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Dr Michail Isupov

Dr Michail Isupov

Postdoctoral researcher

 3451

 Geoffrey Pope 

 

Geoffrey Pope Building, University of Exeter , Stocker Road, Exeter, EX4 4QD, UK

Overview

Research

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Knight AR, Taylor EL, Lukaszewski R, Winyard PG (In Press). A high-sensitivity electrochemiluminescence-based ELISA for the measurement of the oxidative stress biomarker, 3-nitrotyrosine, in human blood serum and cells. Free Radical Biology and Medicine Full text.
Zhang J, Fan F, Zhao Y, Sun L, Liu Y, Keegan RM, Isupov MN, Wu Y (In Press). Crystal structure of the type IV secretion system component CagX from Helicobacter pylori. Acta Crystallogr F Struct Biol Commun, 73(Pt 3), 167-173. Abstract.  Author URL.  Full text.
Romano-Moreno M, Rojas AL, Williamson CD, Gershlick DC, Lucas M, Isupov MN, Bonifacino JS, Machner MP, Hierro A (In Press). Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL. Proc Natl Acad Sci U S A, 114(52), E11151-E11160. Abstract.  Author URL.  Full text.
Sporny M, Guez-Haddad J, Kreusch A, Shakartzi S, Neznansky A, Cross A, Isupov M, Qualmann B, Kessels MM, Opatowsky Y, et al (In Press). Structural History of Human SRGAP2 Proteins. Molecular Biology and Evolution Full text.
Isupov MN, Schröder E, Gibson RP, Beecher J, Donadio G, Saneei V, Dcunha SA, McGhie EJ, Sayer C, Davenport CF, et al (In Press). The oxygenating constituent of 3,6-diketocamphane monooxygenase from the CAM plasmid of Pseudomonas putida: the first crystal structure of a type II Baeyer-Villiger monooxygenase. Corrigendum. Acta Crystallogr D Struct Biol, 74(Pt 4). Abstract.  Author URL.
Soudah N, Padala P, Hassouna F, Kumar M, Mashahreh B, Lebedev AA, Isupov MN, Cohen-Kfir E, Wiener R (2018). An N-Terminal Extension to UBA5 Adenylation Domain Boosts UFM1 Activation: Isoform-Specific Differences in Ubiquitin-like Protein Activation. J Mol Biol Abstract.  Author URL.
Ferrandi EE, Sayer C, De Rose SA, Guazzelli E, Marchesi C, Saneei V, Isupov MN, Littlechild JA, Monti D (2018). New thermophilic α/β class epoxide hydrolases found in metagenomes from hot environments. Frontiers in Bioengineering and Biotechnology, 6(OCT). Abstract.  Full text.
Winter AJ, Williams C, Isupov MN, Crocker H, Gromova M, Marsh P, Wilkinson OJ, Dillingham MS, Harmer NJ, Titball RW, et al (2018). The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA. J Biol Chem Abstract.  Author URL.
Vogeler S, Galloway TS, Isupov M, Bean TP (2017). Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals. PLoS One, 12(4). Abstract.  Author URL.  Full text.
Littlechild JA, Isupov MN (2017). Comments to Article by Willetts A. et al. Microorganisms 2016, 4, 38. Microorganisms, 5(3). Abstract.  Author URL.
Padala P, Soudah N, Giladi M, Haitin Y, Isupov MN, Wiener R (2017). The Crystal Structure and Conformations of an Unbranched Mixed Tri-Ubiquitin Chain Containing K48 and K63 Linkages. J Mol Biol, 429(24), 3801-3813. Abstract.  Author URL.  Full text.
Zarafeta D, Kissas D, Sayer C, Gudbergsdottir SR, Ladoukakis E, Isupov MN, Chatziioannou A, Peng X, Littlechild JA, Skretas G, et al (2016). Discovery and Characterization of a Thermostable and Highly Halotolerant GH5 Cellulase from an Icelandic Hot Spring Isolate. PLoS One, 11(1). Abstract.  Author URL.  Full text.
Sporny M, Guez-Haddad J, Waterman DG, Isupov MN, Opatowsky Y (2016). Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain. Acta Crystallographica Section D Structural Biology, 72(12), 1241-1253. Full text.
sayer C, Finnigan W, Isupov MN, Levisson M, Kengen SWM, van der Oost J, Harmer NJ, Littlechild JA (2016). Structural and biochemical characterisation of Archaeoglobus fulgidus esterase reveals a bound CoA molecule in the vicinity of the active site. Scientific Reports, 6, 25542-25542. Abstract.  Full text.
Ferrandi EE, Sayer C, Isupov MN, Annovazzi C, Marchesi C, Iacobone G, Peng X, Bonch-Osmolovskaya E, Wohlgemuth R, Littlechild JA, et al (2015). Discovery and characterization of thermophilic limonene-1,2-epoxide hydrolases from hot spring metagenomic libraries. FEBS J, 282(15), 2879-2894. Abstract.  Author URL.
Sayer C, Isupov MN, Bonch-Osmolovskaya E, Littlechild JA (2015). Structural studies of a thermophilic esterase from a new Planctomycetes species, Thermogutta terrifontis. FEBS J, 282(15), 2846-2857. Abstract.  Author URL.
Sayer C, Szabo Z, Isupov MN, Ingham C, Littlechild JA (2015). The Structure of a Novel Thermophilic Esterase from the Planctomycetes Species, Thermogutta terrifontis Reveals an Open Active Site Due to a Minimal 'Cap' Domain. Front Microbiol, 6 Abstract.  Author URL.  Full text.
Isupov MN, Schröder E, Gibson RP, Beecher J, Donadio G, Saneei V, Dcunha SA, McGhie EJ, Sayer C, Davenport CF, et al (2015). The oxygenating constituent of 3,6-diketocamphane monooxygenase from the CAM plasmid of Pseudomonas putida: the first crystal structure of a type II Baeyer-Villiger monooxygenase. Acta Crystallogr D Biol Crystallogr, 71(Pt 11), 2344-2353. Abstract.  Author URL.  Full text.
Vivoli M, Isupov MN, Nicholas R, Hill A, Scott AE, Kosma P, Prior JL, Harmer NJ (2015). Unraveling the B. pseudomallei Heptokinase WcbL: from Structure to Drug Discovery. Chemistry and Biology, 22(12), 1622-1632. Abstract.  Full text.
Novak HR, Sayer C, Isupov MN, Gotz D, Spragg AM, Littlechild JA (2014). Biochemical and structural characterisation of a haloalkane dehalogenase from a marine Rhodobacteraceae. FEBS Lett, 588(9), 1616-1622. Abstract.  Author URL.  Full text.
Lebedev AA, Isupov MN (2014). Space-group and origin ambiguity in macromolecular structures with pseudo-symmetry and its treatment with the program Zanuda. Acta Crystallographica Section D: Biological Crystallography, 70(9), 2430-2443. Abstract.  Full text.
Vivoli M, Ayres E, Beaumont E, Isupov MN, Harmer NJ (2014). Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme. IUCrJ, 1, 28-38. Full text.
Littlechild J, Sayer C, Isupov M, Ward J, Littlechild J (2014). Structural studies on transaminase enzymes and applications in biocatalysis. NEW BIOTECHNOLOGY, 31, S19-S19. Author URL.
James P, Isupov MN, Sayer C, Saneei V, Berg S, Lioliou M, Kotlar HK, Littlechild JA (2014). The structure of a tetrameric α-carbonic anhydrase from Thermovibrio ammonificans reveals a core formed around intermolecular disulfides that contribute to its thermostability. Acta Crystallogr D Biol Crystallogr, 70(Pt 10), 2607-2618. Abstract.  Author URL.  Full text.
Sayer C, Martinez-Torres RJ, Richter N, Isupov MN, Hailes HC, Littlechild JA, Ward JM (2014). The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca. FEBS J, 281(9), 2240-2253. Abstract.  Author URL.  Full text.
Reid EL, Weynberg KD, Love J, Isupov MN, Littlechild JA, Wilson WH, Kelly SL, Lamb DC, Allen MJ (2013). Functional and structural characterisation of a viral cytochrome b5. FEBS Lett, 587(22), 3633-3639. Abstract.  Author URL.
Novak HR, Sayer C, Isupov MN, Paszkiewicz K, Gotz D, Spragg AM, Littlechild JA (2013). Marine Rhodobacteraceae L-haloacid dehalogenase contains a novel His/Glu dyad that could activate the catalytic water. FEBS J, 280(7), 1664-1680. Abstract.  Author URL.  Full text.
Sayer C, Isupov MN, Westlake A, Littlechild JA (2013). Structural studies of Pseudomonas and Chromobacterium ω- aminotransferases provide insights into their differing substrate specificity. Acta Crystallographica Section D: Biological Crystallography, 69(4), 564-576. Abstract.  Full text.
Sayer C, Bommer M, Isupov M, Ward J, Littlechild J (2012). Crystal structure and substrate specificity of the thermophilic serine:pyruvate aminotransferase from Sulfolobus solfataricus. Acta Crystallogr D Biol Crystallogr, 68(Pt 7), 763-772. Abstract.  Author URL.  Full text.
