Professor Rick Titball

Professor Rick Titball

Professor Richard Titball
Professor of Molecular Microbiology

Key publications | Publications by category | Publications by year

Key publications



Suwannasaen D, Mahawantung J, Chaowagul W, Limmathurotsakul D, Felgner PL, Davies H, Bancroft GJ, Titball RW, Lertmemongkolchai G (2011). Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis. J Infect Dis, 203(7), 1002-1011. Abstract.  Author URL. DOI.
Nandi T, Ong C, Singh AP, Boddey J, Atkins T, Sarkar-Tyson M, Essex-Lopresti AE, Chua HH, Pearson T, Kreisberg JF, et al (2010). A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence. PLoS pathogens, 6(4). Full text.
Champion OL, Karlyshev AV, Senior NJ, Woodward M, La Ragione R, Howard SL, Wren BW, Titball RW (2010). Insect infection model for Campylobacter jejuni reveals that O-methyl phosphoramidate has insecticidal activity. J Infect Dis, 201(5), 776-782. Abstract.  Author URL. DOI.
Felgner PL, Kayala MA, Vigil A, Burk C, Nakajima-Sasaki R, Pablo J, Molina DM, Hirst S, Chew JSW, Wang D, et al (2009). A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens. Proc Natl Acad Sci U S A, 106(32), 13499-13504. Abstract.  Author URL. DOI.
Rodrigues F, Sarkar-Tyson M, Harding SV, Sim SH, Chua HH, Lin CH, Han X, Krishna R, Karuturi M, Sung K, et al (2006). A global map of growth regulated gene expression in Burkholderia pseudomallei, the Causative Agent of Melioidosis. Journal of Bacteriology, 188, 8178-8188.
RT101, Andersson SGE, Chain P, Chu MC (2005). The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nature Genetics, 37(2), 153-159. DOI.

Publications by category


Books

Oyston, P.C. Titball, R.W. (2003). DNA adenine methylation.

