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Dr Mark Ramsdale

Dr Mark Ramsdale

Director of Education (Biosciences)

 5173

 Geoffrey Pope 321

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

My Office hours are:

 

I am a member of the Microbes and Disease research theme.

Qualifications

2006-2007 Postgraduate Certificate in Academic Practice, University of Exeter
1995 PhD Biological Sciences, University of Bath
1991 BSc (Hons) Applied Biology, University of Bath

Career

2015 - present Director of Education (Biosciences)

2006-2015 Lecturer in Molecular Microbiology, School of Biosciences, University of Exeter

2004-2006 Independent Research Fellow, School of Medical Sciences, University of Aberdeen

2000-2003 Lloyds Tercentenary Foundation Fellow, School of Medical Sciences, University of Aberdeen

1998-2000 Research Fellow, School of Medical Sciences, University of Aberdeen

1996-1998 Research Fellow, Department of Zoology, University of Cambridge

1995-1996 Scientist, Pfizer, Sandwich, Kent

Research

Research interests

The main focus of work in my lab is to further our understanding of stress and programmed cell death responses exhibited by fungi (in particular Candida albicans). This is important since fungal diseases of man have assumed great significance due to changes in the demographic status of the human population, changes in the management practices for chronic health conditions, and the increased use of immunocompromising agents in medicine. Due to similarities in the basic cellular organization of pathogenic fungi and their animal hosts, the control of such diseases poses considerable problems for clinicians. New strategies must therefore be implemented to assist in the identification of novel antifungal agents. We are therefore aiming to (i) identify and characterize the different types of cell death response (apoptotic, autophagic and necrotic) shown by fungi under different conditions, (ii) highlight the key differences between the cell death and stress responses of mammals and fungi, and (iii) identify regulators core to the fungal cell death response using a combination of traditional genetics and genomics based technologies.

Research networks

  • Professor Alistair Brown, University of Aberdeen, Proteomic analysis of PCD
  • Dr Concha Gil and Virginia Cabezon, University of Madrid, Cell death responses of C. albicans.
  • Dr Manuela Corte Real and Dr Bjorn Johansson, University of Braga, Transcriptonal response of S. cerevisiae during weak acid killing.


 

Research grants

  • 2013 British Mycological Society
    Origins of genetic variation during gametogenesis in N. crassa
  • 2012 NIH
    Communication between Candida albicans and oral bacteria.
  • 2012 Woodland Trust
    Funding for forestry project at Alice Holt
  • 2011 The Genetics Society
    Differential allele expression in Candida albicans.
  • 2011 Society for General Microbiology
    Allelic expression patterns in virulence genes of the fungal pathogen Candida albicans.
  • 2010 Royal Society
    Real-time imaging of cellular signals using codon-optimised cameleon variant s in the pathogenic fungus Candida albican
  • 2009 British Mycological Society
    Intracellular calcium dynamics during death of the fungal pathogen Candida albicans
  • 2009 Nuffield Foundation Undergraduate Research Bursary
    Role of AIF1 in the programmed cell death response of the human fungal pathogen Candida albicans.
  • 2009 Society for General Microbiology
    Role of autophagy in the programmed cell death response of the fungal pathogen Candida albicans.
  • 2008 The Nuffield Foundation
    Cloning a transgenic calcium biosensor for expression in the human pathogen Candida albicans.
  • 2008 Union Lifesciences
    Union Life Sciences funded project on human fungal pathogen
  • 2007 Wellcome Trust
    Role of the MSN2 transcription factor in the stress and death responses of the fungal pathogen Candida albicans
  • 2007 British Mycological Society
    GFP and FLAG tagging of the Candida albicans Msn2
  • 2007 BBSRC-COGEME
    Metacaspase substrate identification in the fungal pathogen Candida albicans. BBSRC-COGEME User Fund
  • 2004 BBSRC
    Integrated Proteome and transcriptome analysis of programmed cell death in the fungal pathogen Candida albicans
  • 2002 SHERT
    Dissecting the cell death machinery of the fungal pathogen Candida albicans in a search for novel antifungal therapies
  • 2001 MRC
    Study of the role of the Ras-cAMP signalling pathway in the cell death response of Candida albicans, MRC Studentship

Key publications | Publications by category | Publications by year

Key publications


Wilkinson D, Ramsdale M (2011). Proteases and caspase-like activity in the yeast Saccharomyces cerevisiae. Biochemical Society Transactions, 39, 1502-1508. Abstract.  Full text.
Coste AT, Ramsdale M, Ischer F, Sanglard D (2008). Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae. Microbiology, 154(Pt 5), 1491-1501. Abstract.  Author URL.
Ramsdale M, Selway L, Stead D, Walker J, Yin Z, Nicholls SM, Crowe J, Sheils EM, Brown AJP (2008). MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans. Mol Biol Cell, 19(10), 4393-4403. Abstract.  Author URL.  Full text.
Ramsdale M (2008). Programmed cell death in pathogenic fungi. Biochim Biophys Acta, 1783(7), 1369-1380. Abstract.  Author URL.  Full text.

