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Dr Eduarda Santos

Dr Eduarda Santos

Senior Lecturer in Environmental Biology

 4607

 Geoffrey Pope 222

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Eduarda Santos and Tamsyn Uren-Webster

Illumina HiSeq 2000

Overview

I am an environmental biologist investigating reproductive development and function and the susceptibility of these processes to disruption by environmental stressors. My research focuses on fish and has ranged from investigating the endocrine control of reproduction to addressing the population level effects of chemical exposure for wild fish, using systems biology strategies. I am part of the Environmental Biology research group.

Please contact me if interested in discussing MRes of PhD studies within my research group.

Qualifications

2010 Postgraduate Certificate in Academic Practice, University of Exeter, UK

2002 PhD in Fish Reproductive Endocrinology, Brunel University, UK

1995 Degree in Aquatic Sciences, University of Porto, Portugal

Career

2014-Present Senior Lecturer in Environmental Biology, University of Exeter

2008-2014 Lecturer in Environmental Biology, University of Exeter

2005-2008 NERC Postdoctoral Researcher, University of Exeter

2001-2005 BBSRC Postdoctoral Researcher, University of Exeter

Research group links

Tamsyn Uren-Webster in the lab

Dr Eduarda Santos

Tamsyn Uren-Webster in the lab

Research

Research interests

The research focus in my group is to understand the dynamics of sexual development and function, and how environmental stressors impact on reproduction and health in fish. This area of research is a vast and exiting one and potentially benefits aquaculture and fisheries as well as environmental and human health.

Our research to date spanned from investigations into the endocrine regulation of oocyte development in rainbow trout (Oncorhynchus mykiss), to the identification of the gene pathways underlying sexual dimorphism in the zebrafish (Danio rerio) and how they are disrupted by exposure to oestrogens. This work established links between the gene pathways disrupted by ethinyloestradiol, a potent oestrogen present in the contraceptive pill and widespread in the environment, and the decrease in fecundity in zebrafish colonies. The project raised wide interest and was presented at the Royal Society’s Summer Science Exhibition in 2004.

Further research has aimed to establishing the effects of exposure to model environmental chemicals (including a synthetic oestrogen (ethinyloestradiol), a metal (copper) and a polyaromatic hydrocarbon (dibenzanthracene)) at the individual and population levels, in three-spined stickleback (Gasterosteus aculeatus). This work resulted in the discovery of the involvement of the cholesterol biosynthesis pathway in the toxicological response to copper in this species. These studies were conducted using a systems biology approach where genomics, transcriptomics, metabolomics and population level datasets are integrated to generate a global picture of the consequences of exposure to environmental chemicals in wild populations of fish.

Current projects in my laboratory are focusing on the effects of chemicals stressors on the brown trout (Salmo trutta), a species of ecological and economic importance in UK waters. To address this issue, we are sequencing the transcriptome of the brown trout and using RNA-Seq strategies to provide a comprehensive analysis of the mechanisms of toxicity of a range of chemicals on this species.

We are also investigating the effects of combined stressors on the physiology of a number of fish species, to provide a more realistic analysis of the stressors that fish encounter in their environment.

Research grants

  • 2013 PhD studentship (SWDTP)
    Using integrative physiology to improve the sustainability of fish aquaculture. Co-I.
  • 2013 PhD studentship (Fisheries Society of the British Isles)
    Differential susceptibility to copper in wild populations of three-spined stickleback. PI.
  • 2012 Visiting PhD Studentship (National Taiwan University)
    The role of DNA methylation on sexual determination and development in zebrafish germ cells. PI
  • 2012 PhD Studentship (CEFAS and University of Exeter)
    Effects of hypoxia on the toxicity of model chemicals in the three-spined stickleback (Gasterosteus aculeatus). PI
  • 2012 Society for Reproduction and Fertility
    The role of DNA methylation on sex determination and development in zebrafish germ cells. PI
  • 2012 Cefas and University of Exeter
    Building a Molecular Platform for Understanding the Host-Pathogen Interface in Invertebrates. CoI
  • 2011 Cefas
    Investigating the potential molecular mechanisms associated with white spot virus resistance in Carcinus maenas. CoI
  • 2011 Fisheries Society of the British Isles
    Searching for evidence of adaptation to copper in a population of three-spined stickleback. PI
  • 2011 Wellcome Trust
    Influence of hypoxia on chemical toxicity during embryogenesis. PI
  • 2011 BBSRC PhD Studentship
    Physiology of gut carbonate production by marine fish - roles of hypoxia and sex hormones. CoI
  • 2009 NERC CASE Studentship (open competition)
    PhD studentship (with the Salmon and Trout Association) - Endocrine disrupting chemicals (EDCs) and the sustainability of brown trout populations in the UK: relative impact of EDCs compared with other environmental stressors. PI
  • 2009 AstraZeneca
    DTI KTP - Implementation of Molecular Tools into chemical testing. CoI
  • 2008 Royal Society Travel Grant
    Travel grant to attend the SETAC Europe 18th Annual Meeting
  • 2008 Royal Society Research Grant
    Identifying the molecular basis of sexual dominance in male zebrafish.
  • 2004 Fisheries Society of the British Isles
    Travel Grant to attend the 5th International Symposium on Fish Endocrinology.