Journal articles

Cruz A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, et al (In Press). A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A. Science
Bokori-Brown M, Martin TG, Naylor CE, Basak AK, Titball RW, Savva CG (In Press). Cryo-EM Structure of Lysenin Pore Reveals Membrane Insertion by an Aerolysin family protein. Nature Communications Full text.
Yang ZR, Bullifent HL, Moore K, Paszkiewicz K, Saint RJ, Southern SJ, Champion OL, Senior NJ, Sarkar-Tyson M, Oyston PCF, et al (2017). A Noise Trimming and Positional Significance of Transposon Insertion System to Identify Essential Genes in Yersinia pestis. Sci Rep, 7 Abstract.  Author URL.  Full text. DOI.
Wagley S, Vanaporn M, Rinchai D, Conejero L, Lertmemongkolchai G, Bancroft GJ, Titball RW (2017). A proteasome inhibitor produced by Burkholderia pseudomallei modulates intracellular growth. Microb Pathog, 107, 175-180. Abstract.  Author URL. DOI.
Senior NJ, Sasidharan K, Saint RJ, Scott AE, Sarkar-Tyson M, Ireland PM, Bullifent HL, Rong Yang Z, Moore K, Oyston PCF, et al (2017). An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions. BMC Microbiology, 17(1). Abstract. DOI.
Titball RW, Burtnick MN, Bancroft GJ, Brett P (2017). Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?. Vaccine Abstract.  Full text. DOI.
Vanaporn M, Sarkar-Tyson M, Kovacs-Simon A, Ireland PM, Pumirat P, Korbsrisate S, Titball RW, Butt A (2017). Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts. Virulence, 8(1), 30-40. Abstract.  Full text. DOI.
Hall CA, Flick-Smith HC, Harding SV, Atkins HS, Titball RW (2016). A bioluminescent Francisella tularensis SCHU S4 strain enables noninvasive tracking of bacterial dissemination and the evaluation of antibiotics in an inhalational mouse model of tularemia. Antimicrobial Agents and Chemotherapy, 60(12), 7206-7215. Abstract. DOI.
Butt A, Halliday N, Williams P, Atkins HS, Bancroft GJ, Titball RW (2016). Burkholderia pseudomallei kynB plays a role in AQ production, biofilm formation, bacterial swarming and persistence. Research in Microbiology, 167(3), 159-167. Abstract.  Full text. DOI.
Butt AT, Titball RW (2016). Functional Analysis of the Role of Toxin-Antitoxin (TA) Loci in Bacterial Persistence. Methods Mol Biol, 1333, 121-129. Abstract.  Author URL.  Full text. DOI.
Champion OL, Wagley S, Titball RW (2016). Galleria mellonella as a model host for microbiological and toxin research. Virulence, 7(7), 840-845. Abstract.  Author URL. DOI.
Champion OL, Gourlay LJ, Scott AE, Lassaux P, Conejero L, Perletti L, Hemsley C, Prior J, Bancroft G, Bolognesi M, et al (2016). Immunisation with proteins expressed during chronic murine melioidosis provides enhanced protection against disease. Vaccine, 34(14), 1665-1671. Abstract.  Author URL.  Full text. DOI.
Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW (2016). Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection. Sci Rep, 6 Abstract.  Author URL.  Full text. DOI.
Scott AE, Christ WJ, George AJ, Stokes MGM, Lohman GJS, Guo Y, Jones M, Titball RW, Atkins TP, Campbell AS, et al (2016). Protection against experimental melioidosis with a synthetic manno-heptopyranose hexasaccharide glycoconjugate. Bioconjugate Chemistry, 27(6), 1435-1446. Abstract.  Full text. DOI.
Bokori-Brown M, Petrov PG, Khafaji MA, Mughal MK, Naylor CE, Shore AC, Gooding KM, Casanova F, Mitchell TJ, Titball RW, et al (2016). Red Blood Cell Susceptibility to Pneumolysin: CORRELATION WITH MEMBRANE BIOCHEMICAL AND PHYSICAL PROPERTIES. J Biol Chem, 291(19), 10210-10227. Abstract.  Author URL.  Full text. DOI.
Anutrakunchai C, Hemsley CM, Sermswan RW, Titball RW, Chareonsudjai S, Taweechaisupapong S (2016). Role of RelA and SpoT in Burkholderia pseudomallei survival, biofilm formation and ceftazidime tolerance during nutritional stress. Tropical Biomedicine, 33(4), 786-798. Abstract.
Fernandes da Costa SP, Mot D, Geeraerts S, Bokori-Brown M, Van Immerseel F, Titball RW (2016). Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant. Avian Pathol, 45(3), 381-388. Abstract.  Author URL.  Full text. DOI.
Gregory AE, Judy BM, Qazi O, Blumentritt CA, Brown KA, Shaw AM, Torres AG, Titball RW (2015). A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei. Nanomedicine, 11(2), 447-456. Abstract.  Author URL. DOI.
Nandi T, Holden MTG, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles. Genome Res, 25(1), 129-141. Abstract.  Author URL. DOI.
Nandi T, Holden MTG, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles. Genome Res, 25(4). Author URL.  Full text.
Jewell SA, Titball RW, Huyet J, Naylor CE, Basak AK, Gologan P, Winlove CP, Petrov PG (2015). Clostridium perfringensα-toxin interaction with red cells and model membranes. Soft Matter, 11(39), 7748-7761. Abstract.  Author URL.  Full text. DOI.
Siddiqui FM, Ibrahim M, Noureen N, Noreen Z, Titball RW, Champion OL, Wren BW, Studholme D, Bokhari H (2015). Draft Genome Sequence of the Enteropathogenic Bacterium Campylobacter jejuni Strain cj255. Genome Announc, 3(5). Abstract.  Author URL.  Full text. DOI.
Nandi T, Holden MTG, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Errata: Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles (Genome Research (2015) 25 (129-141)). Genome Research, 25(4).
Benthall G, Touzel RE, Hind CK, Titball RW, Sutton JM, Thomas RJ, Wand ME (2015). Evaluation of antibiotic efficacy against infections caused by planktonic or biofilm cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae in Galleria mellonella. International Journal of Antimicrobial Agents, 46(5), 538-545. Abstract. DOI.
Gourlay LJ, Thomas RJ, Peri C, Conchillo-Solé O, Ferrer-Navarro M, Nithichanon A, Vila J, Daura X, Lertmemongkolchai G, Titball R, et al (2015). From crystal structure to in silico epitope discovery in the Burkholderia pseudomallei flagellar hook-associated protein FlgK. FEBS J, 282(7), 1319-1333. Abstract.  Author URL. DOI.
Rinchai D, Riyapa D, Buddhisa S, Utispan K, Titball RW, Stevens MP, Stevens JM, Ogawa M, Tanida I, Koike M, et al (2015). Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils. Autophagy, 11(5), 748-755. Abstract.  Author URL.  Full text. DOI.
Siddiqui F, Champion O, Akram M, Studholme D, Eqani SAMAS, Wren BW, Titball R, Bokhari H (2015). Molecular detection identified a type six secretion system in Campylobacter jejuni from various sources but not from human cases. J Appl Microbiol, 118(5), 1191-1198. Abstract.  Author URL. DOI.
Torres AG, Gregory AE, Hatcher CL, Vinet-Oliphant H, Morici LA, Titball RW, Roy CJ (2015). Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine. Vaccine, 33(5), 686-692. Abstract. DOI.
Torres AG, Gregory AE, Hatcher CL, Vinet-Oliphant H, Morici LA, Titball RW, Roy CJ (2015). Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine. Vaccine, 33(5), 686-692. Abstract.  Author URL. DOI.
Gaudesi D, Peri C, Quilici G, Gori A, Ferrer-Navarro M, Conchillo-Solé O, Thomas R, Nithichanon A, Lertmemongkolchai G, Titball R, et al (2015). Structure-based design of a B cell antigen from B. pseudomallei. ACS Chem Biol, 10(3), 803-812. Abstract.  Author URL. DOI.
Hemsley CM, Luo JX, Andreae CA, Butler CS, Soyer OS, Titball RW (2014). Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation but not anaerobic respiration. Antimicrob Agents Chemother, 58(10), 5775-5783. Abstract.  Author URL.  Full text. DOI.
Bokori-Brown M, Hall CA, Vance C, Fernandes da Costa SP, Savva CG, Naylor CE, Cole AR, Basak AK, Moss DS, Titball RW, et al (2014). Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia. Vaccine, 32(23), 2682-2687. Abstract. DOI.
Bokori-Brown M, Hall CA, Vance C, Fernandes da Costa SP, Savva CG, Naylor CE, Cole AR, Basak AK, Moss DS, Titball RW, et al (2014). Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia. Vaccine, 32(23), 2682-2687. Abstract.  Author URL.  Full text. DOI.
Wagley S, Newcombe J, Laing E, Yusuf E, Sambles CM, Studholme DJ, La Ragione RM, Titball RW, Champion OL (2014). Differences in carbon source utilisation distinguish Campylobacter jejuni from Campylobacter coli. BMC Microbiol, 14 Abstract.  Author URL.  Full text. DOI.
Benthall G, Touzel RE, Hind CK, Titball RW, Sutton JM, Thomas RJ, Wand ME (2014). Evaluation of antibiotic efficacy against infections caused by planktonic or biofilm cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae in Galleria mellonella. International Journal of Antimicrobial Agents Abstract. DOI.
Moule MG, Hemsley CM, Seet Q, Guerra-Assunção JA, Lim J, Sarkar-Tyson M, Clark TG, Tan PBO, Titball RW, Cuccui J, et al (2014). Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development. mBio, 5(1). Abstract. DOI.
Moule MG, Hemsley CM, Seet Q, Guerra-Assunção JA, Lim J, Sarkar-Tyson M, Clark TG, Tan PBO, Titball RW, Cuccui J, et al (2014). Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development. MBio, 5(1), e00926-e00913. Abstract.  Author URL.  Full text. DOI.
Fernandes da Costa SP, Savva CG, Bokori-Brown M, Naylor CE, Moss DS, Basak AK, Titball RW (2014). Identification of a key residue for oligomerisation and pore-formation of Clostridium perfringens NetB. Toxins (Basel), 6(3), 1049-1061. Abstract.  Author URL.  Full text. DOI.
Harrison JW, Dung TTN, Siddiqui F, Korbrisate S, Bukhari H, Tra MPV, Hoang NVM, Carrique-Mas J, Bryant J, Campbell JI, et al (2014). Identification of possible virulence marker from Campylobacter jejuni isolates. Emerg Infect Dis, 20(6), 1026-1029. Abstract.  Author URL.  Full text. DOI.
Andreae CA, Titball RW, Butler CS (2014). Influence of the molybdenum cofactor biosynthesis on anaerobic respiration, biofilm formation and motility in Burkholderia thailandensis. Research in Microbiology, 165(1), 41-49. Abstract. DOI.
Andreae CA, Titball RW, Butler CS (2014). Influence of the molybdenum cofactor biosynthesis on anaerobic respiration, biofilm formation and motility in Burkholderia thailandensis. Res Microbiol, 165(1), 41-49. Abstract.  Author URL.  Full text. DOI.
Kovacs-Simon A, Leuzzi R, Kasendra M, Minton N, Titball RW, Michell SL (2014). Lipoprotein CD0873 is a novel adhesin of Clostridium difficile. J Infect Dis, 210(2), 274-284. Abstract.  Author URL. DOI.
Scott AE, Ngugi SA, Laws TR, Corser D, Lonsdale CL, D'Elia RV, Titball RW, Williamson ED, Atkins TP, Prior JL, et al (2014). Protection against experimental melioidosis following immunisation with a lipopolysaccharide-protein conjugate. J Immunol Res, 2014 Abstract.  Author URL. DOI.
Butt A, Higman VA, Williams C, Crump MP, Hemsley CM, Harmer N, Titball RW (2014). The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation. Biochem J, 459(2), 333-344. Abstract.  Author URL.  Full text. DOI.
Wagley S, Hemsley C, Thomas R, Moule MG, Vanaporn M, Andreae C, Robinson M, Goldman S, Wren BW, Butler CS, et al (2014). The twin arginine translocation system is essential for aerobic growth and full virulence of Burkholderia thailandensis. J Bacteriol, 196(2), 407-416. Abstract.  Author URL. DOI.
Jitprasutwit S, Ong C, Juntawieng N, Ooi WF, Hemsley CM, Vattanaviboon P, Titball RW, Tan P, Korbsrisate S (2014). Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions. BMC Genomics, 15(1). Abstract. DOI.
Jitprasutwit S, Ong C, Juntawieng N, Ooi WF, Hemsley CM, Vattanaviboon P, Titball RW, Tan P, Korbsrisate S (2014). Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions. BMC Genomics, 15 Abstract.  Author URL.  Full text. DOI.
Bokori-Brown M, Kokkinidou MC, Savva CG, Fernandes da Costa S, Naylor CE, Cole AR, Moss DS, Basak AK, Titball RW (2013). Clostridium perfringens epsilon toxin H149A mutant as a platform for receptor binding studies. Protein Sci, 22(5), 650-659. Abstract.  Author URL.  Full text. DOI.
Peacock SJ, Limmathurotsakul D, Lubell Y, Koh GC, White LJ, Day NP, Titball RW (2013). Correction: Melioidosis Vaccines: a Systematic Review and Appraisal of the Potential to Exploit Biodefense Vaccines for Public Health Purposes. PLoS Negl Trop Dis, 7(2). Abstract.  Author URL. DOI.
Rees DGC, Phillpotts RJ, Griffin KF, Lukaszewski RA, Laws TR, Atkins HS, Krieg AM, Titball RW (2013). CpG oligonucleotides protect against Venezuelan equine encephalitis virus infection in a route-dependent manner. International Journal of Antimicrobial Agents, 42(6), 587-588. DOI.
Rees DGC, Phillpotts RJ, Griffin KF, Lukaszewski RA, Laws TR, Atkins HS, Krieg AM, Titball RW (2013). CpG oligonucleotides protect against Venezuelan equine encephalitis virus infection in a route-dependent manner. Int J Antimicrob Agents, 42(6), 587-588. Author URL. DOI.
Butt E, Foster JAH, Keedwell E, Bell JEA, Titball RW, Bhangu A, Michell SL, Sheridan R (2013). Derivation and validation of a simple, accurate and robust prediction rule for risk of mortality in patients with Clostridium difficile infection. BMC Infect Dis, 13 Abstract.  Author URL.  Full text. DOI.
Gourlay LJ, Peri C, Ferrer-Navarro M, Conchillo-Solé O, Gori A, Rinchai D, Thomas RJ, Champion OL, Michell SL, Kewcharoenwong C, et al (2013). Exploiting the Burkholderia pseudomallei acute phase antigen BPSL2765 for structure-based epitope discovery/design in structural vaccinology. Chem Biol, 20(9), 1147-1156. Abstract.  Author URL. DOI.
Thomas RJ, Hamblin KA, Armstrong SJ, Müller CM, Bokori-Brown M, Goldman S, Atkins HS, Titball RW (2013). Galleria mellonella as a model system to test the pharmacokinetics and efficacy of antibiotics against Burkholderia pseudomallei. International Journal of Antimicrobial Agents, 41(4), 330-336. Abstract. DOI.
Thomas RJ, Hamblin KA, Armstrong SJ, Müller CM, Bokori-Brown M, Goldman S, Atkins HS, Titball RW (2013). Galleria mellonella as a model system to test the pharmacokinetics and efficacy of antibiotics against Burkholderia pseudomallei. Int J Antimicrob Agents, 41(4), 330-336. Abstract.  Author URL. DOI.
Butt A, Müller C, Harmer N, Titball RW (2013). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiol Lett, 338(1), 86-94. Abstract.  Author URL.  Full text. DOI.
Savva CG, Fernandes da Costa SP, Bokori-Brown M, Naylor CE, Cole AR, Moss DS, Titball RW, Basak AK (2013). Molecular architecture and functional analysis of NetB, a pore-forming toxin from Clostridium perfringens. J Biol Chem, 288(5), 3512-3522. Abstract.  Author URL. DOI.
Fernandes da Costa SP, Mot D, Bokori-Brown M, Savva CG, Basak AK, Van Immerseel F, Titball RW (2013). Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids. Vaccine, 31(37), 4003-4008. Abstract. DOI.
Fernandes da Costa SP, Mot D, Bokori-Brown M, Savva CG, Basak AK, Van Immerseel F, Titball RW (2013). Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids. Vaccine, 31(37), 4003-4008. Abstract.  Author URL. DOI.
Van Immerseel F, Studholme DJ, Eeckhaut V, Heyndrickx M, Dewulf J, Dewaele I, Van Hoorebeke S, Haesebrouck F, Van Meirhaeghe H, Ducatelle R, et al (2013). Salmonella Gallinarum field isolates from laying hens are related to the vaccine strain SG9R. Vaccine, 31(43), 4940-4945. Abstract. DOI.
Van Immerseel F, Studholme DJ, Eeckhaut V, Heyndrickx M, Dewulf J, Dewaele I, Van Hoorebeke S, Haesebrouck F, Van Meirhaeghe H, Ducatelle R, et al (2013). Salmonella Gallinarum field isolates from laying hens are related to the vaccine strain SG9R. Vaccine, 31(43), 4940-4945. Abstract.  Author URL. DOI.
Rees DGC, Hartley MG, Green M, Lukaszewski RA, Griffin KF, Atkins HS, Lyons R, Krieg AM, Titball RW (2013). The ability of CpG oligonucleotides to protect mice against Francisella tularensis live vaccine strain but not fully virulent F. tularensis subspecies holarctica is reflected in cell-based assays. Microb Pathog, 63, 16-18. Abstract.  Author URL. DOI.
Ooi WF, Ong C, Nandi T, Kreisberg JF, Chua HH, Sun G, Chen Y, Mueller C, Conejero L, Eshaghi M, et al (2013). The condition-dependent transcriptional landscape of Burkholderia pseudomallei. PLoS Genet, 9(9). Abstract.  Author URL.  Full text. DOI.
Gregory AE, Titball R, Williamson D (2013). Vaccine delivery using nanoparticles. Front Cell Infect Microbiol, 3 Abstract.  Author URL.  Full text. DOI.