Publications by category


Journal articles

Ramsdale M (2012). Programmed cell death in the cellular differentiation of microbial eukaryotes. Current Opinion in Microbiology, 15(6), 646-652. Abstract.
Ramsdale M (2012). Programmed cell death in the cellular differentiation of microbial eukaryotes. Curr Opin Microbiol, 15(6), 646-652. Abstract.  Author URL.
Wilkinson D, Ramsdale M (2011). Proteases and caspase-like activity in the yeast Saccharomyces cerevisiae. Biochemical Society Transactions, 39, 1502-1508. Abstract.  Full text.
Coste AT, Ramsdale M, Ischer F, Sanglard D (2008). Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae. Microbiology, 154(Pt 5), 1491-1501. Abstract.  Author URL.
Ramsdale M, Selway L, Stead D, Walker J, Yin Z, Nicholls SM, Crowe J, Sheils EM, Brown AJP (2008). MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans. Mol Biol Cell, 19(10), 4393-4403. Abstract.  Author URL.  Full text.
Ramsdale M (2008). Programmed cell death in pathogenic fungi. Biochim Biophys Acta, 1783(7), 1369-1380. Abstract.  Author URL.  Full text.
Ramsdale, M. (2007). Fungal Immunology from an organ perspective. Mycological Research
Ramsdale, M. (2006). Candida transcriptional modules online. Mycological Research, 110, 753-754.
Ramsdale M, Crowe JD, Phillips AJ (2006). Ras pathway signalling accelerated programmed cell death in the pathogenic fungus Candida albicans. Proceedings of the National Academy of Sciences, 103(3), 726-731.
Ramsdale M, Brown AJP, Dennison PMJ, Manson CL (2005). Gene disruption in Candida albicans using a synthetic codon-optimised Cre-loxP system. Fungal Genetics and Biology, 42(9), 737-748.
Ramsdale M, Phillips AJ, Sudbery I (2003). Apoptosis induced by environmental stress and amphotericin B in Candida albicans. Proceedings of the National Academy of Sciences, 100(24), 14327-14332.
Phillips AJ, Sudbery I, Ramsdale M (2003). Apoptosis induced by environmental stresses and amphotericin B in Candida albicans. Proceedings of the National Academy of Sciences of the United States of America, 100(SUPPL. 2), 14327-14332. Abstract.
Ramsdale M (2003). Fungi and the bare necessities of life. Mycologist, 17(1).
Ramsdale, M. (2003). Fungi and the bare necessities of life: minimalism in the genome of Encephalitozoon cuniculi. Mycologist, 17
Ramsdale, M. (2001). Fungi with a sense of time: molecular genetics of temporal organization in Neurospora crassa. Mycologist, 15, 10-15.
Ramsdale M, Gooch VD, Lakin-Thomas PL (2001). Rhythms of differentiation and diacylglycerol in Neurospora crassa. Philosophical Transactions of the Royal Society B Biological Sciences, 356(1415), 1711-1715.
Ramsdale M (2001). Sphingolipid-mediated cell death responses in the yeasts Candida albicans and Saccharomyces cerevisiae. YEAST, 18, S173-S173. Author URL.
Brown AJ, Barelle CJ, Budge S, Duncan J, Harris S, Lee PR, Leng P, Macaskill S, Abdul Murad AM, Ramsdale M, et al (2000). Gene regulation during morphogenesis in Candida albicans. Contrib Microbiol, 5, 112-125. Author URL.
Ramsdale M, Lakin-Thomas PL (2000). sn-1,2-diacylglycerol levels in the fungus Neurospora crassa display circadian rhythmicity. J Biol Chem, 275(36), 27541-27550. Abstract.  Author URL.
Ramsdale M, Rayner ADM (1996). Imbalanced nuclear ratios, post-germination mortality and phenotype-genotype relationships in allopatrically-derived heterokaryons of Heterobasidion annosum. New Phytologist, 133(2), 303-319. Abstract.
RAMSDALE M, RAYNER ADM (1994). Distribution patterns of number of nuclei in conidia from heterokaryons of Heterobasidion annosum (Fr.) Bref. and their interpretation in terms of genomic conflict. New Phytologist, 128(1), 123-134. Abstract.