Publications

Key publications | Publications by category | Publications by year

Key publications


Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (In Press). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract.  Author URL.  Full text.
Porteus CS, Hubbard PC, Uren Webster TM, van Aerle R, Canário AVM, Santos EM, Wilson RW (2018). Near-future CO<inf>2</inf>levels impair the olfactory system of a marine fish. Nature Climate Change, 8(8), 737-743. Abstract.  Full text.
Fitzgerald JA, Jameson HM, Fowler VHD, Bond GL, Bickley LK, Webster TMU, Bury NR, Wilson RJ, Santos EM (2016). Hypoxia Suppressed Copper Toxicity during Early Development in Zebrafish Embryos in a Process Mediated by the Activation of the HIF Signaling Pathway. Environ Sci Technol, 50(8), 4502-4512. Abstract.  Author URL.  Full text.
Uren Webster TM, Perry MH, Santos EM (2015). The herbicide linuron inhibits cholesterol biosynthesis and induces cellular stress responses in brown trout. Environ Sci Technol, 49(5), 3110-3118. Abstract.  Author URL.  Full text.
Uren Webster TM, Laing LV, Florance H, Santos EM (2014). Effects of glyphosate and its formulation, roundup, on reproduction in zebrafish (Danio rerio). Environ Sci Technol, 48(2), 1271-1279. Abstract.  Author URL.  Full text.