Lau SK, Winlove P, Moger J, Champion OL, Titball RW, Yang ZH, Yang ZR (2012). A Bayesian Whittaker-Henderson smoother for general-purpose and sample-based spectral baseline estimation and peak extraction. JOURNAL OF RAMAN SPECTROSCOPY, 43(9), 1299-1305. Author URL. DOI.
Lau SK, Champion OL, Titball RW, Yang ZR, Winlove P, Moger J, Yang ZH (2012). A Bayesian Whittaker-Henderson smoother for general-purpose and sample-based spectral baseline estimation and peak extraction. Journal of Raman Spectroscopy Abstract. DOI.
Cuccui J, Milne TS, Harmer N, George AJ, Harding SV, Dean RE, Scott AE, Sarkar-Tyson M, Wren BW, Titball RW, et al (2012). Characterization of the Burkholderia pseudomallei K96243 capsular polysaccharide I coding region. Infect Immun, 80(3), 1209-1221. Abstract.  Author URL. DOI.
Gregory AE, Shaw AM, Titball RW, Williamson ED, Prior JL, Butcher WA, Thompson IJ (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine Abstract. DOI.
Gregory AE, Williamson ED, Prior JL, Butcher WA, Thompson IJ, Shaw AM, Titball RW (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine, 30(48), 6777-6782. Abstract.  Author URL.  Full text. DOI.
Butt A, Müller C, Harmer N, Titball RW (2012). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiology Letters
Peacock SJ, Limmathurotsakul D, Lubell Y, Koh GCKW, White LJ, Day NPJ, Titball RW (2012). Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes. PLoS Negl Trop Dis, 6(1). Abstract.  Author URL.  Full text. DOI.
Monturiol-Gross L, Flores-Díaz M, Araya-Castillo C, Pineda-Padilla M-J, Clark GC, Titball RW, Alape-Girón A (2012). Reactive oxygen species and the MEK/ERK pathway are involved in the toxicity of clostridium perfringens α-toxin, a prototype bacterial phospholipase C. J Infect Dis, 206(8), 1218-1226. Abstract.  Author URL. DOI.
Müller CM, Conejero L, Spink N, Wand ME, Bancroft GJ, Titball RW (2012). Role of RelA and SpoT in Burkholderia pseudomallei virulence and immunity. Infect Immun, 80(9), 3247-3255. Abstract.  Author URL.  Full text. DOI.
Cruz A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, et al (2011). A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A. Science, 334(6057), 821-824. DOI.
Norville IH, Harmer NJ, Harding SV, Fischer G, Keith KE, Brown KA, Sarkar-Tyson M, Titball RW (2011). A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence. Infect Immun, 79(11), 4299-4307. Abstract.  Author URL.  Full text. DOI.
Debieux CM, Dridge EJ, Mueller CM, Splatt P, Paszkiewicz K, Knight I, Florance H, Love J, Titball RW, Lewis RJ, et al (2011). A bacterial process for selenium nanosphere assembly. Proc Natl Acad Sci U S A, 108(33), 13480-13485. Abstract.  Author URL.  Full text. DOI.
Norville IH, Breitbach K, Eske-Pogodda K, Harmer NJ, Sarkar-Tyson M, Titball RW, Steinmetz I (2011). A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei. Microbiology, 157(Pt 9), 2629-2638. Abstract.  Author URL. DOI.
Tippayawat P, Pinsiri M, Rinchai D, Riyapa D, Romphruk A, Gan Y-H, Houghton RL, Felgner PL, Titball RW, Stevens MP, et al (2011). Burkholderia pseudomallei proteins presented by monocyte-derived dendritic cells stimulate human memory T cells in vitro. Infect Immun, 79(1), 305-313. Abstract.  Author URL. DOI.
Easton A, Haque A, Chu K, Patel N, Lukaszewski RA, Krieg AM, Titball RW, Bancroft GJ (2011). Combining vaccination and postexposure CpG therapy provides optimal protection against lethal sepsis in a biodefense model of human melioidosis. J Infect Dis, 204(4), 636-644. Abstract.  Author URL. DOI.
Qazi O, Rani M, Gnanam AJ, Cullen TW, Stead CM, Kensing H, McCaul K, Ngugi S, Prior JL, Lipka A, et al (2011). Development of reagents and assays for the detection of pathogenic Burkholderia species. Faraday Discuss, 149, 23-36. Abstract.  Author URL.
Patel N, Conejero L, De Reynal M, Easton A, Bancroft GJ, Titball RW (2011). Development of vaccines against burkholderia pseudomallei. Front Microbiol, 2 Abstract.  Author URL.  Full text. DOI.
Scott AE, Twine SM, Fulton KM, Titball RW, Essex-Lopresti AE, Atkins TP, Prior JL (2011). Flagellar glycosylation in Burkholderia pseudomallei and Burkholderia thailandensis. J Bacteriol, 193(14), 3577-3587. Abstract.  Author URL. DOI.
Senior NJ, Bagnall MC, Champion OL, Reynolds SE, La Ragione RM, Woodward MJ, Salguero FJ, Titball RW (2011). Galleria mellonella as an infection model for Campylobacter jejuni virulence. J Med Microbiol, 60(Pt 5), 661-669. Abstract.  Author URL. DOI.
Thomas RM, Twine SM, Fulton KM, Tessier L, Kilmury SLN, Ding W, Harmer N, Michell SL, Oyston PCF, Titball RW, et al (2011). Glycosylation of DsbA in Francisella tularensis subsp. tularensis. J Bacteriol, 193(19), 5498-5509. Abstract.  Author URL. DOI.
Suwannasaen D, Mahawantung J, Chaowagul W, Limmathurotsakul D, Felgner PL, Davies H, Bancroft GJ, Titball RW, Letmemongkolchai G (2011). Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis. JOURNAL OF IMMUNOLOGY, 186 Author URL.
Suwannasaen D, Mahawantung J, Chaowagul W, Limmathurotsakul D, Felgner PL, Davies H, Bancroft GJ, Titball RW, Lertmemongkolchai G (2011). Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis. J Infect Dis, 203(7), 1002-1011. Abstract.  Author URL. DOI.
Kovacs-Simon A, Titball RW, Michell SL (2011). Lipoproteins of bacterial pathogens. Infect Immun, 79(2), 548-561. Abstract.  Author URL. DOI.
Conejero L, Patel N, de Reynal M, Oberdorf S, Prior J, Felgner PL, Titball RW, Salguero FJ, Bancroft GJ (2011). Low-dose exposure of C57BL/6 mice to burkholderia pseudomallei mimics chronic human melioidosis. Am J Pathol, 179(1), 270-280. Abstract.  Author URL. DOI.
Wand ME, Müller CM, Titball RW, Michell SL (2011). Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis. BMC Microbiol, 11(1). Abstract.  Author URL.  Full text. DOI.
Wang W, Hale C, Goulding D, Haslam SM, Tissot B, Lindsay C, Michell S, Titball R, Yu J, Toribio AL, et al (2011). Mannosidase 2, alpha 1 deficiency is associated with ricin resistance in embryonic stem (ES) cells. PLoS One, 6(8). Abstract.  Author URL.  Full text. DOI.
Bokori-Brown M, Savva CG, Fernandes da Costa SP, Naylor CE, Basak AK, Titball RW (2011). Molecular basis of toxicity of Clostridium perfringens epsilon toxin. FEBS J, 278(23), 4589-4601. Abstract.  Author URL. DOI.
Egge-Jacobsen W, Salomonsson EN, Aas FE, Forslund A-L, Winther-Larsen HC, Maier J, Macellaro A, Kuoppa K, Oyston PCF, Titball RW, et al (2011). O-linked glycosylation of the PilA pilin protein of Francisella tularensis: identification of the endogenous protein-targeting oligosaccharyltransferase and characterization of the native oligosaccharide. J Bacteriol, 193(19), 5487-5497. Abstract.  Author URL. DOI.
Vanaporn M, Wand M, Michell SL, Sarkar-Tyson M, Ireland P, Goldman S, Kewcharoenwong C, Rinchai D, Lertmemongkolchai G, Titball RW, et al (2011). Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei. Microbiology, 157(Pt 8), 2392-2400. Abstract.  Author URL. DOI.
Norville I, O'Shea K, Sarkar-Tyson M, Zheng S, Titball RW, Varani G, Harmer NJ (2011). The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. Biochemical Journal, 437, 413-422. Abstract.
Norville IH, O'Shea K, Sarkar-Tyson M, Zheng S, Titball RW, Varani G, Harmer NJ (2011). The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. Biochem J, 437(3), 413-422. Abstract.  Author URL. DOI.
Laws TR, Davey MS, Green C, Cooper IAM, Titball RW, Lukaszewski RA (2011). Yersinia pseudotuberculosis is resistant to killing by human neutrophils. Microbes Infect, 13(6), 607-611. Abstract.  Author URL. DOI.
Champion OL, Karlyshev A, Cooper IAM, Ford DC, Wren BW, Duffield M, Oyston PCF, Titball RW (2011). Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1. Microbiology, 157(Pt 4), 1115-1122. Abstract.  Author URL. DOI.
Oyston PCF, Mellado-Sanchez G, Pasetti MF, Nataro JP, Titball RW, Atkins HS (2010). A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection. Microb Pathog, 48(5), 191-195. Abstract.  Author URL. DOI.
Nandi T, Ong C, Singh AP, Boddey J, Atkins T, Sarkar-Tyson M, Essex-Lopresti AE, Chua HH, Pearson T, Kreisberg JF, et al (2010). A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence. PLoS pathogens, 6(4). Full text.
Vachieri SG, Clark GC, Alape-Girón A, Flores-Díaz M, Justin N, Naylor CE, Titball RW, Basak AK (2010). Comparison of a nontoxic variant of Clostridium perfringens α-toxin with the toxic wild-type strain. Acta Crystallogr D Biol Crystallogr, 66(Pt 10), 1067-1074. Abstract.  Author URL. DOI.
Michell SL, Dean RE, Eyles JE, Hartley MG, Waters E, Prior JL, Titball RW, Oyston PCF (2010). Deletion of the Bacillus anthracis capB homologue in Francisella tularensis subspecies tularensis generates an attenuated strain that protects mice against virulent tularaemia. J Med Microbiol, 59(Pt 11), 1275-1284. Abstract.  Author URL. DOI.
Dowling AJ, Wilkinson PA, Holden MTG, Quail MA, Bentley SD, Reger J, Waterfield NR, Titball RW, Ffrench-Constant RH (2010). Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen Burkholderia pseudomallei K96243. PLoS One, 5(12). Abstract.  Author URL.  Full text. DOI.
Champion OL, Karlyshev AV, Senior NJ, Woodward M, La Ragione R, Howard SL, Wren BW, Titball RW (2010). Insect infection model for Campylobacter jejuni reveals that O-methyl phosphoramidate has insecticidal activity. J Infect Dis, 201(5), 776-782. Abstract.  Author URL. DOI.
Ngugi SA, Ventura VV, Qazi O, Harding SV, Kitto GB, Estes DM, Dell A, Titball RW, Atkins TP, Brown KA, et al (2010). Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis. Vaccine, 28(47), 7551-7555. Abstract.  Author URL. DOI.
Laws TR, Davey MS, Titball RW, Lukaszewski R (2010). Neutrophils are important in early control of lung infection by Yersinia pestis. Microbes Infect, 12(4), 331-335. Abstract.  Author URL. DOI.
Sarkar-Tyson M, Titball RW (2010). Progress toward development of vaccines against melioidosis: a review. Clin Ther, 32(8), 1437-1445. Abstract.  Author URL. DOI.
Forslund A-L, Salomonsson EN, Golovliov I, Kuoppa K, Michell S, Titball R, Oyston P, Noppa L, Sjöstedt A, Forsberg A, et al (2010). The type IV pilin, PilA, is required for full virulence of Francisella tularensis subspecies tularensis. BMC Microbiol, 10 Abstract.  Author URL.  Full text. DOI.
Felgner PL, Kayala MA, Vigil A, Burk C, Nakajima-Sasaki R, Pablo J, Molina DM, Hirst S, Chew JSW, Wang D, et al (2009). A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens. Proc Natl Acad Sci U S A, 106(32), 13499-13504. Abstract.  Author URL. DOI.
Yang ZR, Lertmemongkolchai G, Tan G, Felgner PL, Titball R (2009). A genetic programming approach for Burkholderia pseudomallei diagnostic pattern discovery. Bioinformatics, 25(17), 2256-2262. Abstract.  Author URL. DOI.
Titball RW (2009). Bacterial Biothreat Agents. , 21-32. DOI.
Sarkar-Tyson M, Titball RW (2009). Burkholderia mallei and Burkholderia pseudomallei. , 831-843. DOI.
Titball RW (2009). Clostridium perfringens vaccines. Vaccine, 27 Suppl 4, D44-D47. Abstract.  Author URL. DOI.
Champion MD, Zeng Q, Nix EB, Nano FE, Keim P, Kodira CD, Borowsky M, Young S, Koehrsen M, Engels R, et al (2009). Comparative genomic characterization of Francisella tularensis strains belonging to low and high virulence subspecies. PLoS Pathog, 5(5). Abstract.  Author URL.  Full text. DOI.
Thomas RJ, Webber D, Collinge A, Stagg AJ, Bailey SC, Nunez A, Gates A, Jayasekera PN, Taylor RR, Eley S, et al (2009). Different pathologies but equal levels of responsiveness to the recombinant F1 and V antigen vaccine and ciprofloxacin in a murine model of plague caused by small- and large-particle aerosols. Infect Immun, 77(4), 1315-1323. Abstract.  Author URL. DOI.
Titball RW, Oyston PCF (2009). Francisella tularensis. , 1241-1253. DOI.
Champion OL, Cooper IAM, James SL, Ford D, Karlyshev A, Wren BW, Duffield M, Oyston PCF, Titball RW (2009). Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis. Microbiology, 155(Pt 5), 1516-1522. Abstract.  Author URL. DOI.
Thomas RJ, Webber D, Sellors W, Collinge A, Frost A, Stagg AJ, Bailey SC, Jayasekera PN, Taylor RR, Eley S, et al (2009). Generation of large droplet aerosols within microbiological containment using a novel flow-focussing technique. Aerobiologia, 25(2), 75-84. Abstract. DOI.
Hill J, Leary S, Smither S, Best A, Pettersson J, Forsberg A, Lingard B, Lipka A, Brown KA, Williamson ED, et al (2009). N255 is a key residue for recognition by a monoclonal antibody which protects against Yersinia pestis infection. Vaccine, 27(50), 7073-7079. Abstract.  Author URL. DOI.
Tippayawat P, Saenwongsa W, Mahawantung J, Suwannasaen D, Chetchotisakd P, Limmathurotsakul D, Peacock SJ, Felgner PL, Atkins HS, Titball RW, et al (2009). Phenotypic and functional characterization of human memory T cell responses to Burkholderia pseudomallei. PLoS Negl Trop Dis, 3(4). Abstract.  Author URL.  Full text. DOI.
Sarkar-Tyson M, Smither SJ, Harding SV, Atkins TP, Titball RW (2009). Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders. Vaccine, 27(33), 4447-4451. Abstract.  Author URL. DOI.
Halling-Brown M, Shaban R, Frampton D, Sansom CE, Davies M, Flower D, Duffield M, Titball RW, Brusic V, Moss DS, et al (2009). Proteins accessible to immune surveillance show significant T-cell epitope depletion: Implications for vaccine design. Mol Immunol, 46(13), 2699-2705. Abstract.  Author URL. DOI.
Dean RE, Ireland PM, Jordan JE, Titball RW, Oyston PCF (2009). RelA regulates virulence and intracellular survival of Francisella novicida. Microbiology, 155(Pt 12), 4104-4113. Abstract.  Author URL. DOI.
Van Immerseel F, Rood JI, Moore RJ, Titball RW (2009). Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens. Trends Microbiol, 17(1), 32-36. Abstract.  Author URL. DOI.
Stubben CJ, Duffield ML, Cooper IA, Ford DC, Gans JD, Karlyshev AV, Lingard B, Oyston PCF, de Rochefort A, Song J, et al (2009). Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens. BMC Genomics, 10 Abstract.  Author URL.  Full text. DOI.
Thwaite JE, Humphrey S, Fox MA, Savage VL, Laws TR, Ulaeto DO, Titball RW, Atkins HS (2009). The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains. J Med Microbiol, 58(Pt 7), 923-929. Abstract.  Author URL. DOI.
Phan M-D, Kidgell C, Nair S, Holt KE, Turner AK, Hinds J, Butcher P, Cooke FJ, Thomson NR, Titball R, et al (2009). Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever. Antimicrob Agents Chemother, 53(2), 716-727. Abstract.  Author URL. DOI.
Halling-Brown M, Sansom CE, Davies M, Titball RW, Moss DS (2008). Are bacterial vaccine antigens T-cell epitope depleted?. Trends Immunol, 29(8), 374-379. Abstract.  Author URL. DOI.
Titball RW, Russell P, Cuccui J, Easton A, Haque A, Atkins T, Sarkar-Tyson M, Harley V, Wren B, Bancroft GJ, et al (2008). Burkholderia pseudomallei: animal models of infection. Trans R Soc Trop Med Hyg, 102 Suppl 1, S111-S116. Abstract.  Author URL. DOI.
Thomas RJ, Webber D, Sellors W, Collinge A, Frost A, Stagg AJ, Bailey SC, Jayasekera PN, Taylor RR, Eley S, et al (2008). Characterization and deposition of respirable large- and small-particle bioaerosols. Appl Environ Microbiol, 74(20), 6437-6443. Abstract.  Author URL. DOI.
Stabler RA, Dawson LF, Oyston PCF, Titball RW, Wade J, Hinds J, Witney AA, Wren BW (2008). Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux. BMC Microbiol, 8 Abstract.  Author URL.  Full text. DOI.
Gnanam AJ, Hall B, Shen X, Piasecki S, Vernados A, Galyov EE, Smither SJ, Kitto GB, Titball RW, Ellington AD, et al (2008). Development of aptamers specific for potential diagnostic targets in Burkholderia pseudomallei. Trans R Soc Trop Med Hyg, 102 Suppl 1, S55-S57. Abstract.  Author URL. DOI.
Thompson DB, Crandall K, Harding SV, Smither SJ, Kitto GB, Titball RW, Brown KA (2008). In silico analysis of potential diagnostic targets from Burkholderia pseudomallei. Trans R Soc Trop Med Hyg, 102 Suppl 1, S61-S65. Abstract.  Author URL. DOI.
Lukaszewski RA, Yates AM, Jackson MC, Swingler K, Scherer JM, Simpson AJ, Sadler P, McQuillan P, Titball RW, Brooks TJG, et al (2008). Presymptomatic prediction of sepsis in intensive care unit patients. Clin Vaccine Immunol, 15(7), 1089-1094. Abstract.  Author URL. DOI.