Chapters

Ramsdale, M. (2004). Circadian clocks and rhythmic differentiation in fungi. In Kippert F (Ed) Circadian clocks in eukaryotic microbes, USA:.

Conferences

Phillips A, Crowe J, Brown A, Ramsdale M (2003). Programmed cell death in the pathogenic yeast Candida albicans.  Author URL.
RAYNER ADM, RAMSDALE M, WATKINS ZR (1995). ORIGINS AND SIGNIFICANCE OF GENETIC AND EPIGENETIC INSTABILITY IN MYCELIAL SYSTEMS.  Author URL.

Publications by year


2012

Ramsdale M (2012). Programmed cell death in the cellular differentiation of microbial eukaryotes. Current Opinion in Microbiology, 15(6), 646-652. Abstract.
Ramsdale M (2012). Programmed cell death in the cellular differentiation of microbial eukaryotes. Curr Opin Microbiol, 15(6), 646-652. Abstract.  Author URL.

2011

Wilkinson D, Ramsdale M (2011). Proteases and caspase-like activity in the yeast Saccharomyces cerevisiae. Biochemical Society Transactions, 39, 1502-1508. Abstract.  Full text.

2008

Coste AT, Ramsdale M, Ischer F, Sanglard D (2008). Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae. Microbiology, 154(Pt 5), 1491-1501. Abstract.  Author URL.
Ramsdale M, Selway L, Stead D, Walker J, Yin Z, Nicholls SM, Crowe J, Sheils EM, Brown AJP (2008). MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans. Mol Biol Cell, 19(10), 4393-4403. Abstract.  Author URL.  Full text.
Ramsdale M (2008). Programmed cell death in pathogenic fungi. Biochim Biophys Acta, 1783(7), 1369-1380. Abstract.  Author URL.  Full text.

2007

Ramsdale, M. (2007). Fungal Immunology from an organ perspective. Mycological Research

2006

Ramsdale, M. (2006). Candida transcriptional modules online. Mycological Research, 110, 753-754.
Ramsdale M, Crowe JD, Phillips AJ (2006). Ras pathway signalling accelerated programmed cell death in the pathogenic fungus Candida albicans. Proceedings of the National Academy of Sciences, 103(3), 726-731.

2005

Ramsdale M, Brown AJP, Dennison PMJ, Manson CL (2005). Gene disruption in Candida albicans using a synthetic codon-optimised Cre-loxP system. Fungal Genetics and Biology, 42(9), 737-748.

2004

Ramsdale, M. (2004). Circadian clocks and rhythmic differentiation in fungi. In Kippert F (Ed) Circadian clocks in eukaryotic microbes, USA:.

2003

Ramsdale M, Phillips AJ, Sudbery I (2003). Apoptosis induced by environmental stress and amphotericin B in Candida albicans. Proceedings of the National Academy of Sciences, 100(24), 14327-14332.
Phillips AJ, Sudbery I, Ramsdale M (2003). Apoptosis induced by environmental stresses and amphotericin B in Candida albicans. Proceedings of the National Academy of Sciences of the United States of America, 100(SUPPL. 2), 14327-14332. Abstract.
Ramsdale M (2003). Fungi and the bare necessities of life. Mycologist, 17(1).
Ramsdale, M. (2003). Fungi and the bare necessities of life: minimalism in the genome of Encephalitozoon cuniculi. Mycologist, 17
Phillips A, Crowe J, Brown A, Ramsdale M (2003). Programmed cell death in the pathogenic yeast Candida albicans.  Author URL.

2001

Ramsdale, M. (2001). Fungi with a sense of time: molecular genetics of temporal organization in Neurospora crassa. Mycologist, 15, 10-15.
Ramsdale M, Gooch VD, Lakin-Thomas PL (2001). Rhythms of differentiation and diacylglycerol in Neurospora crassa. Philosophical Transactions of the Royal Society B Biological Sciences, 356(1415), 1711-1715.
Ramsdale M (2001). Sphingolipid-mediated cell death responses in the yeasts Candida albicans and Saccharomyces cerevisiae. YEAST, 18, S173-S173. Author URL.