Urusova DV, Isupov MN, Antonyuk S, Kachalova GS, Obmolova G, Vagin AA, Lebedev AA, Burenkov GP, Dauter Z, Bartunik HD, et al (2012). Crystal structure of D-serine dehydratase from Escherichia coli. Biochimica et Biophysica Acta - Proteins and Proteomics, 1824(3), 422-432. Abstract.
Lebedev AA, Young P, Isupov MN, Moroz OV, Vagin AA, Murshudov GN (2012). JLigand: a graphical tool for the CCP4 template-restraint library. Acta Crystallogr D Biol Crystallogr, 68(Pt 4), 431-440. Abstract.  Author URL.  Full text.
Shevtsov MB, Chen Y, Isupov MN, Leech A, Gollnick P, Antson AA (2010). Bacillus licheniformis Anti-TRAP can assemble into two types of dodecameric particles with the same symmetry but inverted orientation of trimers. Journal of Structural Biology, 170(1), 127-133. Abstract.  Full text.
Opperman DJ, Sewell BT, Litthauer D, Isupov MN, Littlechild JA, van Heerden E (2010). Crystal structure of a thermostable old yellow enzyme from Thermus scotoductus SA-01. Biochem Biophys Res Commun, 393(3), 426-431. Abstract.  Author URL.
Willies S, Isupov M, Littlechild J (2010). Thermophilic enzymes and their applications in biocatalysis: a robust aldo-keto reductase. Environ Technol, 31(10), 1159-1167. Abstract.  Author URL.
Rye CA, Isupov MN, Lebedev AA, Littlechild JA (2009). Biochemical and structural studies of a L-haloacid dehalogenase from the thermophilic archaeon Sulfolobus tokodaii. Extremophiles, 13(1), 179-190. Abstract.  Author URL.  Full text.
Ng CL, Waterman DG, Koonin EV, Walters AD, Chong JP, Isupov MN, Lebedev AA, Bunka DH, Stockley PG, Ortiz-Lombardía M, et al (2009). Conformational flexibility and molecular interactions of an archaeal homologue of the Shwachman-Bodian-Diamond syndrome protein. BMC Structural Biology, 9 Abstract.  Full text.
Willies SC, Isupov MN, Garman EF, Littlechild JA (2009). The binding of haem and zinc in the 1.9 a X-ray structure of Escherichia coli bacterioferritin. J Biol Inorg Chem, 14(2), 201-207. Abstract.  Author URL.  Full text.
Littlechild J, Garcia Rodriguez E, Isupov M (2009). Vanadium containing bromoperoxidase--insights into the enzymatic mechanism using X-ray crystallography. J Inorg Biochem, 103(4), 617-621. Abstract.  Author URL.  Full text.
Line K, Isupov MN, Garcia-Rodriguez E, Maggioli G, Parra F, Littlechild JA (2008). The Fasciola hepatica thioredoxin: High resolution structure reveals two oxidation states. Mol Biochem Parasitol, 161(1), 44-48. Abstract.  Author URL.  Full text.
Rye CA, Isupov MN, Lebedev AA, Littlechild JA (2007). An order-disorder twin crystal of L-2-haloacid dehalogenase from Sulfolobus tokodaii. Acta Crystallogr D Biol Crystallogr, 63(Pt 8), 926-930. Abstract.  Author URL.  Full text.
Sayer C, Isupov MN, Littlechild JA (2007). Crystallization and preliminary X-ray diffraction analysis of omega-amino acid:pyruvate transaminase from Chromobacterium violaceum. Acta Crystallogr Sect F Struct Biol Cryst Commun, 63(Pt 2), 117-119. Abstract.  Author URL.  Full text.
Isupov MN, Lebedev AA (2007). NCS-constrained exhaustive search using oligomeric models. Acta Crystallographica Section D: Biological Crystallography, 64(1), 90-98. Abstract.  Full text.
Littlechild JA, Guy J, Connelly S, Mallett L, Waddell S, Rye CA, Line K, Isupov M (2007). Natural methods of protein stabilization: thermostable biocatalysts. Biochem Soc Trans, 35(Pt 6), 1558-1563. Abstract.  Author URL.
Sanders CM, Kovalevskiy OV, Sizov D, Lebedev AA, Isupov MN, Antson AA (2007). Papillomavirus E1 helicase assembly maintains an asymmetric state in the absence of DNA and nucleotide cofactors. Nucleic Acids Research, 35(19), 6451-6457. Abstract.  Full text.
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N (2006). Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme. J Biol Chem, 281(23), 15662-15670. Abstract.  Author URL.
Littlechild J, Garcia-Rodriguez E, Isupov M (2006). INOR 398-Crystallization studies of vanadium haloperoxidases: Insights into halide specificity and enzyme mechanism. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 232 Author URL.
Connelly S, Line K, Isupov MN, Littlechild JA (2005). Synthesis and characterisation of a ligand that forms a stable tetrahedral intermediate in the active site of the Aureobacterium species (-) gamma-lactamase. Org Biomol Chem, 3(18), 3260-3262. Abstract.  Author URL.
Singleton MR, Morales R, Grainge I, Cook N, Isupov MN, Wigley DB (2004). Conformational changes induced by nucleotide binding in Cdc6/ORC from Aeropyrum pernix. Journal of Molecular Biology, 343(3), 547-557. Abstract.
Isupov MN, Brindley AA, Hollingsworth EJ, Murshudov GN, Vagin AA, Littlechild JA (2004). Crystallization and preliminary X-ray diffraction studies of a fungal hydrolase from Ophiostoma novo-ulmi. Acta Crystallogr D Biol Crystallogr, 60(Pt 10), 1879-1882. Abstract.  Author URL.  Full text.
Ohshiro T, Littlechild J, Garcia-Rodriguez E, Isupov MN, Iida Y, Kobayashi T, Izumi Y (2004). Modification of halogen specificity of a vanadium-dependent bromoperoxidase. Protein Sci, 13(6), 1566-1571. Abstract.  Author URL.
Levdikov VM, Blagova EV, Brannigan JA, Cladière L, Antson AA, Isupov MN, Séror SJ, Wilkinson AJ (2004). The crystal structure of YloQ, a circularly permuted GTPase essential for Bacillus subtilis viability. Journal of Molecular Biology, 340(4), 767-782. Abstract.
Line K, Isupov MN, Littlechild JA (2004). The crystal structure of a (-) gamma-lactamase from an Aureobacterium species reveals a tetrahedral intermediate in the active site. J Mol Biol, 338(3), 519-532. Abstract.  Author URL.
Guy JE, Isupov MN, Littlechild JA (2003). Crystallization and preliminary X-ray diffraction studies of a novel alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix. Acta Crystallogr D Biol Crystallogr, 59(Pt 1), 174-176. Abstract.  Author URL.  Full text.
Littlechild JA, Guy JE, Isupov MN (2003). The Structure of an Alcohol Dehydrogenase from the Hyperthermophilic Archaeon Aeropyrum pernix. Journal of Molecular Biology, 331(5), 1041-1051.
Hollingsworth EJ, Isupov MN, Littlechild JA (2002). Crystallization and preliminary X-ray diffraction analysis of L-aminoacylase from the hyperthermophilic archaeon Thermococcus litoralis. Acta Crystallogr D Biol Crystallogr, 58(Pt 3), 507-510. Abstract.  Author URL.  Full text.
Littlechild J, Garcia-Rodriguez E, Dalby A, Isupov M (2002). Structural and functional comparisons between vanadium haloperoxidase and acid phosphatase enzymes. J Mol Recognit, 15(5), 291-296. Abstract.  Author URL.
Qi JF, Isupov MN, Littlechild JA, Anderson LE (2001). Chloroplast glyceraldehyde-3-P dehydrogenase contains a single disulfide bond located in the C-terminal extension to the B subunit. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 222, U121-U121. Author URL.
Qi JF, Isupov MN, Littlechild JA, Anderson LE (2001). Chloroplast glyceraldehyde-3-P dehydrogenase contains a single disulfide bond located in the C-terminal extension to the B subunit. BIOCHEMISTRY, 40(29), 8615-8615. Author URL.
Littlechild JA, Anderson LE, Isupov MN, Qi JF (2001). Chloroplast glyceraldehydes-3-phosphate dehydrogenase contains a single disulfide bond located in the C-terminal extension to the B subunit. Journal of Biological Chemistry, 276(38), 35247-35252.
Harris JR, Schröder E, Isupov MN, Scheffler D, Kristensen P, Littlechild JA, Vagin AA, Meissner U (2001). Comparison of the decameric structure of peroxiredoxin-II by transmission electron microscopy and X-ray crystallography. Biochim Biophys Acta, 1547(2), 221-234. Abstract.  Author URL.
Gonsalvez IS, Isupov MN, Littlechild JA (2001). Crystallization and preliminary X-ray analysis of a gamma-lactamase. Acta Crystallogr D Biol Crystallogr, 57(Pt 2), 284-286. Abstract.  Author URL.  Full text.