Publications by category


Journal articles

van Aerle R, Santos EM (In Press). Advances in the application of high-throughput sequencing in invertebrate virology. J Invertebr Pathol, 147, 145-156. Abstract.  Author URL.
Bickley LK, van Aerle R, Brown AR, Hargreaves A, Huby R, Cammack V, Jackson R, Santos EM, Tyler CR (In Press). Bioavailability and Kidney Responses to Diclofenac in the Fathead Minnow (Pimephales promelas). Environ Sci Technol, 51(3), 1764-1774. Abstract.  Author URL.  Full text.
Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (In Press). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract.  Author URL.  Full text.
Gordon TAC, Harding HR, Clever FK, Davidson IK, Davison W, Montgomery DW, Weatherhead RC, Windsor FM, Armstrong JD, Bardonnet A, et al (2018). Fishes in a changing world: learning from the past to promote sustainability of fish populations. J Fish Biol, 92(3), 804-827. Abstract.  Author URL.  Full text.
Porteus CS, Hubbard PC, Uren Webster TM, van Aerle R, Canário AVM, Santos EM, Wilson RW (2018). Near-future CO<inf>2</inf>levels impair the olfactory system of a marine fish. Nature Climate Change, 8(8), 737-743. Abstract.  Full text.
Laing LV, Viana J, Dempster EL, Uren Webster TM, van Aerle R, Mill J, Santos EM (2018). Sex-specific transcription and DNA methylation profiles of reproductive and epigenetic associated genes in the gonads and livers of breeding zebrafish. Comp Biochem Physiol a Mol Integr Physiol, 222, 16-25. Abstract.  Author URL.  Full text.
Fitzgerald JA, Katsiadaki I, Santos EM (2017). Contrasting effects of hypoxia on copper toxicity during development in the three-spined stickleback (Gasterosteus aculeatus). Environ Pollut, 222, 433-443. Abstract.  Author URL.  Full text.
Uren Webster TM, Williams TD, Katsiadaki I, Lange A, Lewis C, Shears JA, Tyler CR, Santos EM (2017). Hepatic transcriptional responses to copper in the three-spined stickleback are affected by their pollution exposure history. Aquat Toxicol, 184, 26-36. Abstract.  Author URL.  Full text.
Fitzgerald JA, Jameson HM, Fowler VHD, Bond GL, Bickley LK, Webster TMU, Bury NR, Wilson RJ, Santos EM (2016). Hypoxia Suppressed Copper Toxicity during Early Development in Zebrafish Embryos in a Process Mediated by the Activation of the HIF Signaling Pathway. Environ Sci Technol, 50(8), 4502-4512. Abstract.  Author URL.  Full text.
Verbruggen B, Bickley LK, van Aerle R, Bateman KS, Stentiford GD, Santos EM, Tyler CR (2016). Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments. Viruses, 8(1). Abstract.  Author URL.  Full text.
Verbruggen B, Bickley LK, Santos EM, Tyler CR, Stentiford GD, Bateman KS, van Aerle R (2015). De novo assembly of the Carcinus maenas transcriptome and characterization of innate immune system pathways. BMC Genomics, 16 Abstract.  Author URL.  Full text.
Uren Webster TM, Santos EM (2015). Global transcriptomic profiling demonstrates induction of oxidative stress and of compensatory cellular stress responses in brown trout exposed to glyphosate and Roundup. BMC Genomics, 16 Abstract.  Author URL.  Full text.
Uren Webster TM, Shears JA, Moore K, Santos EM (2015). Identification of conserved hepatic transcriptomic responses to 17β-estradiol using high-throughput sequencing in brown trout. Physiol Genomics, 47(9), 420-431. Abstract.  Author URL.  Full text.
Uren Webster TM, Perry MH, Santos EM (2015). The herbicide linuron inhibits cholesterol biosynthesis and induces cellular stress responses in brown trout. Environ Sci Technol, 49(5), 3110-3118. Abstract.  Author URL.  Full text.
Uren Webster TM, Laing LV, Florance H, Santos EM (2014). Effects of glyphosate and its formulation, roundup, on reproduction in zebrafish (Danio rerio). Environ Sci Technol, 48(2), 1271-1279. Abstract.  Author URL.  Full text.
Santos E, Webster TU (2014). Secrets of cornwall's metal-tolerant trout. Planet Earth(SPRING), 28-29.
Uren Webster TM, Bury N, van Aerle R, Santos EM (2013). Global transcriptome profiling reveals molecular mechanisms of metal tolerance in a chronically exposed wild population of brown trout. Environ Sci Technol, 47(15), 8869-8877. Abstract.  Author URL.  Full text.
van Aerle R, Lange A, Moorhouse A, Paszkiewicz K, Ball K, Johnston BD, de-Bastos E, Booth T, Tyler CR, Santos EM, et al (2013). Molecular mechanisms of toxicity of silver nanoparticles in zebrafish embryos. Environ Sci Technol, 47(14), 8005-8014. Abstract.  Author URL.  Full text.
Santos EM, Hamilton PB, Coe TS, Ball JS, Cook AC, Katsiadaki I, Tyler CR (2013). Population bottlenecks, genetic diversity and breeding ability of the three-spined stickleback (Gasterosteus aculeatus) from three polluted English Rivers. Aquatic Toxicology, 142-143, 264-271. Abstract.
Fu J, Han J, Zhou B, Gong Z, Santos EM, Huo X, Zheng W, Liu H, Yu H, Liu C, et al (2013). Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of developmental toxicity. Environ Sci Technol, 47(18), 10574-10582. Abstract.  Author URL.
Al-Jandal NJ, Whittamore JM, Santos EM, Wilson RW (2011). The influence of 17β-estradiol on intestinal calcium carbonate precipitation and osmoregulation in seawater-acclimated rainbow trout (Oncorhynchus mykiss). J Exp Biol, 214(Pt 16), 2791-2798. Abstract.  Author URL.
Scown TM, Santos EM, Johnston BD, Gaiser B, Baalousha M, Mitov S, Lead JR, Stone V, Fernandes TF, Jepson M, et al (2010). Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow trout. Toxicol Sci, 115(2), 521-534. Abstract.  Author URL.