2000

Brown AJ, Barelle CJ, Budge S, Duncan J, Harris S, Lee PR, Leng P, Macaskill S, Abdul Murad AM, Ramsdale M, et al (2000). Gene regulation during morphogenesis in Candida albicans. Contrib Microbiol, 5, 112-125. Author URL.
Ramsdale M, Lakin-Thomas PL (2000). sn-1,2-diacylglycerol levels in the fungus Neurospora crassa display circadian rhythmicity. J Biol Chem, 275(36), 27541-27550. Abstract.  Author URL.

1996

Ramsdale M, Rayner ADM (1996). Imbalanced nuclear ratios, post-germination mortality and phenotype-genotype relationships in allopatrically-derived heterokaryons of Heterobasidion annosum. New Phytologist, 133(2), 303-319. Abstract.

1995

RAYNER ADM, RAMSDALE M, WATKINS ZR (1995). ORIGINS AND SIGNIFICANCE OF GENETIC AND EPIGENETIC INSTABILITY IN MYCELIAL SYSTEMS.  Author URL.

1994

RAMSDALE M, RAYNER ADM (1994). Distribution patterns of number of nuclei in conidia from heterokaryons of Heterobasidion annosum (Fr.) Bref. and their interpretation in terms of genomic conflict. New Phytologist, 128(1), 123-134. Abstract.

mark_ramsdale Details from cache as at 2018-10-15 08:30:24

Refresh publications

Committee/panel activities

Fungal Biology Research Committee - 2009-2014


Editorial responsibilities

Molecular Microbiology, Advisory Board, 2007-present

  • Editor for PLoS ONE (2010-present)

Manuscripts in period 2008-2013 reviewed for  Biochimica et Biophysica Acta, Eukaryotic Cell, PloS pathogens, Fungal Biology, Antimicrobial Agents and Chemotherapy, New Phytologist, Ecology and PLoS Biology, Molecular Microbiology, Applied and Environmental Microbiology

Medical Mycology Editor, Mycological Research, 2004-present


Invited lectures

British Council Representative -  Bangalore & Chennai 2013 “UK Biotechnology”

Programmed cell death in yeast “St Xaviers College, Mumbai 2013

·       Invited Speaker University of Ireland, Maynooth “Stress and death in Candida albicans” (February 2011).

 

·       Invited speaker at British Society for Medical Mycology “Differential allele expression in Candida albicans” (April 2010).

·       Session chair and speaker at “PCD and Autophagy” session at International Mycological Congress, IMC9 Edinburgh (August 2010).

·       Invited speaker at IMC9 “RNA-SEQuencing in Candida albicans” (August 2010).

BSMM (2001), London.Sphingolipid signalling and cell death in Candida.

YGMB (2001), Prague.Ras-cAMP and sphingolipid signalling in the cell death response of yeasts.

Transkingdom Cell Death Meeting (2002), Roscoff.Cell death in Candida and Saccharomyces: responses, pathways and effectors.

1st International Meeting on Yeast Apoptosis. (2002). Braga.Sphingolipid and Ras-mediated cell death signals in Candida albicans.

YGMB (2003) Goteborg.Programmed cell death in the pathogenic yeast Candida albicans.

2nd International Meeting on Yeast Apoptosis. (2003). Bratislava.Dissecting the molecular machinery responsible for Programmed cell death in the pathogenic yeast Candida albicans.

ASM Candida and Candidiasis (2004). Austin, Texas. Invited speakerIntegrated proteome and transcriptome analysis of stress and programmed cell death responses in Candida albicans.

3rd International Meeting on Yeast Apoptosis (2004).Role of Ras in death decision of the human pathogen, Candida albicans.

BBSRC (2005). Manchester. Invited SpeakerGenomics of cell death in Candida albicans.

EU Advanced Course on Apoptosis in Fungi (2005). Univ Minho, Braga. Invited Speaker –Exploitation of programmed cell death in the fight against fungal diseases.

ESF-EMBO Symposium. Comparative Genomics of Eukaryotic Microorganisms (2005). San Feliu de Guixols. Invited Speaker.Global views of apoptosis in Candida albicans and Saccharomyces cerevisiae: combined proteome and transcript profiling data.

British Yeast Group Meeting / BSMM (2005). Canterbury. Keynote Speaker.Cell death in the fungal pathogen Candida albicans.

Molecular Mycology Tenth Anniversary Meeting. (2006)Woods Hole, Invited Speaker. Programmed cell death and stress responses in the fungal pathogen, Candida albicans.

