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Dr Christine Sambles

Dr Christine Sambles

Research Fellow

 3852

 01392 723852

 Biocatalysis Centre BC2.6

 

Biocatalysis Centre, University of Exeter, The Henry Wellcome Building for Biocatalysis, Stocker Road, Exeter, EX4 4QD , UK

Overview

I am a bioinformatician working in the field of plant-microbial interactions at the University of Exeter. My research within the Plant Science group is concentrated in two areas, fungal and oomycete plant pathogens and microalgae and their associated bacteria.

My current research with Dr. David Studholme and Professor Murray Grant (Warwick) involves developing a novel method to screen for resistance to ash dieback disease.

Of particular interest analysing genome, transcriptomic and metabolomic data with a 'multi-omics' approach which could significantly aid metabolic pathway analysis and gene function discovery in a variety of biological systems. Effectively visualising the vast quantities of complex data and communicating this clearly to scientists and the public is also an important aspect of my work.

Qualifications

2007: PhD Biological Sciences, Cardiff University 
2003: MRes Molecular & Ceullar Biology, University of Birmingham
2001: BSc (Hons) Biochemistry, Cardiff University

Career

2013-present: Research Fellow, BBSRC/NORNEX/Shell, University of Exeter.

2012-2013: Experimental Officer, Wellcome Trust Biomedical Informatics Hub, University of Exeter.

2008-2012: Associate Research Fellow, Exeter Microbial Biofuels Group, University of Exeter.

2007-2008: Senior Molecular Biologist, Innovation Centre, Exeter.

2001-2002: Assistant Scientist, South West Water.

Links

Research

Research interests

My previous research was with the BBSRC-funded Nornex project (a response to ash dieback caused by the fungus Chalara fraxinea). Led by Professor Allan Downie at the John Innes Centre (JIC), the consortium includes: The Sainsbury Laboratory, East Malling Research, the University of Exeter, the University of York, The Genepool at the University of Edinburgh, the Norwegian Forest and Landscape Institute, The Genome Analysis Centre, Forest Research and the University of Copenhagen. We plan to understand how the disease spreads and how some ash trees can partially resist attack, to enable the development of effective disease control strategies. It is essential that we uncover this information as quickly as possible in order to respond quickly to the threat. We are already utilising the power of crowd-sourcing, this allows the findings of all the project partners to be instantly shared and analysed through the Open Ash Dieback website www.oadb.tsl.ac.uk.

I also also part of the Exeter Microbial Biofuels Group, directed by Dr. John Love and funded by Shell and the BBSRC. We employ a multidisciplinary combination of high throughput molecular biology, cellular imaging, biochemistry, bioinformatics and synthetic biology to investigate the potential for microscopic algae and bacteria to become viable sources of biofuels in the future.

Publications

Key publications | Publications by category | Publications by year

Key publications


Sambles CM, Salmon DL, Florance H, Howard TP, Smirnoff N, Nielsen LR, McKinney LV, Kjær ED, Buggs RJA, Studholme DJ, et al (In Press). Ash leaf metabolomes reveal differences between trees tolerant and susceptible to ash dieback disease. Sci Data, 4 Abstract.  Author URL.
Sollars ESA, Harper AL, Kelly LJ, Sambles CM, Ramirez-Gonzalez RH, Swarbreck D, Kaithakottil G, Cooper ED, Uauy C, Havlickova L, et al (In Press). Genome sequence and genetic diversity of European ash trees. Nature, 541(7636), 212-216. Abstract.  Author URL.  Full text.
Sambles C, Middelhaufe S, Soanes D, Kolak D, Lux T, Moore K, Matoušková P, Parker D, Lee R, Love J, et al (2017). Genome sequence of the oleaginous yeast Rhodotorula toruloides strain CGMCC 2.1609. Genomics Data, 13, 1-2. Full text.
Tennant RK, Sambles CM, Diffey GE, Moore KA, Love J (2017). Metagenomic Analysis of Silage. Journal of Visualized Experiments, 119, e54936-e54936. Full text.
Sambles C, Moore K, Lux TM, Jones K, Littlejohn GR, Gouveia JD, Aves SJ, Studholme DJ, Lee R, Love J, et al (2017). Metagenomic analysis of the complex microbial consortium associated with cultures of the oil-rich alga. Botryococcus braunii. MicrobiologyOpen, e00482-e00482. Full text.
Bechtold U, Penfold CA, Jenkins DJ, Legaie R, Moore JD, Lawson T, Matthews JSA, Vialet-Chabrand SRM, Baxter L, Subramaniam S, et al (2016). Time-Series Transcriptomics Reveals That AGAMOUS-LIKE22 Affects Primary Metabolism and Developmental Processes in Drought-Stressed Arabidopsis. Plant Cell, 28(2), 345-366. Abstract.  Author URL.  Full text.