Katsiadaki I, Williams TD, Ball JS, Bean TP, Sanders MB, Wu H, Santos EM, Brown MM, Baker P, Ortega F, et al (2010). Hepatic transcriptomic and metabolomic responses in the Stickleback (Gasterosteus aculeatus) exposed to ethinyl-estradiol. Aquat Toxicol, 97(3), 174-187. Abstract.  Author URL.
Santos EM, Ball JS, Williams TD, Wu H, Ortega F, van Aerle R, Katsiadaki I, Falciani F, Viant MR, Chipman JK, et al (2010). Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model. Environ Sci Technol, 44(2), 820-826. Abstract.  Author URL.
Van Aggelen G, Ankley GT, Baldwin WS, Bearden DW, Benson WH, Chipman JK, Collette TW, Craft JA, Denslow ND, Embry MR, et al (2010). Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook. Environ Health Perspect, 118(1), 1-5. Abstract.  Author URL.
Uren-Webster TM, Lewis C, Filby AL, Paull GC, Santos EM (2010). Mechanisms of toxicity of di(2-ethylhexyl) phthalate on the reproductive health of male zebrafish. Aquat Toxicol, 99(3), 360-369. Abstract.  Author URL.
Oehlmann J, Schulte-Oehlmann U, Kloas W, Jagnytsch O, Lutz I, Kusk KO, Wollenberger L, Santos EM, Paull GC, VanLook KJW, et al (2009). A critical analysis of the biological impacts of plasticizers on wildlife. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1526), 2047-2062. Abstract.
Williams TD, Wu H, Santos EM, Ball J, Katsiadaki I, Brown MM, Baker P, Ortega F, Falciani F, Craft JA, et al (2009). Hepatic transcriptomic and metabolomic responses in the stickleback (Gasterosteus aculeatus) exposed to environmentally relevant concentrations of dibenzanthracene. Environ Sci Technol, 43(16), 6341-6348. Abstract.  Author URL.
Williams TD, Brown M, Chipman JK, Falciani F, Ortega F, Geoghegan F, Craft JA, Katsiadaki I, Ball J, Tyler CR, et al (2008). Development of a stickleback (Gasterosteus aculeatus) cDNA microarray and gene expression responses to dibenzanthracene, ethinyl-estradiol and copper. MARINE ENVIRONMENTAL RESEARCH, 66(1), 140-140. Author URL.
Santos EM, Kille P, Workman VL, Paull GC, Tyler CR (2008). Sexually dimorphic gene expression in the brains of mature zebrafish. Comp Biochem Physiol a Mol Integr Physiol, 149(3), 314-324. Abstract.  Author URL.
Paull GC, Van Look KJW, Santos EM, Filby AL, Gray DM, Nash JP, Tyler CR (2008). Variability in measures of reproductive success in laboratory-kept colonies of zebrafish and implications for studies addressing population-level effects of environmental chemicals. Aquat Toxicol, 87(2), 115-126. Abstract.  Author URL.
Filby AL, Santos EM, Thorpe KL, Maack G, Tyler CR (2007). Gene expression profiling for understanding chemical causation of biological effects for complex mixtures: a case study on estrogens. Environ Sci Technol, 41(23), 8187-8194. Abstract.  Author URL.
Santos EM, Paull GC, Van Look KJW, Workman VL, Holt WV, van Aerle R, Kille P, Tyler CR (2007). Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio). Aquat Toxicol, 83(2), 134-142. Abstract.  Author URL.
Santos EM, Workman VL, Paull GC, Filby AL, Van Look KJW, Kille P, Tyler CR (2007). Molecular basis of sex and reproductive status in breeding zebrafish. Physiol Genomics, 30(2), 111-122. Abstract.  Author URL.
Tyler C, Lange A, Santos E, Filby A (2007). The application of transcriptomics and other molecular approaches in advancing our understanding of endocrine disruption. TOXICOLOGY LETTERS, 172, S27-S27. Author URL.
Santos E, Paull G, Filby A, Tyler C, Van Look K, Holt W, Workman V, Kille P (2006). Gender and stage-specific transcriptomic profiles of gonads and brains in breeding zebrafish. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 143(4), S101-S101. Author URL.
Tyler CR, Spary C, Gibson R, Santos EM, Shears J, Hill EM (2005). Accounting for differences in estrogenic responses in rainbow trout (Oncorhynchus mykiss: Salmonidae) and roach (Rutilus rutilus: Cyprinidae) exposed to effluents from wastewater treatment works. Environ Sci Technol, 39(8), 2599-2607. Abstract.  Author URL.
Williams, R. Johnson, A. (2005). Predicted exposures to steroid estrogens in UK Rivers correlate with widespread sexual disruption in wild fish populations. Environmental Health Perspectives, 32-39.
Tyler CR, van Aerle R, Santos EM (2004). ELISAs for detecting vitellogenin in the fathead minnow (Pimephales promelas)-a critical analysis. Response to Mylchreest et al. Comp Biochem Physiol C 134: 251-257, 2003. Comp Biochem Physiol C Toxicol Pharmacol, 138(4), 531-532. Author URL.
Santos EM, Rand-Weaver M, Tyler CR (2001). Follicle-stimulating hormone and its alpha and beta subunits in rainbow trout (Oncorhynchus mykiss): purification, characterization, development of specific radioimmunoassays, and their seasonal plasma and pituitary concentrations in females. Biol Reprod, 65(1), 288-294. Abstract.  Author URL.
Cavaco, J.E.B. Rebers, F.E.M. Vischer, H.F. (2001). Gonadotrophins, their receptors, and regulation of testicular functions in fish. Comparative Biochemistry and Physiology Part B, 129, 407-417.
Harris CA, Santos EM, Janbakhsh A, Pottinger TG, Tyler CR, Sumpter JP (2001). Nonylphenol affects gonadotropin levels in the pituitary gland and plasma of female rainbow trout. Environ Sci Technol, 35(14), 2909-2916. Abstract.  Author URL.
Tyler CR, Pottinger TG, Santos E, Sumpter JP, Price SA, Brooks S, Nagler JJ (1996). Mechanisms controlling egg size and number in the rainbow trout, Oncorhynchus mykiss. Biol Reprod, 54(1), 8-15. Abstract.  Author URL.