Littlechild JA, Isupov M (2001). Glyceraldehyde-3-phosphate dehydrogenase from Sulfolobus solfataricus. Methods Enzymol, 331, 105-117. Author URL.
Vagin AA, Isupov MN (2001). Spherically averaged phased translation function and its application to the search for molecules and fragments in electron-density maps. Acta Crystallographica - Section D Biological Crystallography, 57(10), 1451-1456. Abstract.  Full text.
Littlechild J, Isupov M, Garcia E (2001). Structural studies on the dodecameric vanadium containing bromoperoxidase from Corallina officinalis. JOURNAL OF INORGANIC BIOCHEMISTRY, 86(1), 67-67. Author URL.
Winn MD, Isupov MN, Murshudov GN (2001). Use of TLS parameters to model anisotropic displacements in macromolecular refinement. Acta Crystallographica Section D: Biological Crystallography, 57(1), 122-133. Abstract.  Full text.
Hollingsworth E, Brown R, Isupov M, Taylor S, Littlechild J (2000). Cloning, Expression & Purification of a Thermostable Aminoacylase from Thermococcus litoralis. Biochemical Society Transactions, 28(3), A78.1-A78.
Schröder E, Littlechild JA, Lebedev AA, Errington N, Vagin AA, Isupov MN (2000). Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 a resolution. Structure, 8(6), 605-615. Abstract.  Author URL.
Schroder E, Littlechild JA, Lebedev AA, Errington N, Vagin AA, Isupov MN (2000). Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 angstrom resolution (vol 8, pg 605, 2000). STRUCTURE, 8(12), U5-U5. Author URL.
Isupov MN, Dalby AR, Brindley AA, Izumi Y, Tanabe T, Murshudov GN, Littlechild JA (2000). Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis. J Mol Biol, 299(4), 1035-1049. Abstract.  Author URL.
Schröder E, Littlechild JA, Lebedev AA, Isupov MN (2000). Structure and mechanism of decameric 2-cys peroxiredoxin from human erythrocytes. Biochemical Society Transactions, 28(3), A75.3-A75.
Bourne PC, Isupov MN, Littlechild JA (2000). The atomic-resolution structure of a novel bacterial esterase. Structure, 8(2), 143-151. Abstract.  Author URL.
Charron C, Talfournier F, Isupov MN, Littlechild JA, Branlant G, Vitoux B, Aubry A (2000). The crystal structure of d-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Methanothermus fervidus in the presence of NADP(+) at 2.1 a resolution. J Mol Biol, 297(2), 481-500. Abstract.  Author URL.
Isupov MN, Fleming TM, Dalby AR, Crowhurst GS, Bourne PC, Littlechild JA (1999). Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. J Mol Biol, 291(3), 651-660. Abstract.  Author URL.
Schröder E, Isupov MN, Naran A, Littlechild JA (1999). Crystallization and preliminary X-ray analysis of human thioredoxin peroxidase-B from red blood cells. Acta Crystallogr D Biol Crystallogr, 55(Pt 2), 536-538. Abstract.  Author URL.  Full text.
Charron C, Talfournier F, Isupov MN, Branlant G, Littlechild JA, Vitoux B, Aubry A (1999). Crystallization and preliminary X-ray diffraction studies of D-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Methanothermus fervidus. Acta Crystallogr D Biol Crystallogr, 55(Pt 7), 1353-1355. Abstract.  Author URL.  Full text.
Singleton MR, Isupov MN, Littlechild JA (1999). Crystallization and preliminary X-ray diffraction studies of pyrrolidone carboxyl peptidase from the hyperthermophilic archaeon Thermococcus litoralis. Acta Crystallogr D Biol Crystallogr, 55(Pt 3), 702-703. Abstract.  Author URL.  Full text.
Bourne PC, Isupov MN, Littlechild JA (1999). Crystallization and preliminary x-ray diffraction studies of a novel bacterial esterase. Acta Crystallogr D Biol Crystallogr, 55(Pt 4), 915-917. Abstract.  Author URL.  Full text.
Crowhurst GS, Dalby AR, Isupov MN, Campbell JW, Littlechild JA (1999). Structure of a phosphoglycerate mutase:3-phosphoglyceric acid complex at 1.7 A. Acta Crystallogr D Biol Crystallogr, 55(Pt 11), 1822-1826. Abstract.  Author URL.  Full text.
Morgunova E, Tuuttila A, Bergmann U, Isupov M, Lindqvist Y, Schneider G, Tryggvason K (1999). Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed. Science, 284(5420), 1667-1670. Abstract.  Author URL.
Singleton M, Isupov M, Littlechild J (1999). X-ray structure of pyrrolidone carboxyl peptidase from the hyperthermophilic archaeon Thermococcus litoralis. Structure, 7(3), 237-244. Abstract.  Author URL.
Fleming TM, Jones CE, Piper PW, Cowan DA, Isupov MN, Littlechild JA (1998). Characterization, crystallization and preliminary X-ray investigation of glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. Acta Crystallogr D Biol Crystallogr, 54(Pt 4), 671-674. Abstract.  Author URL.  Full text.
Isupov MN, Antson AA, Dodson EJ, Dodson GG, Dementieva IS, Zakomirdina LN, Wilson KS, Dauter Z, Lebedev AA, Harutyunyan EH, et al (1998). Crystal structure of tryptophanase. Journal of Molecular Biology, 276(3), 603-623. Abstract.
McGhie EJ, Isupov MN, Schröder E, Littlechild JA (1998). Crystallization and preliminary X-ray diffraction studies of the oxygenating subunit of 3,6-diketocamphane monooxygenase from Pseudomonas putida. Acta Crystallogr D Biol Crystallogr, 54(Pt 5), 1035-1038. Abstract.  Author URL.  Full text.
Brindley AA, Dalby AR, Isupov MN, Littlechild JA (1998). Preliminary X-ray analysis of a new crystal form of the vanadium-dependent bromoperoxidase from Corallina officinalis. Acta Crystallogr D Biol Crystallogr, 54(Pt 3), 454-457. Abstract.  Author URL.  Full text.
Crowhurst GSE, Isupov MN, Fleming T, Littlechild JA (1998). Two glycolytic enzymes from Sulfolobus solfataricus. Biochemical Society Transactions, 26(3), S275-S275.
Pletnev SV, Antson AA, Sinitsyna NI, Dauter Z, Isupov MN, Hurs EN, Faleev NG, Wilson KS, Dodson G, Demidkina TV, et al (1997). Crystallographic study of tyrosine phenol-lyase from Erwinia herbicola. Kristallografiya, 42(5), 877-888.
Isupov MN, Obmolova G, Butterworth S, BadetDenisot MA, Badet B, Polikarpov I, Littlechild JA, Teplyakov A (1997). Substrate binding is required for assembly of the active conformation of the catalytic site in Ntn amidotransferases: Evidence from the 1.8 angstrom crystal structure of the glutaminase domain of glucosamine 6-phosphate synthase (vol 4, pg 801, 1996). STRUCTURE, 5(5), 723-723. Author URL.
Pletnev SV, Isupov MN, Dauter Z, Wilson KS, Faleev NG, Harutyunyan EG, Demidkina TV (1996). Purification and crystals of tyrosine phenol-lyase from Erwinia herbicola. Biochemistry and Molecular Biology International, 38(1 Included), 37-42. Abstract.
Isupov MN, Obmolova G, Butterworth S, Badet-Denisot MA, Badet B, Polikarpov I, Littlechild JA, Teplyakov A (1996). Substrate binding is required for assembly of the active conformation of the catalytic site in Ntn amidotransferases: evidence from the 1.8 a crystal structure of the glutaminase domain of glucosamine 6-phosphate synthase. Structure, 4(7), 801-810. Abstract.  Author URL.
Dementieva IS, Zakomirdina LN, Sinitzina NI, Antson AA, Wilson KS, Isupov MN, Lebedev AA, Harutyunyan EH (1994). Crystallization and preliminary X-ray investigation of holotryptophanases from Escherichia coli and Proteus vulgaris. Journal of Molecular Biology, 235(2), 783-786. Abstract.
Strelkov SV, Zurabishvili TG, Nepluev IV, Efimov VP, Isupov MN, Harutyunyan EH, Mesyanzhinov VV (1993). Crystallization and preliminary crystallographic characterization of bacteriophage T4 baseplate protein encoded by gene 9. Journal of Molecular Biology, 234(2), 493-495. Abstract.
Antson AA, Strokopytov BV, Murshudov GN, Isupov MN, Harutyunyan EH, Demidkina TV, Vassylyev DG, Dauter Z, Terry H, Wilson KS, et al (1992). The polypeptide chain fold in tyrosine phenol-lyase, a pyridoxal-5′-phosphate-dependent enzyme. FEBS Letters, 302(3), 256-260. Abstract.
BOGDANKEVICH OV, DAVYDOV VO, ZVEREV MM, ISUPOV MN, KUDEYAROV YA, FAIFER VN (1987). INDUCED CONDUCTIVITY OF CADMIUM-SULFIDE CRYSTALS SUBJECTED TO STRONG EXCITATION. SOVIET PHYSICS SEMICONDUCTORS-USSR, 21(12), 1342-1343. Author URL.