Publications by category


Journal articles

Sambles CM, Salmon DL, Florance H, Howard TP, Smirnoff N, Nielsen LR, McKinney LV, Kjær ED, Buggs RJA, Studholme DJ, et al (In Press). Ash leaf metabolomes reveal differences between trees tolerant and susceptible to ash dieback disease. Sci Data, 4 Abstract.  Author URL.
Sollars ESA, Harper AL, Kelly LJ, Sambles CM, Ramirez-Gonzalez RH, Swarbreck D, Kaithakottil G, Cooper ED, Uauy C, Havlickova L, et al (In Press). Genome sequence and genetic diversity of European ash trees. Nature, 541(7636), 212-216. Abstract.  Author URL.  Full text.
Barchinger SE, Pirbadian S, Sambles C, Baker CS, Leung KM, Burroughs NJ, El-Naggar MY, Golbeck JH (In Press). Regulation of Gene Expression in Shewanella oneidensis MR-1 during Electron Acceptor Limitation and Bacterial Nanowire Formation. Appl Environ Microbiol, 82(17), 5428-5443. Abstract.  Author URL.
Sambles C, Middelhaufe S, Soanes D, Kolak D, Lux T, Moore K, Matoušková P, Parker D, Lee R, Love J, et al (2017). Genome sequence of the oleaginous yeast Rhodotorula toruloides strain CGMCC 2.1609. Genomics Data, 13, 1-2. Full text.
Tennant RK, Sambles CM, Diffey GE, Moore KA, Love J (2017). Metagenomic Analysis of Silage. Journal of Visualized Experiments, 119, e54936-e54936. Full text.
Sambles C, Moore K, Lux TM, Jones K, Littlejohn GR, Gouveia JD, Aves SJ, Studholme DJ, Lee R, Love J, et al (2017). Metagenomic analysis of the complex microbial consortium associated with cultures of the oil-rich alga. Botryococcus braunii. MicrobiologyOpen, e00482-e00482. Full text.
Jones KJ, Moore K, Sambles C, Love J, Studholme DJ, Aves SJ (2016). Draft Genome Sequences of Achromobacter piechaudii GCS2, Agrobacterium sp. Strain SUL3, Microbacterium sp. Strain GCS4, Shinella sp. Strain GWS1, and Shinella sp. Strain SUS2 Isolated from Consortium with the Hydrocarbon-Producing Alga Botryococcus braunii. Genome Announc, 4(1). Abstract.  Author URL.  Full text.
Studholme DJ, McDougal RL, Sambles C, Hansen E, Hardy G, Grant M, Ganley RJ, Williams NM (2016). Genome sequences of six Phytophthora species associated with forests in New Zealand. Genomics Data, 7, 54-56. Abstract.  Full text.
Bechtold U, Penfold CA, Jenkins DJ, Legaie R, Moore JD, Lawson T, Matthews JSA, Vialet-Chabrand SRM, Baxter L, Subramaniam S, et al (2016). Time-Series Transcriptomics Reveals That AGAMOUS-LIKE22 Affects Primary Metabolism and Developmental Processes in Drought-Stressed Arabidopsis. Plant Cell, 28(2), 345-366. Abstract.  Author URL.  Full text.
Sambles C, Schlenzig A, O'Neill P, Grant M, Studholme DJ (2015). Draft genome sequences of Phytophthora kernoviae and Phytophthora ramorum lineage EU2 from Scotland. Genomics Data, 6, 193-194. Full text.
Sambles CM, White DA (2015). Genome Sequence of Rhodococcus sp. Strain PML026, a Trehalolipid Biosurfactant Producer and Biodegrader of Oil and Alkanes. Genome Announc, 3(3). Abstract.  Author URL.
Sharma R, Xia X, Cano LM, Evangelisti E, Kemen E, Judelson H, Oome S, Sambles C, van den Hoogen DJ, Kitner M, et al (2015). Genome analyses of the sunflower pathogen Plasmopara halstedii provide insights into effector evolution in downy mildews and Phytophthora. BMC Genomics, 16 Abstract.  Author URL.  Full text.
Airs RL, Temperton B, Sambles C, Farnham G, Skill SC, Llewellyn CA (2014). Chlorophyll f and chlorophyll d are produced in the cyanobacterium Chlorogloeopsis fritschii when cultured under natural light and near-infrared radiation. FEBS Letters, ---. Abstract.
Wagley S, Newcombe J, Laing E, Yusuf E, Sambles CM, Studholme DJ, La Ragione RM, Titball RW, Champion OL (2014). Differences in carbon source utilisation distinguish Campylobacter jejuni from Campylobacter coli. BMC Microbiol, 14 Abstract.  Author URL.  Full text.
Jameson E, Mann NH, Joint I, Sambles C, Mühling M (2011). The diversity of cyanomyovirus populations along a North-South Atlantic Ocean transect. ISME J, 5(11), 1713-1721. Abstract.  Author URL.
Ford AT, Sambles C, Kille P (2008). Intersexuality in crustaceans: genetic, individual and population level effects. Mar Environ Res, 66(1), 146-148. Abstract.  Author URL.
Blagg SL, Stewart M, Sambles C, Insall RH (2003). PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium. Curr Biol, 13(17), 1480-1487. Abstract.  Author URL.