Chapters

Lewis C, Santos EM (2016). Physiological impacts of chemical pollutants in marine animals. In Solan M, Whiteley N (Eds.) Stressors in the Marine Environment, Oxford University Press, 73-92.
Tyler CR, Filby AL, van Aerle R, Lange A, Ball J, Santos EM (2008). Fish toxicogenomics. In  (Ed) Advances in Experimental Biology, Elsevier.

Conferences

Tyler C, Lange A, Santos E, Coe T, Paull G, Filby A, Hamilton P (2008). The feminization of fish in English rivers: Causation, mechanisms, and significance.  Author URL.
Tyler CR, Ball J, Maack G, Paull G, Santos EM (2002). Endocrine disruption in vertebrate wildlife - Today's story.  Author URL.
Schulz RW, Vischer HF, Cavaco JEB, Santos EM, Tyler CR, Goos HJT, Bogerd J (2001). Gonadotropins, their receptors, and the regulation of testicular functions in fish.  Author URL.

Publications by year


In Press

van Aerle R, Santos EM (In Press). Advances in the application of high-throughput sequencing in invertebrate virology. J Invertebr Pathol, 147, 145-156. Abstract.  Author URL.
Bickley LK, van Aerle R, Brown AR, Hargreaves A, Huby R, Cammack V, Jackson R, Santos EM, Tyler CR (In Press). Bioavailability and Kidney Responses to Diclofenac in the Fathead Minnow (Pimephales promelas). Environ Sci Technol, 51(3), 1764-1774. Abstract.  Author URL.  Full text.
Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (In Press). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract.  Author URL.  Full text.

2018

Gordon TAC, Harding HR, Clever FK, Davidson IK, Davison W, Montgomery DW, Weatherhead RC, Windsor FM, Armstrong JD, Bardonnet A, et al (2018). Fishes in a changing world: learning from the past to promote sustainability of fish populations. J Fish Biol, 92(3), 804-827. Abstract.  Author URL.  Full text.
Porteus CS, Hubbard PC, Uren Webster TM, van Aerle R, Canário AVM, Santos EM, Wilson RW (2018). Near-future CO<inf>2</inf>levels impair the olfactory system of a marine fish. Nature Climate Change, 8(8), 737-743. Abstract.  Full text.
Laing LV, Viana J, Dempster EL, Uren Webster TM, van Aerle R, Mill J, Santos EM (2018). Sex-specific transcription and DNA methylation profiles of reproductive and epigenetic associated genes in the gonads and livers of breeding zebrafish. Comp Biochem Physiol a Mol Integr Physiol, 222, 16-25. Abstract.  Author URL.  Full text.

2017

Fitzgerald JA, Katsiadaki I, Santos EM (2017). Contrasting effects of hypoxia on copper toxicity during development in the three-spined stickleback (Gasterosteus aculeatus). Environ Pollut, 222, 433-443. Abstract.  Author URL.  Full text.
Uren Webster TM, Williams TD, Katsiadaki I, Lange A, Lewis C, Shears JA, Tyler CR, Santos EM (2017). Hepatic transcriptional responses to copper in the three-spined stickleback are affected by their pollution exposure history. Aquat Toxicol, 184, 26-36. Abstract.  Author URL.  Full text.

2016

Fitzgerald JA, Jameson HM, Fowler VHD, Bond GL, Bickley LK, Webster TMU, Bury NR, Wilson RJ, Santos EM (2016). Hypoxia Suppressed Copper Toxicity during Early Development in Zebrafish Embryos in a Process Mediated by the Activation of the HIF Signaling Pathway. Environ Sci Technol, 50(8), 4502-4512. Abstract.  Author URL.  Full text.
Verbruggen B, Bickley LK, van Aerle R, Bateman KS, Stentiford GD, Santos EM, Tyler CR (2016). Molecular Mechanisms of White Spot Syndrome Virus Infection and Perspectives on Treatments. Viruses, 8(1). Abstract.  Author URL.  Full text.
Lewis C, Santos EM (2016). Physiological impacts of chemical pollutants in marine animals. In Solan M, Whiteley N (Eds.) Stressors in the Marine Environment, Oxford University Press, 73-92.

2015

Verbruggen B, Bickley LK, Santos EM, Tyler CR, Stentiford GD, Bateman KS, van Aerle R (2015). De novo assembly of the Carcinus maenas transcriptome and characterization of innate immune system pathways. BMC Genomics, 16 Abstract.  Author URL.  Full text.
Uren Webster TM, Santos EM (2015). Global transcriptomic profiling demonstrates induction of oxidative stress and of compensatory cellular stress responses in brown trout exposed to glyphosate and Roundup. BMC Genomics, 16 Abstract.  Author URL.  Full text.
Uren Webster TM, Shears JA, Moore K, Santos EM (2015). Identification of conserved hepatic transcriptomic responses to 17β-estradiol using high-throughput sequencing in brown trout. Physiol Genomics, 47(9), 420-431. Abstract.  Author URL.  Full text.
Uren Webster TM, Perry MH, Santos EM (2015). The herbicide linuron inhibits cholesterol biosynthesis and induces cellular stress responses in brown trout. Environ Sci Technol, 49(5), 3110-3118. Abstract.  Author URL.  Full text.

