrupting chemicals and sexual behaviors in fish--a critical review on effects and possible consequences. Crit Rev Toxicol, 42(8), 653-668. Abstract.  Author URL.
Filby AL, Paull GC, Searle F, Ortiz-Zarragoitia M, Tyler CR (2012). Environmental estrogen-induced alterations of male aggression and dominance hierarchies in fish: a mechanistic analysis. Environ Sci Technol, 46(6), 3472-3479. Abstract.  Author URL.
Gaiser BK, Fernandes TF, Jepson MA, Lead JR, Tyler CR, Baalousha M, Biswas A, Britton GJ, Cole PA, Johnston BD, et al (2012). Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles. Environmental Toxicology and Chemistry, 31(1), 144-154. Abstract.
Fabrega J, Tantra R, Amer A, Stolpe B, Tomkins J, Fry T, Lead JR, Tyler CR, Galloway TS (2012). Sequestration of zinc from zinc oxide nanoparticles and life cycle effects in the sediment dweller amphipod Corophium volutator. Environ Sci Technol, 46(2), 1128-1135. Abstract.  Author URL.
Croft DP, Hamilton PB, Darden SK, Jacoby DMP, James R, Bettaney EM, Tyler CR (2012). The role of relatedness in structuring the social network of a wild guppy population. Oecologia, 170(4), 955-963. Abstract.
Croft DP, Hamilton PB, Darden SK, Jacoby DMP, James R, Bettaney EM, Tyler CR (2012). The role of relatedness in structuring the social network of a wild guppy population. Oecologia, 1-9.
Al-Salhi R, Abdul-Sada A, Lange A, Tyler CR, Hill EM (2012). The xenometabolome and novel contaminant markers in fish exposed to a wastewater treatment works effluent. Environmental Science and Technology, 46(16), 9080-9088. Abstract.
Larner F, Dogra Y, Dybowska A, Fabrega J, Stolpe B, Bridgestock LJ, Goodhead R, Weiss DJ, Moger J, Lead JR, et al (2012). Tracing bioavailability of ZnO nanoparticles using stable isotope labeling. Environ Sci Technol, 46(21), 12137-12145. Abstract.  Author URL.
Brown AR, Bickley LK, Le Page G, Hosken DJ, Paull GC, Hamilton PB, Owen SF, Robinson J, Sharpe AD, Tyler CR, et al (2011). Are toxicological responses in laboratory (inbred) zebrafish representative of those in outbred (wild) populations? - a case study with an endocrine disrupting chemical. Environ Sci Technol, 45(9), 4166-4172. Abstract.  Author URL.
Rostkowski P, Horwood J, Shears JA, Lange A, Oladapo FO, Besselink HT, Tyler CR, Hill EM (2011). Bioassay-directed identification of novel antiandrogenic compounds in bile of fish exposed to wastewater effluents. Environmental Science and Technology, 45(24), 10660-10667. Abstract.
Gaiser BK, Biswas A, Rosenkranz P, Jepson MA, Lead JR, Stone V, Tyler CR, Fernandes TF (2011). Effects of silver and cerium dioxide micro- and nano-sized particles on Daphnia magna. Journal of Environmental Monitoring, 13(5), 1227-1235. Abstract.
Lange A, Paull GC, Hamilton PB, Iguchi T, Tyler CR (2011). Implications of persistent exposure to treated wastewater effluent for breeding in wild roach (Rutilus rutilus) populations. Environ Sci Technol, 45(4), 1673-1679. Abstract.  Author URL.
García-López Á, Sánchez-Amaya MI, Tyler CR, Prat F (2011). Mechanisms of oocyte development in European sea bass (Dicentrarchus labrax L.): investigations via application of unilateral ovariectomy. Reproduction, 142(2), 243-253. Abstract.  Author URL.
Southam AD, Lange A, Hines A, Hill EM, Katsu Y, Iguchi T, Tyler CR, Viant MR (2011). Metabolomics reveals target and off-target toxicities of a model organophosphate pesticide to roach (Rutilus rutilus): Implications for biomonitoring. Environmental Science and Technology, 45(8), 3759-3767. Abstract.
Sebire M, Katsiadaki I, Taylor NGH, Maack G, Tyler CR (2011). Short-term exposure to a treated sewage effluent alters reproductive behaviour in the three-spined stickleback (Gasterosteus aculeatus). Aquat Toxicol, 105(1-2), 78-88. Abstract.  Author URL.
Fabrega J, Luoma SN, Tyler CR, Galloway TS, Lead JR (2011). Silver nanoparticles: behaviour and effects in the aquatic environment. Environ Int, 37(2), 517-531. Abstract.  Author URL.
Harris CA, Hamilton PB, Runnalls TJ, Vinciotti V, Henshaw A, Hodgson D, Coe TS, Jobling S, Tyler CR, Sumpter JP, et al (2011). The consequences of feminization in breeding groups of wild fish. Environ Health Perspect, 119(3), 306-311. Abstract.  Author URL.  Full text.
Scown TM, Goodhead RM, Johnston BD, Moger J, Baalousha M, Lead JR, Van Aerle R, Iguchi T, Tyler CR (2010). Assessment of cultured fish hepatocytes for studying cellular uptake and (eco)toxicity of nanoparticles. Environmental Chemistry, 7(1), 36-49. Abstract.
Johnston BD, Scown TM, Moger J, Cumberland SA, Baalousha M, Linge K, van Aerle R, Jarvis K, Lead JR, Tyler CR, et al (2010). Bioavailability of nanoscale metal oxides TiO(2), CeO(2), and ZnO to fish. Environ Sci Technol, 44(3), 1144-1151. Abstract.  Author URL.  Full text.
Paull GC, Filby AL, Giddins HG, Coe TS, Hamilton PB, Tyler CR (2010). Dominance hierarchies in zebrafish (Danio rerio) and their relationship with reproductive success. Zebrafish, 7(1), 109-117. Abstract.  Author URL.
Panter GH, Hutchinson TH, Hurd KS, Bamforth J, Stanley RD, Wheeler JR, Tyler CR (2010). Effects of a weak oestrogenic active chemical (4-tert-pentylphenol) on pair-breeding and F1 development in the fathead minnow (Pimephales promelas). Aquatic Toxicology, 97(4), 314-323. Abstract.
Filby AL, Shears JA, Drage BE, Churchley JH, Tyler CR (2010). Effects of advanced treatments of wastewater effluents on estrogenic and reproductive health impacts in fish. Environ Sci Technol, 44(11), 4348-4354. Abstract.  Author URL.
Scown TM, Santos EM, Johnston BD, Gaiser B, Baalousha M, Mitov S, Lead JR, Stone V, Fernandes TF, Jepson M, et al (2010). Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow trout. Toxicol Sci, 115(2), 521-534. Abstract.  Author URL.
Fenlon KA, Johnson AC, Tyler CR, Hill EM (2010). Gas-liquid chromatography-tandem mass spectrometry methodology for the quantitation of estrogenic contaminants in bile of fish exposed to wastewater treatment works effluents and from wild populations. Journal of Chromatography A, 1217(1), 112-118. Abstract.
Katsiadaki I, Williams TD, Ball JS, Bean TP, Sanders MB, Wu H, Santos EM, Brown MM, Baker P, Ortega F, et al (2010). Hepatic transcriptomic and metabolomic responses in the Stickleback (Gasterosteus aculeatus) exposed to ethinyl-estradiol. Aquat Toxicol, 97(3), 174-187. Abstract.  Author URL.
Santos EM, Ball JS, Williams TD, Wu H, Ortega F, van Aerle R, Katsiadaki I, Falciani F, Viant MR, Chipman JK, et al (2010). Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model. Environ Sci Technol, 44(2), 820-826. Abstract.  Author URL.
Coe TS, Söffker MK, Filby AL, Hodgson D, Tyler CR (2010). Impacts of early life exposure to estrogen on subsequent breeding behavior and reproductive success in zebrafish. Environ Sci Technol, 44(16), 6481-6487. Abstract.  Author URL.
Van Aggelen G, Ankley GT, Baldwin WS, Bearden DW, Benson WH, Chipman JK, Collette TW, Craft JA, Denslow ND, Embry MR, et al (2010). Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook. Environ Health Perspect, 118(1), 1-5. Abstract.  Author URL.
Corcoran J, Winter MJ, Tyler CR (2010). Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish. Crit Rev Toxicol, 40(4), 287-304. Abstract.  Author URL.
Filby AL, Paull GC, Bartlett EJ, Van Look KJW, Tyler CR (2010). Physiological and health consequences of social status in zebrafish (Danio rerio). Physiol Behav, 101(5), 576-587. Abstract.  Author URL.
Hill EM, Evans KL, Horwood J, Rostkowski P, Oladapo FO, Gibson R, Shears JA, Tyler CR (2010). Profiles and some initial identifications of (anti)androgenic compounds in fish exposed to wastewater treatment works effluents. Environ Sci Technol, 44(3), 1137-1143. Abstract.  Author URL.
Scown TM, van Aerle R, Tyler CR (2010). Review: Do engineered nanoparticles pose a significant threat to the aquatic environment?. Crit Rev Toxicol, 40(7), 653-670. Abstract.  Author URL.
Filby AL, Paull GC, Hickmore TF, Tyler CR (2010). Unravelling the neurophysiological basis of aggression in a fish model. BMC Genomics, 11 Abstract.  Author URL.
Mehinto AC, Hill EM, Tyler CR (2010). Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (Oncorhynchus mykiss). Environ Sci Technol, 44(6), 2176-2182. Abstract.  Author URL.
Oehlmann J, Schulte-Oehlmann U, Kloas W, Jagnytsch O, Lutz I, Kusk KO, Wollenberger L, Santos EM, Paull GC, VanLook KJW, et al (2009). A critical analysis of the biological impacts of plasticizers on wildlife. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1526), 2047-2062. Abstract.
Tyler CR, Filby AL, Bickley LK, Cumming RI, Gibson R, Labadie P, Katsu Y, Liney KE, Shears JA, Silva-Castro V, et al (2009). Environmental health impacts of equine estrogens derived from hormone replacement therapy. Environ Sci Technol, 43(10), 3897-3904. Abstract.  Author URL.
Thorpe KL, Maack G, Benstead R, Tyler CR (2009). Estrogenic wastewater treatment works effluents reduce egg production in fish. Environ Sci Technol, 43(8), 2976-2982. Abstract.  Author URL.
Bickley LK, Lange A, Winter MJ, Tyler CR (2009). Evaluation of a carp primary hepatocyte culture system for screening chemicals for oestrogenic activity. Aquat Toxicol, 94(3), 195-203. Abstract.  Author URL.
Coe TS, Hamilton PB, Griffiths AM, Hodgson DJ, Wahab MA, Tyler CR (2009). Genetic variation in strains of zebrafish (Danio rerio) and the implications for ecotoxicology studies. Ecotoxicology, 18(1), 144-150. Abstract.  Author URL.
Brown AR, Hosken DJ, Balloux F, Bickley LK, LePage G, Owen SF, Hetheridge MJ, Tyler CR (2009). Genetic variation, inbreeding and chemical exposure--combined effects in wildlife and critical considerations for ecotoxicology. Philos Trans R Soc Lond B Biol Sci, 364(1534), 3377-3390. Abstract.  Author URL.
Paull GC, Filby AL, Tyler CR (2009). Growth rate during early life affects sexual differentiation in roach (Rutilus rutilus). Environmental Biology of Fishes, 85(4), 277-284. Abstract.
Williams TD, Wu H, Santos EM, Ball J, Katsiadaki I, Brown MM, Baker P, Ortega F, Falciani F, Craft JA, et al (2009). Hepatic transcriptomic and metabolomic responses in the stickleback (Gasterosteus aculeatus) exposed to environmentally relevant concentrations of dibenzanthracene. Environ Sci Technol, 43(16), 6341-6348. Abstract.  Author URL.
Scown TM, van Aerle R, Johnston BD, Cumberland S, Lead JR, Owen R, Tyler CR (2009). High doses of intravenously administered titanium dioxide nanoparticles accumulate in the kidneys of rainbow trout but with no observable impairment of renal function. Toxicol Sci, 109(2), 372-380. Abstract.  Author URL.
Coe TS, Hamilton PB, Hodgson D, Paull GC, Tyler CR (2009). Parentage outcomes in response to estrogen exposure are modified by social grouping in zebrafish. Environ Sci Technol, 43(21), 8400-8405. Abstract.  Author URL.
Lange A, Paull GC, Coe TS, Katsu Y, Urushitani H, Iguchi T, Tyler CR (2009). Sexual reprogramming and estrogenic sensitization in wild fish exposed to ethinylestradiol. Environ Sci Technol, 43(4), 1219-1225. Abstract.  Author URL.  Full text.
Jobling S, Burn RW, Thorpe K, Williams R, Tyler C (2009). Statistical modeling suggests that antiandrogens in effluents from wastewater treatment works contribute to widespread sexual disruption in fish living in English rivers. Environ Health Perspect, 117(5), 797-802. Abstract.  Author URL.
Sebire M, Scott AP, Tyler CR, Cresswell J, Hodgson DJ, Morris S, Sanders MB, Stebbing PD, Katsiadaki I (2009). The organophosphorous pesticide, fenitrothion, acts as an anti-androgen and alters reproductive behavior of the male three-spined stickleback, Gasterosteus aculeatus. Ecotoxicology, 18(1), 122-133. Abstract.  Author URL.
Thorpe KL, Benstead R, Eccles P, Maack G, Williams T, Tyler CR (2008). A practicable laboratory flow-through exposure system for assessing the health effects of effluents in fish. Aquat Toxicol, 88(3), 164-172. Abstract.  Author URL.
Lange A, Katsu Y, Ichikawa R, Paull GC, Chidgey LL, Coe TS, Iguchi T, Tyler CR (2008). Altered sexual development in roach (Rutilus rutilus) exposed to environmental concentrations of the pharmaceutical 17alpha-ethinylestradiol and associated expression dynamics of aromatases and estrogen receptors. Toxicol Sci, 106(1), 113-123. Abstract.  Author URL.
Coe TS, Hamilton PB, Hodgson D, Paull GC, Stevens JR, Sumner K, Tyler CR (2008). An environmental estrogen alters reproductive hierarchies, disrupting sexual selection in group-spawning fish. Environ Sci Technol, 42(13), 5020-5025. Abstract.  Author URL.
Williams TD, Brown M, Chipman JK, Falciani F, Ortega F, Geoghegan F, Craft JA, Katsiadaki I, Ball J, Tyler CR, et al (2008). Development of a stickleback (Gasterosteus aculeatus) cDNA microarray and gene expression responses to dibenzanthracene, ethinyl-estradiol and copper. MARINE ENVIRONMENTAL RESEARCH, 66(1), 140-140. Author URL.
Benstead, R. Eccles, P. Maack, G. (2008). Effective assessment of the oestrogenic activity of effluents using a laboratory flow-through exposure system. Aquatic Toxicology
van Aerle R, Kille P, Lange A, Tyler CR (2008). Evidence for the existence of a functional Kiss1/Kiss1 receptor pathway in fish. Peptides, 29(1), 57-64. Abstract.  Author URL.
Johnston, B.J. Tyler, C.R. (2008). Imaging metal oxide nanoparticles in biological structures with CARS microscopy. Optical Express, 16(5), 3408-3419.
Handy RD, Henry TB, Scown TM, Johnston BD, Tyler CR (2008). Manufactured nanoparticles: their uptake and effects on fish--a mechanistic analysis. Ecotoxicology, 17(5), 396-409. Abstract.  Author URL.
Ibañez, A. Tyler, C.R. Prat, F. (2008). Molecular characterisation of growth differentiation factor 9 (gdf9) and bone morphogenetic protein 15 (bmp15) and their patterns of gene expression during the ovarian reproductive cycle in the European sea. bass. Molecular and Cellular Endocrinology
Paull GC, Lange A, Henshaw AC, Tyler CR (2008). Ontogeny of sexual development in the roach (Rutilus rutilus) and its interrelationships with growth and age. J Morphol, 269(7), 884-895. Abstract.  Author URL.
Tyler CR, Jobling S (2008). Roach, sex, and gender-bending chemicals: the feminization of wild fish in English rivers. BioScience, 58(11), 1051-1059. Abstract.
Kille, P. Workman, V.L. Paull, G.C. (2008). Sexually dimorphic gene expression in the brains of mature zebrafish. Comparative Biochemistry and Physiology Part A
Paull, G.C. van Look, K.J.W. Santos, E.M. Filby A.L. Gray D.M. Nash, J.P. & Tyler, C.R (2008). Variability in measures of reproductive success in laboratory-kept colonies of zebrafish (Danio rerio) and implications for studies addressing population-level effects of environmental chemicals. Aquatic Toxicology
Tyler, C.R. (2007).  Cloning and Characterisation of cDNAs for hormones and/or receptors of growth hormone, insulin-like growth factor-I, thyroid hormone, and corticosteroid and the gender- and tissue- and developmental-specific expression of their mRNA transcripts in fathea. General & Comparative Endocrinology, 150, 151-163.
Katsu, Y. Urushitani, H. Lange, A. (2007).  Developmental effects of exposure to. pharmaceutical steroids in the aquatic environment: Studies in Mosquitofish (Gambusia affinis), Roach. (Rutilus rutilus) and Medaka (Oryzias latipes. Journal of Marine Science and Technology
Hetheridge, M. Hutchinson, T.H. Benstead, R. (2007). An optimized experimental test procedure for measuring chemical effects on reproduction in the fathead minnow (<em>Pimephales promelas</em>). Aquatic Toxicology, 8(1), 90-98.
Filby AL, Tyler CR (2007). Appropriate 'housekeeping' genes for use in expression profiling the effects of environmental estrogens in fish. BMC Mol Biol, 8 Abstract.  Author URL.
Benstead, R. Hutchinson, T.H. Tyler, C.R. (2007). Associations between altered vitellogenin concentrations and adverse health effects in fathead minnow (Pimephales promelas. Aquatic Toxicology
Trudeau V, Tyler C (2007). Endocrine disruption. Gen Comp Endocrinol, 153(1-3), 13-14. Author URL.
Schulz RW, Bogerd J, Male R, Ball J, Fenske M, Olsen LC, Tyler CR (2007). Estrogen-induced alterations in amh and dmrt1 expression signal for disruption in male sexual development in the zebrafish. Environmental Science and Technology, 41(17), 6305-6310. Abstract.
Bickley L, Lange A, Tyler C, Winter M (2007). Fish hepatocyte cultures as an alternative to in vivo tests for screening oestrogen receptor active chemicals. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 146(4), S72-S72. Author URL.
Jobling, S. (2007). Fish, Sex and Gender-Bending Chemicals – the Feminization of Fish Living in English Rivers. Biosciences
Lange, A. Ichikawa, R. Urushitani, H.G.C. (2007). Functional associations between two estrogen receptors, environmental oestrogens, and sexual disruption in the roach (<em>Rutilus rutilus</em>). Environmental Science and Technology, 41(9), 3368-3374.
Thorpe, K.L. Maack, G. Tyler, C.R. (2007). Gene expression profiles revealing the mechanisms of anti-androgen- and oestrogen- induced feminisation in fish. Aquatic Toxicology, 81(2), 219-231.
Santos, E.M. Thorpe, K.L. Maack, G. (2007). Gene expression profiling for understanding chemical causation of biological effects of complex mixtures: a Case Study for Estrogens. Environmental Science and Technology
Santos, E.M. Paull, G.C. Van Look, K.J.W. Workman, V.L. Holt, W.V. van Aerle, R. Kille, P. & Tyler, C.R (2007). Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio). Aquatic Toxicology, 83(2), 134-142.
Tyler CR, Filby AL, Galloway TS, Neuparthe T (2007). Health impacts of estrogens in the environment, considering  complex mixture effects.  Full text.
Tyler, C.R. (2007). Identification of microsatellite loci for parentage analysis in roach Rutilus rutilus and 8 other cyprinids by cross-species amplification, and a novel test for detecting hybrids between roach and other cyprinids. Molecular Ecology Notes
Workman, V.L. Paull, G.C. Filby, A.L. (2007). Molecular basis of sex and reproductive status in breeding zebrafish. Physiological Genomics, 30(2), 111-122.
Boegard, J. Male, R. Ball, J. (2007). Oestrogen-induced alterations in the expression of AMH and DMRT-1 during sexual differentiation signal for impacts on male sexual development in the zebrafish (<em>Danio rerio</em>). Environmental Science and Technology, 41(17), 6305-6310.
Tyler C, Lange A, Santos E, Filby A (2007). The application of transcriptomics and other molecular approaches in advancing our understanding of endocrine disruption. TOXICOLOGY LETTERS, 172, S27-S27. Author URL.
Katsu, Y. Kato, Y. Tooi, O. (2007). The medaka (Oryyzias latipes) for assessing developmental effects of endocrine disrupting chemicals with special reference to gonadal intersex (testis-ova. Environmental Science
Tyler CR, Lange A, Paull GC, Katsu Y, Iguchi T (2007). The roach (Rutilus rutilus) as a sentinel for assessing endocrine disruption. Environ Sci, 14(5), 235-253. Abstract.  Author URL.
Hutchinson, T.H. Hurd, K.S. Bamforth, J. (2006).  Development of chronic tests for endocrine active chemicals. Part I. An extended fish early- life stage test for oestrogen active chemicals in the fathead minnow <em>Pimephales promelas</em>. Aquatic Toxicology, 77, 279-290.
Kennedy, S. Snape, J. Tillet, D. (2006). An Evaluation of the Potential Role of Genomics in Regulatory Ecotoxicology. Environmental Science and Technology, 40(13), 4055-4065.
Gross-Sorokin, M. Johnson, I. Brighty, G. (2006). An assessment of the model of concentration addition for predicting the estrogenic activity of chemical mixtures in wastewater treatment works effluent. Environmental Health Perspectives, 114, 90-97.
Schulte-Oehlmann, U, Albanis T, Allera A, Bachmann J, Berntsson P, Beresford N, Carnevali DC, Ciceri F, Dagnac T, Falandysz J, et al (2006). COMPRENDO: Focus and approach. Environmental Health Perspectives, 114(1), 98-100.
Eidem JK, Kleivdal H, Kroll K, Denslow N, van Aerle R, Tyler C, Panter G, Hutchinson T, Goksoyr A (2006). Development and validation of a direct homologous quantitative sandwich ELISA for fathead minnow (Pimephales promelas) vitellogenin. Aquatic Toxicology, 78(2), 202-206.
Santos E, Paull G, Filby A, Tyler C, Van Look K, Holt W, Workman V, Kille P (2006). Gender and stage-specific transcriptomic profiles of gonads and brains in breeding zebrafish. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 143(4), S101-S101. Author URL.
tsgallo1, Hagger JA, Liney KE, Tyler CR (2006). Health effects in fish of long-term exposure to effluents from wastewater treatment works. Environmental Health Perspectives, 114(S1), 81-89. Full text.
Jobling S, Tyler CR (2006). Introduction: the ecological relevance of chemically induced endocrine disruption in wildlife. ENVIRONMENTAL HEALTH PERSPECTIVES, 114, 7-8. Author URL.
Thorpe, K.L. Tyler, C.R. (2006). Multiple molecular effect pathways for an environmental. oestrogen in fish. Journal of Endocrinology, 37, 121-134.
Ankley, G.T. Segner, H. Tyler, C.R. (2006). Screening and testing for endocrine. disruption in fish -. biomarkers as signposts not traffic lights in risk assessment. Environmental Health Perspectives, 114, 106-114.
Filby A, Thorpe K, Tyler C (2006). The developmental expression of three oestrogen receptor subtypes and their differential responses to oestrogen in fish. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 143(4), S101-S101. Author URL.
Tyler, C.R. (2006). The ecological relevance of chemically-induced endocrine disruption in wildlife. Environmental Health Perspectives, 114, 7-8.