Conferences

Pirbadian S, Barchinger SE, Subramanian P, Sambles CM, Baker CS, Burroughs NJ, Jensen GJ, Golbeck JH, El-Naggar MY (2016). Multiheme Cytochromes and the Bacterial Nanowires of Shewanella oneidensis MR-1: Regulation, Structure, and Extracellular Electron Transport Mechanisms.  Author URL.

Publications by year


In Press

Sambles CM, Salmon DL, Florance H, Howard TP, Smirnoff N, Nielsen LR, McKinney LV, Kjær ED, Buggs RJA, Studholme DJ, et al (In Press). Ash leaf metabolomes reveal differences between trees tolerant and susceptible to ash dieback disease. Sci Data, 4 Abstract.  Author URL.
Sollars ESA, Harper AL, Kelly LJ, Sambles CM, Ramirez-Gonzalez RH, Swarbreck D, Kaithakottil G, Cooper ED, Uauy C, Havlickova L, et al (In Press). Genome sequence and genetic diversity of European ash trees. Nature, 541(7636), 212-216. Abstract.  Author URL.  Full text.
Barchinger SE, Pirbadian S, Sambles C, Baker CS, Leung KM, Burroughs NJ, El-Naggar MY, Golbeck JH (In Press). Regulation of Gene Expression in Shewanella oneidensis MR-1 during Electron Acceptor Limitation and Bacterial Nanowire Formation. Appl Environ Microbiol, 82(17), 5428-5443. Abstract.  Author URL.

2017

Sambles C (2017). Genome annotation of the oleaginous yeast Rhodotorula toruloides strain CGMCC 2.1609.  Abstract.  Author URL.
Sambles C, Middelhaufe S, Soanes D, Kolak D, Lux T, Moore K, Matoušková P, Parker D, Lee R, Love J, et al (2017). Genome sequence of the oleaginous yeast Rhodotorula toruloides strain CGMCC 2.1609. Genomics Data, 13, 1-2. Full text.
Tennant RK, Sambles CM, Diffey GE, Moore KA, Love J (2017). Metagenomic Analysis of Silage. Journal of Visualized Experiments, 119, e54936-e54936. Full text.
Sambles C, Moore K, Lux TM, Jones K, Littlejohn GR, Gouveia JD, Aves SJ, Studholme DJ, Lee R, Love J, et al (2017). Metagenomic analysis of the complex microbial consortium associated with cultures of the oil-rich alga. Botryococcus braunii. MicrobiologyOpen, e00482-e00482. Full text.