Chapters

Littlechild J, Isupov M (2014). Haloperoxidase enzymes as 'redox catalysts' important for industrial biocatalysis. In  (Ed) Recent Advances in Redox Active Plant and Microbial Products: from Basic Chemistry to Widespread Applications in Medicine and Agriculture, 425-446.  Abstract.
Littlechild JA, Garcia-Rodriguez E, Coupe E, Watts A, Isupov M (2007). Structural Studies of Vanadium Haloperoxidases:Insight into Halide Specificity,Stability and Enzyme Mechanism. In Kustin K, Pessoa JC, Crans D (Eds.) Vanadium:The versatile Metal, Washington, USA: ACS, 136-147.
Isupov M, Dementieva I, Zakomirdina L, Wilson KS, Dauter Z, Antson AA, Dodson GG, Harutyunyan EG (1994). X-ray study of tryptophanase at 2.1 Å resolution. In Marino G, Sannia G, Bossa F (Eds.) Biochemistry of Vitamin B6 and PQQ, Basel: Birkhäuser Basel, 183-185.  Abstract.

Conferences

Littlechild JA, Guy JE, Isupov MN (2004). Hyperthermophilic dehydrogenase enzymes.  Abstract.  Author URL.
Crowhurst GS, Isupov MN, Fleming T, Littlechild JA (1998). Two glycolytic enzymes from Sulfolobus solfataricus.  Author URL.
Lilly MD, Chauhan R, French C, Gyamerah M, Hobbs GR, Humphrey A, Isupov M, Littlechild JA, Mitra RK, Morris KG, et al (1996). Carbon-carbon bond synthesis: the impact of rDNA technology on the production and use of E. coli transketolase.  Abstract.
Teplyakovi A, Isupov MN (1996). STRUCTURE DETERMINATION OF GLUCOSAMINE-6P SYNTHASE: FIGHTING AGAINST PSEUDOSYMMETRY.  Author URL.