Eyles JE, Hartley MG, Laws TR, Oyston PCF, Griffin KF, Titball RW (2008). Protection afforded against aerosol challenge by systemic immunisation with inactivated Francisella tularensis live vaccine strain (LVS). Microb Pathog, 44(2), 164-168. Abstract.  Author URL. DOI.
Hoang TH, Hong HA, Clark GC, Titball RW, Cutting SM (2008). Recombinant Bacillus subtilis expressing the Clostridium perfringens alpha toxoid is a candidate orally delivered vaccine against necrotic enteritis. Infect Immun, 76(11), 5257-5265. Abstract.  Author URL. DOI.
Titball RW (2008). Vaccines against intracellular bacterial pathogens. Drug Discov Today, 13(13-14), 596-600. Abstract.  Author URL. DOI.
Michell, S.L. Diaper, H. Wikstrom, P. Titball, RW (2007). A 55 kDa hypothetical membrane protein is an iron-regulated virulence factor of Francisella tularensis subspecies novicida U112. Journal of Medical Microbiology, 56, 1268-1276.
Isherwood, K.E. Michell, S.L. Diaper, H. Titball, RW (2007). A Francisella tularensis subspecies novicida purF mutant, but not a purA mutant, induces protective immunity to tularemia in mice. Vaccine, 25, 2011-2018.
Oyston, P. Titball, RW (2007). A plague upon fibrin. Nature Medicine, 13, 253-254.
Harland DN, Dassa E, Titball RW, Brown KA, Atkins HS (2007). ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei. BMC Genomics, 8 Abstract.  Author URL.  Full text. DOI.
Nelson, M. Titball, R.W. Galloway, D.R. (2007). Analysis of Peptide Mimotopes of Burkholderia pseudomallei Exopolysaccharide. Vaccine, 25, 7796-7805.
Neeson BN, Clark GC, Atkins HS, Lingard B, Titball RW (2007). Analysis of protection afforded by a Clostridium perfringens alpha-toxoid against heterologous clostridial phospholipases C. Microb Pathog, 43(4), 161-165. Abstract.  Author URL. DOI.
Kwaik YA, Metzger D, Nano F, Sjostedt A, Titball R (2007). Annals of the New York Academy: Preface. Annals of the New York Academy of Sciences, 1105 DOI.
Sjostedt, A. Pevelka, M.S. Nano, F. (2007). Biosafety and Selectable Markers. Annals of the New York Academy of Sciences, 1105, 405-417.
Butcher, W.A. Titball, R.W. Hill, J. (2007). Concomitant administration of Yersinia pestis specific monoclonal antibodies with plague vaccine has a detrimental effect on vaccine mediated immunity. Vaccine, 25, 7301-7306.
Cuccui J, Easton A, Chu KK, Bancroft GJ, Oyston PCF, Titball RW, Wren BW (2007). Development of signature-tagged mutagenesis in Burkholderia pseudomallei to identify genes important in survival and pathogenesis. Infect Immun, 75(3), 1186-1195. Abstract.  Author URL. DOI.
Duffield, M.L. Titball, R.W. Lindsay, C.D. (2007). Down-regulation of gene transcripts associated with ricin tolerance in human RPMI 2650 cells. Toxicology in vitro, 21, 509-520.
Titball RW, Petrosino JF (2007). Francisella tularensis genomics and proteomics. Ann N Y Acad Sci, 1105, 98-121. Abstract.  Author URL. DOI.
Griffin KF, Oyston PCF, Titball RW (2007). Francisella tularensis vaccines. FEMS Immunol Med Microbiol, 49(3), 315-323. Abstract.  Author URL. DOI.
Unal, B. Petersen, J.M. Hartley, G. (2007). From protein microarrays to diagnostic antigen discovery: a study of the pathogen F. tularensis. Bioinformatics, 23, 508-518.
Chaudhuri RR, Ren C-P, Desmond L, Vincent GA, Silman NJ, Brehm JK, Elmore MJ, Hudson MJ, Forsman M, Isherwood KE, et al (2007). Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4. PLoS One, 2(4). Abstract.  Author URL.  Full text. DOI.
Smither SJ, Hill J, van Baar BLM, Hulst AG, de Jong AL, & Titball RW (2007). Identification of Outer Membrane Proteins of <em>Yersinia pestis</em> through Biotinylation. Journal of Microbiological Methods, 68, 26-31.
Chu, K. Hawue, A. Nelson, M. (2007). Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis. Infection and Immunity, 75, 4173-4180.
Duc LH, Hong HA, Atkins HS, Flick-Smith HC, Durrani Z, Ripkema S, Titball RW & Cutting SM (2007). Immunisation against anthrax using <em>Bacillus subtilis</em> spores expressing the anthrax protective antigen. Vaccine, 25, 346-355.
Clark, G.C. Atkins, H.S. Lingard, B. (2007). Immunisation of mice with a Clostridium perfringens &#945;-toxoid protects against heterologous Clostridial phospholipases C. Microbial Pathogen, 43, 161-165.
Atkins, H.S. Johnson, L. Titball, R.W. (2007). Immunization with Anthrolysin O or a genetic toxoid protects against challenge with the toxin but not against Bacillus anthracis. Vaccine, 25, 7197-7205.
Eyles JE, Unal B, Hartley MG, Newstead SL, Flick-Smith H, Prior JL, Oyston PCF, Randall A, Mu Y, Hirst S, et al (2007). Immunodominant Francisella tularensis antigens identified using proteome microarray. Proteomics, 7(13), 2172-2183. Abstract.  Author URL. DOI.
Wood RJ, Maynard-Smith MD, Robinson VL, Oyston PCF, Titball RW, Roach PL (2007). Kinetic analysis of Yersinia pestis DNA adenine methyltransferase activity using a hemimethylated molecular break light oligonucleotide. PLoS One, 2(8). Abstract.  Author URL.  Full text. DOI.
Stagg, A.J. Eley, S.M. Taylor, R. (2007). Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague. Vaccine, 25, 1142-1148.
Stokes MGM, Titball RW, Neeson BN, Galen JE, Walker NJ, Stagg AJ, Jenner DC, Thwaite JE, Nataro JP, Baillie LWJ, Atkins HS (2007). Oral administration of a Salmonella-based vaccine espressing Bacillus anthracis protective antigen confers protection against aerosolized <em>B. anthracis</em>. Infection and Immunity, 75, 1827-1834.
Garbom S, Olofsson M, Bjornfot AC, Srivastava MK, Robinson VL, Oyston PCF, Titball RW, Wolf-Watz H (2007). Phenotypic characterizartion of a virulence-associated protein, VagH, of <em>Yersinia pseudotuberculosis</em> reveals a tight link between VagH and the type III secretion system. Microbiology, 153, 1464-1473.
Thwaite, J.E. Harding, S.V. Smither, S.J. (2007). Polysaccharides and virulence of Burkholderia pseudomallei. Journal of Medical Microbiology, 56, 1005-1010.
Tanabe M, Mirza O, Bertrand T, Atkins HS, Titball RW, Iwata S, Brown KA, Byrne B (2007). Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains. Acta Crystallogr D Biol Crystallogr, 63(Pt 11), 1185-1193. Abstract.  Author URL. DOI.
Harding SV, Sarkar-Tyson M, Smither SJ, Atkins TP, Oyston PCF, Brown KA, Liu Y, Wait R, & Titball RW (2007). The identification of surface proteins of <em>Burkholeria pseudomallei</em>. Vaccine, 25, 2664-2672.
sm202, Grice ID, Griffin K, Hitchen PG (2007). The immunologically distinct O-antigens from Francisella tularensis subspecies tuarensis and Francisella novicida are both virulence determinants and protective antigens. Infection and Immunity, 75(1), 371-378. DOI.
Clark GC, Basak AK, Titball RW (2007). The rational design of bacterial toxin inhibitors. Current Computer-Aided Drug Design, 3(1), 1-12. Abstract. DOI.
Rodrigues F, Sarkar-Tyson M, Harding SV, Sim SH, Chua HH, Lin CH, Han X, Krishna R, Karuturi M, Sung K, et al (2006). A global map of growth regulated gene expression in Burkholderia pseudomallei, the Causative Agent of Melioidosis. Journal of Bacteriology, 188, 8178-8188.
Chu, K. Easton, A. Stevens, M. (2006). A live vaccine against Burkholderia pseudomallei elicits CD4+ T cell-mediated immunity, priming T cells specific for 2 Type III secretion system proteins. Journal of Infectious Diseases, 194, 1241-1248.
Eyles, J.E. Elvin, S.J. Healey, G.D. (2006). Administration of antibody to the lung protects mice against pneumonic plague. Infection and Immunity, 74, 3068-3070.
Bayer, C.R. Aldape, M.J. Wallace, R.J. (2006). Clostridium perfringens Phospholopase C-induced platelet/leukocyte interactions impede neutrophil diapedesis. Journal of Medical Microbiology, 55, 495-504.
sm202, Bystrom A, Forslund AL, Johansson A (2006). Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis. Molecular Microbiology, 59(6), 1818-1830. DOI.
Taylor, R. Prior, J. Newstead, S. (2006). Grey variants of the live vaccine strain of <em>Francisella tularensis</em> lack lipopolysaccharide O-antigen, show reduced ability to survive in macrophages and do not induce protective immunity in mice. Vaccine, 24, 989-996.
Atkins, H.S. Harland, D.N. Elvin, S.J. (2006). Identification and evaluation of ABC transporter components that protect against <em>Yersinia pestis</em>. Infection and Immunity, 74, 3687-3691.
Hibbs, S. Titball, R.W. Atkins, T.P. (2006). Proteolytic degradation of the human antimicrobial peptide LL-37 by <em>Bacillus anthracis</em> may contribute to virulence. Antimicrobial Agents and Chemotherapy, 50, 2316-2322.
Morton, M. Griffin, K.F. Stockes, M. (2006). Recombinant Salmonella vaccines for biodefence. Vaccine, 24, 2710-2717.
Rasko, D.A. Cheung, J.K. Ravel, J. (2006). Skewed genomic variability in strains of the toxigenic bacterial pathogen, <em>Clostridium perfringens</em>. Genome Research, 16, 1031-1040.
Tanabe M, Atkins HS, Harland DN, Elvin SJ, Stagg AJ, Mirza O, Titball RW, Byrne B, Brown KA (2006). The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection. Infect Immun, 74(6), 3687-3691. Abstract.  Author URL. DOI.
Dassa, E. Walker, N.J. Griffin, K.F. (2006). The identification and evaluation of ATP-binding cassette systems in the intracellular bacterium <em>Francisella tularensis</em>. Research in Microbiology, 157, 593-604.
Laws TR, Atkins HS, Atkins TP, Titball RW (2006). The pathogen Pseudomonas aeruginosa negatively affects the attraction response of the nematode Caenorhabditis elegans to bacteria. Microb Pathog, 40(6), 293-297. Abstract.  Author URL. DOI.
Easton, A. Smith, D. O'Garra, A. (2006). The role of T-cells in innate and adptive immunity against murine <em>Burkholderia pseudomallei</em> infection. Journal of Infectious Diseases, 193, 370-379. Full text.
Oyston, P.C.F. Titball, R.W. (2005). A dam mutant of Yersinia pestis is attenuated and induces protection against plague. FEMS Microbiology Letters, 252, 251-256.
Boddey, J.A. Thomas, R. Smith, M.P. (2005). A type IV pilin, pilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo. Infection and Immunity, 73, 1260-1264.
Garmory, H.S. Brown, K.A. Titball, R.W. (2005). An association between ATP binding cassette systems, genome sizes and lifestyles of bacteria. Research in Microbiology, 156, 434-442.
Alape-Giron, A. Clark, G. Catimel, B. (2005). Cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C. Journal of Biological Chemistry, 280, 26680-26689.
Gates, A.J. Green, M. Eastaugh, L. (2005). CpG-DNA protects against a lethal orthopoxvirus infection in a murine model. Antiviral Research, 65, 87-95.
Perkins, S.D. Phillpotts, R.J. Titball, R.W. (2005). DNA vaccines for biodefence. Advanced Drug Delivery Reviews, 57, 1343-1361.
Choules, G. Rogers, D. Titball, R.W. (2005). Efficacy of the live attenuated Francisella tularensis vaccine (LVS) in a murine model of disease. Vaccine, 23, 2680-2686.
Oyston, P.C. Crossett, B. Fairweather, N.F. (2005). Functional characterization of OXA-57, a Class D &#946;-lactamase from <em>Burkholderia pseudomallei</em>. Antimicrobial Agents and Chemotherapy, 49, 1639-1641.
Titball, R.W. (2005). Gas gangrene: an open and closed case. Microbiology, 151, 2821-2828.
Harrison B, Raju D, Garmory HS, Brett MM, Titball RW, Sarker MR (2005). Molecular characterization of Clostridium perfringens isolates from humans with sporadic diarrhea: evidence for transcriptional regulation of the beta2-toxin-encoding gene. Appl Environ Microbiol, 71(12), 8362-8370. Abstract.  Author URL. DOI.
Taylor VL, Titball RW, Oyston PCF (2005). Oral immunization with a dam mutant of Yersinia pseudotuberculosis protects against plague. Microbiology, 151(6), 1919-1926. Abstract. DOI.
Taylor VL, Titball RW, Oyston PCF (2005). Oral immunization with a dam mutant of Yersinia pseudotuberculosis protects against plague. Microbiology, 151(Pt 6), 1919-1926. Abstract.  Author URL. DOI.
Bedford, R. Townson, K. Phillpotts, R. (2005). Protective efficacy of a recombinant plague vaccine when co-administered with another sub-unit or live attenuated vaccine. FEMS Immunology and Medical Microbiology, 43, 425-430.
RT101, Andersson SGE, Chain P, Chu MC (2005). The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nature Genetics, 37(2), 153-159. DOI.
Laws TR, Smith SA, Smith MP, Harding SV, Atkins TP, Titball RW (2005). The nematode Panagrellus redivivus is susceptible to killing by human pathogens at 37 degrees C. FEMS Microbiol Lett, 250(1), 77-83. Abstract.  Author URL. DOI.
Isherwood KE, Titball RW, Davies DH, Felgner PL, Morrow WJW (2005). Vaccination strategies for Francisella tularensis. Adv Drug Deliv Rev, 57(9), 1403-1414. Abstract.  Author URL. DOI.
Garmory, H.S. Perkins, S.D. O'Dowd, A.M. (2004). A Salmonella enterica serovar Typhi vaccine expressing Yersinia pestis F1 antigen on its surface provides protection against plague in mice. Vaccine, 22, 2524-2532.
Titball, R.W. (2004). ATP-Binding Cassette Transporters Are Targets for the Development of Antibacterial Vaccines and Therapies. Infection and Immunity, 72, 6757-6763.
TP, J. Cuccui, W. White, N. (2004). Absence of Yersinia pestis-specific DNA in human teeth from five European excavations of putative plague victims. Microbiology, 150, 341-354.
Laws TR, Harding SV, Smith MP, Atkins TP, Titball RW (2004). Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria. FEMS Microbiol Lett, 234(2), 281-287. Abstract.  Author URL. DOI.
Harding, S.V. Smith, M.P. Atkins, T.P. (2004). Aging and bacterial disease in the nematode <em>Caenorhabditis elegans</em>. FEMS Microbiology Letters, 234, 281-287.
Titball, R.W. (2004). An elusive serial killer. Nature, 430, 145-146.
Haque, A. Atkins, T. Hill, J. (2004). Attenuated virulence and protective efficacy of a <em>Burkholderia pseudomallei</em> bsa type III secretion mutant in a murine model of melioidosis. Microbiology, 150, 2669-2676.
Cole AR, Gilbert M, Popoff M, Moss DS, Titball RW, Basak A (2004). Clostridium perfringens epsilon toxin shows structural similarity with the pore forming toxin aerolysin. Nature Structural Biology, 11, 797-798.
Thelestam, T. Clark, G. Titball, R.W. (2004). Effects of Clostridium perfringens phospholipase C in mammalian cells. Anaerobe, 10, 115-123.
Prior, J.L. Lever, M.S. Jones, H.E. (2004). Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis. Journal of Medical Microbiology, 53, 1177-1182.
Rijnbrand, R.C. Wang, H. Ryman, K.D. (2004). Genetic Relationships and Evolution of Genotypes of Yellow Fever Virus and Other Members of the Yellow Fever Virus Group within the Flavivirus Genus Based on the 3' Noncoding Region. Journal of Virology, 78, 9652-9665.
RT101, Atkins T, Bason N, Beacham IR (2004). Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proceedings of the National Academy of Sciences, 101(39), 14240-14245. DOI.
Titball, R.W. Jepson, M. Bayer, C. (2004). Immunization with C-domain of alpha-toxin prevents lethal infection, localises tissue injury and promotes host response to challenge with viable <em>Clostridium perfringens</em>. Journal of Infectious Diseases, 190, 767-773. Full text.
Drancourt M, Raoult D, Gilbert MTP, Cuccui J, White W, Lynnerup N, Titball RW, Cooper A, Prentice MB (2004). Molecular detection of Yersinia pestis in dental pulp. Microbiology, 150(2), 263-265.
Titball RW (2004). Plague: the mysterious past and terrifying future of the world's most dangerous disease. NATURE, 430(6996), 145-146. Author URL. DOI.
Green, M. Choules, G.R. Ogers, D. (2004). Protection afforded by heat shock protein 60 from <em>Francisella tularensis</em> is due to co-purified lipopolysaccharide. Infection and Immunity, 72, 4109-4113.
Freeman, D. Brown, K.A. Titball, R.W. (2004). Protection against plague afforded by immunisation with DNA vaccines optimised for expression of the <em>Yersinia pestis</em> V antigen. Vaccine, 22, 947-957.
Gilbert MTP, Cuccui J, White W, Lynnerup N, Titball RW, Cooper A, Prentice MB (2004). Response to Drancourt and Raoult. MICROBIOLOGY-SGM, 150, 264-265. Author URL. DOI.
Titball RW (2004). Return of the black death: the world's greatest serial killer. NATURE, 430(6996), 145-146. Author URL. DOI.