Ankley GT, Daston GP, Degitz SJ, Denslow ND, Hoke RA, Kennedy SW, Miracle AL, Perkins EJ, Snape J, Tillitt DE, et al (2006). Toxicogenomics in regulatory ecotoxicology. Environmental Science and Technology, 40(13), 4055-4065. Abstract.
Tyler CR, Spary C, Gibson R, Santos EM, Shears J, Hill EM (2005). Accounting for differences in estrogenic responses in rainbow trout (Oncorhynchus mykiss: Salmonidae) and roach (Rutilus rutilus: Cyprinidae) exposed to effluents from wastewater treatment works. Environ Sci Technol, 39(8), 2599-2607. Abstract.  Author URL.
Tyler, C.R. Hill, E.M. (2005). An analytical methodology for the identification of estrogenic contaminants in fish bile. Journal of Chromatography A, 1066, 33-40.
Jobling, S. Shears, J. Simpson, P. (2005). Assessing the sensitivity of different life stages. for sexual disruption in roach (<em>Rutilus rutilus</em>) exposed to effluents from wastewater treatment works. Environmental Health Perspectives, 113(10), 1299-1307.
Fenske, M. Verslycke, T. Tyler, C.R. (2005). Development of a quantitative enzyme- linked immunosorbent assay for vitellin and its application in a preliminary study on vitellogenesis in the mysid, Neomysis intege. Comparative Biochemistry and Physiology Part B
Ghekiere A, Fenske M, Verslycke T, Tyler C, Janssen C (2005). Development of a quantitative enzyme-linked immunosorbent assay for vitellin in the mysid Neomysis integer (Crustacea: Mysidacea). Comp Biochem Physiol a Mol Integr Physiol, 142(1), 43-49. Abstract.  Author URL.
Shears, J. van Aerle, R. (2005). Endocrine (sexual) disruption is not a prominent feature in the pike (Esox lucius), a top predator, living in English waters. Environmental Toxicology and Chemistry, 24(6), 1436-1443.
Smith, M.D. Spary, C. Tyler, C.R. (2005). Mixtures of oestrogenic contaminants in bile in fish exposed to wastewater treatment works effluents. Environmental Science and Technology, 39(8), 2461-2471.
Tyler, C.R. (2005). Molecular characterization of estrogen receptors 1, 2a and 2b and their tissue and ontogenic expression profiles in fathead minnow (<em>Pimephales promelas</em>). Biology of Reproduction, 73, 648-662.
Williams, R. Johnson, A. (2005). Predicted exposures to steroid estrogens in UK Rivers correlate with widespread sexual disruption in wild fish populations. Environmental Health Perspectives, 32-39.
Sauer, A. Shears, J. Tyler, C.R. (2004).  Androgenic and oestrogenic effects of the synthetic androgen, 17-methyltestosterone on sexual development and reproductive performance in the fathead minnow (<em>Pimephales promelas</em>) determined using a gonadal recrudescence assay. Aquatic Toxicology, 68(3), 277-291.
Jobling S, Casey D, Rodgers-Gray T, Oehlmann J, Schulte-Oehlmann U, Pawlowski S, Baunbeck T, Turner AP, Tyler CR (2004). Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent (vol 65, pg 205, 2003). AQUATIC TOXICOLOGY, 66(2), 205-+. Author URL.
Jobling S, Casey D, Rogers-Gray T, Oehlmann J, Schulte-Oehlmann U, Pawlowski S, Baunbeck T, Turner AP, Tyler CR (2004). Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent. Aquat Toxicol, 66(2), 207-222. Abstract.  Author URL.
Tyler CR, van Aerle R, Santos EM (2004). ELISAs for detecting vitellogenin in the fathead minnow (Pimephales promelas)-a critical analysis. Response to Mylchreest et al. Comp Biochem Physiol C 134: 251-257, 2003. Comp Biochem Physiol C Toxicol Pharmacol, 138(4), 531-532. Author URL.
van Aerle, R. Tyler, C.R. (2004). Effects of 17 alpha-ethinylestradiol in a fathead minnow (Pimephales promelas) gonadal recrudescence assay. Ecotoxicology and Environmental Safety, 57(3), 330-345.
Spano, L. Tyler, C.R. van Aerle R, Devos, P. Mandiki SNM, Silvestre F, Thome JP, Kestemont P (2004). Effects of atrazine on sex steroid dynamics, plasma vitellogenin concentration and gonad development in adult goldfish (Carassius auratus). Aquatic Toxicology, 66(4), 369-379.
Jobling S, Casey C, Rodgers-Gray T, Oehlmannd J, Schulte-Oehlmann U, Pawlowski S, Baunbeck T, Turner AP, Tyler CR (2004). Erratum: Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent (Aquatic Toxicology (2003) 65 (205-220)). Aquatic Toxicology, 66(2), 205-222.
Tyler, C.R. Palazzi, X. Laillet, B. (2004). Impacts of. 17- estradiol, including environmentally relevant concentrations, on reproduction after exposure during embryo-larval-juvenile and adult-life stages in zebrafish (<em>Danio rerio</em>). Aquatic Toxicology, 68(3), 193-217.
Nash, J.P. Kime, D.E. Van der Ven, L.T.M. (2004). Long-term exposure to environmental concentrations of the pharmaceutical ethinyloestradiol cause \r reproductive failure in fish. Environmental Health Perspectives, 112(17), 1725-1733. Full text.
van Aerle, R. Runnalls, T. & Tyler, C.R (2004). Ontogeny of gonadal sex development relative to growth in. fathead minnow (<em>Pimephales promelas</em>). Journal of Fish Biology, 64, 355-369.
van Aerle, R, Runnalls, T.J. Tyler, C.R. (2004). Ontogeny of gonadal sex development relative to growth in fathead minnow. Journal of Fish Biology, 64(2), 355-369.
Benstead, R. Hutchinson, T.H. Cummings, R.I. (2004). Reproductive effects of. exposure to oestrone in the fathead minnow. Fish Physiology and Biochemistry, 28, 451-452.
Hutchinson, T.H. Hurd, K.S. Sherren, A. (2004). Successful detection of (anti-) androgenic and aromatase inhibitors in pre-spawning fathead minnows (<em>Pimephales promelas</em>) using easily measured endpoints of sexual development. Aquatic Toxicology, 70, 11-21.
Kwon, J. Rand-Weaver, M. Sumpter, J.P. (2003). Cloning and gene expression of 17,20- lyase cDNA in the gonads and brain of the fathead minnow (<em>Pimephales promelas</em>). General & Comparative Endocrinology, 130, 256-266.
Casey, D. Rodgers-Gray, T. Oehlmann, J. (2003). Comparative responses of molluscs and fish to environmental oestrogens and an oestrogenic effluent. Aquatic Toxicology, 65, 205-220.
Thomas-Jones E, Thorpe K, Harrison N, Thomas G, Morris C, Hutchinson T, Woodhead S, Tyler C (2003). Dynamics of estrogen biomarker responses in rainbow trout exposed to 17beta-estradiol and 17alpha-ethinylestradiol. Environ Toxicol Chem, 22(12), 3001-3008. Abstract.  Author URL.
Tyler, C.R. (2003). Endocrine Disruption in Wild Freshwater Fish. Pure and Applied Chemistry, 75(11-12), 2219-2234.
Tyler, C.R. (2003). Impacts of Endocrine Disruption, Parasites and Pollution in Freshwater Fish. Journal of Parasitology, 126, 103-108.
Segner, H. Tyler, C.R. (2003). Ontogeny of sexual differentiation in different strains of zebrafish (<em>Danio rerio</em>). Fish Physiology and Biochemistry, 28, 125-128.
Tyler CR, Hetheridge MJ, Scholze M, Thorpe K (2003). Relative potencies and combination effects of steroidal oestrogens in fish. Environmental Science & Technology, 37(6), 1142-1149.
Pickford, K.A. Wheale, B.Thomas,-Jones, E. Tyler, C.R. & Sumpter, J.P (2003). Route of exposure affects the oestrogenic responses of fish to 4-tert nonylphenol. Aquatic Toxicology, 65, 267-279.
Tyler CR, Beresford N, Jobling S, Nolan M (2002). Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents. Biology of Reproduction, 66(2), 272-281.
Lye, C. Tyler, C.R. Sumpter, J.P. (2002). Effects of treatment processes on the endocrine activity of various influents as they pass through waster water treatment works\r. Environmental Toxicology and Chemistry, 21(5), 972-979.
Rand-Weaver, M. Sumpter, J.P. Tyler, C.R. (2002). Exposure to exogenous oestradiol 17 disrupts P450 aromatase B mRNA expression in the brain and ovary of adult fathead minnow (<em>Pimephales promelas</em>).\r. Aquatic Toxicology, 60, 285-299.
Tyler CR, van Aerle R, Nilsen MV, Blackwell R, Maddix S, Nilsen BM, Berg K, Hutchinson TH, Goksøyr A (2002). Monoclonal antibody enzyme-linked immunosorbent assay to quantify vitellogenin for studies on environmental estrogens in the rainbow trout (Oncorhynchus mykiss). Environ Toxicol Chem, 21(1), 47-54. Abstract.  Author URL.
Tyler, C.R. Maddix, S. Karbe, L. (2002). Plasma biomarkers in fish provide evidence for endocrine modulation in the Elbe River, Germany. Environmental Science and Technology, 36(11), 2311-2321.
Campbell, P.M. Hutchinson, T.H. Kime, D.E. (2002). Utility of. a fathead. minnow juvenile fish screening assay for detecting. (anti-) oestrogenic substances. Environmental Toxicology and Chemistry, 21, 319-326.
Jobling S, Coey S, Whitmore JG, Kime DE, Van Look KJW, McAllister BG, Beresford N, Henshaw AC, Brighty G, Tyler CR, et al (2002). Wild intersex roach (Rutilus rutilus) have reduced fertility. Biol Reprod, 67(2), 515-524. Abstract.  Author URL.
van Aerle R, Pounds N, Hutchinson TH, Maddix S, Tyler CR (2002). Window of sensitivity for the estrogenic effects of ethinylestradiol in early life-stages of fathead minnow, Pimephales promelas. Ecotoxicology, 11(6), 423-434. Abstract.  Author URL.
Jobling, S. Sumpter, J.P. Brighty, G. (2001). A histological. description of intersexuality in the roach. Journal of Fish Biology, 58, 160-176.
Tyler CR, Hetheridge M, Scholze M, Thorpe K (2001). Assessing the Biological Potency of Binary Mixtures of Environmental Estrogens using Vitellogenin Induction in Juvenile Rainbow Trout (Oncorhynchus mykiss) . Environmental Science & Technology, 35(12), 2476-2481.
Rand-Weaver, M. Sumpter, J.P. Tyler, C.R. (2001). Cloning and molecular characterisation of an ovarian-derived (brain-like) P450-aromatase. and development. of a. competitive rtPCR bioassay to quantify its expression in the fathead minnow (Pimephales promelas ). Fish Physiology and Biochemistry, 24, 49-62.
van Aerle, R. Brack, S. (2001). Development and validation of a homologous zebrafish (Danio rerio Hamilton-Buchanan) vitellogenin enzyme-linked immunosorbent assay (ELISA) and its application for studies on estrogenic chemicals. Comparative Biochemistry and Physiology C-Toxicology & Pharmacology, 129(3), 217-232.
Rand-Weaver, M. Tyler, C.R. (2001). Development and validation of radioimmunoassays for follicle stimulating hormone and its alpha and beta sub-units and their seasonal plasma and pituitary concentrations in the rainbow trout (<em>Oncorhynchus mykiss</em>). Biology of Reproduction, 65, 288-294.
van Aerle, R. Jobling, S. Christiansen. L. Sumpter, J.P and Tyler, C.R. (2001). Evidence for sexual disruption in a second species of freshwater fish (<em>gudgeon, Gobio gobio</em>) living in UK rivers receiving sewage treatment works effluent. Environmental Toxicology and Chemistry, 20, 2841-2847.
Jobling, S. Kelly, C. (2001). Exposure of juvenile roach, <em>Rutilus rutilus</em>, to treated sewage effluent induces dose-dependent and persistent disruption in gonadal development. Environmental Science and Technology, 35(3), 462-470.
Santos, E. Pottinger, T.G. Tyler, C.R. (2001). Exposure to 4 tert –nonylphenol alters gonadotrophin dynamics. in the pituitary and. plasma of. female rainbow trout (Oncorhynchus mykiss ). Environmental Science and Technology, 35, 2909-2916.
Santos EM, Rand-Weaver M, Tyler CR (2001). Follicle-stimulating hormone and its alpha and beta subunits in rainbow trout (Oncorhynchus mykiss): purification, characterization, development of specific radioimmunoassays, and their seasonal plasma and pituitary concentrations in females. Biol Reprod, 65(1), 288-294. Abstract.  Author URL.
Cavaco, J.E.B. Rebers, F.E.M. Vischer, H.F. (2001). Gonadotrophins, their receptors, and regulation of testicular functions in fish. Comparative Biochemistry and Physiology Part B, 129, 407-417.
Prat, F. Randall, C. Tyler, C.R. (2001). Molecular characterisation of putative yolk processing enzymes and their expression during oogenesis and embryo development in the rainbow trout, <em>Oncorhynchus mykiss</em>. Biology of Reproduction, 65, 1701-1709.
Harris CA, Santos EM, Janbakhsh A, Pottinger TG, Tyler CR, Sumpter JP (2001). Nonylphenol affects gonadotropin levels in the pituitary gland and plasma of female rainbow trout. Environ Sci Technol, 35(14), 2909-2916. Abstract.  Author URL.
Tyler, C.R. Toy, R. Caunter, J. (2001). Reproductive effects of long term exposure to Bisphenol a in the fathead minnow (Pimephales promelas ). Environmental Science and Technology, 35, 2917-2925.
Van Aerle R, Christiansen LB, Jobling S, Tyler CR (2001). Sexual disruption in a second species of wild cyprinid fish (the Gudgeon, Gobio gobio) in United Kingdom freshwaters. Environmental Toxicology and Chemistry, 20(12), 2841-2847.
Runnalls, T. Harris, C. Hill, E. (2000). Development of a reproduction performance test for endocrine-disrupting chemicals in the fathead minnow (Pimephales promelas. Environmental Science and Technology, 34, 3003-3011.
Hutchinson, T.H. Hetheridge, M. Sumpter, J.P. (2000). Development of an in vivo. screening assay for estrogenic chemicals using juvenile rainbow trout, Oncorhynchus mykiss. Environmental Toxicology and Chemistry, 19, 2812-2820.
Brion, F. Palazzi, X. Babut, M. (2000). Estrogenic effects in chub (Leuciscus cephalus): Induction of vitellogenin and alterations in testicular structure. Ecotoxicology, 9, 127-135.
Jobling, S. Morris, S. Kelly, C. (2000). Long-term temporal changes in the oestrogenic composition of treated sewage effluent and its biological effects in fish. Environmental Science and Technology, 34, 1521-1528.
Tyler, C.R. Beresford, N. van der Woning, M. Sumpter, J.P. & Thorpe, K (2000). Metabolism and. environmental degradation of pyrethroid. insecticides produce compounds with endocrine activities. Environmental Toxicology and Chemistry, 19, 801-809.
May, D. Rand-Weaver, M. Tyler, C.R. (2000). Molecular characterisation of the first non-mammalian p73 cDNA. Comparative Biochemistry and Physiology Part B, 126, 49-57.
Tyler, C.R. van Aerle, R. Hutchinson, T. Maddix, S, & Trip, H (1999). An in vivo. testing system for endocrine disrupters in fish early life stages using induction of vitellogenin. Environmental Toxicology and Chemistry, 18(2), 337-347.
Perazzolo, L. Coward, K. Davail, B. Normand, E. Tyler, C.R. Pakdel, F. Schneider, W. & Le Menn, F (1999). Expression and localisation of messenger ribonucleic acid for the vitellogenin receptor in ovarian follicles throughout oogenesis in the rainbow trout, <em>Oncorhynchus mykiss</em>. Biology of Reproduction, 60, 1057-1068.
May, D. Rand-Weaver, M. Tyler, C.R. (1999). Fish p53 - a possible biomarker for genotoxins in the aquatic environment?. Environmental and Molecular Mutagenesis, 33, 144-151.
Bhaskaran A, May D, Rand-Weaver M, Tyler CR (1999). Fish p53 as a possible biomarker for genotoxins in the aquatic environment. Environ Mol Mutagen, 33(3), 177-184. Abstract.  Author URL.
Jambakhsh, A. Jobling, S. Matthiessen, P. (1999). Oestrogenic potency of effluent from two sewage-treatment works in the United Kingdom. Environmental Toxicology and Chemistry, 18, 932-937.
Jobling, S. Sumpter, J.P. (1998). Endocrine disruption in wildlife: a critical review of the. evidence\r. Critical Reviews in Toxicology, 28(4), 319-361.
Coward, K. Sumpter, J.P. Tyler, C.R. (1998). Molecular characterisation and expression of two ovarian lipoprotein receptors in the rainbow trout, <em>Oncorhynchus mykiss</em>. Biology of Reproduction, 58, 1146-1153.
Routledge, E. (1998). Oestrogenic effects in fish in English rivers with evidence for causation. Pure and Applied Chemistry, 70, 1795-1804.
Nolan, M. Tyler, C.R. Brighty, G. (1998). Widespread sexual disruption in wild fish. Environmental Science and Technology, 32, 2498-2506.
Tyler, C.R. Sumpter, J.P. (1997). Egg quality in fish; what makes a good egg? \r. Reviews in Fish Biology and Fisheries, 7, 387-416.
Tyler, C.R. Carnevali, O. Coward, K. (1997). Molecular characterisation of ovarian cathepsin D in the rainbow trout, Oncorhynchus mykiss. Gene, 201, 45-54.
Brooks S, Tyler CR, Sumpter JP (1997). Quality in fish: what makes a good egg?. REVIEWS IN FISH BIOLOGY AND FISHERIES, 7(4), 387-416. Author URL.
Pottinger, T.G. Coward, K. Prat, F. (1997). Salmonid follicle stimulating hormone (GtH I) mediates. vitellogenic development of oocytes in the rainbow trout, Oncorhynchus mykiss. Biology of Reproduction, 57, 1238-1244.
Nagler JJ, Scott AP, Tyler CR, Sumpter JP (1996). Gonadotropins I and II do not stimulate the in vitro secretion of 17 alpha,20 beta-dihydroxy-4-pregnen-3-one 20-sulphate by rainbow trout gonads during final sexual maturation. FISH PHYSIOLOGY AND BIOCHEMISTRY, 15(2), 149-156. Author URL.
Lubberink, K. (1996). Identification of four ovarian receptor proteins that bind vitellogenin, but not other homologous plasma lipoproteins, in the rainbow trout, <em>Oncorhynchus mykiss</em>. Journal of Comp. Physiol.B, 166, 11-20.
Tyler, C.R. van der Eerden, Sumpter, J.P. Jobling, S. & Panter, G (1996). Measurement of vitellogenin, a biomarker for exposure to oestrogen, in a wide variety of cyprinids. Journal of Comp. Physiol.B, 166, 418-426.
Tyler CR, Pottinger TG, Santos E, Sumpter JP, Price SA, Brooks S, Nagler JJ (1996). Mechanisms controlling egg size and number in the rainbow trout, Oncorhynchus mykiss. Biol Reprod, 54(1), 8-15. Abstract.  Author URL.
Sumpter, J.P. (1996). Oocyte growth and development in teleosts. Reviews in Fish Biology and Fisheries, 6, 287-318.
Sumpter, J.P. Tyler, C.R. (1996). Validation of radioimmunoassays for two salmon gonadotropins (gonadotropins I and II) and their plasma concentrations throughout the reproductive cycle in male and female rainbow trout, Oncorhynchus mykiss. Biology of Reproduction, 54, 1375-1382.
Tyler, C.R. (1994). Developmental expression and modulation of the vitellogenin receptor in ovarian follicles of the rainbow trout, <em>Oncorhynchus mykiss</em>. Journal of Experimental Zoology, 269, 458-466.
Nagler, J.J. Pottinger, T.P. Turner, M. (1994). Effects of unilateral ovariectomy on recruitment and growth of follicles in the rainbow trout, <em>Oncorhynchus mykiss</em>. Fish Physiology and Biochemistry, 13, 309-316.
Purdom CE, Hardiman PA, Bye VJ, Eno NC, Tyler CR, Sumpter JP (1994). Estrogenic Effects of Effluents from Sewage Treatment Works. Chemistry and Ecology, 8(4), 275-285. Abstract.
Hardiman, P.A. Bye, V. Eno, N.C. (1994). Oestrogenic effects of effluent from sewage treatment works. Chemistry and Ecology, 8, 275-285.
Tyler, C.R. Sumpter, J.P. (1994). Ovarian follicles of rainbow trout (<em>Oncorhynchus mykiss</em>) cultured within lamellae survive well, and sequester and process vitellogenin. Journal of Experimental Zoology, 269, 45-52.
Tyler, C.R. (1993). Electrophoretic patterns of yolk proteins throughout ovarian development and their relationship to vitellogenin in the rainbow trout, <em>Oncorhynchus mykiss</em>. Comparative Biochemistry and Physiology Part B, 106, 321-329.
Everett, S. (1993). Gross morphological disorders in barbel (<em>Barbus barbus</em>) in three rivers in southern England. Journal of Fish Biology, 43, 739-748.
Tyler CR, Everett S (1993). Incidences of gross morphological disorders in barbel (Barbus barbus) in three rivers in southern England. Journal of Fish Biology, 43(5), 739-748. Abstract.
Tyler CR, Lancaster P (1993). Isolation and characterization of the receptor for vitellogenin from follicles of the rainbow trout, Oncorhynchus mykiss. Journal of Comparative Physiology B, 163(3), 225-233. Abstract.
Tyler CR, Sumpter JP, Kawauchi H, Swanson P (1991). Involvement of gonadotropin in the uptake of vitellogenin into vitellogenic oocytes of the rainbow trout, Oncorhynchus mykiss. Gen Comp Endocrinol, 84(2), 291-299. Abstract.  Author URL.
Sumpter, J.P. Campbell, P.M. (1991). Uptake of vitellogenin into oocytes during early vitellogenic development in the rainbow trout, <em>Oncorhynchus mykiss</em> (Walbaum). Journal of Fish Biology, 38, 681-689.
Tyler CR, Sumpter JP, Bromage NR (1990). An in vitro culture system for studying vitellogenin uptake into ovarian follicles of the rainbow trout, Salmo gairdneri. Journal of Experimental Zoology, 255(2), 216-231. Abstract.
Sumpter, J.P. (1990). The development of a radioimmunoassay for carp, <em>Cyprinus carpio</em>, vitellogenin. Fish Physiology and Biochemistry, 8, 129-140.
Tyler CR, Sumpter JP, Witthames PR (1990). The dynamics of oocyte growth during vitellogenesis in the rainbow trout (Oncorhynchus mykiss). Biol Reprod, 43(2), 202-209. Abstract.  Author URL.
Tyler CR, Sumpter JP, Handford RM (1990). The dynamics of vitellogenin sequestration into vitellogenic ovarian follicles of the rainbow trout, Salmo gairdneri. Fish Physiology and Biochemistry, 8(3), 211-219. Abstract.
Sumpter, J.P. (1990). The purification and partial characterisation of carp, <em>Cyprinus carpio</em>, vitellogenin. Fish Physiology and Biochemistry, 8, 111-120.
TYLER CR, SUMPTER JP, BROMAGE NR (1988). INVIVO OVARIAN UPTAKE AND PROCESSING OF VITELLOGENIN IN THE RAINBOW-TROUT, SALMO-GAIRDNERI. JOURNAL OF EXPERIMENTAL ZOOLOGY, 246(2), 171-179. Author URL.
TYLER CR, SUMPTER JP, BROMAGE NR (1988). SELECTIVITY OF PROTEIN SEQUESTRATION BY VITELLOGENIC OOCYTES OF THE RAINBOW-TROUT, SALMO-GAIRDNERI. JOURNAL OF EXPERIMENTAL ZOOLOGY, 248(2), 199-206. Author URL.
Sumpter, J.P. Bromage, N.R. (1988). The selectivity of protein sequestration by vitellogenic oocytes of the rainbow trout, <em>Salmo gairdneri</em>, in vivo. Journal of Experimental Zoology, 248, 199-206.
TYLER C, SUMPTER J, BROMAGE N (1987). THE SPECIFICITY OF VITELLOGENIN UPTAKE INTO OVARIAN FOLLICLES OF RAINBOW-TROUT, SALMO-GAIRDNERI. JOURNAL OF ENDOCRINOLOGY, 112, 50-50. Author URL.
TYLER C, SUMPTER J, BROMAGE N (1987). VITELLOGENIN UPTAKE BY CULTURED OOCYTES OF RAINBOW-TROUT (SALMO-GAIRDNERI). GENERAL AND COMPARATIVE ENDOCRINOLOGY, 66(1), 19-20. Author URL.