2014

Uren Webster TM, Laing LV, Florance H, Santos EM (2014). Effects of glyphosate and its formulation, roundup, on reproduction in zebrafish (Danio rerio). Environ Sci Technol, 48(2), 1271-1279. Abstract.  Author URL.  Full text.
Santos E, Webster TU (2014). Secrets of cornwall's metal-tolerant trout. Planet Earth(SPRING), 28-29.

2013

Uren Webster TM, Bury N, van Aerle R, Santos EM (2013). Global transcriptome profiling reveals molecular mechanisms of metal tolerance in a chronically exposed wild population of brown trout. Environ Sci Technol, 47(15), 8869-8877. Abstract.  Author URL.  Full text.
van Aerle R, Lange A, Moorhouse A, Paszkiewicz K, Ball K, Johnston BD, de-Bastos E, Booth T, Tyler CR, Santos EM, et al (2013). Molecular mechanisms of toxicity of silver nanoparticles in zebrafish embryos. Environ Sci Technol, 47(14), 8005-8014. Abstract.  Author URL.  Full text.
Santos EM, Hamilton PB, Coe TS, Ball JS, Cook AC, Katsiadaki I, Tyler CR (2013). Population bottlenecks, genetic diversity and breeding ability of the three-spined stickleback (Gasterosteus aculeatus) from three polluted English Rivers. Aquatic Toxicology, 142-143, 264-271. Abstract.
Fu J, Han J, Zhou B, Gong Z, Santos EM, Huo X, Zheng W, Liu H, Yu H, Liu C, et al (2013). Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of developmental toxicity. Environ Sci Technol, 47(18), 10574-10582. Abstract.  Author URL.

2011

Al-Jandal NJ, Whittamore JM, Santos EM, Wilson RW (2011). The influence of 17β-estradiol on intestinal calcium carbonate precipitation and osmoregulation in seawater-acclimated rainbow trout (Oncorhynchus mykiss). J Exp Biol, 214(Pt 16), 2791-2798. Abstract.  Author URL.

2010

Scown TM, Santos EM, Johnston BD, Gaiser B, Baalousha M, Mitov S, Lead JR, Stone V, Fernandes TF, Jepson M, et al (2010). Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow trout. Toxicol Sci, 115(2), 521-534. Abstract.  Author URL.
Katsiadaki I, Williams TD, Ball JS, Bean TP, Sanders MB, Wu H, Santos EM, Brown MM, Baker P, Ortega F, et al (2010). Hepatic transcriptomic and metabolomic responses in the Stickleback (Gasterosteus aculeatus) exposed to ethinyl-estradiol. Aquat Toxicol, 97(3), 174-187. Abstract.  Author URL.
Santos EM, Ball JS, Williams TD, Wu H, Ortega F, van Aerle R, Katsiadaki I, Falciani F, Viant MR, Chipman JK, et al (2010). Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model. Environ Sci Technol, 44(2), 820-826. Abstract.  Author URL.
Van Aggelen G, Ankley GT, Baldwin WS, Bearden DW, Benson WH, Chipman JK, Collette TW, Craft JA, Denslow ND, Embry MR, et al (2010). Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook. Environ Health Perspect, 118(1), 1-5. Abstract.  Author URL.
Uren-Webster TM, Lewis C, Filby AL, Paull GC, Santos EM (2010). Mechanisms of toxicity of di(2-ethylhexyl) phthalate on the reproductive health of male zebrafish. Aquat Toxicol, 99(3), 360-369. Abstract.  Author URL.

2009

Oehlmann J, Schulte-Oehlmann U, Kloas W, Jagnytsch O, Lutz I, Kusk KO, Wollenberger L, Santos EM, Paull GC, VanLook KJW, et al (2009). A critical analysis of the biological impacts of plasticizers on wildlife. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1526), 2047-2062. Abstract.
Williams TD, Wu H, Santos EM, Ball J, Katsiadaki I, Brown MM, Baker P, Ortega F, Falciani F, Craft JA, et al (2009). Hepatic transcriptomic and metabolomic responses in the stickleback (Gasterosteus aculeatus) exposed to environmentally relevant concentrations of dibenzanthracene. Environ Sci Technol, 43(16), 6341-6348. Abstract.  Author URL.