Titball RW, Basak AK (2004). The bacterial zinc-metallophospholipases C. Journal of Toxicology - Toxin Reviews, 23(4), 509-554. Abstract. DOI.
Basak, A.K. (2004). The bacterial zinc-metallophospholipases C. Journal of Toxicology - Toxin Reviews, 23, 509-554.
Titball, R.W. Lindsay, C.D. (2004). The interaction of <em>Pseudomonas aeruginosa</em> PAK with human and animal respiratory tract cell lines. FEMS Microbiology Letters, 238, 49-55.
Leary, S. EC, K.F. Griffin, E.D. (2004). The use of live attenuated bacteria as a delivery system for heterologous antigens. Journal of Drug Targeting, 11, 471-479.
Sjostedt, A. Titball, R.W. (2004). Tularemia: bioterrorism defence renews interest in Francisella tularensis. Nature Reviews Microbiology, 2, 967-978.
Titball RW, Williamson ED (2004). Yersinia pestis (plague) vaccines. Expert Opin Biol Ther, 4(6), 965-973. Abstract.  Author URL. DOI.
Titball, R.W. (2004). Yersinia pestis. The Biochemist, 26, 11-14.
WP, A. Karleyshev, M. Smith, K. (2003). A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface. Microbiology, 149, 3221-3229.
Titball RW, Oyston PCF (2003). A vaccine for tularaemia. Expert Opin Biol Ther, 3(4), 645-653. Abstract.  Author URL. DOI.
Mayers C, Duffield M, Rowe S, Miller J, Lingard B, Hayward S, Titball RW (2003). Analysis of known bacterial protein vaccine antigens reveals biased physical properties and amino acid composition. Comp Funct Genomics, 4(5), 468-478. Abstract.  Author URL.  Full text. DOI.
RT101, Hinchcliffe SJ, Hinds J, Isherwood KE (2003). Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis . Genome Research, 13(9), 2018-2029. DOI.
Prior JL, Prior RG, Hitchen PG, Diaper H, Griffin KF, Morris HR, Dell A, Titball RW (2003). Characterization of the O antigen gene cluster and structural analysis of the O antigen of Francisella tularensis subsp. tularensis. J Med Microbiol, 52(Pt 10), 845-851. Abstract.  Author URL. DOI.
Briggs, D.C. Karasawa, T. Wang, X. (2003). Clostridium absonum alpha-toxin: new insights into Clostridial alpha-toxin substrate binding and specificity. Journal of Molecular Biology, 333, 759-769.
Garmory HS, Titball RW, Brown KA, Bennett AM (2003). Construction and evaluation of a eukaryotic expression plasmid for stable delivery using attenuated Salmonella. Microb Pathog, 34(3), 115-119. Abstract.  Author URL.
Hinds, J. Witney, A.A. Isherwood, K. (2003). Construction of a <em>Yersinia pestis</em> microarray. Advances in Experimental Medicine and Biology, 529, 47-49.
Garmory HS, Brown KA, Titball RW (2003). DNA vaccines: improving expression of antigens. Genet Vaccines Ther, 1(1). Abstract.  Author URL.  Full text. DOI.
Thomas R, Johansson A, Neeson B, Isherwood K, Sjöstedt A, Ellis J, Titball RW (2003). Discrimination of human pathogenic subspecies of Francisella tularensis by using restriction fragment length polymorphism. J Clin Microbiol, 41(1), 50-57. Abstract.  Author URL.
Donelli G, Fiorentini C, Matarrese P, Falzano L, Cardines R, Mastrantonio P, Payne DW, Titball RW (2003). Evidence for cytoskeletal changes secondary to plasma membrane functional alterations in the in vitro cell response to Clostridium perfringens epsilon-toxin. Comp Immunol Microbiol Infect Dis, 26(3), 145-156. Abstract.  Author URL.
Lever MS, Nelson M, Ireland PI, Stagg AJ, Beedham RJ, Hall GA, Knight G, Titball RW (2003). Experimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouse. J Med Microbiol, 52(Pt 12), 1109-1115. Abstract.  Author URL. DOI.
Oyston PCF, Prior JL, Kiljunen S, Skurnik M, Hill J, Titball RW (2003). Expression of heterologous O-antigen in Yersinia pestis KIM does not affect virulence by the intravenous route. J Med Microbiol, 52(Pt 4), 289-294. Abstract.  Author URL. DOI.
Titball RW, Sjostedt A (2003). Francisella tularensis: an overview. ASM NEWS, 69(11), 558-+. Author URL.
Broekhuijsen M, Larsson P, Johansson A, Byström M, Eriksson U, Larsson E, Prior RG, Sjöstedt A, Titball RW, Forsman M, et al (2003). Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis. J Clin Microbiol, 41(7), 2924-2931. Abstract.  Author URL.
Waters M, Savoie A, Garmory HS, Bueschel D, Popoff MR, Songer JG, Titball RW, McClane BA, Sarker MR (2003). Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets. J Clin Microbiol, 41(8), 3584-3591. Abstract.  Author URL.
Underwood, C.D. Sundberg, L. Astrom, H. (2003). Immunological characterisation of sub-units of the Yersinia type III secretion apparatus. Advances in Experimental Medicine and Biology, 529, 415-417.
Garmory HS, Griffin KF, Brown KA, Titball RW (2003). Oral immunisation with live aroA attenuated Salmonella enterica serovar Typhimurium expressing the Yersinia pestis V antigen protects mice against plague. Vaccine, 21(21-22), 3051-3057. Abstract.  Author URL.
Garmory HS, Titball RW, Griffin KF, Hahn U, Böhm R, Beyer W (2003). Salmonella enterica serovar typhimurium expressing a chromosomally integrated copy of the Bacillus anthracis protective antigen gene protects mice against an anthrax spore challenge. Infect Immun, 71(7), 3831-3836. Abstract.  Author URL.
Williamson, E.D. (2003). Second and third generation plague vaccines. Advances in Experimental Medicine and Biology, 529, 397-406.
Hill J, Copse C, Leary S, Stagg AJ, Williamson ED, Titball RW (2003). Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis. Infect Immun, 71(4), 2234-2238. Abstract.  Author URL.
Titball, R.W. Lindsay, C.D. (2003). The development of tolderance to Clostridium perfringens type D &#949;-toxin in MDCK and G402 cells. Human & Experimental Toxicology, 22, 593-605.
Foynes S, Holley JL, Garmory HS, Titball RW, Fairweather NF (2003). Vaccination against type F botulinum toxin using attenuated Salmonella enterica var Typhimurium strains expressing the BoNT/F H(C) fragment. Vaccine, 21(11-12), 1052-1059. Abstract.  Author URL.
Titball RW, Williamson ED (2003). Vaccine development for potential bioterrorism agents. Curr Drug Targets Infect Disord, 3(3), 255-262. Abstract.  Author URL.
Titball RW, Johansson A, Forsman M (2003). Will the enigma of Francisella tularensis virulence soon be solved?. Trends Microbiol, 11(3), 118-123. Abstract.  Author URL.
Smith MP, Laws TR, Atkins TP, Oyston PCF, de Pomerai DI, Titball RW (2002). A liquid-based method for the assessment of bacterial pathogenicity using the nematode Caenorhabditis elegans. FEMS Microbiol Lett, 210(2), 181-185. Abstract.  Author URL.
Atkins T, Prior RG, Mack K, Russell P, Nelson M, Oyston PCF, Dougan G, Titball RW (2002). A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis. Infect Immun, 70(9), 5290-5294. Abstract.  Author URL.
Flick-Smith HC, Walker NJ, Gibson P, Bullifent H, Hayward S, Miller J, Titball RW, Williamson ED (2002). A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection. Infect Immun, 70(3), 1653-1656. Abstract.  Author URL.
Atkins T, Prior R, Mack K, Russell P, Nelson M, Prior J, Ellis J, Oyston PCF, Dougan G, Titball RW, et al (2002). Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis. J Med Microbiol, 51(7), 539-547. Abstract.  Author URL. DOI.
Eaton JT, Naylor CE, Howells AM, Moss DS, Titball RW, Basak AK (2002). Crystal structure of the C. perfringens alpha-toxin with the active site closed by a flexible loop region. J Mol Biol, 319(2), 275-281. Abstract.  Author URL. DOI.
Lawton DG, Longstaff C, Wallace BA, Hill J, Leary SEC, Titball RW, Brown KA (2002). Interactions of the type III secretion pathway proteins LcrV and LcrG from Yersinia pestis are mediated by coiled-coil domains. J Biol Chem, 277(41), 38714-38722. Abstract.  Author URL. DOI.
Prior JL, Titball RW (2002). Monoclonal antibodies against Yersinia pestis lipopolysaccharide detect bacteria cultured at 28 degrees C or 37 degrees C. Mol Cell Probes, 16(4), 251-256. Abstract.  Author URL.
Howells AM, Bullifent HL, Dhaliwal K, Griffin K, García de Castro A, Frith G, Tunnacliffe A, Titball RW (2002). Role of trehalose biosynthesis in environmental survival and virulence of Salmonella enterica serovar typhimurium. Res Microbiol, 153(5), 281-287. Abstract.  Author URL.
Garmory HS, Brown KA, Titball RW (2002). Salmonella vaccines for use in humans: present and future perspectives. FEMS Microbiol Rev, 26(4), 339-353. Abstract.  Author URL.
Baker MD, Papageorgiou AC, Titball RW, Miller J, White S, Lingard B, Lee JJ, Cavanagh D, Kehoe MA, Robinson JH, et al (2002). Structural and functional role of threonine 112 in a superantigen Staphylococcus aureus enterotoxin B. J Biol Chem, 277(4), 2756-2762. Abstract.  Author URL. DOI.
Hitchen PG, Prior JL, Oyston PCF, Panico M, Wren BW, Titball RW, Morris HR, Dell A (2002). Structural characterization of lipo-oligosaccharide (LOS) from Yersinia pestis: regulation of LOS structure by the PhoPQ system. Mol Microbiol, 44(6), 1637-1650. Abstract.  Author URL.
Garmory HS, Griffin KF, Leary SEC, Perkins SD, Brown KA, Titball RW (2002). The effect of recombinant plasmids on in vivo colonisation of Salmonella enterica serovar Typhimurium strains is not reflected by in vitro cellular invasion assays. Vaccine, 20(27-28), 3239-3243. Abstract.  Author URL.
Justin N, Walker N, Bullifent HL, Songer G, Bueschel DM, Jost H, Naylor C, Miller J, Moss DS, Titball RW, et al (2002). The first strain of Clostridium perfringens isolated from an avian source has an alpha-toxin with divergent structural and kinetic properties. Biochemistry, 41(20), 6253-6262. Abstract.  Author URL.
Ellis J, Oyston PCF, Green M, Titball RW (2002). Tularemia. CLINICAL MICROBIOLOGY REVIEWS, 15(4), 631-+. Author URL. DOI.
Ellis J, Oyston PCF, Green M, Titball RW (2002). Tularemia. Clin Microbiol Rev, 15(4), 631-646. Abstract.  Author URL.
Williamson ED, Titball RW (2002). Vaccines against dangerous pathogens. Br Med Bull, 62, 163-173. Abstract.  Author URL.
Karlyshev AV, Oyston PC, Williams K, Clark GC, Titball RW, Winzeler EA, Wren BW (2001). Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes. Infect Immun, 69(12), 7810-7819. Abstract.  Author URL. DOI.
Prior JL, Hitchen PG, Williamson DE, Reason AJ, Morris HR, Dell A, Wren BW, Titball RW (2001). Characterization of the lipopolysaccharide of Yersinia pestis. Microb Pathog, 30(2), 49-57. Abstract.  Author URL. DOI.
RT101, Cerdeno-Tarraga AM, Chillingworth T, Churcher C (2001). Genome sequence of Yersinia pestis, the causative agent of plague. Nature, 413(6855), 523-527. DOI.
Tito MA, Miller J, Griffin KF, Williamson ED, Titball RW, Robinson CV (2001). Macromolecular organization of the Yersinia pestis capsular F1 antigen: insights from time-of-flight mass spectrometry. Protein Sci, 10(11), 2408-2413. Abstract.  Author URL. DOI.
Tito MA, Miller J, Walker N, Griffin KF, Williamson ED, Despeyroux-Hill D, Titball RW, Robinson CV (2001). Probing molecular interactions in intact antibody: antigen complexes, an electrospray time-of-flight mass spectrometry approach. Biophys J, 81(6), 3503-3509. Abstract.  Author URL. DOI.
Fulop M, Mastroeni P, Green M, Titball RW (2001). Role of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensis. Vaccine, 19(31), 4465-4472. Abstract.  Author URL.
Prior JL, Parkhill J, Hitchen PG, Mungall KL, Stevens K, Morris HR, Reason AJ, Oyston PC, Dell A, Wren BW, et al (2001). The failure of different strains of Yersinia pestis to produce lipopolysaccharide O-antigen under different growth conditions is due to mutations in the O-antigen gene cluster. FEMS Microbiol Lett, 197(2), 229-233. Abstract.  Author URL.
Jepson M, Bullifent HL, Crane D, Flores-Diaz M, Alape-Giron A, Jayasekeera P, Lingard B, Moss D, Titball RW (2001). Tyrosine 331 and phenylalanine 334 in Clostridium perfringens alpha-toxin are essential for cytotoxic activity. FEBS Lett, 495(3), 172-177. Abstract.  Author URL.
Titball RW, Williamson ED (2001). Vaccination against bubonic and pneumonic plague. Vaccine, 19(30), 4175-4184. Abstract.  Author URL.
Prentice MB, James KD, Parkhill J, Baker SG, Stevens K, Simmonds MN, Mungall KL, Churcher C, Oyston PC, Titball RW, et al (2001). Yersinia pestis pFra shows biovar-specific differences and recent common ancestry with a Salmonella enterica serovar Typhi plasmid. J Bacteriol, 183(8), 2586-2594. Abstract.  Author URL. DOI.
Williamson ED, Eley SM, Stagg AJ, Green M, Russell P, Titball RW (2000). A single dose sub-unit vaccine protects against pneumonic plague. Vaccine, 19(4-5), 566-571. Abstract.  Author URL.
Shortt SJ, Titball RW, Lindsay CD (2000). An assessment of the in vitro toxicology of Clostridium perfringens type D epsilon-toxin in human and animal cells. Hum Exp Toxicol, 19(2), 108-116. Abstract.  Author URL. DOI.
Bullifent HL, Griffin KF, Jones SM, Yates A, Harrington L, Titball RW (2000). Antibody responses to Yersinia pestis F1-antigen expressed in Salmonella typhimurium aroA from in vivo-inducible promoters. Vaccine, 18(24), 2668-2676. Abstract.  Author URL.
Holley JL, Elmore M, Mauchline M, Minton N, Titball RW (2000). Cloning, expression and evaluation of a recombinant sub-unit vaccine against Clostridium botulinum type F toxin. Vaccine, 19(2-3), 288-297. Abstract.  Author URL.
Byrne MP, Titball RW, Holley J, Smith LA (2000). Fermentation, purification, and efficacy of a recombinant vaccine candidate against botulinum neurotoxin type F from Pichia pastoris. Protein Expr Purif, 18(3), 327-337. Abstract.  Author URL. DOI.
Walker C, Goodyear C, Anderson D, Titball RW (2000). Identification of arsenic-resistant bacteria in the soil of a former munitions factory at Locknitz, Germany. Land Contamination and Reclamation, 8(1), 13-18. Abstract.
Alape-Girón A, Flores-Díaz M, Guillouard I, Naylor CE, Titball RW, Rucavado A, Lomonte B, Basak AK, Gutiérrez JM, Cole ST, et al (2000). Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene. Eur J Biochem, 267(16), 5191-5197. Abstract.  Author URL.
Walker N, Holley J, Naylor CE, Flores-Díaz M, Alape-Girón A, Carter G, Carr FJ, Thelestam M, Keyte M, Moss DS, et al (2000). Identification of residues in the carboxy-terminal domain of Clostridium perfringens alpha-toxin (phospholipase C) which are required for its biological activities. Arch Biochem Biophys, 384(1), 24-30. Abstract.  Author URL. DOI.
Wright A, Andrews PL, Titball RW (2000). Induction of emetic, pyrexic, and behavioral effects of Staphylococcus aureus enterotoxin B in the ferret. Infect Immun, 68(4), 2386-2389. Abstract.  Author URL.
Williams K, Oyston PC, Dorrell N, Li S, Titball RW, Wren BW (2000). Investigation into the role of the serine protease HtrA in Yersinia pestis pathogenesis. FEMS Microbiol Lett, 186(2), 281-286. Abstract.  Author URL.
Garmory HS, Chanter N, French NP, Bueschel D, Songer JG, Titball RM (2000). Occurrence of Clostridium perfringens beta 2-toxin amongst animals, determined using genotyping and subtyping PCR assays (vol 124, pg 61, 2000). EPIDEMIOLOGY AND INFECTION, 125(1), 227-227. Author URL. DOI.
Garmory HS, Chanter N, French NP, Bueschel D, Songer JG, Titball RW (2000). Occurrence of Clostridium perfringens beta2-toxin amongst animals, determined using genotyping and subtyping PCR assays. Epidemiol Infect, 124(1), 61-67. Abstract.  Author URL.
Karlsson J, Prior RG, Williams K, Lindler L, Brown KA, Chatwell N, Hjalmarsson K, Loman N, Mack KA, Pallen M, et al (2000). Sequencing of the Francisella tularensis strain Schu 4 genome reveals the shikimate and purine metabolic pathways, targets for the construction of a rationally attenuated auxotrophic vaccine. Microb Comp Genomics, 5(1), 25-39. Abstract.  Author URL. DOI.
Bullifent HL, Dhaliwal K, Howells AM, Goan K, Griffin K, Lindsay CD, Tunnacliffe A, Titball RW (2000). Stabilisation of Salmonella vaccine vectors by the induction of trehalose biosynthesis. Vaccine, 19(9-10), 1239-1245. Abstract.  Author URL.
Jepson M, Titball R (2000). Structure and function of clostridial phospholipases C. Microbes Infect, 2(10), 1277-1284. Abstract.  Author URL.
Oyston PC, Dorrell N, Williams K, Li SR, Green M, Titball RW, Wren BW (2000). The response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in Yersinia pestis. Infect Immun, 68(6), 3419-3425. Abstract.  Author URL.