Chapters

Tyler CR, Goodhead RM (2010). Impacts of hormone-disrupting chemicals on wildlife. In  (Ed) Silent Summer: the State of Wildlife in Britain and Ireland, 125-140.  Abstract.
Tyler CR, Filby AL, van Aerle R, Lange A, Ball J, Santos EM (2008). Fish toxicogenomics. In  (Ed) Advances in Experimental Biology, Elsevier.

Conferences

Goodhead RM, Johnston BD, Cole PA, Baalousha M, Hodgson D, Iguchi T, Lead JR, Tyler CR (2015). Does natural organic matter increase the bioavailability of cerium dioxide nanoparticles to fish?.  Abstract.
Cross RK, Tyler C, Galloway TS (2015). Transformations that affect fate, form and bioavailability of inorganic nanoparticles in aquatic sediments.  Abstract.
Moreman J, Lee O, Kudoh T, Tyler CR (2012). Application of ERE-transgenic biosensor zebrafish to identify target tissues and effect mechanisms of the environmental estrogen, bisphenol A.  Author URL.
Lange A, Sebire M, Rostkowski P, Horwood J, Miyagawa S, Mizutani T, Iguchi T, Hill EM, Tyler CR (2012). Bioavailable environmental antiandrogens and their potential effects on endpoints relevant to reproduction in fish.  Author URL.
Tyler CR, Hamilton PB, Lange A, Filby AL, Soffkar M, Lee O, Takesono A, Kudoh T, Paull GC, Iguchi T, et al (2012). Health impacts of exposure to environmental oestrogens in fish.  Author URL.
Filby AL, Paull GC, Searle F, Ortiz-Zarragoitia M, Tyler CR (2012). Investigating the mechanisms by which environmental oestrogens affect male aggression and dominance hierarchies in fish.  Author URL.
Al-Sahli R, Abdul-Sada A, Lange A, Tyler CR, Hill EM (2012). The xenometabolome and novel contaminant biomarkers in fish exposed to a wastewater treatment works effluent.  Author URL.
Southam AD, Hines A, Viant MR, Lange A, Tyler CR, Hill EM (2010). A metabolomic investigation to identify molecular changes induced in roach after exposure to the anti-androgen organophosphate pesticide fenitrothion.  Author URL.
Corcoran J, Lange A, Tyler CR, Winter MJ (2010). Investigating drug-metabolising cytochrome P450 (cyp) isoforms in a fish hepatocyte model.  Author URL.
Gaiser BK, Fernandes TF, Jepson M, Lead JR, Tyler CR, Stone V (2009). Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments.  Abstract.
Tyler C, Lange A, Santos E, Coe T, Paull G, Filby A, Hamilton P (2008). The feminization of fish in English rivers: Causation, mechanisms, and significance.  Author URL.
Jobling S, Tyler CR (2003). Endocrine disruption, parasites and pollutants in wild freshwater fish.  Abstract.  Author URL.
Kirk LA, Tyler CR, Lye CM, Sumpter JP (2002). Changes in estrogenic and androgenic activities at different stages of treatment in wastewater treatment works.  Abstract.  Author URL.
Tyler CR, Ball J, Maack G, Paull G, Santos EM (2002). Endocrine disruption in vertebrate wildlife - Today's story.  Author URL.
Schulz RW, Vischer HF, Cavaco JEB, Santos EM, Tyler CR, Goos HJT, Bogerd J (2001). Gonadotropins, their receptors, and the regulation of testicular functions in fish.  Author URL.
Flammarion P, Brion F, Babut M, Garric J, Migeon B, Noury P, Thybaud E, Palazzi X, Tyler CR (2000). Induction of fish vitellogenin and alterations in testicular structure: Preliminary results of estrogenic effects in chub (Leuciscus cephalus).  Abstract.

Internet publications

Filby AL, van Aerle R, Duitman J, Tyler CR (2008). The kisspeptin/gonadotropin-releasing hormone pathway and molecular signaling of puberty in fish. Biol Reprod, 78(2), 278-289. Abstract.  Author URL.

Publications by year


In Press

Hamilton PB, Rolshausen G, Uren Webster TM, Tyler CR (In Press). Adaptive capabilities and fitness consequences associated with pollution exposure in fish. Philos Trans R Soc Lond B Biol Sci, 372(1712). Abstract.  Author URL.
Le Page G, Gunnarsson L, Snape J, Tyler CR (In Press). Antibiotic risk assessment needs to protect both environmental and human health. Environ Int, 115, 397-399. Author URL.
Bickley LK, van Aerle R, Brown AR, Hargreaves A, Huby R, Cammack V, Jackson R, Santos EM, Tyler CR (In Press). Bioavailability and Kidney Responses to Diclofenac in the Fathead Minnow (Pimephales promelas). Environ Sci Technol, 51(3), 1764-1774. Abstract.  Author URL.  Full text.
David A, Lange A, Abdul-Sada A, Tyler CR, Hill EM (In Press). Disruption of the Prostaglandin Metabolome and Characterization of the Pharmaceutical Exposome in Fish Exposed to Wastewater Treatment Works Effluent As Revealed by Nanoflow-Nanospray Mass Spectrometry-Based Metabolomics. Environ Sci Technol, 51(1), 616-624. Abstract.  Author URL.
Windsor FM, Ormerod SJ, Tyler CR (In Press). Endocrine disruption in aquatic systems: up-scaling research to address ecological consequences. Biol Rev Camb Philos Soc, 93(1), 626-641. Abstract.  Author URL.
Green JM, Metz J, Lee O, Trznadel M, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR (In Press). High-Content and Semi-Automated Quantification of Responses to Estrogenic Chemicals Using a Novel Translucent Transgenic Zebrafish. Environ Sci Technol, 50(12), 6536-6545. Abstract.  Author URL.
Le Page G, Gunnarsson L, Snape J, Tyler CR (In Press). Integrating human and environmental health in antibiotic risk assessment: a critical analysis of protection goals, species sensitivity and antimicrobial resistance. Environ Int, 109, 155-169. Abstract.  Author URL.
Osborne OJ, Mukaigasa K, Nakajima H, Stolpe B, Romer I, Philips U, Lynch I, Mourabit S, Hirose S, Lead JR, et al (In Press). Sensory systems and ionocytes are targets for silver nanoparticle effects in fish. Nanotoxicology, 10(9), 1276-1286. Abstract.  Author URL.
Stevens CH, Croft DP, Paull, Tyler (In Press). Stress and welfare in ornamental fishes: what can be learned from aquaculture?. Jounral of Fish Biology Full text.
Edenbrow M, Bleakley BH, Darden SK, Tyler CR, Ramnarine IW, Croft DP (In Press). The evolution of cooperation: Interacting phenotypes among social partners. The American Naturalist Full text.