Publications by year


In Press

Knight AR, Taylor EL, Lukaszewski R, Winyard PG (In Press). A high-sensitivity electrochemiluminescence-based ELISA for the measurement of the oxidative stress biomarker, 3-nitrotyrosine, in human blood serum and cells. Free Radical Biology and Medicine Full text.
Zhang J, Fan F, Zhao Y, Sun L, Liu Y, Keegan RM, Isupov MN, Wu Y (In Press). Crystal structure of the type IV secretion system component CagX from Helicobacter pylori. Acta Crystallogr F Struct Biol Commun, 73(Pt 3), 167-173. Abstract.  Author URL.  Full text.
Romano-Moreno M, Rojas AL, Williamson CD, Gershlick DC, Lucas M, Isupov MN, Bonifacino JS, Machner MP, Hierro A (In Press). Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL. Proc Natl Acad Sci U S A, 114(52), E11151-E11160. Abstract.  Author URL.  Full text.
Sporny M, Guez-Haddad J, Kreusch A, Shakartzi S, Neznansky A, Cross A, Isupov M, Qualmann B, Kessels MM, Opatowsky Y, et al (In Press). Structural History of Human SRGAP2 Proteins. Molecular Biology and Evolution Full text.
Isupov MN, Schröder E, Gibson RP, Beecher J, Donadio G, Saneei V, Dcunha SA, McGhie EJ, Sayer C, Davenport CF, et al (In Press). The oxygenating constituent of 3,6-diketocamphane monooxygenase from the CAM plasmid of Pseudomonas putida: the first crystal structure of a type II Baeyer-Villiger monooxygenase. Corrigendum. Acta Crystallogr D Struct Biol, 74(Pt 4). Abstract.  Author URL.

2018

Soudah N, Padala P, Hassouna F, Kumar M, Mashahreh B, Lebedev AA, Isupov MN, Cohen-Kfir E, Wiener R (2018). An N-Terminal Extension to UBA5 Adenylation Domain Boosts UFM1 Activation: Isoform-Specific Differences in Ubiquitin-like Protein Activation. J Mol Biol Abstract.  Author URL.
Ferrandi EE, Sayer C, De Rose SA, Guazzelli E, Marchesi C, Saneei V, Isupov MN, Littlechild JA, Monti D (2018). New thermophilic α/β class epoxide hydrolases found in metagenomes from hot environments. Frontiers in Bioengineering and Biotechnology, 6(OCT). Abstract.  Full text.
Winter AJ, Williams C, Isupov MN, Crocker H, Gromova M, Marsh P, Wilkinson OJ, Dillingham MS, Harmer NJ, Titball RW, et al (2018). The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA. J Biol Chem Abstract.  Author URL.

2017

Vogeler S, Galloway TS, Isupov M, Bean TP (2017). Cloning retinoid and peroxisome proliferator-activated nuclear receptors of the Pacific oyster and in silico binding to environmental chemicals. PLoS One, 12(4). Abstract.  Author URL.  Full text.
Littlechild JA, Isupov MN (2017). Comments to Article by Willetts A. et al. Microorganisms 2016, 4, 38. Microorganisms, 5(3). Abstract.  Author URL.
Padala P, Soudah N, Giladi M, Haitin Y, Isupov MN, Wiener R (2017). The Crystal Structure and Conformations of an Unbranched Mixed Tri-Ubiquitin Chain Containing K48 and K63 Linkages. J Mol Biol, 429(24), 3801-3813. Abstract.  Author URL.  Full text.

2016

Zarafeta D, Kissas D, Sayer C, Gudbergsdottir SR, Ladoukakis E, Isupov MN, Chatziioannou A, Peng X, Littlechild JA, Skretas G, et al (2016). Discovery and Characterization of a Thermostable and Highly Halotolerant GH5 Cellulase from an Icelandic Hot Spring Isolate. PLoS One, 11(1). Abstract.  Author URL.  Full text.
Sporny M, Guez-Haddad J, Waterman DG, Isupov MN, Opatowsky Y (2016). Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain. Acta Crystallographica Section D Structural Biology, 72(12), 1241-1253. Full text.
sayer C, Finnigan W, Isupov MN, Levisson M, Kengen SWM, van der Oost J, Harmer NJ, Littlechild JA (2016). Structural and biochemical characterisation of Archaeoglobus fulgidus esterase reveals a bound CoA molecule in the vicinity of the active site. Scientific Reports, 6, 25542-25542. Abstract.  Full text.

2015

Ferrandi EE, Sayer C, Isupov MN, Annovazzi C, Marchesi C, Iacobone G, Peng X, Bonch-Osmolovskaya E, Wohlgemuth R, Littlechild JA, et al (2015). Discovery and characterization of thermophilic limonene-1,2-epoxide hydrolases from hot spring metagenomic libraries. FEBS J, 282(15), 2879-2894. Abstract.  Author URL.
Sayer C, Isupov MN, Bonch-Osmolovskaya E, Littlechild JA (2015). Structural studies of a thermophilic esterase from a new Planctomycetes species, Thermogutta terrifontis. FEBS J, 282(15), 2846-2857. Abstract.  Author URL.
Sayer C, Szabo Z, Isupov MN, Ingham C, Littlechild JA (2015). The Structure of a Novel Thermophilic Esterase from the Planctomycetes Species, Thermogutta terrifontis Reveals an Open Active Site Due to a Minimal 'Cap' Domain. Front Microbiol, 6 Abstract.  Author URL.  Full text.
Isupov MN, Schröder E, Gibson RP, Beecher J, Donadio G, Saneei V, Dcunha SA, McGhie EJ, Sayer C, Davenport CF, et al (2015). The oxygenating constituent of 3,6-diketocamphane monooxygenase from the CAM plasmid of Pseudomonas putida: the first crystal structure of a type II Baeyer-Villiger monooxygenase. Acta Crystallogr D Biol Crystallogr, 71(Pt 11), 2344-2353. Abstract.  Author URL.  Full text.
Vivoli M, Isupov MN, Nicholas R, Hill A, Scott AE, Kosma P, Prior JL, Harmer NJ (2015). Unraveling the B. pseudomallei Heptokinase WcbL: from Structure to Drug Discovery. Chemistry and Biology, 22(12), 1622-1632. Abstract.  Full text.

2014

Novak HR, Sayer C, Isupov MN, Gotz D, Spragg AM, Littlechild JA (2014). Biochemical and structural characterisation of a haloalkane dehalogenase from a marine Rhodobacteraceae. FEBS Lett, 588(9), 1616-1622. Abstract.  Author URL.  Full text.
Littlechild J, Isupov M (2014). Haloperoxidase enzymes as 'redox catalysts' important for industrial biocatalysis. In  (Ed) Recent Advances in Redox Active Plant and Microbial Products: from Basic Chemistry to Widespread Applications in Medicine and Agriculture, 425-446.  Abstract.
Lebedev AA, Isupov MN (2014). Space-group and origin ambiguity in macromolecular structures with pseudo-symmetry and its treatment with the program Zanuda. Acta Crystallographica Section D: Biological Crystallography, 70(9), 2430-2443. Abstract.  Full text.
Vivoli M, Ayres E, Beaumont E, Isupov MN, Harmer NJ (2014). Structural insights into WcbI, a novel polysaccharide-biosynthesis enzyme. IUCrJ, 1, 28-38. Full text.
Littlechild J, Sayer C, Isupov M, Ward J, Littlechild J (2014). Structural studies on transaminase enzymes and applications in biocatalysis. NEW BIOTECHNOLOGY, 31, S19-S19. Author URL.
James P, Isupov MN, Sayer C, Saneei V, Berg S, Lioliou M, Kotlar HK, Littlechild JA (2014). The structure of a tetrameric α-carbonic anhydrase from Thermovibrio ammonificans reveals a core formed around intermolecular disulfides that contribute to its thermostability. Acta Crystallogr D Biol Crystallogr, 70(Pt 10), 2607-2618. Abstract.  Author URL.  Full text.
Sayer C, Martinez-Torres RJ, Richter N, Isupov MN, Hailes HC, Littlechild JA, Ward JM (2014). The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca. FEBS J, 281(9), 2240-2253. Abstract.  Author URL.  Full text.