Williamson ED, Vesey PM, Gillhespy KJ, Eley SM, Green M, Titball RW (1999). An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse model. Clin Exp Immunol, 116(1), 107-114. Abstract.  Author URL.
Naylor CE, Jepson M, Crane DT, Titball RW, Miller J, Basak AK, Bolgiano B (1999). Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin. J Mol Biol, 294(3), 757-770. Abstract.  Author URL. DOI.
Jepson M, Howells A, Bullifent HL, Bolgiano B, Crane D, Miller J, Holley J, Jayasekera P, Titball RW (1999). Differences in the carboxy-terminal (Putative phospholipid binding) domains of Clostridium perfringens and Clostridium bifermentans phospholipases C influence the hemolytic and lethal properties of these enzymes. Infect Immun, 67(7), 3297-3301. Abstract.  Author URL.
Kenny DJ, Russell P, Rogers D, Eley SM, Titball RW (1999). In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp. Antimicrob Agents Chemother, 43(11), 2773-2775. Abstract.  Author URL.
Bennett AM, Lescott T, Phillpotts RJ, Mackett M, Titball RW (1999). Recombinant vaccinia viruses protect against Clostridium perfringens alpha-toxin. Viral Immunol, 12(2), 97-105. Abstract.  Author URL. DOI.
Justin N, Eaton J, Naylor C, Howells A, Moss D, Titball R, Basak A (1999). Structure Function Studies of Clostridium perfringens Alpha-Toxin; a Gas Gangrene Causing Protein. Journal of Chemical Society of Pakistan, 21(3), 239-247.
Titball RW, Naylor CE, Basak AK (1999). The Clostridium perfringens alpha-toxin. Anaerobe, 5(2), 51-64. Abstract.  Author URL. DOI.
Green M, Rogers D, Russell P, Stagg AJ, Bell DL, Eley SM, Titball RW, Williamson ED (1999). The SCID/Beige mouse as a model to investigate protection against Yersinia pestis. FEMS Immunol Med Microbiol, 23(2), 107-113. Abstract.  Author URL.
Pettersson J, Holmström A, Hill J, Leary S, Frithz-Lindsten E, von Euler-Matell A, Carlsson E, Titball R, Forsberg A, Wolf-Watz H, et al (1999). The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation. Mol Microbiol, 32(5), 961-976. Abstract.  Author URL.
Leary SE, Griffin KF, Galyov EE, Hewer J, Williamson ED, Holmström A, Forsberg A, Titball RW (1999). Yersinia outer proteins (YOPS) E, K and N are antigenic but non-protective compared to V antigen, in a murine model of bubonic plague. Microb Pathog, 26(3), 159-169. Abstract.  Author URL. DOI.
Titball RW (1998). Bacterial phospholipases. Journal of Applied Microbiology Symposium Supplement, 84(27). Abstract.
Titball RW (1998). Bacterial phospholipases. Symp Ser Soc Appl Microbiol, 27, 127S-137S. Abstract.  Author URL.
Basak AK, Howells A, Eaton JT, Moss DS, Naylor CE, Miller J, Titball RW (1998). Crystallization and preliminary X-ray diffraction studies of alpha-toxin from two different strains (NCTC8237 and CER89L43) of Clostridium perfringens. Acta Crystallogr D Biol Crystallogr, 54(Pt 6 Pt 2), 1425-1428. Abstract.  Author URL.
Russell P, Eley SM, Green M, Stagg AJ, Taylor RR, Nelson M, Beedham RJ, Bell DL, Rogers D, Whittington D, et al (1998). Efficacy of doxycycline and ciprofloxacin against experimental Yersinia pestis infection. J Antimicrob Chemother, 41(2), 301-305. Abstract.  Author URL.
Carter G, White P, Fernie M, King S, McLean G, Titball R, Carr FJ (1998). Enhanced antitumour effect of liposomal daunorubicin using antibody-phospholipase C conjugates or fusion protein. Int J Oncol, 13(4), 819-825. Abstract.  Author URL.
Miller J, Williamson ED, Lakey JH, Pearce MJ, Jones SM, Titball RW (1998). Macromolecular organisation of recombinant Yersinia pestis F1 antigen and the effect of structure on immunogenicity. FEMS Immunol Med Microbiol, 21(3), 213-221. Abstract.  Author URL.
Oyston PC, Payne DW, Havard HL, Williamson ED, Titball RW (1998). Production of a non-toxic site-directed mutant of Clostridium perfringens epsilon-toxin which induces protective immunity in mice. Microbiology, 144 ( Pt 2), 333-341. Abstract.  Author URL. DOI.
Basak AK, Eaton TJ, Howells A, Justin N, Miller J, Moss DS, Naylor CE, Titball RW (1998). Structure and function of clostridial A-toxin and its role in gas-gangrene. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 216, U66-U66. Author URL.
Naylor CE, Eaton JT, Howells A, Justin N, Moss DS, Titball RW, Basak AK (1998). Structure of the key toxin in gas gangrene. Nat Struct Biol, 5(8), 738-746. Abstract.  Author URL. DOI.
Mack K, Titball RW (1998). The detection of insertion sequences within the human pathogen Burkholderia pseudomallei which have been identified previously in Burkholderia cepacia. FEMS Microbiol Lett, 162(1), 69-74. Abstract.  Author URL.
Russell P, Eley SM, Fulop MJ, Bell DL, Titball RW (1998). The efficacy of ciprofloxacin and doxycycline against experimental tularaemia. J Antimicrob Chemother, 41(4), 461-465. Abstract.  Author URL.
Payne D, Tatham D, Williamson ED, Titball RW (1998). The pH 6 antigen of Yersinia pestis binds to beta1-linked galactosyl residues in glycosphingolipids. Infect Immun, 66(9), 4545-4548. Abstract.  Author URL.
Flores-Díaz M, Alape-Girón A, Titball RW, Moos M, Guillouard I, Cole S, Howells AM, von Eichel-Streiber C, Florin I, Thelestam M, et al (1998). UDP-glucose deficiency causes hypersensitivity to the cytotoxic effect of Clostridium perfringens phospholipase C. J Biol Chem, 273(38), 24433-24438. Abstract.  Author URL.
Williamson ED, Eley SM, Stagg AJ, Green M, Russell P, Titball RW (1997). A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunized animals against pneumonic plague. Vaccine, 15(10), 1079-1084. Abstract.  Author URL.
Titball RW (1997). Bacterial phospholipases. Trends Microbiol, 5(7). Author URL. DOI.
Leary SE, Griffin KF, Garmory HS, Williamson ED, Titball RW (1997). Expression of an F1/V fusion protein in attenuated Salmonella typhimurium and protection of mice against plague. Microb Pathog, 23(3), 167-179. Abstract.  Author URL. DOI.
Titball RW, Howells AM, Oyston PC, Williamson ED (1997). Expression of the Yersinia pestis capsular antigen (F1 antigen) on the surface of an aroA mutant of Salmonella typhimurium induces high levels of protection against plague. Infect Immun, 65(5), 1926-1930. Abstract.  Author URL.
Russell P, Nelson M, Whittington D, Green M, Eley SM, Titball RW (1997). Laboratory diagnosis of plague. Br J Biomed Sci, 54(4), 231-236. Abstract.  Author URL.
Hill J, Leary SE, Griffin KF, Williamson ED, Titball RW (1997). Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunization. Infect Immun, 65(11), 4476-4482. Abstract.  Author URL.
Fulop M, Leslie D, Titball R (1996). A rapid, highly sensitive method for the detection of Francisella tularensis in clinical samples using the polymerase chain reaction. Am J Trop Med Hyg, 54(4), 364-366. Abstract.  Author URL.
Oyston PC, Russell P, Williamson ED, Titball RW (1996). An aroA mutant of Yersinia pestis is attenuated in guinea-pigs, but virulent in mice. Microbiology, 142 ( Pt 7), 1847-1853. Abstract.  Author URL. DOI.
Ivanov A, Titball RW, Kostadinova S (1996). Characterisation of a phospholipase C produced by Pseudomonas fluorescens. New Microbiol, 19(2), 113-121. Abstract.  Author URL.
Russell P, Eley SM, Bell DL, Manchee RJ, Titball RW (1996). Doxycycline or ciprofloxacin prophylaxis and therapy against experimental Yersinia pestis infection in mice. J Antimicrob Chemother, 37(4), 769-774. Abstract.  Author URL.
Williamson ED, Sharp GJ, Eley SM, Vesey PM, Pepper TC, Titball RW, Alpar HO (1996). Local and systemic immune response to a microencapsulated sub-unit vaccine for plague. Vaccine, 14(17-18), 1613-1619. Abstract.  Author URL.
Ginter A, Williamson ED, Dessy F, Coppe P, Bullifent H, Howells A, Titball RW (1996). Molecular variation between the alpha-toxins from the type strain (NCTC 8237) and clinical isolates of Clostridium perfringens associated with disease in man and animals. Microbiology, 142 ( Pt 1), 191-198. Abstract.  Author URL. DOI.
Anderson GW, Leary SE, Williamson ED, Titball RW, Welkos SL, Worsham PL, Friedlander AM (1996). Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis. Infect Immun, 64(11), 4580-4585. Abstract.  Author URL.
McGregor DP, Forster S, Steven J, Adair J, Leary SE, Leslie DL, Harris WJ, Titball RW (1996). Simultaneous detection of microorganisms in soil suspension based on PCR amplification of bacterial 16S rRNA fragments. Biotechniques, 21(3), 463-471. Abstract.  Author URL.
Bullifent HL, Moir A, Awad MM, Scott PT, Rood JI, Titball RW (1996). The level of expression of α-toxin by different strains of Clostridium perfringens is dependent on differences in promoter structure and genetic background. Anaerobe, 2(6), 365-371. Abstract. DOI.
Mack K, Titball RW (1996). Transformation of Burkholderia pseudomallei by electroporation. Anal Biochem, 242(1), 73-76. Abstract.  Author URL. DOI.
Russell P, Eley SM, Hibbs SE, Manchee RJ, Stagg AJ, Titball RW (1995). A comparison of Plague vaccine, USP and EV76 vaccine induced protection against Yersinia pestis in a murine model. Vaccine, 13(16), 1551-1556. Abstract.  Author URL.
Diane Williamson E, Eley SM, Griffin KF, Green M, Russell P, Leary SEC, Oyston PCF, Easterbrook T, Reddin KM, Robinson A, et al (1995). A new improved sub-unit vaccine for plague: the basis of protection. FEMS Immunology and Medical Microbiology, 12(3-4), 223-230. Abstract. DOI.
Leary SE, Williamson ED, Griffin KF, Russell P, Eley SM, Titball RW (1995). Active immunization with recombinant V antigen from Yersinia pestis protects mice against plague. Infect Immun, 63(8), 2854-2858. Abstract.  Author URL.
Oyston PC, Williamson ED, Leary SE, Eley SM, Griffin KF, Titball RW (1995). Immunization with live recombinant Salmonella typhimurium aroA producing F1 antigen protects against plague. Infect Immun, 63(2), 563-568. Abstract.  Author URL.
Fulop LD, Barrett AD, Titball RW (1995). Nucleotide sequence of the NS5 gene of Banzi virus: comparison with other flaviviruses. J Gen Virol, 76 ( Pt 9), 2317-2321. Abstract.  Author URL. DOI.
Fulop M, Manchee R, Titball R (1995). Role of lipopolysaccharide and a major outer membrane protein from Francisella tularensis in the induction of immunity against tularemia. Vaccine, 13(13), 1220-1225. Abstract.  Author URL.
Bullifent HL, Moir A, Titball RW (1995). The construction of a reporter system and use for the investigation of Clostridium perfringens gene expression. FEMS Microbiol Lett, 131(1), 99-105. Abstract.  Author URL.
Coulson NM, Fulop M, Titball RW (1994). Bacillus anthracis protective antigen, expressed in Salmonella typhimurium SL 3261, affords protection against anthrax spore challenge. Vaccine, 12(15), 1395-1401. Abstract.  Author URL.
Coulson NM, Fulop M, Titball RW (1994). Effect of different plasmids on colonization of mouse tissues by the aromatic amino acid dependent Salmonella typhimurium SL 3261. Microb Pathog, 16(4), 305-311. Abstract.  Author URL. DOI.
Tempest PR, White P, Williamson ED, Titball RW, Kelly DC, Kemp GJ, Gray PM, Forster SJ, Carr FJ, Harris WJ, et al (1994). Efficient generation of a reshaped human mAb specific for the alpha toxin of Clostridium perfringens. Protein Eng, 7(12), 1501-1507. Abstract.  Author URL.
Johns M, Harrington L, Titball RW, Leslie DL (1994). Improved methods for the detection of Bacillus anthracis spores by the polymerase chain reaction. Letters in Applied Microbiology, 18(4), 236-238. Abstract. DOI.
Basak AK, Stuart DI, Nikura T, Bishop DH, Kelly DC, Fearn A, Titball RW (1994). Purification, crystallization and preliminary X-ray diffraction studies of alpha-toxin of Clostridium perfringens. J Mol Biol, 244(5), 648-650. Abstract.  Author URL. DOI.
Williamson ED, Titball RW (1993). A genetically engineered vaccine against the alpha-toxin of Clostridium perfringens protects mice against experimental gas gangrene. Vaccine, 11(12), 1253-1258. Abstract.  Author URL.
Leslie DL, Cox J, Lee M, Titball RW (1993). Analysis of a cloned Francisella tularensis outer membrane protein gene and expression in attenuated Salmonella typhimurium. FEMS Microbiol Lett, 111(2-3), 331-335. Abstract.  Author URL.
TITBALL RW, PEARSON GS (1993). BWC VERIFICATION MEASURES - TECHNOLOGIES FOR THE IDENTIFICATION OF BIOLOGICAL WARFARE AGENTS. POLITICS AND THE LIFE SCIENCES, 12(2), 255-263. Author URL.
Titball RW (1993). Bacterial phospholipases C. Microbiol Rev, 57(2), 347-366. Abstract.  Author URL.
Titball RW, Fearn AM, Williamson ED (1993). Biochemical and immunological properties of the C-terminal domain of the alpha-toxin of Clostridium perfringens. FEMS Microbiol Lett, 110(1), 45-50. Abstract.  Author URL.
Hunter SE, Brown JE, Oyston PC, Sakurai J, Titball RW (1993). Molecular genetic analysis of beta-toxin of Clostridium perfringens reveals sequence homology with alpha-toxin, gamma-toxin, and leukocidin of Staphylococcus aureus. Infect Immun, 61(9), 3958-3965. Abstract.  Author URL.
Fulop L, Barrett AD, Phillpotts R, Martin K, Leslie D, Titball RW (1993). Rapid identification of flaviviruses based on conserved NS5 gene sequences. J Virol Methods, 44(2-3), 179-188. Abstract.  Author URL.
Hunter SE, Clarke IN, Kelly DC, Titball RW (1992). Cloning and nucleotide sequencing of the Clostridium perfringens epsilon-toxin gene and its expression in Escherichia coli. Infect Immun, 60(1), 102-110. Abstract.  Author URL.
Havard HL, Hunter SE, Titball RW (1992). Comparison of the nucleotide sequence and development of a PCR test for the epsilon toxin gene of Clostridium perfringens type B and type D. FEMS Microbiol Lett, 76(1-2), 77-81. Abstract.  Author URL.
Carl M, Hawkins R, Coulson N, Lowe J, Robertson DL, Nelson WM, Titball RW, Woody JN (1992). Detection of spores of Bacillus anthracis using the polymerase chain reaction. J Infect Dis, 165(6), 1145-1148. Abstract.  Author URL.
Logan AJ, Williamson ED, Titball RW, Percival DA, Shuttleworth AD, Conlan JW, Kelly DC (1991). Epitope mapping of the alpha-toxin of Clostridium perfringens. Infect Immun, 59(12), 4338-4342. Abstract.  Author URL.
Titball RW, Leslie DL, Harvey S, Kelly D (1991). Hemolytic and sphingomyelinase activities of Clostridium perfringens alpha-toxin are dependent on a domain homologous to that of an enzyme from the human arachidonic acid pathway. Infect Immun, 59(5), 1872-1874. Abstract.  Author URL.
Titball RW, Turnbull PCB, Hutson RA (1991). The monitoring and detection of Bacillus anthracis in the environment. Journal of Applied Bacteriology Symposium Supplement(20).
Titball RW, Turnbull PC, Hutson RA (1991). The monitoring and detection of Bacillus anthracis in the environment. Soc Appl Bacteriol Symp Ser, 20, 9S-18S. Author URL.
Titball RW, Rubidge T (1990). The role of histidine residues in the alpha toxin of Clostridium perfringens. FEMS Microbiol Lett, 56(3), 261-265. Abstract.  Author URL.
Titball RW, Hunter SE, Martin KL, Morris BC, Shuttleworth AD, Rubidge T, Anderson DW, Kelly DC (1989). Molecular cloning and nucleotide sequence of the alpha-toxin (phospholipase C) of Clostridium perfringens. Infect Immun, 57(2), 367-376. Abstract.  Author URL.
Titball RW, Manchee RJ (1987). Factors affecting the germination of spores of Bacillus anthracis. J Appl Bacteriol, 62(3), 269-273. Abstract.  Author URL.
TITBALL RW (1986). PATHOGENIC BACTERIA IN THE SOIL. JOURNAL OF APPLIED BACTERIOLOGY, 61(6), R6-R6. Author URL.
TITBALL RW, MANCHEE RJ (1985). FACTORS AFFECTING THE GERMINATION OF SPORES OF BACILLUS-ANTHRACIS. JOURNAL OF APPLIED BACTERIOLOGY, 59(6), R18-R18. Author URL.
Titball RW, Bell A, Munn CB (1985). Role of caseinase from Aeromonas salmonicida in activation of hemolysin. Infect Immun, 49(3), 756-759. Abstract.  Author URL.
Titball RW, Munn CB (1985). The purification and some properties of H-lysin from Aeromonas salmonicida. J Gen Microbiol, 131(7), 1603-1609. Abstract.  Author URL. DOI.
Titball RW, Munn CB (1983). Partial purification and properties of a haemolytic activity (T-lysin) from Aeromonas salmonicida. FEMS Microbiology Letters, 20(2), 207-210. Abstract.
TITBALL RW (1981). CORRECTION. FEMS MICROBIOLOGY LETTERS, 12(4), 428-428. Author URL.
Titball RW, Munn CB (1981). Evidence for two haemolytic activities from Aeromonas salmonicida. FEMS Microbiology Letters, 12(1), 27-30.