2018

Johnston HJ, Verdon R, Gillies S, Brown DM, Fernandes TF, Henry TB, Rossi AG, Tran L, Tucker C, Tyler CR, et al (2018). Adoption of in vitro systems and zebrafish embryos as alternative models for reducing rodent use in assessments of immunological and oxidative stress responses to nanomaterials. Crit Rev Toxicol, 48(3), 252-271. Abstract.  Author URL.
Lee CJ, Tyler CR, Paull GC (2018). Can simple tank changes benefit the welfare of laboratory zebrafish Danio rerio?. J Fish Biol, 92(3), 653-659. Abstract.  Author URL.
Mintram KS, Brown AR, Maynard SK, Thorbek P, Tyler CR (2018). Capturing ecology in modeling approaches applied to environmental risk assessment of endocrine active chemicals in fish. Crit Rev Toxicol, 48(2), 109-120. Abstract.  Author URL.
David A, Lange A, Tyler CR, Hill EM (2018). Concentrating mixtures of neuroactive pharmaceuticals and altered neurotransmitter levels in the brain of fish exposed to a wastewater effluent. Science of the Total Environment, 621, 782-790. Abstract.
Verbruggen B, Gunnarsson L, Kristiansson E, Österlund T, Owen SF, Snape JR, Tyler CR (2018). ECOdrug: a database connecting drugs and conservation of their targets across species. Nucleic Acids Res, 46(D1), D930-D936. Abstract.  Author URL.
Green JM, Lange A, Scott A, Trznadel M, Wai HA, Takesono A, Brown AR, Owen SF, Kudoh T, Tyler CR, et al (2018). Early life exposure to ethinylestradiol enhances subsequent responses to environmental estrogens measured in a novel transgenic zebrafish. Sci Rep, 8(1). Abstract.  Author URL.  Full text.

2017

Winter MJ, Windell D, Metz J, Matthews P, Pinion J, Brown JT, Hetheridge MJ, Ball JS, Owen SF, Redfern WS, et al (2017). 4-dimensional functional profiling in the convulsant-treated larval zebrafish brain. Sci Rep, 7(1). Abstract.  Author URL.  Full text.
Moreman J, Lee O, Trznadel M, David A, Kudoh T, Tyler CR (2017). Acute Toxicity, Teratogenic, and Estrogenic Effects of Bisphenol a and its Alternative Replacements Bisphenol S, Bisphenol F, and Bisphenol AF in Zebrafish Embryo-Larvae. Environ Sci Technol, 51(21), 12796-12805. Abstract.  Author URL.
Bickley LK, van Aerle R, Brown AR, Hargreaves A, Huby R, Cammack V, Jackson R, Santos EM, Tyler CR (2017). Bioavailability and Kidney Responses to Diclofenac in the Fathead Minnow (Pimephales promelas). ENVIRONMENTAL SCIENCE & TECHNOLOGY, 51(3), 1764-1774. Author URL.
Lange A, Corcoran J, Miyagawa S, Iguchi T, Winter MJ, Tyler CR (2017). Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals. Toxicol in Vitro, 41, 114-122. Abstract.  Author URL.  Full text.
Galloway TS, Dogra Y, Garrett N, Rowe D, Tyler CR, Moger J, Lammer E, Landsiedel R, Sauer UG, Scherer G, et al (2017). Ecotoxicological assessment of nanoparticle-containing acrylic copolymer dispersions in fairy shrimp and zebrafish embryos. Environmental Science: Nano, 4(10), 1981-1997. Abstract.
Tohyama S, Ogino Y, Lange A, Myosho T, Kobayashi T, Hirano Y, Yamada G, Sato T, Tatarazako N, Tyler CR, et al (2017). Establishment of estrogen receptor 1 (ESR1)-knockout medaka: ESR1 is dispensable for sexual development and reproduction in medaka, Oryzias latipes. Dev Growth Differ, 59(6), 552-561. Abstract.  Author URL.
Uren Webster TM, Williams TD, Katsiadaki I, Lange A, Lewis C, Shears JA, Tyler CR, Santos EM (2017). Hepatic transcriptional responses to copper in the three-spined stickleback are affected by their pollution exposure history. Aquat Toxicol, 184, 26-36. Abstract.  Author URL.  Full text.
Sherman KD, King RA, Dahlgren CP, Simpson SD, Stevens JR, Tyler CR (2017). Historical processes and contemporary anthropogenic activities influence genetic population dynamics of Nassau grouper (Epinephelus striatus) within the Bahamas. Frontiers in Marine Science, 4(DEC). Abstract.  Full text.
Bruintjes R, Harding HR, Bunce T, Birch F, Lister J, Spiga I, Benson T, Rossington K, Jones D, Tyler CR, et al (2017). Shipbuilding Docks as Experimental Systems for Realistic Assessments of Anthropogenic Stressors on Marine Organisms. BIOSCIENCE, 67(9), 853-859. Author URL.  Full text.

2016

Lillicrap A, Springer T, Tyler CR (2016). A tiered assessment strategy for more effective evaluation of bioaccumulation of chemicals in fish. Regul Toxicol Pharmacol, 75, 20-26. Abstract.  Author URL.
Dogra Y, Arkill KP, Elgy C, Stolpe B, Lead J, Valsami-Jones E, Tyler CR, Galloway TS (2016). Cerium oxide nanoparticles induce oxidative stress in the sediment-dwelling amphipod Corophium volutator. Nanotoxicology, 10(4), 480-487. Abstract.  Author URL.  Full text.
Tohyama S, Miyagawa S, Lange A, Ogino Y, Mizutani T, Ihara M, Tanaka H, Tatarazako N, Kobayashi T, Tyler CR, et al (2016). Evolution of estrogen receptors in ray-finned fish and their comparative responses to estrogenic substances. J Steroid Biochem Mol Biol, 158, 189-197. Abstract.  Author URL.
Sherman KD, Dahlgren CP, Stevens JR, Tyler CR (2016). Integrating population biology into conservation management for endangered Nassau grouper Epinephelus striatus. Marine Ecology Progress Series, 554, 263-280. Abstract.  Full text.
Collison E, Hird H, Cresswell J, Tyler C (2016). Interactive effects of pesticide exposure and pathogen infection on bee health – a critical analysis. Biological Reviews, 91(4), 1006-1019. Abstract.
Verbruggen B, Bickley LK, van Aerle R, Bateman KS, Stentiford GD, Santos EM, Tyler CR (2016). Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments. Viruses, 8(1). Abstract.  Author URL.  Full text.
Hamilton PB, Cowx IG, Oleksiak MF, Griffiths AM, Grahn M, Stevens JR, Carvalho GR, Nicol E, Tyler CR (2016). Population-level consequences for wild fish exposed to sublethal concentrations of chemicals – a critical review. Fish and Fisheries, 17(3), 545-566. Abstract.

2015

Song L, Vijver MG, Peijnenburg WJGM, Galloway TS, Tyler CR (2015). A comparative analysis on the in vivo toxicity of copper nanoparticles in three species of freshwater fish. Chemosphere, 139, 181-189. Abstract.  Author URL.
Miyagawa S, Lange A, Tohyama S, Ogino Y, Mizutani T, Kobayashi T, Tatarazako N, Tyler CR, Iguchi T (2015). Characterization of Oryzias latipes glucocorticoid receptors and their unique response to progestins. Journal of Applied Toxicology, 35(3), 302-309. Abstract.
Brown AR, Owen SF, Peters J, Zhang Y, Soffker M, Paull GC, Hosken DJ, Wahab MA, Tyler CR (2015). Climate change and pollution speed declines in zebrafish populations. Proc Natl Acad Sci U S A, 112(11), E1237-E1246. Abstract.  Author URL.  Full text.
Verbruggen B, Bickley LK, Santos EM, Tyler CR, Stentiford GD, Bateman KS, van Aerle R (2015). De novo assembly of the Carcinus maenas transcriptome and characterization of innate immune system pathways. BMC Genomics, 16 Abstract.  Author URL.  Full text.
Orton F, Tyler CR (2015). Do hormone-modulating chemicals impact on reproduction and development of wild amphibians?. Biol Rev Camb Philos Soc, 90(4), 1100-1117. Abstract.  Author URL.
Rolshausen G, Phillip DAT, Beckles DM, Akbari A, Ghoshal S, Hamilton PB, Tyler CR, Scarlett AG, Ramnarine I, Bentzen P, et al (2015). Do stressful conditions make adaptation difficult? Guppies in the oil-polluted environments of southern Trinidad. Evol Appl, 8(9), 854-870. Abstract.  Author URL.
Goodhead RM, Johnston BD, Cole PA, Baalousha M, Hodgson D, Iguchi T, Lead JR, Tyler CR (2015). Does natural organic matter increase the bioavailability of cerium dioxide nanoparticles to fish?.  Abstract.
Jennings V, Goodhead R, Tyler CR (2015). Ecotoxicology of Nanomaterials in Aquatic Systems. Frontiers of Nanoscience, 8, 3-45. Abstract.
Hamilton PB, Lange A, Nicol E, Bickley LK, De-Bastos ESR, Jobling S, Tyler CR (2015). Effects of Exposure to WwTW Effluents over Two Generations on Sexual Development and Breeding in Roach Rutilus rutilus. Environ Sci Technol, 49(21), 12994-13002. Abstract.  Author URL.
Corcoran J, Winter MJ, Lange A, Cumming R, Owen SF, Tyler CR (2015). Effects of the lipid regulating drug clofibric acid on PPARα-regulated gene transcript levels in common carp (Cyprinus carpio) at pharmacological and environmental exposure levels. Aquat Toxicol, 161, 127-137. Abstract.  Author URL.
Lange A, Sebire M, Rostkowski P, Mizutani T, Miyagawa S, Iguchi T, Hill EM, Tyler CR (2015). Environmental chemicals active as human antiandrogens do not activate a stickleback androgen receptor but enhance a feminising effect of oestrogen in roach. Aquat Toxicol, 168, 48-59. Abstract.  Author URL.
Pountney A, Filby AL, Thomas GO, Simpson VR, Chadwick EA, Stevens JR, Tyler CR (2015). High liver content of polybrominated diphenyl ether (PBDE) in otters (Lutra lutra) from England and Wales. Chemosphere, 118, 81-86. Abstract.  Author URL.
Heindel JJ, Newbold RR, Williams CJ, Iguchi T, Tyler CR (2015). Lou Guillette--in memorandum. Mol Reprod Dev, 82(10), Fmi-v. Author URL.
Goodhead RM, Moger J, Galloway TS, Tyler CR (2015). Tracing engineered nanomaterials in biological tissues using coherent anti-Stokes Raman scattering (CARS) microscopy - a critical review. Nanotoxicology, 9(7), 928-939. Abstract.  Author URL.
Cross RK, Tyler C, Galloway TS (2015). Transformations that affect fate, form and bioavailability of inorganic nanoparticles in aquatic sediments.  Abstract.
Lee O, Green JM, Tyler CR (2015). Transgenic fish systems and their application in ecotoxicology. Crit Rev Toxicol, 45(2), 124-141. Abstract.  Author URL.
Tohyama S, Miyagawa S, Lange A, Ogino Y, Mizutani T, Tatarazako N, Katsu Y, Ihara M, Tanaka H, Ishibashi H, et al (2015). Understanding the Molecular Basis for Differences in Responses of Fish Estrogen Receptor Subtypes to Environmental Estrogens. Environmental Science and Technology, 49(12), 7439-7447. Abstract.

2014

David A, Abdul-Sada A, Lange A, Tyler CR, Hill EM (2014). A new approach for plasma (xeno)metabolomics based on solid-phase extraction and nanoflow liquid chromatography-nanoelectrospray ionisation mass spectrometry. J Chromatogr A, 1365, 72-85. Abstract.  Author URL.
Brown AR, Gunnarsson L, Kristiansson E, Tyler CR (2014). Assessing variation in the potential susceptibility of fish to pharmaceuticals, considering evolutionary differences in their physiology and ecology. Philosophical Transactions of the Royal Society B: Biological Sciences, 369(1656). Abstract.  Full text.
Corcoran J, Lange A, Cumming RI, Owen SF, Ball JS, Tyler CR, Winter MJ (2014). Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio). Aquat Toxicol, 152, 57-65. Abstract.  Author URL.
Miyagawa S, Lange A, Tohyama S, Ogino Y, Mizutani T, Kobayashi T, Tatarazako N, Tyler CR, Iguchi T (2014). Characterization of Oryzias latipes glucocorticoid receptors and their unique response to progestins. Journal of Applied Toxicology
Morrissey CA, Stanton DW, Tyler CR, Pereira MG, Newton J, Durance I, Ormerod SJ (2014). Developmental impairment in eurasian dipper nestlings exposed to urban stream pollutants. Environmental Toxicology and Chemistry
Morrissey CA, Stanton DWG, Tyler CR, Pereira MG, Newton J, Durance I, Ormerod SJ (2014). Developmental impairment in eurasian dipper nestlings exposed to urban stream pollutants. Environmental Toxicology and Chemistry, 33(6), 1315-1323. Abstract.
Miyagawa S, Lange A, Hirakawa I, Tohyama S, Ogino Y, Mizutani T, Kagami Y, Kusano T, Ihara M, Tanaka H, et al (2014). Differing species responsiveness of estrogenic contaminants in fish is conferred by the ligand binding domain of the estrogen receptor. Environmental Science and Technology, 48(9), 5254-5263. Abstract.
Southam AD, Lange A, Al-Salhi R, Hill EM, Tyler CR, Viant MR (2014). Distinguishing between the metabolome and xenobiotic exposome in environmental field samples analysed by direct-infusion mass spectrometry based metabolomics and lipidomics. Metabolomics, 10(6), 1050-1058. Abstract.  Author URL.
Kermorgant M, Lancien F, Mimassi N, Tyler CR, Le Mével J-C (2014). Effects of intracerebroventricular administered fluoxetine on cardio-ventilatory functions in rainbow trout (Oncorhynchus mykiss). Gen Comp Endocrinol, 205, 176-184. Abstract.  Author URL.
Baker TJ, Tyler CR, Galloway TS (2014). Impacts of metal and metal oxide nanoparticles on marine organisms. Environmental Pollution, 186, 257-271. Abstract.
Baker TJ, Tyler CR, Galloway TS (2014). Impacts of metal and metal oxide nanoparticles on marine organisms. Environ Pollut, 186, 257-271. Abstract.  Author URL.
Hazlerigg CRE, Tyler CR, Lorenzen K, Wheeler JR, Thorbek P (2014). Population relevance of toxicant mediated changes in sex ratio in fish: an assessment using an individual-based zebrafish (Danio rerio) model. Ecological Modelling
Hazlerigg CRE, Tyler CR, Lorenzen K, Wheeler JR, Thorbek P (2014). Population relevance of toxicant mediated changes in sex ratio in fish: an assessment using an individual-based zebrafish (Danio rerio) model. Ecological Modelling, 280, 76-88. Abstract.
Hamilton PB, Nicol E, De-Bastos ESR, Williams RJ, Sumpter JP, Jobling S, Stevens JR, Tyler CR (2014). Populations of a cyprinid fish are self-sustaining despite widespread feminization of males. BMC Biol, 12 Abstract.  Author URL.  Full text.
Filby AL, Ortiz-Zarragoitia M, Tyler CR (2014). The vas:: Egfp transgenic zebrafish: a practical model for studies on the molecular mechanisms by which environmental estrogens affect gonadal sex differentiation. Environmental Toxicology and Chemistry, 33(3), 602-605. Abstract.
Filby AL, Ortiz-Zarragoitia M, Tyler CR (2014). The vas::egfp transgenic zebrafish: a practical model for studies on the molecular mechanisms by which environmental estrogens affect gonadal sex differentiation. Environ Toxicol Chem, 33(3), 602-605. Abstract.  Author URL.
Watts AJR, Lewis C, Goodhead RM, Beckett SJ, Moger J, Tyler CR, Galloway TS (2014). Uptake and retention of microplastics by the shore crab Carcinus maenas. Environ Sci Technol, 48(15), 8823-8830. Abstract.  Author URL.