2013

Reid EL, Weynberg KD, Love J, Isupov MN, Littlechild JA, Wilson WH, Kelly SL, Lamb DC, Allen MJ (2013). Functional and structural characterisation of a viral cytochrome b5. FEBS Lett, 587(22), 3633-3639. Abstract.  Author URL.
Novak HR, Sayer C, Isupov MN, Paszkiewicz K, Gotz D, Spragg AM, Littlechild JA (2013). Marine Rhodobacteraceae L-haloacid dehalogenase contains a novel His/Glu dyad that could activate the catalytic water. FEBS J, 280(7), 1664-1680. Abstract.  Author URL.  Full text.
Sayer C, Isupov MN, Westlake A, Littlechild JA (2013). Structural studies of Pseudomonas and Chromobacterium ω- aminotransferases provide insights into their differing substrate specificity. Acta Crystallographica Section D: Biological Crystallography, 69(4), 564-576. Abstract.  Full text.

2012

Sayer C, Bommer M, Isupov M, Ward J, Littlechild J (2012). Crystal structure and substrate specificity of the thermophilic serine:pyruvate aminotransferase from Sulfolobus solfataricus. Acta Crystallogr D Biol Crystallogr, 68(Pt 7), 763-772. Abstract.  Author URL.  Full text.
Urusova DV, Isupov MN, Antonyuk S, Kachalova GS, Obmolova G, Vagin AA, Lebedev AA, Burenkov GP, Dauter Z, Bartunik HD, et al (2012). Crystal structure of D-serine dehydratase from Escherichia coli. Biochimica et Biophysica Acta - Proteins and Proteomics, 1824(3), 422-432. Abstract.
Lebedev AA, Young P, Isupov MN, Moroz OV, Vagin AA, Murshudov GN (2012). JLigand: a graphical tool for the CCP4 template-restraint library. Acta Crystallogr D Biol Crystallogr, 68(Pt 4), 431-440. Abstract.  Author URL.  Full text.

2010

Shevtsov MB, Chen Y, Isupov MN, Leech A, Gollnick P, Antson AA (2010). Bacillus licheniformis Anti-TRAP can assemble into two types of dodecameric particles with the same symmetry but inverted orientation of trimers. Journal of Structural Biology, 170(1), 127-133. Abstract.  Full text.
Opperman DJ, Sewell BT, Litthauer D, Isupov MN, Littlechild JA, van Heerden E (2010). Crystal structure of a thermostable old yellow enzyme from Thermus scotoductus SA-01. Biochem Biophys Res Commun, 393(3), 426-431. Abstract.  Author URL.
Willies S, Isupov M, Littlechild J (2010). Thermophilic enzymes and their applications in biocatalysis: a robust aldo-keto reductase. Environ Technol, 31(10), 1159-1167. Abstract.  Author URL.

2009

Rye CA, Isupov MN, Lebedev AA, Littlechild JA (2009). Biochemical and structural studies of a L-haloacid dehalogenase from the thermophilic archaeon Sulfolobus tokodaii. Extremophiles, 13(1), 179-190. Abstract.  Author URL.  Full text.
Ng CL, Waterman DG, Koonin EV, Walters AD, Chong JP, Isupov MN, Lebedev AA, Bunka DH, Stockley PG, Ortiz-Lombardía M, et al (2009). Conformational flexibility and molecular interactions of an archaeal homologue of the Shwachman-Bodian-Diamond syndrome protein. BMC Structural Biology, 9 Abstract.  Full text.
Willies SC, Isupov MN, Garman EF, Littlechild JA (2009). The binding of haem and zinc in the 1.9 a X-ray structure of Escherichia coli bacterioferritin. J Biol Inorg Chem, 14(2), 201-207. Abstract.  Author URL.  Full text.
Littlechild J, Garcia Rodriguez E, Isupov M (2009). Vanadium containing bromoperoxidase--insights into the enzymatic mechanism using X-ray crystallography. J Inorg Biochem, 103(4), 617-621. Abstract.  Author URL.  Full text.

2008

Line K, Isupov MN, Garcia-Rodriguez E, Maggioli G, Parra F, Littlechild JA (2008). The Fasciola hepatica thioredoxin: High resolution structure reveals two oxidation states. Mol Biochem Parasitol, 161(1), 44-48. Abstract.  Author URL.  Full text.

2007

Rye CA, Isupov MN, Lebedev AA, Littlechild JA (2007). An order-disorder twin crystal of L-2-haloacid dehalogenase from Sulfolobus tokodaii. Acta Crystallogr D Biol Crystallogr, 63(Pt 8), 926-930. Abstract.  Author URL.  Full text.
Sayer C, Isupov MN, Littlechild JA (2007). Crystallization and preliminary X-ray diffraction analysis of omega-amino acid:pyruvate transaminase from Chromobacterium violaceum. Acta Crystallogr Sect F Struct Biol Cryst Commun, 63(Pt 2), 117-119. Abstract.  Author URL.  Full text.
Isupov MN, Lebedev AA (2007). NCS-constrained exhaustive search using oligomeric models. Acta Crystallographica Section D: Biological Crystallography, 64(1), 90-98. Abstract.  Full text.
Littlechild JA, Guy J, Connelly S, Mallett L, Waddell S, Rye CA, Line K, Isupov M (2007). Natural methods of protein stabilization: thermostable biocatalysts. Biochem Soc Trans, 35(Pt 6), 1558-1563. Abstract.  Author URL.
Sanders CM, Kovalevskiy OV, Sizov D, Lebedev AA, Isupov MN, Antson AA (2007). Papillomavirus E1 helicase assembly maintains an asymmetric state in the absence of DNA and nucleotide cofactors. Nucleic Acids Research, 35(19), 6451-6457. Abstract.  Full text.
Littlechild JA, Garcia-Rodriguez E, Coupe E, Watts A, Isupov M (2007). Structural Studies of Vanadium Haloperoxidases:Insight into Halide Specificity,Stability and Enzyme Mechanism. In Kustin K, Pessoa JC, Crans D (Eds.) Vanadium:The versatile Metal, Washington, USA: ACS, 136-147.

2006

Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N (2006). Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme. J Biol Chem, 281(23), 15662-15670. Abstract.  Author URL.
Littlechild J, Garcia-Rodriguez E, Isupov M (2006). INOR 398-Crystallization studies of vanadium haloperoxidases: Insights into halide specificity and enzyme mechanism. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 232 Author URL.