Chapters

Atkins, H.S. (2006). Bacillus. In Greenwood D, Slack R, Peutherer J, Barer M (Eds.) Medical Microbiology, 17th edition, Elsevier.
Popoff, M. Titball, R.W. Cole, A. (2006). Clostridium perfringens ε-toxin. In Joseph JE, Michel M, Popoff (Eds.) The Comprehensive Sourcebook of Bacterial Protein Toxins, London: , 631-642.
Duffield, M. (2006). Comparative genomics – what do such studies tell us about the emergence and spread of. key pathogens. In Logan NA, Lappin-Scott HM, Oyston PCF (Eds.) Prokaryotic diversity: mechanisms and significance, Cambridge University Press, 175-186.
Basak, A.K. (2006). Membrane damaging and cytotoxic phospholipases. In Joseph JE, Michel M, Popopoff (Eds.) The Comprehensive Sourcebook of Bacterial Protein Toxins, London: Academic Press, 516-534.
Simpson, A.J. Titball, R.W. (2006). Plague. In Plotkin SA, Orenstein WA (Eds.) Vaccines 5th edn, Philadelphia: , 999-1010.
Michell S, Griffin, K.F. Titball, R.W. (2006). Tularemia Pathogenesis and Immunity. In Friedman H, Anderson B (Eds.) Microbial Infection and Bioterrorism, Kluwer Academic Publishers, 121-138.
Forsman, M. Oyston, P. Titball, R. (2005). Genomics for Biodefence: Exploiting the Francisella tularensis genome sequence. In Lindler L, Lebeda F, Korch GW (Eds.) Biological Weapons Defense. Infectious Diseases and Counterbioterrorism, Totowa, USA: Humana Press Inc, 435-452.
Titball, R.W. (2005). Membrane active toxins. In Duerre P (Ed) Handbook on Clostridia, Boca Raton: Taylor & Francis, 451-490.
Krieg, A. Titball, R.W. (2005). Non-specific Immunomodulator Therapy; CpG. In Lindler L, Lebeda F, Korch GW (Eds.) Biological Weapons Defense. Infectious Diseases and Counterbioterrorism, Totowa, USA: Humana Press Inc, 317-331.
Oyston, P.C.F. (2005). Plague. In Lutwick LI, Lutwick SM (Eds.) Bioterror: the Weaponization of Infectious Diseases, New Jersey:.

Conferences

Gourlay LJ, Lassaux P, Thomas RJ, Peri C, Conchillo-Sole O, Nithichanon A, Ferrer-Navarro M, Vila J, Daura X, Lertmemongkolchai G, et al (2015). Flagellar subunits as targets for structure-based epitope discovery approaches and melioidosis vaccine development.  Author URL.
Campbell AS, Christ WJ, Lohmanb G, Guo Y, Jones M, Scott AE, George AJ, Titball RW, Atkins TP, Prior JL, et al (2014). De novo synthesis, conjugation, and immnunogenicity of the Burkholderia pseudomallei manno-heptose capsule.  Author URL.
Sundaresh S, Randall A, Unal B, Petersen JM, Belisle JT, Hartley MG, Duffield M, Titball RW, Davies DH, Felgner PL, et al (2007). From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis. England.  Abstract.  Author URL. DOI.
Stabler RA, Hinds J, Witney AA, Isherwood K, Oyston P, Titball R, Wren B, Hinchliffe S, Prentice M, Mangan JA, et al (2003). Construction of a Yersinia pestis microarray. United States.  Author URL. DOI.
Oyston PCF, Karlyshev AV, Wren BW, Titball RW (2003). Signature-tagged mutagenesis of Yersinia pestis. United States.  Author URL. DOI.
Titball RW, Hill J, Lawton DG, Brown KA (2003). Yersinia pestis and plague. England.  Abstract.  Author URL.
Hinchliffe SJ, Isherwood KE, Stabler RA, Oyston PCF, Hinds J, Titbal RW, Wren BW (2002). Separated at birth? Microarray analysis of two strikingly similar yersinia species. Egypt.  Author URL.  Full text. DOI.
Prior RG, Klasson L, Larsson P, Williams K, Lindler L, Sjöstedt A, Svensson T, Tamas I, Wren BW, Oyston PC, et al (2001). Preliminary analysis and annotation of the partial genome sequence of Francisella tularensis strain Schu 4. England.  Author URL.
Russell P, Eley SM, Ellis J, Green M, Bell DL, Kenny DJ, Titball RW (2000). Comparison of efficacy of ciprofloxacin and doxycycline against experimental melioidosis and glanders. England.  Abstract.  Author URL.
Titball RW, Naylor CE, Miller J, Moss DS, Basak AK (2000). Opening of the active site of Clostridium perfringens alpha-toxin may be triggered by membrane binding. Germany.  Abstract.  Author URL.
Payne D, Williamson ED, Titball RW (1997). The Clostridium perfringens epsilon-toxin.  Abstract.
Fulop M, Manchee R, Titball R (1996). Role of two outer membrane antigens in the induction of protective immunity against Francisella tularensis strains of different virulence. England.  Abstract.  Author URL.
Leary SE, Eley SM, Williamson ED, Titball RW (1995). Expression of Yersinia pestis V antigen in attenuated salmonella typhimurium: development of a novel vaccine for plague. Switzerland.  Author URL.
YEOMAN HL, MOIR A, TITBALL RW (1994). ANALYSIS OF GENE-EXPRESSION IN HIGH AND LOW ALPHA-TOXIN PRODUCING STRAINS OF CLOSTRIDIUM-PERFRINGENS.  Author URL.
TITBALL RW, NIKURAKANEKO T, STUART DI, KELLY DC, BISHOP DL, BASAK A (1994). CRYSTALLIZATION AND STRUCTURAL-ANALYSIS OF THE ALPHA-TOXIN (PHOSPHOLIPASE-C) FROM CLOSTRIDIUM-PERFRINGENS.  Author URL.
HUNTER SEC, SAKURAI J, BROWN JE, TITBALL RW (1994). GENETIC-ANALYSIS OF THE BETA-TOXIN OF CLOSTRIDIUM-PERFRINGENS REVEALS HOMOLOGY WITH THE ALPHA-TOXIN, GAMMA-TOXIN AND LEUKOCIDIN OF STAPHYLOCOCCUS-AUREUS.  Author URL.
COULSON NM, TITBALL RW (1993). EXPRESSION OF BACILLUS-ANTHRACIS PROTECTIVE ANTIGEN IN SALMONELLA-TYPHIMURIUM.  Author URL.
HUNTER SEC, TITBALL RW (1993). MOLECULAR-CLONING OF CLOSTRIDIUM-PERFRINGENS EPSILON-TOXIN.  Author URL.
TITBALL RW (1992). MOLECULAR ASPECTS OF CLOSTRIDIUM-PERFRINGENS TOXIN.  Author URL.

Publications by year



In Press

Cruz A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, et al (In Press). A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A. Science
Bokori-Brown M, Martin TG, Naylor CE, Basak AK, Titball RW, Savva CG (In Press). Cryo-EM Structure of Lysenin Pore Reveals Membrane Insertion by an Aerolysin family protein. Nature Communications Full text.

2017

Yang ZR, Bullifent HL, Moore K, Paszkiewicz K, Saint RJ, Southern SJ, Champion OL, Senior NJ, Sarkar-Tyson M, Oyston PCF, et al (2017). A Noise Trimming and Positional Significance of Transposon Insertion System to Identify Essential Genes in Yersinia pestis. Sci Rep, 7 Abstract.  Author URL.  Full text. DOI.
Wagley S, Vanaporn M, Rinchai D, Conejero L, Lertmemongkolchai G, Bancroft GJ, Titball RW (2017). A proteasome inhibitor produced by Burkholderia pseudomallei modulates intracellular growth. Microb Pathog, 107, 175-180. Abstract.  Author URL. DOI.
Senior NJ, Sasidharan K, Saint RJ, Scott AE, Sarkar-Tyson M, Ireland PM, Bullifent HL, Rong Yang Z, Moore K, Oyston PCF, et al (2017). An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions. BMC Microbiology, 17(1). Abstract. DOI.
Titball RW, Burtnick MN, Bancroft GJ, Brett P (2017). Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?. Vaccine Abstract.  Full text. DOI.
Vanaporn M, Sarkar-Tyson M, Kovacs-Simon A, Ireland PM, Pumirat P, Korbsrisate S, Titball RW, Butt A (2017). Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts. Virulence, 8(1), 30-40. Abstract.  Full text. DOI.

2016

Hall CA, Flick-Smith HC, Harding SV, Atkins HS, Titball RW (2016). A bioluminescent Francisella tularensis SCHU S4 strain enables noninvasive tracking of bacterial dissemination and the evaluation of antibiotics in an inhalational mouse model of tularemia. Antimicrobial Agents and Chemotherapy, 60(12), 7206-7215. Abstract. DOI.
Butt A, Halliday N, Williams P, Atkins HS, Bancroft GJ, Titball RW (2016). Burkholderia pseudomallei kynB plays a role in AQ production, biofilm formation, bacterial swarming and persistence. Research in Microbiology, 167(3), 159-167. Abstract.  Full text. DOI.
Butt AT, Titball RW (2016). Functional Analysis of the Role of Toxin-Antitoxin (TA) Loci in Bacterial Persistence. Methods Mol Biol, 1333, 121-129. Abstract.  Author URL.  Full text. DOI.
Champion OL, Wagley S, Titball RW (2016). Galleria mellonella as a model host for microbiological and toxin research. Virulence, 7(7), 840-845. Abstract.  Author URL. DOI.
Champion OL, Gourlay LJ, Scott AE, Lassaux P, Conejero L, Perletti L, Hemsley C, Prior J, Bancroft G, Bolognesi M, et al (2016). Immunisation with proteins expressed during chronic murine melioidosis provides enhanced protection against disease. Vaccine, 34(14), 1665-1671. Abstract.  Author URL.  Full text. DOI.
Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW (2016). Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection. Sci Rep, 6 Abstract.  Author URL.  Full text. DOI.
Scott AE, Christ WJ, George AJ, Stokes MGM, Lohman GJS, Guo Y, Jones M, Titball RW, Atkins TP, Campbell AS, et al (2016). Protection against experimental melioidosis with a synthetic manno-heptopyranose hexasaccharide glycoconjugate. Bioconjugate Chemistry, 27(6), 1435-1446. Abstract.  Full text. DOI.
Bokori-Brown M, Petrov PG, Khafaji MA, Mughal MK, Naylor CE, Shore AC, Gooding KM, Casanova F, Mitchell TJ, Titball RW, et al (2016). Red Blood Cell Susceptibility to Pneumolysin: CORRELATION WITH MEMBRANE BIOCHEMICAL AND PHYSICAL PROPERTIES. J Biol Chem, 291(19), 10210-10227. Abstract.  Author URL.  Full text. DOI.
Anutrakunchai C, Hemsley CM, Sermswan RW, Titball RW, Chareonsudjai S, Taweechaisupapong S (2016). Role of RelA and SpoT in Burkholderia pseudomallei survival, biofilm formation and ceftazidime tolerance during nutritional stress. Tropical Biomedicine, 33(4), 786-798. Abstract.
Fernandes da Costa SP, Mot D, Geeraerts S, Bokori-Brown M, Van Immerseel F, Titball RW (2016). Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant. Avian Pathol, 45(3), 381-388. Abstract.  Author URL.  Full text. DOI.

2015

Gregory AE, Judy BM, Qazi O, Blumentritt CA, Brown KA, Shaw AM, Torres AG, Titball RW (2015). A gold nanoparticle-linked glycoconjugate vaccine against Burkholderia mallei. Nanomedicine, 11(2), 447-456. Abstract.  Author URL. DOI.
Nandi T, Holden MTG, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles. Genome Res, 25(1), 129-141. Abstract.  Author URL. DOI.
Nandi T, Holden MTG, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles. Genome Res, 25(4). Author URL.  Full text.
Jewell SA, Titball RW, Huyet J, Naylor CE, Basak AK, Gologan P, Winlove CP, Petrov PG (2015). Clostridium perfringensα-toxin interaction with red cells and model membranes. Soft Matter, 11(39), 7748-7761. Abstract.  Author URL.  Full text. DOI.
Siddiqui FM, Ibrahim M, Noureen N, Noreen Z, Titball RW, Champion OL, Wren BW, Studholme D, Bokhari H (2015). Draft Genome Sequence of the Enteropathogenic Bacterium Campylobacter jejuni Strain cj255. Genome Announc, 3(5). Abstract.  Author URL.  Full text. DOI.
Nandi T, Holden MTG, Didelot X, Mehershahi K, Boddey JA, Beacham I, Peak I, Harting J, Baybayan P, Guo Y, et al (2015). Errata: Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles (Genome Research (2015) 25 (129-141)). Genome Research, 25(4).
Benthall G, Touzel RE, Hind CK, Titball RW, Sutton JM, Thomas RJ, Wand ME (2015). Evaluation of antibiotic efficacy against infections caused by planktonic or biofilm cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae in Galleria mellonella. International Journal of Antimicrobial Agents, 46(5), 538-545. Abstract. DOI.
Gourlay LJ, Lassaux P, Thomas RJ, Peri C, Conchillo-Sole O, Nithichanon A, Ferrer-Navarro M, Vila J, Daura X, Lertmemongkolchai G, et al (2015). Flagellar subunits as targets for structure-based epitope discovery approaches and melioidosis vaccine development.  Author URL.
Gourlay LJ, Thomas RJ, Peri C, Conchillo-Solé O, Ferrer-Navarro M, Nithichanon A, Vila J, Daura X, Lertmemongkolchai G, Titball R, et al (2015). From crystal structure to in silico epitope discovery in the Burkholderia pseudomallei flagellar hook-associated protein FlgK. FEBS J, 282(7), 1319-1333. Abstract.  Author URL. DOI.
Rinchai D, Riyapa D, Buddhisa S, Utispan K, Titball RW, Stevens MP, Stevens JM, Ogawa M, Tanida I, Koike M, et al (2015). Macroautophagy is essential for killing of intracellular Burkholderia pseudomallei in human neutrophils. Autophagy, 11(5), 748-755. Abstract.  Author URL.  Full text. DOI.
Titball RW, Champion O (2015). Method for preparation of research organisms.  Abstract.
Siddiqui F, Champion O, Akram M, Studholme D, Eqani SAMAS, Wren BW, Titball R, Bokhari H (2015). Molecular detection identified a type six secretion system in Campylobacter jejuni from various sources but not from human cases. J Appl Microbiol, 118(5), 1191-1198. Abstract.  Author URL. DOI.
Torres AG, Gregory AE, Hatcher CL, Vinet-Oliphant H, Morici LA, Titball RW, Roy CJ (2015). Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine. Vaccine, 33(5), 686-692. Abstract. DOI.
Torres AG, Gregory AE, Hatcher CL, Vinet-Oliphant H, Morici LA, Titball RW, Roy CJ (2015). Protection of non-human primates against glanders with a gold nanoparticle glycoconjugate vaccine. Vaccine, 33(5), 686-692. Abstract.  Author URL. DOI.
Gaudesi D, Peri C, Quilici G, Gori A, Ferrer-Navarro M, Conchillo-Solé O, Thomas R, Nithichanon A, Lertmemongkolchai G, Titball R, et al (2015). Structure-based design of a B cell antigen from B. pseudomallei. ACS Chem Biol, 10(3), 803-812. Abstract.  Author URL. DOI.