2013

Katsu Y, Lange A, Miyagawa S, Urushitani H, Tatarazako N, Kawashima Y, Tyler CR, Iguchi T (2013). Cloning, expression and functional characterization of carp, cyprinus carpio, estrogen receptors and their differential activations by estrogens. Journal of Applied Toxicology, 33(1), 41-49. Abstract.
Ankley GT, Tyler CR (2013). Development of methods to detect occurrence and effects of endocrine-disrupting chemicals: Fueling a fundamental shift in regulatory ecotoxicology. Environmental Toxicology and Chemistry, 32(12), 2661-2662.
Osborne OJ, Johnston BD, Moger J, Balousha M, Lead JR, Kudoh T, Tyler CR (2013). Effects of particle size and coating on nanoscale Ag and TiO₂ exposure in zebrafish (Danio rerio) embryos. Nanotoxicology, 7(8), 1315-1324. Abstract.  Author URL.
Hawkes LA, McGowan A, Godley BJ, Gore S, Lange A, Tyler CR, Wheatley D, White J, Witt MJ, Broderick AC, et al (2013). Estimating sex ratios in Caribbean hawksbill turtles: Testosterone levels and climate effects. Aquatic Biology, 18(1), 9-19. Abstract.
Morrissey CA, Stanton DWG, Pereira MG, Newton J, Durance I, Tyler CR, Ormerod SJ (2013). Eurasian dipper eggs indicate elevated organohalogenated contaminants in urban rivers. Environmental Science and Technology, 47(15), 8931-8939. Abstract.
Segner H, Casanova-Nakayama A, Kase R, Tyler CR (2013). Impact of environmental estrogens on Yfish considering the diversity of estrogen signaling. General and Comparative Endocrinology, 191, 190-201. Abstract.
Bickley LK, Brown AR, Hosken DJ, Hamilton PB, Le Page G, Paull GC, Owen SF, Tyler CR (2013). Interactive effects of inbreeding and endocrine disruption on reproduction in a model laboratory fish. Evolutionary Applications, 6(2), 279-289. Abstract.  Full text.
van Aerle R, Lange A, Moorhouse A, Paszkiewicz K, Ball K, Johnston BD, de-Bastos E, Booth T, Tyler CR, Santos EM, et al (2013). Molecular mechanisms of toxicity of silver nanoparticles in zebrafish embryos. Environ Sci Technol, 47(14), 8005-8014. Abstract.  Author URL.  Full text.
Santos EM, Hamilton PB, Coe TS, Ball JS, Cook AC, Katsiadaki I, Tyler CR (2013). Population bottlenecks, genetic diversity and breeding ability of the three-spined stickleback (Gasterosteus aculeatus) from three polluted English Rivers. Aquatic Toxicology, 142-143, 264-271. Abstract.
Bergman A, Andersson AM, Becher G, Van Den Berg M, Blumberg B, Bjerregaard P, Bornehag CG, Bornman R, Brandt I, Brian JV, et al (2013). Science and policy on endocrine disrupters must not be mixed: a reply to a "common sense" intervention by toxicology journal editors. Environmental Health: a Global Access Science Source, 12(1). Abstract.

2012

Moreman J, Lee O, Kudoh T, Tyler CR (2012). Application of ERE-transgenic biosensor zebrafish to identify target tissues and effect mechanisms of the environmental estrogen, bisphenol A.  Author URL.
Lange A, Sebire M, Rostkowski P, Horwood J, Miyagawa S, Mizutani T, Iguchi T, Hill EM, Tyler CR (2012). Bioavailable environmental antiandrogens and their potential effects on endpoints relevant to reproduction in fish.  Author URL.
Lee OH, Takesono A, Tada M, Tyler CR, Kudoh T (2012). Biosensor zebrafish provide new insights into potential health effects of environmental estrogens. Environ Health Perspect, 120, 990-996. Full text.
Baalousha M, Ju-Nam Y, Cole PA, Gaiser B, Fernandes TF, Hriljac JA, Jepson MA, Stone V, Tyler CR, Lead JR, et al (2012). Characterization of cerium oxide nanoparticles-Part 1: Size measurements. Environmental Toxicology and Chemistry, 31(5), 983-993. Abstract.
Baalousha M, Ju-Nam Y, Cole PA, Hriljac JA, Jones IP, Tyler CR, Stone V, Fernandes TF, Jepson MA, Lead JR, et al (2012). Characterization of cerium oxide nanoparticles-Part 2: Nonsize measurements. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 31(5), 994-1003. Author URL.
Baalousha M, Ju-Nam Y, Cole PA, Hriljac JA, Jones IP, Tyler CR, Stone V, Fernandes TF, Jepson MA, Lead JR, et al (2012). Characterization of cerium oxide nanoparticles-Part 2: Nonsize measurements. Environmental Toxicology and Chemistry, 31(5), 994-1003. Abstract.
Baalousha M, Ju-Nam Y, Cole PA, Gaiser B, Fernandes TF, Hriljac JA, Jepson MA, Stone V, Tyler CR, Lead JR, et al (2012). Characterization of cerium oxide nanoparticles-part 1: Size measurements. Environmental Toxicology and Chemistry
Baalousha M, Ju-Nam Y, Cole PA, Hriljac JA, Jones IP, Tyler CR, Stone V, Fernandes TF, Jepson MA, Lead JR, et al (2012). Characterization of cerium oxide nanoparticles-part 2: Nonsize measurements. Environmental Toxicology and Chemistry
Katsu Y, Lange A, Miyagawa S, Urushitani H, Tatarazako N, Kawashima CR, Iguchi T (2012). Cloning, expression and functional characterization of carp, Cyprinus carpio, estrogen receptors and their differential activations by estrogens. Journal of Applied Toxicology Abstract.
Söffker M, Stevens JR, Tyler CR (2012). Comparative breeding and behavioral responses to ethinylestradiol exposure in wild and laboratory maintained zebrafish (Danio rerio) populations. Environ Sci Technol, 46(20), 11377-11383. Abstract.  Author URL.
Lange A, Katsu Y, Miyagawa S, Ogino Y, Urushitani H, Kobayashi T, Hirai T, Shears JA, Nagae M, Yamamoto J, et al (2012). Comparative responsiveness to natural and synthetic estrogens of fish species commonly used in the laboratory and field monitoring. Aquat Toxicol, 109, 250-258. Abstract.  Author URL.
Hazlerigg CRE, Lorenzen K, Thorbek P, Wheeler JR, Tyler CR (2012). Density-dependent processes in the life history of fishes: Evidence from laboratory populations of zebrafish Danio rerio. PLoS ONE, 7(5). Abstract.
Lee O, Tyler CR, Kudoh T (2012). Development of a transient expression assay for detecting environmental oestrogens in zebrafish and medaka embryos. BMC Biotechnol, 12 Abstract.  Author URL.  Full text.
Brown AR, Bickley LK, Ryan TA, Paull GC, Hamilton PB, Owen SF, Sharpe AD, Tyler CR (2012). Differences in sexual development in inbred and outbred zebrafish (Danio rerio) and implications for chemical testing. Aquat Toxicol, 112-113, 27-38. Abstract.  Author URL.
Cresswell JE, Page CJ, Uygun MB, Holmbergh M, Li Y, Wheeler JG, Laycock I, Pook CJ, de Ibarra NH, Smirnoff N, et al (2012). Differential sensitivity of honey bees and bumble bees to a dietary insecticide (imidacloprid). Zoology
Cresswell JE, Page CJ, Uygun MB, Holmbergh M, Li Y, Wheeler JG, Laycock I, Pook CJ, de Ibarra NH, Smirnoff N, et al (2012). Differential sensitivity of honey bees and bumble bees to a dietary insecticide (imidacloprid). Zoology, 115(6), 365-371. Abstract.
Corcoran J, Lange A, Winter MJ, Tyler CR (2012). Effects of Pharmaceuticals on the Expression of Genes Involved in Detoxification in a Carp Primary Hepatocyte Model. Environmental Science and Technology, 46(11), 6306-6314. Abstract.
Söffker M, Tyler CR (2012). Endocrine disrupting chemicals and sexual behaviors in fish--a critical review on effects and possible consequences. Crit Rev Toxicol, 42(8), 653-668. Abstract.  Author URL.
Filby AL, Paull GC, Searle F, Ortiz-Zarragoitia M, Tyler CR (2012). Environmental estrogen-induced alterations of male aggression and dominance hierarchies in fish: a mechanistic analysis. Environ Sci Technol, 46(6), 3472-3479. Abstract.  Author URL.
Tyler CR, Hamilton PB, Lange A, Filby AL, Soffkar M, Lee O, Takesono A, Kudoh T, Paull GC, Iguchi T, et al (2012). Health impacts of exposure to environmental oestrogens in fish.  Author URL.
Gaiser BK, Fernandes TF, Jepson MA, Lead JR, Tyler CR, Baalousha M, Biswas A, Britton GJ, Cole PA, Johnston BD, et al (2012). Interspecies comparisons on the uptake and toxicity of silver and cerium dioxide nanoparticles. Environmental Toxicology and Chemistry, 31(1), 144-154. Abstract.
Filby AL, Paull GC, Searle F, Ortiz-Zarragoitia M, Tyler CR (2012). Investigating the mechanisms by which environmental oestrogens affect male aggression and dominance hierarchies in fish.  Author URL.
Fabrega J, Tantra R, Amer A, Stolpe B, Tomkins J, Fry T, Lead JR, Tyler CR, Galloway TS (2012). Sequestration of zinc from zinc oxide nanoparticles and life cycle effects in the sediment dweller amphipod Corophium volutator. Environ Sci Technol, 46(2), 1128-1135. Abstract.  Author URL.
Croft DP, Hamilton PB, Darden SK, Jacoby DMP, James R, Bettaney EM, Tyler CR (2012). The role of relatedness in structuring the social network of a wild guppy population. Oecologia, 170(4), 955-963. Abstract.
Croft DP, Hamilton PB, Darden SK, Jacoby DMP, James R, Bettaney EM, Tyler CR (2012). The role of relatedness in structuring the social network of a wild guppy population. Oecologia, 1-9.
Al-Sahli R, Abdul-Sada A, Lange A, Tyler CR, Hill EM (2012). The xenometabolome and novel contaminant biomarkers in fish exposed to a wastewater treatment works effluent.  Author URL.
Al-Salhi R, Abdul-Sada A, Lange A, Tyler CR, Hill EM (2012). The xenometabolome and novel contaminant markers in fish exposed to a wastewater treatment works effluent. Environmental Science and Technology, 46(16), 9080-9088. Abstract.
Larner F, Dogra Y, Dybowska A, Fabrega J, Stolpe B, Bridgestock LJ, Goodhead R, Weiss DJ, Moger J, Lead JR, et al (2012). Tracing bioavailability of ZnO nanoparticles using stable isotope labeling. Environ Sci Technol, 46(21), 12137-12145. Abstract.  Author URL.

2011

Brown AR, Bickley LK, Le Page G, Hosken DJ, Paull GC, Hamilton PB, Owen SF, Robinson J, Sharpe AD, Tyler CR, et al (2011). Are toxicological responses in laboratory (inbred) zebrafish representative of those in outbred (wild) populations? - a case study with an endocrine disrupting chemical. Environ Sci Technol, 45(9), 4166-4172. Abstract.  Author URL.
Rostkowski P, Horwood J, Shears JA, Lange A, Oladapo FO, Besselink HT, Tyler CR, Hill EM (2011). Bioassay-directed identification of novel antiandrogenic compounds in bile of fish exposed to wastewater effluents. Environmental Science and Technology, 45(24), 10660-10667. Abstract.
Gaiser BK, Biswas A, Rosenkranz P, Jepson MA, Lead JR, Stone V, Tyler CR, Fernandes TF (2011). Effects of silver and cerium dioxide micro- and nano-sized particles on Daphnia magna. Journal of Environmental Monitoring, 13(5), 1227-1235. Abstract.
Lange A, Paull GC, Hamilton PB, Iguchi T, Tyler CR (2011). Implications of persistent exposure to treated wastewater effluent for breeding in wild roach (Rutilus rutilus) populations. Environ Sci Technol, 45(4), 1673-1679. Abstract.  Author URL.
García-López Á, Sánchez-Amaya MI, Tyler CR, Prat F (2011). Mechanisms of oocyte development in European sea bass (Dicentrarchus labrax L.): investigations via application of unilateral ovariectomy. Reproduction, 142(2), 243-253. Abstract.  Author URL.
Southam AD, Lange A, Hines A, Hill EM, Katsu Y, Iguchi T, Tyler CR, Viant MR (2011). Metabolomics reveals target and off-target toxicities of a model organophosphate pesticide to roach (Rutilus rutilus): Implications for biomonitoring. Environmental Science and Technology, 45(8), 3759-3767. Abstract.
Sebire M, Katsiadaki I, Taylor NGH, Maack G, Tyler CR (2011). Short-term exposure to a treated sewage effluent alters reproductive behaviour in the three-spined stickleback (Gasterosteus aculeatus). Aquat Toxicol, 105(1-2), 78-88. Abstract.  Author URL.
Fabrega J, Luoma SN, Tyler CR, Galloway TS, Lead JR (2011). Silver nanoparticles: behaviour and effects in the aquatic environment. Environ Int, 37(2), 517-531. Abstract.  Author URL.
Harris CA, Hamilton PB, Runnalls TJ, Vinciotti V, Henshaw A, Hodgson D, Coe TS, Jobling S, Tyler CR, Sumpter JP, et al (2011). The consequences of feminization in breeding groups of wild fish. Environ Health Perspect, 119(3), 306-311. Abstract.  Author URL.  Full text.

2010

Southam AD, Hines A, Viant MR, Lange A, Tyler CR, Hill EM (2010). A metabolomic investigation to identify molecular changes induced in roach after exposure to the anti-androgen organophosphate pesticide fenitrothion.  Author URL.
Scown TM, Goodhead RM, Johnston BD, Moger J, Baalousha M, Lead JR, Van Aerle R, Iguchi T, Tyler CR (2010). Assessment of cultured fish hepatocytes for studying cellular uptake and (eco)toxicity of nanoparticles. Environmental Chemistry, 7(1), 36-49. Abstract.
Johnston BD, Scown TM, Moger J, Cumberland SA, Baalousha M, Linge K, van Aerle R, Jarvis K, Lead JR, Tyler CR, et al (2010). Bioavailability of nanoscale metal oxides TiO(2), CeO(2), and ZnO to fish. Environ Sci Technol, 44(3), 1144-1151. Abstract.  Author URL.  Full text.
Paull GC, Filby AL, Giddins HG, Coe TS, Hamilton PB, Tyler CR (2010). Dominance hierarchies in zebrafish (Danio rerio) and their relationship with reproductive success. Zebrafish, 7(1), 109-117. Abstract.  Author URL.
Panter GH, Hutchinson TH, Hurd KS, Bamforth J, Stanley RD, Wheeler JR, Tyler CR (2010). Effects of a weak oestrogenic active chemical (4-tert-pentylphenol) on pair-breeding and F1 development in the fathead minnow (Pimephales promelas). Aquatic Toxicology, 97(4), 314-323. Abstract.
Filby AL, Shears JA, Drage BE, Churchley JH, Tyler CR (2010). Effects of advanced treatments of wastewater effluents on estrogenic and reproductive health impacts in fish. Environ Sci Technol, 44(11), 4348-4354. Abstract.  Author URL.
Scown TM, Santos EM, Johnston BD, Gaiser B, Baalousha M, Mitov S, Lead JR, Stone V, Fernandes TF, Jepson M, et al (2010). Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow trout. Toxicol Sci, 115(2), 521-534. Abstract.  Author URL.
Fenlon KA, Johnson AC, Tyler CR, Hill EM (2010). Gas-liquid chromatography-tandem mass spectrometry methodology for the quantitation of estrogenic contaminants in bile of fish exposed to wastewater treatment works effluents and from wild populations. Journal of Chromatography A, 1217(1), 112-118. Abstract.
Katsiadaki I, Williams TD, Ball JS, Bean TP, Sanders MB, Wu H, Santos EM, Brown MM, Baker P, Ortega F, et al (2010). Hepatic transcriptomic and metabolomic responses in the Stickleback (Gasterosteus aculeatus) exposed to ethinyl-estradiol. Aquat Toxicol, 97(3), 174-187. Abstract.  Author URL.
Santos EM, Ball JS, Williams TD, Wu H, Ortega F, van Aerle R, Katsiadaki I, Falciani F, Viant MR, Chipman JK, et al (2010). Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model. Environ Sci Technol, 44(2), 820-826. Abstract.  Author URL.
Coe TS, Söffker MK, Filby AL, Hodgson D, Tyler CR (2010). Impacts of early life exposure to estrogen on subsequent breeding behavior and reproductive success in zebrafish. Environ Sci Technol, 44(16), 6481-6487. Abstract.  Author URL.
Tyler CR, Goodhead RM (2010). Impacts of hormone-disrupting chemicals on wildlife. In  (Ed) Silent Summer: the State of Wildlife in Britain and Ireland, 125-140.  Abstract.
Van Aggelen G, Ankley GT, Baldwin WS, Bearden DW, Benson WH, Chipman JK, Collette TW, Craft JA, Denslow ND, Embry MR, et al (2010). Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook. Environ Health Perspect, 118(1), 1-5. Abstract.  Author URL.
Corcoran J, Lange A, Tyler CR, Winter MJ (2010). Investigating drug-metabolising cytochrome P450 (cyp) isoforms in a fish hepatocyte model.  Author URL.
Corcoran J, Winter MJ, Tyler CR (2010). Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish. Crit Rev Toxicol, 40(4), 287-304. Abstract.  Author URL.
Filby AL, Paull GC, Bartlett EJ, Van Look KJW, Tyler CR (2010). Physiological and health consequences of social status in zebrafish (Danio rerio). Physiol Behav, 101(5), 576-587. Abstract.  Author URL.
Hill EM, Evans KL, Horwood J, Rostkowski P, Oladapo FO, Gibson R, Shears JA, Tyler CR (2010). Profiles and some initial identifications of (anti)androgenic compounds in fish exposed to wastewater treatment works effluents. Environ Sci Technol, 44(3), 1137-1143. Abstract.  Author URL.
Scown TM, van Aerle R, Tyler CR (2010). Review: Do engineered nanoparticles pose a significant threat to the aquatic environment?. Crit Rev Toxicol, 40(7), 653-670. Abstract.  Author URL.
Filby AL, Paull GC, Hickmore TF, Tyler CR (2010). Unravelling the neurophysiological basis of aggression in a fish model. BMC Genomics, 11 Abstract.  Author URL.
Mehinto AC, Hill EM, Tyler CR (2010). Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (Oncorhynchus mykiss). Environ Sci Technol, 44(6), 2176-2182. Abstract.  Author URL.