2005

Connelly S, Line K, Isupov MN, Littlechild JA (2005). Synthesis and characterisation of a ligand that forms a stable tetrahedral intermediate in the active site of the Aureobacterium species (-) gamma-lactamase. Org Biomol Chem, 3(18), 3260-3262. Abstract.  Author URL.

2004

Singleton MR, Morales R, Grainge I, Cook N, Isupov MN, Wigley DB (2004). Conformational changes induced by nucleotide binding in Cdc6/ORC from Aeropyrum pernix. Journal of Molecular Biology, 343(3), 547-557. Abstract.
Isupov MN, Brindley AA, Hollingsworth EJ, Murshudov GN, Vagin AA, Littlechild JA (2004). Crystallization and preliminary X-ray diffraction studies of a fungal hydrolase from Ophiostoma novo-ulmi. Acta Crystallogr D Biol Crystallogr, 60(Pt 10), 1879-1882. Abstract.  Author URL.  Full text.
Littlechild JA, Guy JE, Isupov MN (2004). Hyperthermophilic dehydrogenase enzymes.  Abstract.  Author URL.
Ohshiro T, Littlechild J, Garcia-Rodriguez E, Isupov MN, Iida Y, Kobayashi T, Izumi Y (2004). Modification of halogen specificity of a vanadium-dependent bromoperoxidase. Protein Sci, 13(6), 1566-1571. Abstract.  Author URL.
Levdikov VM, Blagova EV, Brannigan JA, Cladière L, Antson AA, Isupov MN, Séror SJ, Wilkinson AJ (2004). The crystal structure of YloQ, a circularly permuted GTPase essential for Bacillus subtilis viability. Journal of Molecular Biology, 340(4), 767-782. Abstract.
Line K, Isupov MN, Littlechild JA (2004). The crystal structure of a (-) gamma-lactamase from an Aureobacterium species reveals a tetrahedral intermediate in the active site. J Mol Biol, 338(3), 519-532. Abstract.  Author URL.

2003

Guy JE, Isupov MN, Littlechild JA (2003). Crystallization and preliminary X-ray diffraction studies of a novel alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix. Acta Crystallogr D Biol Crystallogr, 59(Pt 1), 174-176. Abstract.  Author URL.  Full text.
Littlechild JA, Guy JE, Isupov MN (2003). The Structure of an Alcohol Dehydrogenase from the Hyperthermophilic Archaeon Aeropyrum pernix. Journal of Molecular Biology, 331(5), 1041-1051.

2002

Hollingsworth EJ, Isupov MN, Littlechild JA (2002). Crystallization and preliminary X-ray diffraction analysis of L-aminoacylase from the hyperthermophilic archaeon Thermococcus litoralis. Acta Crystallogr D Biol Crystallogr, 58(Pt 3), 507-510. Abstract.  Author URL.  Full text.
Littlechild J, Garcia-Rodriguez E, Dalby A, Isupov M (2002). Structural and functional comparisons between vanadium haloperoxidase and acid phosphatase enzymes. J Mol Recognit, 15(5), 291-296. Abstract.  Author URL.

2001

Qi JF, Isupov MN, Littlechild JA, Anderson LE (2001). Chloroplast glyceraldehyde-3-P dehydrogenase contains a single disulfide bond located in the C-terminal extension to the B subunit. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 222, U121-U121. Author URL.
Qi JF, Isupov MN, Littlechild JA, Anderson LE (2001). Chloroplast glyceraldehyde-3-P dehydrogenase contains a single disulfide bond located in the C-terminal extension to the B subunit. BIOCHEMISTRY, 40(29), 8615-8615. Author URL.
Littlechild JA, Anderson LE, Isupov MN, Qi JF (2001). Chloroplast glyceraldehydes-3-phosphate dehydrogenase contains a single disulfide bond located in the C-terminal extension to the B subunit. Journal of Biological Chemistry, 276(38), 35247-35252.
Harris JR, Schröder E, Isupov MN, Scheffler D, Kristensen P, Littlechild JA, Vagin AA, Meissner U (2001). Comparison of the decameric structure of peroxiredoxin-II by transmission electron microscopy and X-ray crystallography. Biochim Biophys Acta, 1547(2), 221-234. Abstract.  Author URL.
Gonsalvez IS, Isupov MN, Littlechild JA (2001). Crystallization and preliminary X-ray analysis of a gamma-lactamase. Acta Crystallogr D Biol Crystallogr, 57(Pt 2), 284-286. Abstract.  Author URL.  Full text.
Littlechild JA, Isupov M (2001). Glyceraldehyde-3-phosphate dehydrogenase from Sulfolobus solfataricus. Methods Enzymol, 331, 105-117. Author URL.
Vagin AA, Isupov MN (2001). Spherically averaged phased translation function and its application to the search for molecules and fragments in electron-density maps. Acta Crystallographica - Section D Biological Crystallography, 57(10), 1451-1456. Abstract.  Full text.
Littlechild J, Isupov M, Garcia E (2001). Structural studies on the dodecameric vanadium containing bromoperoxidase from Corallina officinalis. JOURNAL OF INORGANIC BIOCHEMISTRY, 86(1), 67-67. Author URL.
Winn MD, Isupov MN, Murshudov GN (2001). Use of TLS parameters to model anisotropic displacements in macromolecular refinement. Acta Crystallographica Section D: Biological Crystallography, 57(1), 122-133. Abstract.  Full text.

2000

Hollingsworth E, Brown R, Isupov M, Taylor S, Littlechild J (2000). Cloning, Expression & Purification of a Thermostable Aminoacylase from Thermococcus litoralis. Biochemical Society Transactions, 28(3), A78.1-A78.
Schröder E, Littlechild JA, Lebedev AA, Errington N, Vagin AA, Isupov MN (2000). Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 a resolution. Structure, 8(6), 605-615. Abstract.  Author URL.
Schroder E, Littlechild JA, Lebedev AA, Errington N, Vagin AA, Isupov MN (2000). Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 angstrom resolution (vol 8, pg 605, 2000). STRUCTURE, 8(12), U5-U5. Author URL.
Isupov MN, Dalby AR, Brindley AA, Izumi Y, Tanabe T, Murshudov GN, Littlechild JA (2000). Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis. J Mol Biol, 299(4), 1035-1049. Abstract.  Author URL.
Schröder E, Littlechild JA, Lebedev AA, Isupov MN (2000). Structure and mechanism of decameric 2-cys peroxiredoxin from human erythrocytes. Biochemical Society Transactions, 28(3), A75.3-A75.
Bourne PC, Isupov MN, Littlechild JA (2000). The atomic-resolution structure of a novel bacterial esterase. Structure, 8(2), 143-151. Abstract.  Author URL.
Charron C, Talfournier F, Isupov MN, Littlechild JA, Branlant G, Vitoux B, Aubry A (2000). The crystal structure of d-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Methanothermus fervidus in the presence of NADP(+) at 2.1 a resolution. J Mol Biol, 297(2), 481-500. Abstract.  Author URL.