2008

Williams TD, Brown M, Chipman JK, Falciani F, Ortega F, Geoghegan F, Craft JA, Katsiadaki I, Ball J, Tyler CR, et al (2008). Development of a stickleback (Gasterosteus aculeatus) cDNA microarray and gene expression responses to dibenzanthracene, ethinyl-estradiol and copper. MARINE ENVIRONMENTAL RESEARCH, 66(1), 140-140. Author URL.
Tyler CR, Filby AL, van Aerle R, Lange A, Ball J, Santos EM (2008). Fish toxicogenomics. In  (Ed) Advances in Experimental Biology, Elsevier.
Santos EM, Kille P, Workman VL, Paull GC, Tyler CR (2008). Sexually dimorphic gene expression in the brains of mature zebrafish. Comp Biochem Physiol a Mol Integr Physiol, 149(3), 314-324. Abstract.  Author URL.
Tyler C, Lange A, Santos E, Coe T, Paull G, Filby A, Hamilton P (2008). The feminization of fish in English rivers: Causation, mechanisms, and significance.  Author URL.
Paull GC, Van Look KJW, Santos EM, Filby AL, Gray DM, Nash JP, Tyler CR (2008). Variability in measures of reproductive success in laboratory-kept colonies of zebrafish and implications for studies addressing population-level effects of environmental chemicals. Aquat Toxicol, 87(2), 115-126. Abstract.  Author URL.

2007

Filby AL, Santos EM, Thorpe KL, Maack G, Tyler CR (2007). Gene expression profiling for understanding chemical causation of biological effects for complex mixtures: a case study on estrogens. Environ Sci Technol, 41(23), 8187-8194. Abstract.  Author URL.
Santos EM, Paull GC, Van Look KJW, Workman VL, Holt WV, van Aerle R, Kille P, Tyler CR (2007). Gonadal transcriptome responses and physiological consequences of exposure to oestrogen in breeding zebrafish (Danio rerio). Aquat Toxicol, 83(2), 134-142. Abstract.  Author URL.
Santos EM, Workman VL, Paull GC, Filby AL, Van Look KJW, Kille P, Tyler CR (2007). Molecular basis of sex and reproductive status in breeding zebrafish. Physiol Genomics, 30(2), 111-122. Abstract.  Author URL.
Tyler C, Lange A, Santos E, Filby A (2007). The application of transcriptomics and other molecular approaches in advancing our understanding of endocrine disruption. TOXICOLOGY LETTERS, 172, S27-S27. Author URL.

2006

Santos E, Paull G, Filby A, Tyler C, Van Look K, Holt W, Workman V, Kille P (2006). Gender and stage-specific transcriptomic profiles of gonads and brains in breeding zebrafish. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, 143(4), S101-S101. Author URL.

2005

Tyler CR, Spary C, Gibson R, Santos EM, Shears J, Hill EM (2005). Accounting for differences in estrogenic responses in rainbow trout (Oncorhynchus mykiss: Salmonidae) and roach (Rutilus rutilus: Cyprinidae) exposed to effluents from wastewater treatment works. Environ Sci Technol, 39(8), 2599-2607. Abstract.  Author URL.
Williams, R. Johnson, A. (2005). Predicted exposures to steroid estrogens in UK Rivers correlate with widespread sexual disruption in wild fish populations. Environmental Health Perspectives, 32-39.

2004

Tyler CR, van Aerle R, Santos EM (2004). ELISAs for detecting vitellogenin in the fathead minnow (Pimephales promelas)-a critical analysis. Response to Mylchreest et al. Comp Biochem Physiol C 134: 251-257, 2003. Comp Biochem Physiol C Toxicol Pharmacol, 138(4), 531-532. Author URL.

2002

Tyler CR, Ball J, Maack G, Paull G, Santos EM (2002). Endocrine disruption in vertebrate wildlife - Today's story.  Author URL.

2001

Santos EM, Rand-Weaver M, Tyler CR (2001). Follicle-stimulating hormone and its alpha and beta subunits in rainbow trout (Oncorhynchus mykiss): purification, characterization, development of specific radioimmunoassays, and their seasonal plasma and pituitary concentrations in females. Biol Reprod, 65(1), 288-294. Abstract.  Author URL.
Cavaco, J.E.B. Rebers, F.E.M. Vischer, H.F. (2001). Gonadotrophins, their receptors, and regulation of testicular functions in fish. Comparative Biochemistry and Physiology Part B, 129, 407-417.
Schulz RW, Vischer HF, Cavaco JEB, Santos EM, Tyler CR, Goos HJT, Bogerd J (2001). Gonadotropins, their receptors, and the regulation of testicular functions in fish.  Author URL.
Harris CA, Santos EM, Janbakhsh A, Pottinger TG, Tyler CR, Sumpter JP (2001). Nonylphenol affects gonadotropin levels in the pituitary gland and plasma of female rainbow trout. Environ Sci Technol, 35(14), 2909-2916. Abstract.  Author URL.