2009

Oehlmann J, Schulte-Oehlmann U, Kloas W, Jagnytsch O, Lutz I, Kusk KO, Wollenberger L, Santos EM, Paull GC, VanLook KJW, et al (2009). A critical analysis of the biological impacts of plasticizers on wildlife. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1526), 2047-2062. Abstract.
Gaiser BK, Fernandes TF, Jepson M, Lead JR, Tyler CR, Stone V (2009). Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments.  Abstract.
Tyler CR, Filby AL, Bickley LK, Cumming RI, Gibson R, Labadie P, Katsu Y, Liney KE, Shears JA, Silva-Castro V, et al (2009). Environmental health impacts of equine estrogens derived from hormone replacement therapy. Environ Sci Technol, 43(10), 3897-3904. Abstract.  Author URL.
Thorpe KL, Maack G, Benstead R, Tyler CR (2009). Estrogenic wastewater treatment works effluents reduce egg production in fish. Environ Sci Technol, 43(8), 2976-2982. Abstract.  Author URL.
Bickley LK, Lange A, Winter MJ, Tyler CR (2009). Evaluation of a carp primary hepatocyte culture system for screening chemicals for oestrogenic activity. Aquat Toxicol, 94(3), 195-203. Abstract.  Author URL.
Coe TS, Hamilton PB, Griffiths AM, Hodgson DJ, Wahab MA, Tyler CR (2009). Genetic variation in strains of zebrafish (Danio rerio) and the implications for ecotoxicology studies. Ecotoxicology, 18(1), 144-150. Abstract.  Author URL.
Brown AR, Hosken DJ, Balloux F, Bickley LK, LePage G, Owen SF, Hetheridge MJ, Tyler CR (2009). Genetic variation, inbreeding and chemical exposure--combined effects in wildlife and critical considerations for ecotoxicology. Philos Trans R Soc Lond B Biol Sci, 364(1534), 3377-3390. Abstract.  Author URL.
Paull GC, Filby AL, Tyler CR (2009). Growth rate during early life affects sexual differentiation in roach (Rutilus rutilus). Environmental Biology of Fishes, 85(4), 277-284. Abstract.
Williams TD, Wu H, Santos EM, Ball J, Katsiadaki I, Brown MM, Baker P, Ortega F, Falciani F, Craft JA, et al (2009). Hepatic transcriptomic and metabolomic responses in the stickleback (Gasterosteus aculeatus) exposed to environmentally relevant concentrations of dibenzanthracene. Environ Sci Technol, 43(16), 6341-6348. Abstract.  Author URL.
Scown TM, van Aerle R, Johnston BD, Cumberland S, Lead JR, Owen R, Tyler CR (2009). High doses of intravenously administered titanium dioxide nanoparticles accumulate in the kidneys of rainbow trout but with no observable impairment of renal function. Toxicol Sci, 109(2), 372-380. Abstract.  Author URL.
Coe TS, Hamilton PB, Hodgson D, Paull GC, Tyler CR (2009). Parentage outcomes in response to estrogen exposure are modified by social grouping in zebrafish. Environ Sci Technol, 43(21), 8400-8405. Abstract.  Author URL.
Lange A, Paull GC, Coe TS, Katsu Y, Urushitani H, Iguchi T, Tyler CR (2009). Sexual reprogramming and estrogenic sensitization in wild fish exposed to ethinylestradiol. Environ Sci Technol, 43(4), 1219-1225. Abstract.  Author URL.  Full text.
Jobling S, Burn RW, Thorpe K, Williams R, Tyler C (2009). Statistical modeling suggests that antiandrogens in effluents from wastewater treatment works contribute to widespread sexual disruption in fish living in English rivers. Environ Health Perspect, 117(5), 797-802. Abstract.  Author URL.
Sebire M, Scott AP, Tyler CR, Cresswell J, Hodgson DJ, Morris S, Sanders MB, Stebbing PD, Katsiadaki I (2009). The organophosphorous pesticide, fenitrothion, acts as an anti-androgen and alters reproductive behavior of the male three-spined stickleback, Gasterosteus aculeatus. Ecotoxicology, 18(1), 122-133. Abstract.  Author URL.

2008

Thorpe KL, Benstead R, Eccles P, Maack G, Williams T, Tyler CR (2008). A practicable laboratory flow-through exposure system for assessing the health effects of effluents in fish. Aquat Toxicol, 88(3), 164-172. Abstract.  Author URL.
Lange A, Katsu Y, Ichikawa R, Paull GC, Chidgey LL, Coe TS, Iguchi T, Tyler CR (2008). Altered sexual development in roach (Rutilus rutilus) exposed to environmental concentrations of the pharmaceutical 17alpha-ethinylestradiol and associated expression dynamics of aromatases and estrogen receptors. Toxicol Sci, 106(1), 113-123. Abstract.  Author URL.
Coe TS, Hamilton PB, Hodgson D, Paull GC, Stevens JR, Sumner K, Tyler CR (2008). An environmental estrogen alters reproductive hierarchies, disrupting sexual selection in group-spawning fish. Environ Sci Technol, 42(13), 5020-5025. Abstract.  Author URL.
Williams TD, Brown M, Chipman JK, Falciani F, Ortega F, Geoghegan F, Craft JA, Katsiadaki I, Ball J, Tyler CR, et al (2008). Development of a stickleback (Gasterosteus aculeatus) cDNA microarray and gene expression responses to dibenzanthracene, ethinyl-estradiol and copper. MARINE ENVIRONMENTAL RESEARCH, 66(1), 140-140. Author URL.
Benstead, R. Eccles, P. Maack, G. (2008). Effective assessment of the oestrogenic activity of effluents using a laboratory flow-through exposure system. Aquatic Toxicology
van Aerle R, Kille P, Lange A, Tyler CR (2008). Evidence for the existence of a functional Kiss1/Kiss1 receptor pathway in fish. Peptides, 29(1), 57-64. Abstract.  Author URL.
Tyler CR, Filby AL, van Aerle R, Lange A, Ball J, Santos EM (2008). Fish toxicogenomics. In  (Ed) Advances in Experimental Biology, Elsevier.
Johnston, B.J. Tyler, C.R. (2008). Imaging metal oxide nanoparticles in biological structures with CARS microscopy. Optical Express, 16(5), 3408-3419.
Handy RD, Henry TB, Scown TM, Johnston BD, Tyler CR (2008). Manufactured nanoparticles: their uptake and effects on fish--a mechanistic analysis. Ecotoxicology, 17(5), 396-409. Abstract.  Author URL.
Ibañez, A. Tyler, C.R. Prat, F. (2008). Molecular characterisation of growth differentiation factor 9 (gdf9) and bone morphogenetic protein 15 (bmp15) and their patterns of gene expression during the ovarian reproductive cycle in the European sea. bass. Molecular and Cellular Endocrinology
Paull GC, Lange A, Henshaw AC, Tyler CR (2008). Ontogeny of sexual development in the roach (Rutilus rutilus) and its interrelationships with growth and age. J Morphol, 269(7), 884-895. Abstract.  Author URL.
Tyler CR, Jobling S (2008). Roach, sex, and gender-bending chemicals: the feminization of wild fish in English rivers. BioScience, 58(11), 1051-1059. Abstract.
Kille, P. Workman, V.L. Paull, G.C. (2008). Sexually dimorphic gene expression in the brains of mature zebrafish. Comparative Biochemistry and Physiology Part A
Tyler C, Lange A, Santos E, Coe T, Paull G, Filby A, Hamilton P (2008). The feminization of fish in English rivers: Causation, mechanisms, and significance.  Author URL.
Filby AL, van Aerle R, Duitman J, Tyler CR (2008). The kisspeptin/gonadotropin-releasing hormone pathway and molecular signaling of puberty in fish. Biol Reprod, 78(2), 278-289. Abstract.  Author URL.
Paull, G.C. van Look, K.J.W. Santos, E.M. Filby A.L. Gray D.M. Nash, J.P. & Tyler, C.R (2008). Variability in measures of reproductive success in laboratory-kept colonies of zebrafish (Danio rerio) and implications for studies addressing population-level effects of environmental chemicals. Aquatic Toxicology

2007

Tyler, C.R. (2007).  Cloning and Characterisation of cDNAs for hormones and/or receptors of growth hormone, insulin-like growth factor-I, thyroid hormone, and corticosteroid and the gender- and tissue- and developmental-specific expression of their mRNA transcripts in fathea. General & Comparative Endocrinology, 150, 151-163.
Katsu, Y. Urushitani, H. Lange, A. (2007).  Developmental effects of exposure to. pharmaceutical steroids in the aquatic environment: Studies in Mosquitofish (Gambusia affinis), Roach. (Rutilus rutilus) and Medaka (Oryzias latipes. Journal of Marine Science and Technology
Hetheridge, M. Hutchinson, T.H. Benstead, R. (2007). An optimized experimental test procedure for measuring chemical effects on reproduction in the fathead minnow (<em>Pimephales promelas</em>). Aquatic Toxicology, 8(1), 90-98.
Filby AL, Tyler CR (2007). Appropriate 'housekeeping' genes for use in expression profiling the effects of environmental estrogens in fish. BMC Mol Biol, 8 Abstract.  Author URL.
Benstead, R. Hutchinson, T.H. Tyler, C.R. (2007). Associations between altered vitellogenin concentrations and adverse health effects in fathead minnow (Pimephales promelas. Aquatic Toxicology
Trudeau V, Tyler C (2007). Endocrine disruption. Gen Comp Endocrinol, 153(1-3), 13-14. Author URL.
Schulz RW, Bogerd J, Male R, Ball J, Fenske M, Olsen LC, Tyler CR (2007). Estrogen-induced alterations in amh and dmrt1 expression signal for disruption in male sexual development in the zebrafish. Environmental Science and Technology, 41(17), 6305-6310. Abstract.
Bickley L, Lange A, Tyler C, Winter M (2007). Fish hepatocyte cultures as an alternative to in vivo tests for screening oestrogen receptor active chemicals. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 146(4), S72-S72. Author URL.
Jobling, S. (2007). Fish, Sex and Gender-Bending Chemicals – the Feminization of Fish Living in English Rivers. Biosciences
Lange, A. Ichikawa, R. Urushitani, H.G.C. (2007). Functional associations between two estrogen receptors, environmental oestrogens, and sexual disruption in the roach (<em>Rutilus rutilus</em>). Environmental Science and Technology, 41(9), 3368-3374.
Thorpe, K.L. Maack, G. Tyler, C.R. (2007). Gene expression profiles revealing the mechanisms of anti-androgen- and oestrogen- induced feminisation in fish. Aquatic Toxicology, 81(2), 219-231.
Santos, E.M. Thorpe, K.L. Maack, G. (2007). Gene expression profiling for understanding chemical causation of biological effects of complex mixtures: a Case Study for Estrogens. Environmental Science and Technology
Santos, E.M. Paull, G.C. Van Look, K.J.W. Workman, V.L. Holt, W.V. van Aerle, R. Kille, P. & Tyler, C.R (2007). Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio). Aquatic Toxicology, 83(2), 134-142.
Tyler CR, Filby AL, Galloway TS, Neuparthe T (2007). Health impacts of estrogens in the environment, considering  complex mixture effects.  Full text.
Tyler, C.R. (2007). Identification of microsatellite loci for parentage analysis in roach Rutilus rutilus and 8 other cyprinids by cross-species amplification, and a novel test for detecting hybrids between roach and other cyprinids. Molecular Ecology Notes
Workman, V.L. Paull, G.C. Filby, A.L. (2007). Molecular basis of sex and reproductive status in breeding zebrafish. Physiological Genomics, 30(2), 111-122.
Boegard, J. Male, R. Ball, J. (2007). Oestrogen-induced alterations in the expression of AMH and DMRT-1 during sexual differentiation signal for impacts on male sexual development in the zebrafish (<em>Danio rerio</em>). Environmental Science and Technology, 41(17), 6305-6310.
Tyler C, Lange A, Santos E, Filby A (2007). The application of transcriptomics and other molecular approaches in advancing our understanding of endocrine disruption. TOXICOLOGY LETTERS, 172, S27-S27. Author URL.
Katsu, Y. Kato, Y. Tooi, O. (2007). The medaka (Oryyzias latipes) for assessing developmental effects of endocrine disrupting chemicals with special reference to gonadal intersex (testis-ova. Environmental Science
Tyler CR, Lange A, Paull GC, Katsu Y, Iguchi T (2007). The roach (Rutilus rutilus) as a sentinel for assessing endocrine disruption. Environ Sci, 14(5), 235-253. Abstract.  Author URL.

2006

Hutchinson, T.H. Hurd, K.S. Bamforth, J. (2006).  Development of chronic tests for endocrine active chemicals. Part I. An extended fish early- life stage test for oestrogen active chemicals in the fathead minnow <em>Pimephales promelas</em>. Aquatic Toxicology, 77, 279-290.
Kennedy, S. Snape, J. Tillet, D. (2006). An Evaluation of the Potential Role of Genomics in Regulatory Ecotoxicology. Environmental Science and Technology, 40(13), 4055-4065.
Gross-Sorokin, M. Johnson, I. Brighty, G. (2006). An assessment of the model of concentration addition for predicting the estrogenic activity of chemical mixtures in wastewater treatment works effluent. Environmental Health Perspectives, 114, 90-97.
Schulte-Oehlmann, U, Albanis T, Allera A, Bachmann J, Berntsson P, Beresford N, Carnevali DC, Ciceri F, Dagnac T, Falandysz J, et al (2006). COMPRENDO: Focus and approach. Environmental Health Perspectives, 114(1), 98-100.
Eidem JK, Kleivdal H, Kroll K, Denslow N, van Aerle R, Tyler C, Panter G, Hutchinson T, Goksoyr A (2006). Development and validation of a direct homologous quantitative sandwich ELISA for fathead minnow (Pimephales promelas) vitellogenin. Aquatic Toxicology, 78(2), 202-206.
Santos E, Paull G, Filby A, Tyler C, Van Look K, Holt W, Workman V, Kille P (2006). Gender and stage-specific transcriptomic profiles of gonads and brains in breeding zebrafish. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 143(4), S101-S101. Author URL.
tsgallo1, Hagger JA, Liney KE, Tyler CR (2006). Health effects in fish of long-term exposure to effluents from wastewater treatment works. Environmental Health Perspectives, 114(S1), 81-89. Full text.
Jobling S, Tyler CR (2006). Introduction: the ecological relevance of chemically induced endocrine disruption in wildlife. ENVIRONMENTAL HEALTH PERSPECTIVES, 114, 7-8. Author URL.
Thorpe, K.L. Tyler, C.R. (2006). Multiple molecular effect pathways for an environmental. oestrogen in fish. Journal of Endocrinology, 37, 121-134.
Ankley, G.T. Segner, H. Tyler, C.R. (2006). Screening and testing for endocrine. disruption in fish -. biomarkers as signposts not traffic lights in risk assessment. Environmental Health Perspectives, 114, 106-114.
Filby A, Thorpe K, Tyler C (2006). The developmental expression of three oestrogen receptor subtypes and their differential responses to oestrogen in fish. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 143(4), S101-S101. Author URL.
Tyler, C.R. (2006). The ecological relevance of chemically-induced endocrine disruption in wildlife. Environmental Health Perspectives, 114, 7-8.
Ankley GT, Daston GP, Degitz SJ, Denslow ND, Hoke RA, Kennedy SW, Miracle AL, Perkins EJ, Snape J, Tillitt DE, et al (2006). Toxicogenomics in regulatory ecotoxicology. Environmental Science and Technology, 40(13), 4055-4065. Abstract.

2005

Tyler CR, Spary C, Gibson R, Santos EM, Shears J, Hill EM (2005). Accounting for differences in estrogenic responses in rainbow trout (Oncorhynchus mykiss: Salmonidae) and roach (Rutilus rutilus: Cyprinidae) exposed to effluents from wastewater treatment works. Environ Sci Technol, 39(8), 2599-2607. Abstract.  Author URL.
Tyler, C.R. Hill, E.M. (2005). An analytical methodology for the identification of estrogenic contaminants in fish bile. Journal of Chromatography A, 1066, 33-40.
Jobling, S. Shears, J. Simpson, P. (2005). Assessing the sensitivity of different life stages. for sexual disruption in roach (<em>Rutilus rutilus</em>) exposed to effluents from wastewater treatment works. Environmental Health Perspectives, 113(10), 1299-1307.
Fenske, M. Verslycke, T. Tyler, C.R. (2005). Development of a quantitative enzyme- linked immunosorbent assay for vitellin and its application in a preliminary study on vitellogenesis in the mysid, Neomysis intege. Comparative Biochemistry and Physiology Part B
Ghekiere A, Fenske M, Verslycke T, Tyler C, Janssen C (2005). Development of a quantitative enzyme-linked immunosorbent assay for vitellin in the mysid Neomysis integer (Crustacea: Mysidacea). Comp Biochem Physiol a Mol Integr Physiol, 142(1), 43-49. Abstract.  Author URL.
Shears, J. van Aerle, R. (2005). Endocrine (sexual) disruption is not a prominent feature in the pike (Esox lucius), a top predator, living in English waters. Environmental Toxicology and Chemistry, 24(6), 1436-1443.
Smith, M.D. Spary, C. Tyler, C.R. (2005). Mixtures of oestrogenic contaminants in bile in fish exposed to wastewater treatment works effluents. Environmental Science and Technology, 39(8), 2461-2471.
Tyler, C.R. (2005). Molecular characterization of estrogen receptors 1, 2a and 2b and their tissue and ontogenic expression profiles in fathead minnow (<em>Pimephales promelas</em>). Biology of Reproduction, 73, 648-662.
Williams, R. Johnson, A. (2005). Predicted exposures to steroid estrogens in UK Rivers correlate with widespread sexual disruption in wild fish populations. Environmental Health Perspectives, 32-39.