1999

Isupov MN, Fleming TM, Dalby AR, Crowhurst GS, Bourne PC, Littlechild JA (1999). Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. J Mol Biol, 291(3), 651-660. Abstract.  Author URL.
Schröder E, Isupov MN, Naran A, Littlechild JA (1999). Crystallization and preliminary X-ray analysis of human thioredoxin peroxidase-B from red blood cells. Acta Crystallogr D Biol Crystallogr, 55(Pt 2), 536-538. Abstract.  Author URL.  Full text.
Charron C, Talfournier F, Isupov MN, Branlant G, Littlechild JA, Vitoux B, Aubry A (1999). Crystallization and preliminary X-ray diffraction studies of D-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Methanothermus fervidus. Acta Crystallogr D Biol Crystallogr, 55(Pt 7), 1353-1355. Abstract.  Author URL.  Full text.
Singleton MR, Isupov MN, Littlechild JA (1999). Crystallization and preliminary X-ray diffraction studies of pyrrolidone carboxyl peptidase from the hyperthermophilic archaeon Thermococcus litoralis. Acta Crystallogr D Biol Crystallogr, 55(Pt 3), 702-703. Abstract.  Author URL.  Full text.
Bourne PC, Isupov MN, Littlechild JA (1999). Crystallization and preliminary x-ray diffraction studies of a novel bacterial esterase. Acta Crystallogr D Biol Crystallogr, 55(Pt 4), 915-917. Abstract.  Author URL.  Full text.
Crowhurst GS, Dalby AR, Isupov MN, Campbell JW, Littlechild JA (1999). Structure of a phosphoglycerate mutase:3-phosphoglyceric acid complex at 1.7 A. Acta Crystallogr D Biol Crystallogr, 55(Pt 11), 1822-1826. Abstract.  Author URL.  Full text.
Morgunova E, Tuuttila A, Bergmann U, Isupov M, Lindqvist Y, Schneider G, Tryggvason K (1999). Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed. Science, 284(5420), 1667-1670. Abstract.  Author URL.
Singleton M, Isupov M, Littlechild J (1999). X-ray structure of pyrrolidone carboxyl peptidase from the hyperthermophilic archaeon Thermococcus litoralis. Structure, 7(3), 237-244. Abstract.  Author URL.

1998

Fleming TM, Jones CE, Piper PW, Cowan DA, Isupov MN, Littlechild JA (1998). Characterization, crystallization and preliminary X-ray investigation of glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus. Acta Crystallogr D Biol Crystallogr, 54(Pt 4), 671-674. Abstract.  Author URL.  Full text.
Isupov MN, Antson AA, Dodson EJ, Dodson GG, Dementieva IS, Zakomirdina LN, Wilson KS, Dauter Z, Lebedev AA, Harutyunyan EH, et al (1998). Crystal structure of tryptophanase. Journal of Molecular Biology, 276(3), 603-623. Abstract.
McGhie EJ, Isupov MN, Schröder E, Littlechild JA (1998). Crystallization and preliminary X-ray diffraction studies of the oxygenating subunit of 3,6-diketocamphane monooxygenase from Pseudomonas putida. Acta Crystallogr D Biol Crystallogr, 54(Pt 5), 1035-1038. Abstract.  Author URL.  Full text.
Brindley AA, Dalby AR, Isupov MN, Littlechild JA (1998). Preliminary X-ray analysis of a new crystal form of the vanadium-dependent bromoperoxidase from Corallina officinalis. Acta Crystallogr D Biol Crystallogr, 54(Pt 3), 454-457. Abstract.  Author URL.  Full text.
Crowhurst GSE, Isupov MN, Fleming T, Littlechild JA (1998). Two glycolytic enzymes from Sulfolobus solfataricus. Biochemical Society Transactions, 26(3), S275-S275.
Crowhurst GS, Isupov MN, Fleming T, Littlechild JA (1998). Two glycolytic enzymes from Sulfolobus solfataricus.  Author URL.

1997

Pletnev SV, Antson AA, Sinitsyna NI, Dauter Z, Isupov MN, Hurs EN, Faleev NG, Wilson KS, Dodson G, Demidkina TV, et al (1997). Crystallographic study of tyrosine phenol-lyase from Erwinia herbicola. Kristallografiya, 42(5), 877-888.
Isupov MN, Obmolova G, Butterworth S, BadetDenisot MA, Badet B, Polikarpov I, Littlechild JA, Teplyakov A (1997). Substrate binding is required for assembly of the active conformation of the catalytic site in Ntn amidotransferases: Evidence from the 1.8 angstrom crystal structure of the glutaminase domain of glucosamine 6-phosphate synthase (vol 4, pg 801, 1996). STRUCTURE, 5(5), 723-723. Author URL.

1996

Lilly MD, Chauhan R, French C, Gyamerah M, Hobbs GR, Humphrey A, Isupov M, Littlechild JA, Mitra RK, Morris KG, et al (1996). Carbon-carbon bond synthesis: the impact of rDNA technology on the production and use of E. coli transketolase.  Abstract.
Pletnev SV, Isupov MN, Dauter Z, Wilson KS, Faleev NG, Harutyunyan EG, Demidkina TV (1996). Purification and crystals of tyrosine phenol-lyase from Erwinia herbicola. Biochemistry and Molecular Biology International, 38(1 Included), 37-42. Abstract.
Teplyakovi A, Isupov MN (1996). STRUCTURE DETERMINATION OF GLUCOSAMINE-6P SYNTHASE: FIGHTING AGAINST PSEUDOSYMMETRY.  Author URL.
Isupov MN, Obmolova G, Butterworth S, Badet-Denisot MA, Badet B, Polikarpov I, Littlechild JA, Teplyakov A (1996). Substrate binding is required for assembly of the active conformation of the catalytic site in Ntn amidotransferases: evidence from the 1.8 a crystal structure of the glutaminase domain of glucosamine 6-phosphate synthase. Structure, 4(7), 801-810. Abstract.  Author URL.

1994

Dementieva IS, Zakomirdina LN, Sinitzina NI, Antson AA, Wilson KS, Isupov MN, Lebedev AA, Harutyunyan EH (1994). Crystallization and preliminary X-ray investigation of holotryptophanases from Escherichia coli and Proteus vulgaris. Journal of Molecular Biology, 235(2), 783-786. Abstract.
Isupov M, Dementieva I, Zakomirdina L, Wilson KS, Dauter Z, Antson AA, Dodson GG, Harutyunyan EG (1994). X-ray study of tryptophanase at 2.1 Å resolution. In Marino G, Sannia G, Bossa F (Eds.) Biochemistry of Vitamin B6 and PQQ, Basel: Birkhäuser Basel, 183-185.  Abstract.

1993

Strelkov SV, Zurabishvili TG, Nepluev IV, Efimov VP, Isupov MN, Harutyunyan EH, Mesyanzhinov VV (1993). Crystallization and preliminary crystallographic characterization of bacteriophage T4 baseplate protein encoded by gene 9. Journal of Molecular Biology, 234(2), 493-495. Abstract.

1992

Antson AA, Strokopytov BV, Murshudov GN, Isupov MN, Harutyunyan EH, Demidkina TV, Vassylyev DG, Dauter Z, Terry H, Wilson KS, et al (1992). The polypeptide chain fold in tyrosine phenol-lyase, a pyridoxal-5′-phosphate-dependent enzyme. FEBS Letters, 302(3), 256-260. Abstract.

1987

BOGDANKEVICH OV, DAVYDOV VO, ZVEREV MM, ISUPOV MN, KUDEYAROV YA, FAIFER VN (1987). INDUCED CONDUCTIVITY OF CADMIUM-SULFIDE CRYSTALS SUBJECTED TO STRONG EXCITATION. SOVIET PHYSICS SEMICONDUCTORS-USSR, 21(12), 1342-1343. Author URL.

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