2016

Jones KJ, Moore K, Sambles C, Love J, Studholme DJ, Aves SJ (2016). Draft Genome Sequences of Achromobacter piechaudii GCS2, Agrobacterium sp. Strain SUL3, Microbacterium sp. Strain GCS4, Shinella sp. Strain GWS1, and Shinella sp. Strain SUS2 Isolated from Consortium with the Hydrocarbon-Producing Alga Botryococcus braunii. Genome Announc, 4(1). Abstract.  Author URL.  Full text.
Studholme DJ, McDougal RL, Sambles C, Hansen E, Hardy G, Grant M, Ganley RJ, Williams NM (2016). Genome sequences of six Phytophthora species associated with forests in New Zealand. Genomics Data, 7, 54-56. Abstract.  Full text.
Pirbadian S, Barchinger SE, Subramanian P, Sambles CM, Baker CS, Burroughs NJ, Jensen GJ, Golbeck JH, El-Naggar MY (2016). Multiheme Cytochromes and the Bacterial Nanowires of Shewanella oneidensis MR-1: Regulation, Structure, and Extracellular Electron Transport Mechanisms.  Author URL.
Bechtold U, Penfold CA, Jenkins DJ, Legaie R, Moore JD, Lawson T, Matthews JSA, Vialet-Chabrand SRM, Baxter L, Subramaniam S, et al (2016). Time-Series Transcriptomics Reveals That AGAMOUS-LIKE22 Affects Primary Metabolism and Developmental Processes in Drought-Stressed Arabidopsis. Plant Cell, 28(2), 345-366. Abstract.  Author URL.  Full text.

2015

Sambles C, Schlenzig A, O'Neill P, Grant M, Studholme DJ (2015). Draft genome sequences of Phytophthora kernoviae and Phytophthora ramorum lineage EU2 from Scotland. Genomics Data, 6, 193-194. Full text.
Sambles CM, White DA (2015). Genome Sequence of Rhodococcus sp. Strain PML026, a Trehalolipid Biosurfactant Producer and Biodegrader of Oil and Alkanes. Genome Announc, 3(3). Abstract.  Author URL.
Sharma R, Xia X, Cano LM, Evangelisti E, Kemen E, Judelson H, Oome S, Sambles C, van den Hoogen DJ, Kitner M, et al (2015). Genome analyses of the sunflower pathogen Plasmopara halstedii provide insights into effector evolution in downy mildews and Phytophthora. BMC Genomics, 16 Abstract.  Author URL.  Full text.

2014

Airs RL, Temperton B, Sambles C, Farnham G, Skill SC, Llewellyn CA (2014). Chlorophyll f and chlorophyll d are produced in the cyanobacterium Chlorogloeopsis fritschii when cultured under natural light and near-infrared radiation. FEBS Letters, ---. Abstract.
Wagley S, Newcombe J, Laing E, Yusuf E, Sambles CM, Studholme DJ, La Ragione RM, Titball RW, Champion OL (2014). Differences in carbon source utilisation distinguish Campylobacter jejuni from Campylobacter coli. BMC Microbiol, 14 Abstract.  Author URL.  Full text.

2011

Jameson E, Mann NH, Joint I, Sambles C, Mühling M (2011). The diversity of cyanomyovirus populations along a North-South Atlantic Ocean transect. ISME J, 5(11), 1713-1721. Abstract.  Author URL.

2008

Ford AT, Sambles C, Kille P (2008). Intersexuality in crustaceans: genetic, individual and population level effects. Mar Environ Res, 66(1), 146-148. Abstract.  Author URL.

2003

Blagg SL, Stewart M, Sambles C, Insall RH (2003). PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium. Curr Biol, 13(17), 1480-1487. Abstract.  Author URL.

christine_sambles Details from cache as at 2018-12-13 01:23:46

Refresh publications

External Engagment and Impact

Media Coverage

Metabolite markers of resistance to ash dieback

Teaching

I train PDRAs and supervise PhD and undergraduate students in aspects of bioinformatics analyses, visualisation of complex data and programming and was an advisor for the Exeter International Genetically Engineered Machine (iGEM) competition team (2012, 2014-2015). In 2012, our Exeter e-candi (http://2012.igem.org/Team:Exeter) team won a bronze medal at the European rounds in Amsterdam for their work towards rapid biosynthesis of designer polysaccharides. In 2014, the E.R.A.S.E (http://2014.igem.org/Team:Exeter) team worked on "Explosive remediation by applied synthetic E.coli" and won a gold award at the Giant Jamboree in Boston, USA.

 

Supervision / Group

Alumni

  • Charlotte Cook PhD student: Completed 2015

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