2004

Sauer, A. Shears, J. Tyler, C.R. (2004).  Androgenic and oestrogenic effects of the synthetic androgen, 17-methyltestosterone on sexual development and reproductive performance in the fathead minnow (<em>Pimephales promelas</em>) determined using a gonadal recrudescence assay. Aquatic Toxicology, 68(3), 277-291.
Jobling S, Casey D, Rodgers-Gray T, Oehlmann J, Schulte-Oehlmann U, Pawlowski S, Baunbeck T, Turner AP, Tyler CR (2004). Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent (vol 65, pg 205, 2003). AQUATIC TOXICOLOGY, 66(2), 205-+. Author URL.
Jobling S, Casey D, Rogers-Gray T, Oehlmann J, Schulte-Oehlmann U, Pawlowski S, Baunbeck T, Turner AP, Tyler CR (2004). Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent. Aquat Toxicol, 66(2), 207-222. Abstract.  Author URL.
Tyler CR, van Aerle R, Santos EM (2004). ELISAs for detecting vitellogenin in the fathead minnow (Pimephales promelas)-a critical analysis. Response to Mylchreest et al. Comp Biochem Physiol C 134: 251-257, 2003. Comp Biochem Physiol C Toxicol Pharmacol, 138(4), 531-532. Author URL.
van Aerle, R. Tyler, C.R. (2004). Effects of 17 alpha-ethinylestradiol in a fathead minnow (Pimephales promelas) gonadal recrudescence assay. Ecotoxicology and Environmental Safety, 57(3), 330-345.
Spano, L. Tyler, C.R. van Aerle R, Devos, P. Mandiki SNM, Silvestre F, Thome JP, Kestemont P (2004). Effects of atrazine on sex steroid dynamics, plasma vitellogenin concentration and gonad development in adult goldfish (Carassius auratus). Aquatic Toxicology, 66(4), 369-379.
Jobling S, Casey C, Rodgers-Gray T, Oehlmannd J, Schulte-Oehlmann U, Pawlowski S, Baunbeck T, Turner AP, Tyler CR (2004). Erratum: Comparative responses of molluscs and fish to environmental estrogens and an estrogenic effluent (Aquatic Toxicology (2003) 65 (205-220)). Aquatic Toxicology, 66(2), 205-222.
Tyler, C.R. Palazzi, X. Laillet, B. (2004). Impacts of. 17- estradiol, including environmentally relevant concentrations, on reproduction after exposure during embryo-larval-juvenile and adult-life stages in zebrafish (<em>Danio rerio</em>). Aquatic Toxicology, 68(3), 193-217.
Nash, J.P. Kime, D.E. Van der Ven, L.T.M. (2004). Long-term exposure to environmental concentrations of the pharmaceutical ethinyloestradiol cause \r reproductive failure in fish. Environmental Health Perspectives, 112(17), 1725-1733. Full text.
van Aerle, R. Runnalls, T. & Tyler, C.R (2004). Ontogeny of gonadal sex development relative to growth in. fathead minnow (<em>Pimephales promelas</em>). Journal of Fish Biology, 64, 355-369.
van Aerle, R, Runnalls, T.J. Tyler, C.R. (2004). Ontogeny of gonadal sex development relative to growth in fathead minnow. Journal of Fish Biology, 64(2), 355-369.
Benstead, R. Hutchinson, T.H. Cummings, R.I. (2004). Reproductive effects of. exposure to oestrone in the fathead minnow. Fish Physiology and Biochemistry, 28, 451-452.
Hutchinson, T.H. Hurd, K.S. Sherren, A. (2004). Successful detection of (anti-) androgenic and aromatase inhibitors in pre-spawning fathead minnows (<em>Pimephales promelas</em>) using easily measured endpoints of sexual development. Aquatic Toxicology, 70, 11-21.

2003

Kwon, J. Rand-Weaver, M. Sumpter, J.P. (2003). Cloning and gene expression of 17,20- lyase cDNA in the gonads and brain of the fathead minnow (<em>Pimephales promelas</em>). General & Comparative Endocrinology, 130, 256-266.
Casey, D. Rodgers-Gray, T. Oehlmann, J. (2003). Comparative responses of molluscs and fish to environmental oestrogens and an oestrogenic effluent. Aquatic Toxicology, 65, 205-220.
Thomas-Jones E, Thorpe K, Harrison N, Thomas G, Morris C, Hutchinson T, Woodhead S, Tyler C (2003). Dynamics of estrogen biomarker responses in rainbow trout exposed to 17beta-estradiol and 17alpha-ethinylestradiol. Environ Toxicol Chem, 22(12), 3001-3008. Abstract.  Author URL.
Tyler, C.R. (2003). Endocrine Disruption in Wild Freshwater Fish. Pure and Applied Chemistry, 75(11-12), 2219-2234.
Jobling S, Tyler CR (2003). Endocrine disruption, parasites and pollutants in wild freshwater fish.  Abstract.  Author URL.
Tyler, C.R. (2003). Impacts of Endocrine Disruption, Parasites and Pollution in Freshwater Fish. Journal of Parasitology, 126, 103-108.
Segner, H. Tyler, C.R. (2003). Ontogeny of sexual differentiation in different strains of zebrafish (<em>Danio rerio</em>). Fish Physiology and Biochemistry, 28, 125-128.
Tyler CR, Hetheridge MJ, Scholze M, Thorpe K (2003). Relative potencies and combination effects of steroidal oestrogens in fish. Environmental Science & Technology, 37(6), 1142-1149.
Pickford, K.A. Wheale, B.Thomas,-Jones, E. Tyler, C.R. & Sumpter, J.P (2003). Route of exposure affects the oestrogenic responses of fish to 4-tert nonylphenol. Aquatic Toxicology, 65, 267-279.

2002

Tyler CR, Beresford N, Jobling S, Nolan M (2002). Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents. Biology of Reproduction, 66(2), 272-281.
Kirk LA, Tyler CR, Lye CM, Sumpter JP (2002). Changes in estrogenic and androgenic activities at different stages of treatment in wastewater treatment works.  Abstract.  Author URL.
Lye, C. Tyler, C.R. Sumpter, J.P. (2002). Effects of treatment processes on the endocrine activity of various influents as they pass through waster water treatment works\r. Environmental Toxicology and Chemistry, 21(5), 972-979.
Tyler CR, Ball J, Maack G, Paull G, Santos EM (2002). Endocrine disruption in vertebrate wildlife - Today's story.  Author URL.
Rand-Weaver, M. Sumpter, J.P. Tyler, C.R. (2002). Exposure to exogenous oestradiol 17 disrupts P450 aromatase B mRNA expression in the brain and ovary of adult fathead minnow (<em>Pimephales promelas</em>).\r. Aquatic Toxicology, 60, 285-299.
Tyler CR, van Aerle R, Nilsen MV, Blackwell R, Maddix S, Nilsen BM, Berg K, Hutchinson TH, Goksøyr A (2002). Monoclonal antibody enzyme-linked immunosorbent assay to quantify vitellogenin for studies on environmental estrogens in the rainbow trout (Oncorhynchus mykiss). Environ Toxicol Chem, 21(1), 47-54. Abstract.  Author URL.
Tyler, C.R. Maddix, S. Karbe, L. (2002). Plasma biomarkers in fish provide evidence for endocrine modulation in the Elbe River, Germany. Environmental Science and Technology, 36(11), 2311-2321.
Campbell, P.M. Hutchinson, T.H. Kime, D.E. (2002). Utility of. a fathead. minnow juvenile fish screening assay for detecting. (anti-) oestrogenic substances. Environmental Toxicology and Chemistry, 21, 319-326.
Jobling S, Coey S, Whitmore JG, Kime DE, Van Look KJW, McAllister BG, Beresford N, Henshaw AC, Brighty G, Tyler CR, et al (2002). Wild intersex roach (Rutilus rutilus) have reduced fertility. Biol Reprod, 67(2), 515-524. Abstract.  Author URL.
van Aerle R, Pounds N, Hutchinson TH, Maddix S, Tyler CR (2002). Window of sensitivity for the estrogenic effects of ethinylestradiol in early life-stages of fathead minnow, Pimephales promelas. Ecotoxicology, 11(6), 423-434. Abstract.  Author URL.

2001

Jobling, S. Sumpter, J.P. Brighty, G. (2001). A histological. description of intersexuality in the roach. Journal of Fish Biology, 58, 160-176.
Tyler CR, Hetheridge M, Scholze M, Thorpe K (2001). Assessing the Biological Potency of Binary Mixtures of Environmental Estrogens using Vitellogenin Induction in Juvenile Rainbow Trout (Oncorhynchus mykiss) . Environmental Science & Technology, 35(12), 2476-2481.
Rand-Weaver, M. Sumpter, J.P. Tyler, C.R. (2001). Cloning and molecular characterisation of an ovarian-derived (brain-like) P450-aromatase. and development. of a. competitive rtPCR bioassay to quantify its expression in the fathead minnow (Pimephales promelas ). Fish Physiology and Biochemistry, 24, 49-62.
van Aerle, R. Brack, S. (2001). Development and validation of a homologous zebrafish (Danio rerio Hamilton-Buchanan) vitellogenin enzyme-linked immunosorbent assay (ELISA) and its application for studies on estrogenic chemicals. Comparative Biochemistry and Physiology C-Toxicology & Pharmacology, 129(3), 217-232.
Rand-Weaver, M. Tyler, C.R. (2001). Development and validation of radioimmunoassays for follicle stimulating hormone and its alpha and beta sub-units and their seasonal plasma and pituitary concentrations in the rainbow trout (<em>Oncorhynchus mykiss</em>). Biology of Reproduction, 65, 288-294.
van Aerle, R. Jobling, S. Christiansen. L. Sumpter, J.P and Tyler, C.R. (2001). Evidence for sexual disruption in a second species of freshwater fish (<em>gudgeon, Gobio gobio</em>) living in UK rivers receiving sewage treatment works effluent. Environmental Toxicology and Chemistry, 20, 2841-2847.
Jobling, S. Kelly, C. (2001). Exposure of juvenile roach, <em>Rutilus rutilus</em>, to treated sewage effluent induces dose-dependent and persistent disruption in gonadal development. Environmental Science and Technology, 35(3), 462-470.
Santos, E. Pottinger, T.G. Tyler, C.R. (2001). Exposure to 4 tert –nonylphenol alters gonadotrophin dynamics. in the pituitary and. plasma of. female rainbow trout (Oncorhynchus mykiss ). Environmental Science and Technology, 35, 2909-2916.
Santos EM, Rand-Weaver M, Tyler CR (2001). Follicle-stimulating hormone and its alpha and beta subunits in rainbow trout (Oncorhynchus mykiss): purification, characterization, development of specific radioimmunoassays, and their seasonal plasma and pituitary concentrations in females. Biol Reprod, 65(1), 288-294. Abstract.  Author URL.
Cavaco, J.E.B. Rebers, F.E.M. Vischer, H.F. (2001). Gonadotrophins, their receptors, and regulation of testicular functions in fish. Comparative Biochemistry and Physiology Part B, 129, 407-417.
Schulz RW, Vischer HF, Cavaco JEB, Santos EM, Tyler CR, Goos HJT, Bogerd J (2001). Gonadotropins, their receptors, and the regulation of testicular functions in fish.  Author URL.
Prat, F. Randall, C. Tyler, C.R. (2001). Molecular characterisation of putative yolk processing enzymes and their expression during oogenesis and embryo development in the rainbow trout, <em>Oncorhynchus mykiss</em>. Biology of Reproduction, 65, 1701-1709.
Harris CA, Santos EM, Janbakhsh A, Pottinger TG, Tyler CR, Sumpter JP (2001). Nonylphenol affects gonadotropin levels in the pituitary gland and plasma of female rainbow trout. Environ Sci Technol, 35(14), 2909-2916. Abstract.  Author URL.
Tyler, C.R. Toy, R. Caunter, J. (2001). Reproductive effects of long term exposure to Bisphenol a in the fathead minnow (Pimephales promelas ). Environmental Science and Technology, 35, 2917-2925.
Van Aerle R, Christiansen LB, Jobling S, Tyler CR (2001). Sexual disruption in a second species of wild cyprinid fish (the Gudgeon, Gobio gobio) in United Kingdom freshwaters. Environmental Toxicology and Chemistry, 20(12), 2841-2847.

2000

Runnalls, T. Harris, C. Hill, E. (2000). Development of a reproduction performance test for endocrine-disrupting chemicals in the fathead minnow (Pimephales promelas. Environmental Science and Technology, 34, 3003-3011.
Hutchinson, T.H. Hetheridge, M. Sumpter, J.P. (2000). Development of an in vivo. screening assay for estrogenic chemicals using juvenile rainbow trout, Oncorhynchus mykiss. Environmental Toxicology and Chemistry, 19, 2812-2820.
Brion, F. Palazzi, X. Babut, M. (2000). Estrogenic effects in chub (Leuciscus cephalus): Induction of vitellogenin and alterations in testicular structure. Ecotoxicology, 9, 127-135.
Flammarion P, Brion F, Babut M, Garric J, Migeon B, Noury P, Thybaud E, Palazzi X, Tyler CR (2000). Induction of fish vitellogenin and alterations in testicular structure: Preliminary results of estrogenic effects in chub (Leuciscus cephalus).  Abstract.
Jobling, S. Morris, S. Kelly, C. (2000). Long-term temporal changes in the oestrogenic composition of treated sewage effluent and its biological effects in fish. Environmental Science and Technology, 34, 1521-1528.
Tyler, C.R. Beresford, N. van der Woning, M. Sumpter, J.P. & Thorpe, K (2000). Metabolism and. environmental degradation of pyrethroid. insecticides produce compounds with endocrine activities. Environmental Toxicology and Chemistry, 19, 801-809.
May, D. Rand-Weaver, M. Tyler, C.R. (2000). Molecular characterisation of the first non-mammalian p73 cDNA. Comparative Biochemistry and Physiology Part B, 126, 49-57.

1999

Tyler, C.R. van Aerle, R. Hutchinson, T. Maddix, S, & Trip, H (1999). An in vivo. testing system for endocrine disrupters in fish early life stages using induction of vitellogenin. Environmental Toxicology and Chemistry, 18(2), 337-347.
Perazzolo, L. Coward, K. Davail, B. Normand, E. Tyler, C.R. Pakdel, F. Schneider, W. & Le Menn, F (1999). Expression and localisation of messenger ribonucleic acid for the vitellogenin receptor in ovarian follicles throughout oogenesis in the rainbow trout, <em>Oncorhynchus mykiss</em>. Biology of Reproduction, 60, 1057-1068.
May, D. Rand-Weaver, M. Tyler, C.R. (1999). Fish p53 - a possible biomarker for genotoxins in the aquatic environment?. Environmental and Molecular Mutagenesis, 33, 144-151.
Bhaskaran A, May D, Rand-Weaver M, Tyler CR (1999). Fish p53 as a possible biomarker for genotoxins in the aquatic environment. Environ Mol Mutagen, 33(3), 177-184. Abstract.  Author URL.
Jambakhsh, A. Jobling, S. Matthiessen, P. (1999). Oestrogenic potency of effluent from two sewage-treatment works in the United Kingdom. Environmental Toxicology and Chemistry, 18, 932-937.

1998

Jobling, S. Sumpter, J.P. (1998). Endocrine disruption in wildlife: a critical review of the. evidence\r. Critical Reviews in Toxicology, 28(4), 319-361.
Coward, K. Sumpter, J.P. Tyler, C.R. (1998). Molecular characterisation and expression of two ovarian lipoprotein receptors in the rainbow trout, <em>Oncorhynchus mykiss</em>. Biology of Reproduction, 58, 1146-1153.
Routledge, E. (1998). Oestrogenic effects in fish in English rivers with evidence for causation. Pure and Applied Chemistry, 70, 1795-1804.
Nolan, M. Tyler, C.R. Brighty, G. (1998). Widespread sexual disruption in wild fish. Environmental Science and Technology, 32, 2498-2506.

1997

Tyler, C.R. Sumpter, J.P. (1997). Egg quality in fish; what makes a good egg? \r. Reviews in Fish Biology and Fisheries, 7, 387-416.
Tyler, C.R. Carnevali, O. Coward, K. (1997). Molecular characterisation of ovarian cathepsin D in the rainbow trout, Oncorhynchus mykiss. Gene, 201, 45-54.
Brooks S, Tyler CR, Sumpter JP (1997). Quality in fish: what makes a good egg?. REVIEWS IN FISH BIOLOGY AND FISHERIES, 7(4), 387-416. Author URL.
Pottinger, T.G. Coward, K. Prat, F. (1997). Salmonid follicle stimulating hormone (GtH I) mediates. vitellogenic development of oocytes in the rainbow trout, Oncorhynchus mykiss. Biology of Reproduction, 57, 1238-1244.

1996

Nagler JJ, Scott AP, Tyler CR, Sumpter JP (1996). Gonadotropins I and II do not stimulate the in vitro secretion of 17 alpha,20 beta-dihydroxy-4-pregnen-3-one 20-sulphate by rainbow trout gonads during final sexual maturation. FISH PHYSIOLOGY AND BIOCHEMISTRY, 15(2), 149-156. Author URL.
Lubberink, K. (1996). Identification of four ovarian receptor proteins that bind vitellogenin, but not other homologous plasma lipoproteins, in the rainbow trout, <em>Oncorhynchus mykiss</em>. Journal of Comp. Physiol.B, 166, 11-20.
Tyler, C.R. van der Eerden, Sumpter, J.P. Jobling, S. & Panter, G (1996). Measurement of vitellogenin, a biomarker for exposure to oestrogen, in a wide variety of cyprinids. Journal of Comp. Physiol.B, 166, 418-426.
Tyler CR, Pottinger TG, Santos E, Sumpter JP, Price SA, Brooks S, Nagler JJ (1996). Mechanisms controlling egg size and number in the rainbow trout, Oncorhynchus mykiss. Biol Reprod, 54(1), 8-15. Abstract.  Author URL.
Sumpter, J.P. (1996). Oocyte growth and development in teleosts. Reviews in Fish Biology and Fisheries, 6, 287-318.
Sumpter, J.P. Tyler, C.R. (1996). Validation of radioimmunoassays for two salmon gonadotropins (gonadotropins I and II) and their plasma concentrations throughout the reproductive cycle in male and female rainbow trout, Oncorhynchus mykiss. Biology of Reproduction, 54, 1375-1382.