1996

Tyler CR, Pottinger TG, Santos E, Sumpter JP, Price SA, Brooks S, Nagler JJ (1996). Mechanisms controlling egg size and number in the rainbow trout, Oncorhynchus mykiss. Biol Reprod, 54(1), 8-15. Abstract.  Author URL.

eduarda_santos Details from cache as at 2018-12-19 04:23:33

Refresh publications

External Engagment and Impact

Editorial responsibilities

Reviewer for a number of international journals including, Environmental Science and Technology, Environmental Health Perspectives, Environmental Toxicology and Chemistry, General and Comparative Endocrinology, Aquatic Toxicology, Journal of Fish Biology, Aquaculture, PLOS One, Molecular Biology Reports and Comparative Physiology and Biochemistry.

Top Reviewer Award from Environmental Science and Technology (2012).

Top Reviewer Award from General and Comparative Endocrinology (2009).


Invited lectures

11th International Congress on the Biology of Fish, August 2014, Edinburgh (Plenary Speaker)

Cardill University, December 2013

Cardiff University, December 2012.

20th Annual Meeting of Society of Environmental Toxicology and Chemistry (SETAC), May 2010, Seville, Spain.

NERC-KT workshop on Fish Toxicogenomics. May 2009, Exeter, UK.

NERC International workshop on fish toxicogenomics moving into monitoring and regulation April 2008, Environment Canada, North Vancouver, Canada.

SEB Annual Main Meeting, April 2006, Canterbury, UK.


Media Coverage

Our research on endocrine disrupting chemicals has been communicated widely to the public and received extensive press coverage over time.

 

In 2004, our work on the application of transcriptomics approaches to understand the effects of oestrogenic chemicals in fish was presented at the Royal Society Summer Science Exhibition.

 

In 2011, our work on endocrine disrupting chemicals received the Exeter Impact Award for Outstanding Impact in Public Policy and Services.

 

In 2013, our work on metal tolerance in brown trout received extensive local, national and international media coverage and was featured in the ITV news.

 


Workshops/Conferences organised

Chair of Knowledge Transfer workshop on Analysis of gene expression using next generation sequencing. Exeter, 2011.

 

Chair of the session Endocrine Disruption, SETAC Europe 18th Annual Meeting, Warsaw, Poland, 2008.

Member of the organising committee of the UK-Japan consortium on endocrine disruptors.

Member of the organising committee of the Credo workshop on Ecological Relevance of Chemically Induced Endocrine Disruption in Wildlife, Exeter 2004.

Chair of the session Effects of Anthropogenic and Environmental Factors on the Endocrine System, 5th International Symposium on Fish Endocrinology, Spain, 2004.

Teaching

In my teaching activities I use innovative approaches that deliver state-of-the-art, research-led teaching in formats that engage student participation, to give students the best possible experience and preparation for their future careers.

I act as a personal tutor for over 50 undergraduate and postgraduate students.

Undergraduate

  • NSC1003 Foundations in Natural Sciences
  • NSC1001 Frontiers in Science
  • BIO2092 Genomics and Introductory Bioinformatics

Postgraduate

  • Deputy Director for the Aquatic Biology and Resource Management MSc.

Modules

2018/19

Information not currently available


Supervision / Group

Postdoctoral researchers

  • Dr Lisa Bickley (Cefas and Open Inovation Platform; CoI with Dr Ronny van Aerle and Prof Charles Tyler). Building a Molecular Platform for Understanding the Host-Pathogen Interface in Invertebrates.

Postgraduate researchers

  • Sylvia Dimitriadou (CoI with Dr Safi Darden). Behavior in fish.
  • Emily Dow (MRes). Developing the zebrafish as a model to understand reproductive aging
  • Jennifer Fitzgerald (CEFAS and University of Exeter). Effects of hypoxia on the toxicity of model chemicals in the three-spined stickleback (Gasterosteus aculeatus).
  • IC Hung (National Science Council, Taiwan). The role of DNA methylation on sexual determination and development in zebrafish germ cells.
  • Lauren Laing (Fisheries Society of the British Isles). Differential susceptibility to copper in wild populations of three-spined stickleback.
  • Hannah Littler
  • Rebecca Millard
  • Nicholas Rogers (NERC; CoI with Dr Rod Wilson). Physiology of gut carbonate production by marine fish - roles of hypoxia and sex hormones.
  • Bas Verbruggen (Cefas and Open Inovation Platform; CoI with Dr Ronny van Aerle and Prof Charles Tyler). Building a Molecular Platform for Understanding the Host-Pathogen Interface in Invertebrates.
  • Joana Viana (CoI with Prof Jon Mill). Modeling epigenetic responses to schizophrenia-associated environmental risks and antipsychotic medication.

Alumni

  • Louisa Taplin (BBSRC; Co-I with Dr Rod Wilson). Using integrative physiology to improve the sustainability of fish aquaculture.
  • Tamsyn Uren Webster (NERC CASE Studentship with the Salmon and Trout Association). Endocrine disrupting chemicals (EDCs) and the sustainability of brown trout populations in the UK: relative impact of EDCs compared with other environmental stressors.

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