School of Biosciences, University of Kent. (2007). Invited Speaker. Post Traumatic Stress and Cell Death in Candida albicans.

ASM Fungal Genetics Meeting, Asilomar (2007). Invited Speaker.Stress and death esponses in the fungal pathogens Candida albicans.

ASM Candida and Candidiasis (2008) New York. Invited Speaker. Functional analysis of the programmed cell death response of Candida albicans.

Gene Expression and Cell Signalling Seminars, Faculty of Life Sciences, University of Manchester (2008). Stress and death in the fungal pathogen Candida albicans.


Media Coverage

$2 million for oral disease study

Dental News 19 March 2012

Sarawak News - STEM in Malaysia (June 2012).


Research funding

·       Jenkins (PI), Lamont (PI), Kadioglu (coPI), Ramsdale (CoPI). Barbour (Co-PI), Jepson (CoPI), Communication between Candida albicans and oral bacteria. Top Ranked Grant in Round. Funded March 2012-2017 (£1.34 million/2012-2017)

·       Ramsdale, Partridge, Denman – Woodland Trust Forest Research Placement (£13,529 / 2012-2013)

·       Royal Society Ramsdale (PI) 01/10/10-30/06/11 (£13,250).

Real-time imaging of cellular signals using codon-optimised cameleon variant s in the pathogenic fungus Candida albicans.

The aim of this project is to develop new tools for imaging of intracellular signals (calcium, cAMP, MAPK and ROS) in Candida albicans using cameleon biosensors.

·  

·       Exeter University Strategic Fund. Ramsdale (PI) 01/04/09-30/09/09

Illumina RNA-SEQuencing in C. albicans (£3,579).

The aim of this project was to provide proof of principle data regarding the expression of virulence genes in C. albicans during planktonic growth in C. albicans.

 

·       British Mycological Society. Ramsdale (PI) 07/07/09-07/10/09 (£2,100).

Intracellular calcium dynamics during death of the fungal pathogen Candida albicans.

The aim of this project was to develop a transgenic cameleon biosensor for use in Candida albicans.

 

·       British Mycological Society. Ramsdale (PI) 07/07/13-07/10/13 (£2,250).

Origins of genetic variation during gametogenesis in N. crassa

The aim of this project is to assess the origins of genetic variation during meiosis.


Workshops/Conferences organised

Main organizer of British Mycological Society Scientific Meeting "Fungal Development and Pathogeneis" - University of Exeter (2011)

·       Scientific advisory board member “International Meeting on Yeast Apoptosis” (May 2011).

·       Scientific advisory board member “International Meeting on Yeast Apoptosis” (May 2011).

Scientifc Programme organizer - British Mycological Society annual meeting “Fungi and Environmental Change - Cardiff University (2013)

Scientifc Programme organizer - British Mycological Society annual meeting “Fungi and Environmental Change - Cardiff University (2013)

Workshop organizer and co-chair Society for General Microbiology, Nottingham “Microbial Cell death” (September 2010).

Director of Education (Biosciences) with repsonsibility for curriculum design, course management and student experience.

Fellow of the Higher Education Academy


Programme Director - BIological Sciences with Professional Placement, Biochemistry with Industrial Experience, Biological & Medicinal Chemistry with Industrial Experience


Module coordinator - BIO1333 Fundamental Skills for Bioscientists, BIO1339 Cells, BIO2071 Research Skills and Bioethics, BIO3087 Professional Placement Scientific Report, BIO3088 Learning from Professional Placement;

I am keen to ensure that students are able to experience a wide range of activities and biological disciplines early on in their careers. My underlying aim when teaching is always to encourage students to adopt a more questioning attitude to the world around them. Taught modules include:

Year 1

BIO1333 Fundamental Principles for Bioscientists
BIO1334 Genetics
BIO1335 Cell Biology
BIO1337 Microbiology

Year 2

BIO2071 Research Skills and Bioethics
BIO2096 Molecular Microbiology

Year 3
BIO3087 Industrial Placement and Report
BIO3088 Learning from Industrial Experience
BIO3086 Cellular Basis of Disease
BIO3079 Molecular Basis of Infection

Masters

BIOM503 Essentials of Molecular Biology

 


 


 

 

 

Postdoctoral researchers

Postgraduate researchers

  • Sophie Clarke PhD student
  • Atyaf Hamied PhD Student
  • Derek Wilkinson PhD student (completed)

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