1994

Tyler, C.R. (1994). Developmental expression and modulation of the vitellogenin receptor in ovarian follicles of the rainbow trout, <em>Oncorhynchus mykiss</em>. Journal of Experimental Zoology, 269, 458-466.
Nagler, J.J. Pottinger, T.P. Turner, M. (1994). Effects of unilateral ovariectomy on recruitment and growth of follicles in the rainbow trout, <em>Oncorhynchus mykiss</em>. Fish Physiology and Biochemistry, 13, 309-316.
Purdom CE, Hardiman PA, Bye VJ, Eno NC, Tyler CR, Sumpter JP (1994). Estrogenic Effects of Effluents from Sewage Treatment Works. Chemistry and Ecology, 8(4), 275-285. Abstract.
Hardiman, P.A. Bye, V. Eno, N.C. (1994). Oestrogenic effects of effluent from sewage treatment works. Chemistry and Ecology, 8, 275-285.
Tyler, C.R. Sumpter, J.P. (1994). Ovarian follicles of rainbow trout (<em>Oncorhynchus mykiss</em>) cultured within lamellae survive well, and sequester and process vitellogenin. Journal of Experimental Zoology, 269, 45-52.

1993

Tyler, C.R. (1993). Electrophoretic patterns of yolk proteins throughout ovarian development and their relationship to vitellogenin in the rainbow trout, <em>Oncorhynchus mykiss</em>. Comparative Biochemistry and Physiology Part B, 106, 321-329.
Everett, S. (1993). Gross morphological disorders in barbel (<em>Barbus barbus</em>) in three rivers in southern England. Journal of Fish Biology, 43, 739-748.
Tyler CR, Everett S (1993). Incidences of gross morphological disorders in barbel (Barbus barbus) in three rivers in southern England. Journal of Fish Biology, 43(5), 739-748. Abstract.
Tyler CR, Lancaster P (1993). Isolation and characterization of the receptor for vitellogenin from follicles of the rainbow trout, Oncorhynchus mykiss. Journal of Comparative Physiology B, 163(3), 225-233. Abstract.

1991

Tyler CR, Sumpter JP, Kawauchi H, Swanson P (1991). Involvement of gonadotropin in the uptake of vitellogenin into vitellogenic oocytes of the rainbow trout, Oncorhynchus mykiss. Gen Comp Endocrinol, 84(2), 291-299. Abstract.  Author URL.
Sumpter, J.P. Campbell, P.M. (1991). Uptake of vitellogenin into oocytes during early vitellogenic development in the rainbow trout, <em>Oncorhynchus mykiss</em> (Walbaum). Journal of Fish Biology, 38, 681-689.

1990

Tyler CR, Sumpter JP, Bromage NR (1990). An in vitro culture system for studying vitellogenin uptake into ovarian follicles of the rainbow trout, Salmo gairdneri. Journal of Experimental Zoology, 255(2), 216-231. Abstract.
Sumpter, J.P. (1990). The development of a radioimmunoassay for carp, <em>Cyprinus carpio</em>, vitellogenin. Fish Physiology and Biochemistry, 8, 129-140.
Tyler CR, Sumpter JP, Witthames PR (1990). The dynamics of oocyte growth during vitellogenesis in the rainbow trout (Oncorhynchus mykiss). Biol Reprod, 43(2), 202-209. Abstract.  Author URL.
Tyler CR, Sumpter JP, Handford RM (1990). The dynamics of vitellogenin sequestration into vitellogenic ovarian follicles of the rainbow trout, Salmo gairdneri. Fish Physiology and Biochemistry, 8(3), 211-219. Abstract.
Sumpter, J.P. (1990). The purification and partial characterisation of carp, <em>Cyprinus carpio</em>, vitellogenin. Fish Physiology and Biochemistry, 8, 111-120.

1988

TYLER CR, SUMPTER JP, BROMAGE NR (1988). INVIVO OVARIAN UPTAKE AND PROCESSING OF VITELLOGENIN IN THE RAINBOW-TROUT, SALMO-GAIRDNERI. JOURNAL OF EXPERIMENTAL ZOOLOGY, 246(2), 171-179. Author URL.
TYLER CR, SUMPTER JP, BROMAGE NR (1988). SELECTIVITY OF PROTEIN SEQUESTRATION BY VITELLOGENIC OOCYTES OF THE RAINBOW-TROUT, SALMO-GAIRDNERI. JOURNAL OF EXPERIMENTAL ZOOLOGY, 248(2), 199-206. Author URL.
Sumpter, J.P. Bromage, N.R. (1988). The selectivity of protein sequestration by vitellogenic oocytes of the rainbow trout, <em>Salmo gairdneri</em>, in vivo. Journal of Experimental Zoology, 248, 199-206.

1987

TYLER C, SUMPTER J, BROMAGE N (1987). THE SPECIFICITY OF VITELLOGENIN UPTAKE INTO OVARIAN FOLLICLES OF RAINBOW-TROUT, SALMO-GAIRDNERI. JOURNAL OF ENDOCRINOLOGY, 112, 50-50. Author URL.
TYLER C, SUMPTER J, BROMAGE N (1987). VITELLOGENIN UPTAKE BY CULTURED OOCYTES OF RAINBOW-TROUT (SALMO-GAIRDNERI). GENERAL AND COMPARATIVE ENDOCRINOLOGY, 66(1), 19-20. Author URL.

charles_tyler Details from cache as at 2018-12-09 18:06:03

Refresh publications

External Engagment and Impact

Committee/panel activities

1997-2001 European chemical industry (CEFIC-EMSG) Endocrine Modulators Steering Group working on endocrine disrupters

1998-to date OECD fish expert working group panel member for endocrine disruptors

2003-2006 International Advisory Panel for Bisphenol A

2003-2006 Member, Regional (Southwest) Environment Protection Advisory Committee

2003-2007 Member, Environment Agency's National Scientific Advisory Board

2005-200 Member, NERC Fish Genomics Travel/Science Grants Panel

2005-2010 Chair Defra Travel/ Science Grants Panel

2006 Chair, BBSRC Strategic Panel for Environmental Genomics

2006-2007 Chair, NERC Environmental Nanoparticles Initiative grants panel

2007-to date Editorial Board, Environmental Sciences

2006- to date Member, Peninsula Environment and Human Health Initiative

2008- to date Advisory Panel for the FP7 project - ENRHES (Engineered Nanomaterials -  Review of Health & Environmental Safety).

2008- to date Panel for the International Symposium for Fish Endocrinology

2009 -2010 National Ecosystem Assessment Group - Advisor for Freshwater Fish

2010-to date Scientific Advisory and Recruitment Panel for the European Centre for the Environment and Human Health

2010 NERC Neomics Expert Working Group

2010-2015 Chief Scientific Advisor for UK-Japan partnership for studies on emerging contaminants

2012-to date NERC Peer Review College

2013-2016 Advisory Board member for German Government on Nanomaterial Safety

2014 NERC Core Review Panel Member


Editorial responsibilities

Referee for many scientific journals including; Science, Biology of Reproduction, Journal of Fish Biology, Fish Physiology and Biochemistry, Journal of Comparative Physiology, Journal of Experimental Zoology, General and Comparative Endocrinology, Comparative Biochemistry and Physiology, Journal of Aquatic Living Resources, Aquaculture, Environmental Toxicology and Chemistry, Aquatic Toxicology and Environmental Science and Technology, Proceeding of the Royal Society Series.

Referee for (inter)national grants, including submissions to NERC, BBSRC, The Wellcome Trust, Leverhulme Trust, European Union, NIH, USA, NSERC Canada.

Regular reviewer of research articles and risk assessment documents for the EU, various industries, the Environment Agency and DEFRA.

Examined more than 20 PhD theses.


Invited lectures

Selected invited lectures (since 2008)

2008 Endocrine Disruption in the Aquatic Environment- Molecular Approaches for Resolving Chemical effects. Endocrine Disruption in  Aquatic Environments- Lessons for Taking The Science Forward in Support of Chemical Management. Burnham –on-Crouch, UK. May 2008.

2008 Feminization of fish in English Rivers - Causation, Mechanisms and Significance. World Congress on Reproductive Biology. Kailua-Kona, Hawaii  May 2008. . Keynote.

2008 The role of anti-androgens (and estrogens) in the feminization of fish in English Rivers. Gordon Conference. New Hampshire, USA. June 2008. Keynote.

2008 The roles of estrogens and anti-androgens in the feminization of fish in English Rivers. International Symposium on Fish Endocrinology. Calgary, Canada. June 2008. Keynote.

2009 Endocrine Disruption. Association for Chemicals and Hazardous Substances, DEFRA London,  2009. Keynote.

2009 Anti-androgens and their contribution to sexual disruption in wild fish populations. International meeting on Endocrine disruption, Copenhagen. May  2009. Keynote.

2009 Endocrine disrupting chemical and sexual disruption in aquatic wildlife. International Symposium on Reproduction and Climate Change Impacts, Institute of Zoology, London, September  2009. Keynote.

2009 Application of molecular approaches in unravelling chemical effects in fish. NERC-funded workshop on genomic resources in fish. Exeter, May 2009. Keynote.

2009 Endocrine disrupting chemical and sexual disruption in aquatic wildlife. International Symposium on Reproduction and Climate Change Impacts, Institute of Zoology, London, September 2009. Keynote.

2010 Communicating Science -Endocrine Disruption. University of Florida, Florida 2010. Howard Hughes Lecture

2010 Endocrine Disruption in Fish in UK Rivers. 9th International Symposium on Fish Biology. Barcelona Spain. July 2010. Keynote.

2010 Understanding the Molecular basis of Dominance in Fish. 9th International Symposium on Fish Biology. Barcelona Spain. July 2010. Invited Presentation.

2010 Bioavailability of Metal oxide Nanoparticles to Fish. 5th International Congress on Environmental Fate and Effects of Nanomaterials and Nanoparticles. Clemson, USA. August. 2010. Invited Presentation.

2010 Nanoparticle effects in Fish. International Meeting on Nanoparticles. Austria September 2010. Keynote

2010 Population level impacts of Endocrine Disruption in Fish. UK Water Industry and Stakeholder Forum. London. May  2010. Keynote

2010 Endocrine Disruption in Fish: From molecular mechanisms to population level impacts.  International Reproduction Meeting, Uppsala, Sweden, October 2010. Keynote.

2010 Applying ‘Systems Biology’ to unravel the molecular mechanism and functional consequences of effects of EDCs and other emerging contaminants in fish and fish populations. UK-Japan Partnership for Endocrine Disruption. Newcastle. UK. November 2010. Keynote.

2011 The Chemical Climate and Concerns for Fish – Now and in the Future Cefas  Weymouth. Invited Presentation

2011 Applying  Molecular ’Systems Biology’ for Establishing the Mechanisms and
Functional Consequences of Exposure to Endocrine Disrupting Chemicals and other Emerging Contaminants in Fish. Astrazeneca, Brixham, UK

2011 Endocrine disruption in fish in English rivers: Addressing the population level effects question. iSmithers International Conference on Endocrine Disruption, February , Zurich. Keynote

2011 Health Impacts of Environmental Oestrogens on Fish and Fish Populations. 6th International Symposium on Endocrine Disruptors, Copenhagen, Denmark, May 2011 Keynote

2011 Fish, Sex and Gender bending Chemicals, The Feminisation of Fish in English Rivers. South West Water, UK. May  2011.  Invited Presentation

2011 Endocrine disruption in fish in English rivers: Addressing the population level effects question. 9th International Symposium on the Reproductive Physiology of Fish, Cochin, India, Keynote

2011 Critical Considerations for Understanding the Potential Toxicity of Nanoparticles in Fish.  Annual Meeting of SETAC-Europe,  London. Invited Presentation.

2012 Applying Molecular Approaches to Understand the Functional Consequences of Endocrine Disruption in Fish.  British Toxicological Society. Warwick. Keynote

2012 Environmental Oestrogens and Sex in Fish.  European Society for Comparative Physiology and Biochemistry. Bilbao, Spain. Keynote

2012 New systems for understanding the wider health impacts of Environmental Endocrine Disruptors and their mixtures in fish. Gordon Conference. Mount Snow Vermont, USA. Keynote.

2012 The Andrew Stratton Convocation Lecture.  Dartmoors Wildlife – A Photographic Exploration. Exeter, UK

2012 Environmental Endocrine Disruptors. Shaping the Future of Water. Harvard University, USA. Keynote.

2012 Application of molecular tools for advancing understanding on the impacts of Endocrine Disrupting Chemicals in Fish. French Endocrine Disruptor Research Programme, Paris. Keynote

2013 Are manufactured metal/metal oxide nanomaterials in the environment a problem for fish? 8th International Conference on the Environmental Effects of Nanoparticles and Nanomaterials. Marseilles, July 2013. Keynote


Media Coverage

Some of our data have been instrumental in establishing an environmental quality standard for endocrine active chemicals and highlighted other chemicals for further hazard identification. Thus, our research findings have served to improve environmental quality standards.

Our work with colleagues at Brunel University was instrumental in driving the UK Endocrine Disruption Demonstration Programme – a £40M investment by to investigate the more effective treatment technologies for removal of EDCs from wastewater effluent discharges.

Our research has been presented at The Royal Society, House of Commons, and European Commission.

In 2011, our research on endocrine disruption won the University of Exeter Impact Award for Outstanding contribution to Policy and Public Services and was part of the Queens Aniversary Award received by Brunel |University - Protecting the environment from hormone-disrupting chemicals and pollutants.

In 2012, I was awarded the Fisheries Society of the British Isles Beverton Medal for ground breaking research in fish biology

My teams studies on the impact of pollutants on freshwater fish have received considerable media attention and have been the focus of articles published in Science, The Lancet, Science News, Nature and in many of the quality newspapers. Our research has been featured/reported many times in the quality press nationally (Times, Sunday Times, Telegraph, Observer, Guardian and Independent) and in the German, French, US and Japanese press. I have appeared on BBC radio and BBC and Independent television programmes (including, Newsnight, the 9 o'clock and 10 o'clock news, BBC World Service TV, and Country File) to discuss the implications of endocrine disruption and tumours in fish. I have also appeared on programmes broadcast in America, Japan, France and Germany. Our research has been the focus of two Horizon programmes and a Dispatches programme and has also featured in two popular books – Our Stolen Future (Theo Colburn) and The Feminisation of Nature (Deborah Cadbury). Through the media, I have publicised my research teams activities to a very wide audience  and I have written articles on our work for the ‘popular press’, including feature articles for magazines such as BBC wildlife.

I very extensive national and international collaborations with academic institutions, government bodies and industry and funding for it research work is received from UK Research Councils, The European Union, The Environment Agency, DEFRA, and various industries.

Teaching

I teach a wide range of subjects spanning Ecotoxicology (as a final year module), Animal Biology and Evolution, Human Reproduction and Field Courses in Ecology and Wildlife Photography. Lectures on these subjects are delivered to both undergraduates and postgraduates.

Modules

2018/19

Information not currently available


Supervision / Group

Postdoctoral researchers

  • TBA 2013-1015 (NERC KTP)
  • Dr Lisa Bickley 2008-2014 (NERC, DTi KTP, cefas)
  • Dr Shelly Dogra 2012-2015 (EU with Prof Galloway)
  • Dr Amy Filby 2005-2012 (Environment Agency, EU)
  • Dr Rhys Goodhead 2012-2015 (EU)
  • Dr Patrick Hamilton 2005-2012 (DEFRA/NERC)
  • Dr Anke Lange 2003-2013 (NERC/DEFRA)
  • Dr Okyun Lee 2011-2014 (NERC)
  • Dr Aya Takesono 2012-2013 (EU, Interegg)
  • Dr Andrew Watts 2013-2015 (EU project with Prof Galloway)

Postgraduate researchers

  • Anthony Baker 2012-2015 (DEFRA - NanoMaPP)
  • Adam Bates 2013-2016 (Cefas)
  • Ross Brown 2007-2012 (NERC/Industry)
  • Emma Clarke 2011-2014 (MEPS)
  • Elizabeth Collison 2011-2014 (FERA)
  • Ruth Cooper 2011-2014 (KTP)
  • Jenna Corcoran 2008-2013 (BBSRC-CASE)
  • Richard Cross 2014-2017 (Guidenano)
  • Amy Foreman 2013-2016 (EPSRC)
  • James Gardener 2013-2016 (BBSRC Industrial CASE with AstraZeneca)
  • Joanne Gardener 2013-2016 (UoE /Defra/AtstraZeneca)
  • Jon Green 2012-2015 (BBSRC CASE with Astrazeneca)
  • Victoria Jennings 2011-2014 (NERC)
  • Carole Lee 2017-present
  • Lowell Mills 2014-2017 (NERC)
  • John Moreman 2011-2014 (Environment Agency /University of Exeter)
  • Sam Newbatt 2011-2014 (Cefas)
  • Olivia Osbourne 2009-2013 (University funded/Env Agency)
  • Aoife Parsons 2012-2015 (DEFRA/CEFAS)
  • Nicholas Rogers 2011-2014 (KTP)
  • Krista D. Sherman
  • Charlotte Teague 2012-2015 (cefas)
  • Simone Tinguely 2011-2013 (Self funded)
  • Tamsin Uren 2009-2012 (NERC-CASE)
  • Bas Verbruggen 2012-2015 (UoE)
  • Stephanie Wright 2011-2014 (Defra)
  • Sara Zonneveld 2013-2016 (UoE/DNP)

Alumni

  • Dr Jon Aust
  • Dr Jon Ball
  • Dr Kevin Coward
  • Dr Julia Fabregas
  • Dr Martina Fenske
  • Dr Jules Harries
  • Dr Blair Johnston
  • Dr Joon Kwon
  • Dr Katherine Liney
  • Dr Gerd Maack
  • Dr Jon Nash
  • Dr Maren Ortiz Zarragoitia (Visiting Research Fellow)
  • Dr Greg Paull
  • Dr Francisco Prat
  • Dr Eduarda Santos
  • Dr Marion Sebire
  • Colin Spray
  • Dr Karen Thorpe
  • Dr Ronny van Aerle

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