Dr Michelle Hares (nee Pound )
Project Manager for Estates, logistics & Infrastructure (Postdoctoral Research Fellow)
Peter Lanyon A042
Peter Lanyon Building, University of Exeter, Penryn Campus, Treliever Road, Penryn, Cornwall, TR10 9FE, UK
I am Project manager for major capital projects on Cornwall campuses for the University of Exeter.
Within this role I ensure smooth end to end completion of projects by;
- Developing, writing and co-ordinate funding bids both within the University and external agencies with UoE client.
- Agree project objectives with stakeholders, the project board and any other relevant parties
- Represent client side interests through project life-cycle, providing operational advice and supporting project boards and other internal governance infrastructure.
-Stakeholder management including developing communications plans and customer occupation
To date I have successfully project managed the Capital bid and project delivery of the University of Masters Suite facility on Penryn campus worth £1.2 million and the £ 1.77 million Renewable Energy Engineering Facility (REEF)
Current projects include;
- £12 million Science and Engineering Research Support Facility (SERSF)Extension
I also Project manage small infrastructure project delivery on Penryn Campus.
In addition as UoE representative for Health, Safety, Welfare, Accessibility, Business Continuity and Sustainability on Penryn campus; deputising for Head of Professional services where applicable.
PhD Investigation into the insecticidal Toxin complexes from Photorhabdus luminescens and Yersinia
MPhil Deletion screening and haplotype analysis in the FRAXE region at Xq28
BSc (Hons) Biochemistry
I first Joined the University of Exeter in 2006 as research Technician for Richard ffrench-Constant, while completing a PhD researching the mechanisms and evolution in bacterial TC toxins. After my PhD I secured a permenant position as an Experimental officer for the Centre for Ecology & Conservation. Within this role, I worked with academic colleagues to develop the reseach laboratories to support new tools for research such as cell biology and molecular biology. I also carried out R&D pilot studies to provide preliminary data to support grant applications. Subsequently I was promoted to Senior Laboratory manager, managing the operation of 10 research laboratories within CLES. This was in tandem to fundend research with academic colleagues in CLES. During this time, I was lucky enough to have a sabatical as a lecturer within CLES where I developed and taught Approaches to Evolutionary and Behavioural Ecolgy module as part of the MSc Evolution and Behavioural Ecology. I also spent a year teaching the UG module Developmental Biology and Diversity.
Subsequently I was asked to represent CLES requirements to develop the design of the Biological research facilites in the ESI building. This lead me to my new role as Project Manager; Estates, Logistics and Infrastructure. Within this roles I project manage both capital building projects and refurbishment projects on Penryn Campus.
I am interested in ageing and telomere dynamics and how differences in telomere length and telomerase activity have co-evolved with fitness traits in wild populations of animals.
Telomere Dynamics and life history in wild populations
Currently, I am working with Mike Cant and Jon Blount as a postdoctoral Research Fellow to investigate telomere length using QPCR in the banded mongoose. Banded Mongoose are highly cooperative and are unusual as females from the same mate group give birth to offspring on the same day. Interestingly, offspring are cared for by non-breeding males and this care varies. We are investigating whether there is a cost with respect to telomere length, in offspring who have high levels of care compared to those who have low level care.
Hares MC, Vitikainen EIK, Marshall HH, Thompson FJ, Blount JD, Cant MA. (2018) Telomere dynamics in wild banded mongooses; Evaluating Longitudinal and quasi longitudinal markers of senescence. Exp Gerontol. 107:67-73.
Marshall HH, Vitikainen EI, Mwanguhya F, Businge R, Kyabulima S, Hares MC, Inzani E, Kalema-Zikusoka G, Mwesige K, Nichols HJ, Sanderson JL, Thompson FJ, Cant MA. (2017) Lifetime fitness consequences of early-life ecological hardship in will mammal population. Ecol Evol. 7(6):1712-1724. .
Marshall HH, Sanderson JL, Mwanghuya F, Businge R, Kyabulima S, Hares MC, Inzani E, Kalema-Zikusoka G, Mwesige K, Thompson FJ, Vitikainen EI, Cant MA. (2016) Variable ecological conditions promote male helping by changing banded group composition. Behav Ecol. 27(4):978-987.
Beirne C, Delahay R, Hares M, Young A. (2014) Age-related declines and disease-associated variation in immune cell telomere length in a wild animal. PLoS One 9:e108964.
Harrison X. A, York J. E, Cram D. L, Hares M. C, Young A. J. (2013) Complete Reproductive Skew within White-browed Sparrow Weaver Groups Despite Outbreeding Opportunities for Subordinates of Both Sexes. Behav Ecol Sociobiol 69 (12) 1997-2004
Evolution of bacterial toxins
I previously carried out research with Richard ffrench-Constant investigating bacterial pathogens and how they interact with their host to illicit their effects. I am particularly interested in the toxins bacteria use to invade their host and how homologous toxins from different bacteria have evolved to target different hosts. In particular, the evolution of the bacterial toxins of Photorhabdus. In particular, I am interested in the Toxin complexes (Tc).
The Tc genes were first identified in the insect pathogen Photorhabdus luminescens strain W14. These high molecular weight proteins (~1MDa) have been shown to be orally and injectably toxic to several orders of insects and represent a novel bio-insectide. They are encoded by four loci; tca, tcb, tcc and tcd, the genes within these loci labeled according to their order ( tcdA, tcbB, tccC) (Waterfield et al 2001). Significant homology is observed between the four loci and previous work has shown that three components are required for full toxicity towards the model insect pest Manduca sexta, the tcdA-like [A], the tcbB-like [B] and tccC-like [C] genes Waterfield, Hares et al 2005).
Subsequently these Tc’s have been identified in a variety of gram-negative pathogenic bacteria including the mammalian pathogens Yersinia pestis and Y. pseudotuberculosis, suggesting an evolving function or targets for these proteins directed towards insect and /or mammalian hosts (Waterfield, Hares et al 2007).
Indeed, Y. pestis Tc or Y. pseudotuberculosis Tc, which are mammalian pathogens, showed no toxic effects when fed to the model insect host Manduca sexta. However, we have shown that when the Y. pseudotuberculosis Tc’s are applied to the mammalian gut cell line CACO2 membrane ruffling, vacuolation and multinucleation is induced, whereas Tc gene knockouts were comparable to the control. These results were recapitulated when heterologously expressed ABC were applied to CACO2 cells or when individual Tc genes were transfected into CACO2 cells. This suggests the Tc toxins have adapted to their hosts. It is yet to be determined whether this is due to a change in function or change in host target (Hares, Hinchliffe et al 2008). Further compounding evidence for evolutionary adaptation of the Tc’s has been demonstrated in the insect pathogen Y. entomophagus. Unlike Y. pestis and Y. pseudotuberculosis this insect pathogen, however, like Y. pestis and Y. pseudotuberculosis is has been shown to have similar phenotypic effects on host cells (Marshall, Hares et al 2012). This suggesting that it is changes in host specificity rather than mode of action that have been adapted.
University of Exeter
Dr Michael Cant
Dr Jon Blount
Dr Andrew Young
Professor Richard ffrench-Constant
Professor Brendan Godley
Dr Nick Waterfield, University of Bath
Dr Mark Hurst, AgResearch, New Zealand
Publications by category
Publications by year
michelle_hares Details from cache as at 2018-10-21 14:45:55
I developed and ran the module; Approaches in Evolution and Behavioral Ecology within the Evolution and Behavioral Ecology Masters Programme from 2009-2013 coordinated by Professor Nina Wedell.
In 2011 I also taught UG module Development and Biodiversity.
Outreach activities included supporting A level student currium by providing experimental laboratory experients for students from Redruth School.
I also ran University Laboratory taster days in Conservation genetics for local secondary schools.
I have also been guest speaker at Falmouth School discussing the merits and future of DNA sequencing technology and genetics with Biology A level students.