2014

Hemsley CM, Luo JX, Andreae CA, Butler CS, Soyer OS, Titball RW (2014). Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation but not anaerobic respiration. Antimicrob Agents Chemother, 58(10), 5775-5783. Abstract.  Author URL.  Full text. DOI.
Bokori-Brown M, Hall CA, Vance C, Fernandes da Costa SP, Savva CG, Naylor CE, Cole AR, Basak AK, Moss DS, Titball RW, et al (2014). Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia. Vaccine, 32(23), 2682-2687. Abstract. DOI.
Bokori-Brown M, Hall CA, Vance C, Fernandes da Costa SP, Savva CG, Naylor CE, Cole AR, Basak AK, Moss DS, Titball RW, et al (2014). Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia. Vaccine, 32(23), 2682-2687. Abstract.  Author URL.  Full text. DOI.
Campbell AS, Christ WJ, Lohmanb G, Guo Y, Jones M, Scott AE, George AJ, Titball RW, Atkins TP, Prior JL, et al (2014). De novo synthesis, conjugation, and immnunogenicity of the Burkholderia pseudomallei manno-heptose capsule.  Author URL.
Wagley S, Newcombe J, Laing E, Yusuf E, Sambles CM, Studholme DJ, La Ragione RM, Titball RW, Champion OL (2014). Differences in carbon source utilisation distinguish Campylobacter jejuni from Campylobacter coli. BMC Microbiol, 14 Abstract.  Author URL.  Full text. DOI.
Benthall G, Touzel RE, Hind CK, Titball RW, Sutton JM, Thomas RJ, Wand ME (2014). Evaluation of antibiotic efficacy against infections caused by planktonic or biofilm cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae in Galleria mellonella. International Journal of Antimicrobial Agents Abstract. DOI.
Moule MG, Hemsley CM, Seet Q, Guerra-Assunção JA, Lim J, Sarkar-Tyson M, Clark TG, Tan PBO, Titball RW, Cuccui J, et al (2014). Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development. mBio, 5(1). Abstract. DOI.
Moule MG, Hemsley CM, Seet Q, Guerra-Assunção JA, Lim J, Sarkar-Tyson M, Clark TG, Tan PBO, Titball RW, Cuccui J, et al (2014). Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development. MBio, 5(1), e00926-e00913. Abstract.  Author URL.  Full text. DOI.
Fernandes da Costa SP, Savva CG, Bokori-Brown M, Naylor CE, Moss DS, Basak AK, Titball RW (2014). Identification of a key residue for oligomerisation and pore-formation of Clostridium perfringens NetB. Toxins (Basel), 6(3), 1049-1061. Abstract.  Author URL.  Full text. DOI.
Harrison JW, Dung TTN, Siddiqui F, Korbrisate S, Bukhari H, Tra MPV, Hoang NVM, Carrique-Mas J, Bryant J, Campbell JI, et al (2014). Identification of possible virulence marker from Campylobacter jejuni isolates. Emerg Infect Dis, 20(6), 1026-1029. Abstract.  Author URL.  Full text. DOI.
Andreae CA, Titball RW, Butler CS (2014). Influence of the molybdenum cofactor biosynthesis on anaerobic respiration, biofilm formation and motility in Burkholderia thailandensis. Research in Microbiology, 165(1), 41-49. Abstract. DOI.
Andreae CA, Titball RW, Butler CS (2014). Influence of the molybdenum cofactor biosynthesis on anaerobic respiration, biofilm formation and motility in Burkholderia thailandensis. Res Microbiol, 165(1), 41-49. Abstract.  Author URL.  Full text. DOI.
Kovacs-Simon A, Leuzzi R, Kasendra M, Minton N, Titball RW, Michell SL (2014). Lipoprotein CD0873 is a novel adhesin of Clostridium difficile. J Infect Dis, 210(2), 274-284. Abstract.  Author URL. DOI.
Scott AE, Ngugi SA, Laws TR, Corser D, Lonsdale CL, D'Elia RV, Titball RW, Williamson ED, Atkins TP, Prior JL, et al (2014). Protection against experimental melioidosis following immunisation with a lipopolysaccharide-protein conjugate. J Immunol Res, 2014 Abstract.  Author URL. DOI.
Butt A, Higman VA, Williams C, Crump MP, Hemsley CM, Harmer N, Titball RW (2014). The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation. Biochem J, 459(2), 333-344. Abstract.  Author URL.  Full text. DOI.
Wagley S, Hemsley C, Thomas R, Moule MG, Vanaporn M, Andreae C, Robinson M, Goldman S, Wren BW, Butler CS, et al (2014). The twin arginine translocation system is essential for aerobic growth and full virulence of Burkholderia thailandensis. J Bacteriol, 196(2), 407-416. Abstract.  Author URL. DOI.
Jitprasutwit S, Ong C, Juntawieng N, Ooi WF, Hemsley CM, Vattanaviboon P, Titball RW, Tan P, Korbsrisate S (2014). Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions. BMC Genomics, 15(1). Abstract. DOI.
Jitprasutwit S, Ong C, Juntawieng N, Ooi WF, Hemsley CM, Vattanaviboon P, Titball RW, Tan P, Korbsrisate S (2014). Transcriptional profiles of Burkholderia pseudomallei reveal the direct and indirect roles of Sigma E under oxidative stress conditions. BMC Genomics, 15 Abstract.  Author URL.  Full text. DOI.

2013

Bokori-Brown M, Kokkinidou MC, Savva CG, Fernandes da Costa S, Naylor CE, Cole AR, Moss DS, Basak AK, Titball RW (2013). Clostridium perfringens epsilon toxin H149A mutant as a platform for receptor binding studies. Protein Sci, 22(5), 650-659. Abstract.  Author URL.  Full text. DOI.
Peacock SJ, Limmathurotsakul D, Lubell Y, Koh GC, White LJ, Day NP, Titball RW (2013). Correction: Melioidosis Vaccines: a Systematic Review and Appraisal of the Potential to Exploit Biodefense Vaccines for Public Health Purposes. PLoS Negl Trop Dis, 7(2). Abstract.  Author URL. DOI.
Rees DGC, Phillpotts RJ, Griffin KF, Lukaszewski RA, Laws TR, Atkins HS, Krieg AM, Titball RW (2013). CpG oligonucleotides protect against Venezuelan equine encephalitis virus infection in a route-dependent manner. International Journal of Antimicrobial Agents, 42(6), 587-588. DOI.
Rees DGC, Phillpotts RJ, Griffin KF, Lukaszewski RA, Laws TR, Atkins HS, Krieg AM, Titball RW (2013). CpG oligonucleotides protect against Venezuelan equine encephalitis virus infection in a route-dependent manner. Int J Antimicrob Agents, 42(6), 587-588. Author URL. DOI.
Butt E, Foster JAH, Keedwell E, Bell JEA, Titball RW, Bhangu A, Michell SL, Sheridan R (2013). Derivation and validation of a simple, accurate and robust prediction rule for risk of mortality in patients with Clostridium difficile infection. BMC Infect Dis, 13 Abstract.  Author URL.  Full text. DOI.
Gourlay LJ, Peri C, Ferrer-Navarro M, Conchillo-Solé O, Gori A, Rinchai D, Thomas RJ, Champion OL, Michell SL, Kewcharoenwong C, et al (2013). Exploiting the Burkholderia pseudomallei acute phase antigen BPSL2765 for structure-based epitope discovery/design in structural vaccinology. Chem Biol, 20(9), 1147-1156. Abstract.  Author URL. DOI.
Thomas RJ, Hamblin KA, Armstrong SJ, Müller CM, Bokori-Brown M, Goldman S, Atkins HS, Titball RW (2013). Galleria mellonella as a model system to test the pharmacokinetics and efficacy of antibiotics against Burkholderia pseudomallei. International Journal of Antimicrobial Agents, 41(4), 330-336. Abstract. DOI.
Thomas RJ, Hamblin KA, Armstrong SJ, Müller CM, Bokori-Brown M, Goldman S, Atkins HS, Titball RW (2013). Galleria mellonella as a model system to test the pharmacokinetics and efficacy of antibiotics against Burkholderia pseudomallei. Int J Antimicrob Agents, 41(4), 330-336. Abstract.  Author URL. DOI.
Butt A, Müller C, Harmer N, Titball RW (2013). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiol Lett, 338(1), 86-94. Abstract.  Author URL.  Full text. DOI.
Savva CG, Fernandes da Costa SP, Bokori-Brown M, Naylor CE, Cole AR, Moss DS, Titball RW, Basak AK (2013). Molecular architecture and functional analysis of NetB, a pore-forming toxin from Clostridium perfringens. J Biol Chem, 288(5), 3512-3522. Abstract.  Author URL. DOI.
Fernandes da Costa SP, Mot D, Bokori-Brown M, Savva CG, Basak AK, Van Immerseel F, Titball RW (2013). Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids. Vaccine, 31(37), 4003-4008. Abstract. DOI.
Fernandes da Costa SP, Mot D, Bokori-Brown M, Savva CG, Basak AK, Van Immerseel F, Titball RW (2013). Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids. Vaccine, 31(37), 4003-4008. Abstract.  Author URL. DOI.
Van Immerseel F, Studholme DJ, Eeckhaut V, Heyndrickx M, Dewulf J, Dewaele I, Van Hoorebeke S, Haesebrouck F, Van Meirhaeghe H, Ducatelle R, et al (2013). Salmonella Gallinarum field isolates from laying hens are related to the vaccine strain SG9R. Vaccine, 31(43), 4940-4945. Abstract. DOI.
Van Immerseel F, Studholme DJ, Eeckhaut V, Heyndrickx M, Dewulf J, Dewaele I, Van Hoorebeke S, Haesebrouck F, Van Meirhaeghe H, Ducatelle R, et al (2013). Salmonella Gallinarum field isolates from laying hens are related to the vaccine strain SG9R. Vaccine, 31(43), 4940-4945. Abstract.  Author URL. DOI.
Rees DGC, Hartley MG, Green M, Lukaszewski RA, Griffin KF, Atkins HS, Lyons R, Krieg AM, Titball RW (2013). The ability of CpG oligonucleotides to protect mice against Francisella tularensis live vaccine strain but not fully virulent F. tularensis subspecies holarctica is reflected in cell-based assays. Microb Pathog, 63, 16-18. Abstract.  Author URL. DOI.
Ooi WF, Ong C, Nandi T, Kreisberg JF, Chua HH, Sun G, Chen Y, Mueller C, Conejero L, Eshaghi M, et al (2013). The condition-dependent transcriptional landscape of Burkholderia pseudomallei. PLoS Genet, 9(9). Abstract.  Author URL.  Full text. DOI.
Gregory AE, Titball R, Williamson D (2013). Vaccine delivery using nanoparticles. Front Cell Infect Microbiol, 3 Abstract.  Author URL.  Full text. DOI.

2012

Lau SK, Winlove P, Moger J, Champion OL, Titball RW, Yang ZH, Yang ZR (2012). A Bayesian Whittaker-Henderson smoother for general-purpose and sample-based spectral baseline estimation and peak extraction. JOURNAL OF RAMAN SPECTROSCOPY, 43(9), 1299-1305. Author URL. DOI.
Lau SK, Champion OL, Titball RW, Yang ZR, Winlove P, Moger J, Yang ZH (2012). A Bayesian Whittaker-Henderson smoother for general-purpose and sample-based spectral baseline estimation and peak extraction. Journal of Raman Spectroscopy Abstract. DOI.
Cuccui J, Milne TS, Harmer N, George AJ, Harding SV, Dean RE, Scott AE, Sarkar-Tyson M, Wren BW, Titball RW, et al (2012). Characterization of the Burkholderia pseudomallei K96243 capsular polysaccharide I coding region. Infect Immun, 80(3), 1209-1221. Abstract.  Author URL. DOI.
Gregory AE, Shaw AM, Titball RW, Williamson ED, Prior JL, Butcher WA, Thompson IJ (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine Abstract. DOI.
Gregory AE, Williamson ED, Prior JL, Butcher WA, Thompson IJ, Shaw AM, Titball RW (2012). Conjugation of Y. pestis F1-antigen to gold nanoparticles improves immunogenicity. Vaccine, 30(48), 6777-6782. Abstract.  Author URL.  Full text. DOI.
Butt A, Müller C, Harmer N, Titball RW (2012). Identification of type II toxin-antitoxin modules in Burkholderia pseudomallei. FEMS Microbiology Letters
Peacock SJ, Limmathurotsakul D, Lubell Y, Koh GCKW, White LJ, Day NPJ, Titball RW (2012). Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes. PLoS Negl Trop Dis, 6(1). Abstract.  Author URL.  Full text. DOI.
Monturiol-Gross L, Flores-Díaz M, Araya-Castillo C, Pineda-Padilla M-J, Clark GC, Titball RW, Alape-Girón A (2012). Reactive oxygen species and the MEK/ERK pathway are involved in the toxicity of clostridium perfringens α-toxin, a prototype bacterial phospholipase C. J Infect Dis, 206(8), 1218-1226. Abstract.  Author URL. DOI.
Müller CM, Conejero L, Spink N, Wand ME, Bancroft GJ, Titball RW (2012). Role of RelA and SpoT in Burkholderia pseudomallei virulence and immunity. Infect Immun, 80(9), 3247-3255. Abstract.  Author URL.  Full text. DOI.

2011

Cruz A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, et al (2011). A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A. Science, 334(6057), 821-824. DOI.
Norville IH, Harmer NJ, Harding SV, Fischer G, Keith KE, Brown KA, Sarkar-Tyson M, Titball RW (2011). A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence. Infect Immun, 79(11), 4299-4307. Abstract.  Author URL.  Full text. DOI.
Debieux CM, Dridge EJ, Mueller CM, Splatt P, Paszkiewicz K, Knight I, Florance H, Love J, Titball RW, Lewis RJ, et al (2011). A bacterial process for selenium nanosphere assembly. Proc Natl Acad Sci U S A, 108(33), 13480-13485. Abstract.  Author URL.  Full text. DOI.
Norville IH, Breitbach K, Eske-Pogodda K, Harmer NJ, Sarkar-Tyson M, Titball RW, Steinmetz I (2011). A novel FK-506-binding-like protein that lacks peptidyl-prolyl isomerase activity is involved in intracellular infection and in vivo virulence of Burkholderia pseudomallei. Microbiology, 157(Pt 9), 2629-2638. Abstract.  Author URL. DOI.
Tippayawat P, Pinsiri M, Rinchai D, Riyapa D, Romphruk A, Gan Y-H, Houghton RL, Felgner PL, Titball RW, Stevens MP, et al (2011). Burkholderia pseudomallei proteins presented by monocyte-derived dendritic cells stimulate human memory T cells in vitro. Infect Immun, 79(1), 305-313. Abstract.  Author URL. DOI.
Easton A, Haque A, Chu K, Patel N, Lukaszewski RA, Krieg AM, Titball RW, Bancroft GJ (2011). Combining vaccination and postexposure CpG therapy provides optimal protection against lethal sepsis in a biodefense model of human melioidosis. J Infect Dis, 204(4), 636-644. Abstract.  Author URL. DOI.
Qazi O, Rani M, Gnanam AJ, Cullen TW, Stead CM, Kensing H, McCaul K, Ngugi S, Prior JL, Lipka A, et al (2011). Development of reagents and assays for the detection of pathogenic Burkholderia species. Faraday Discuss, 149, 23-36. Abstract.  Author URL.
Patel N, Conejero L, De Reynal M, Easton A, Bancroft GJ, Titball RW (2011). Development of vaccines against burkholderia pseudomallei. Front Microbiol, 2 Abstract.  Author URL.  Full text. DOI.
Scott AE, Twine SM, Fulton KM, Titball RW, Essex-Lopresti AE, Atkins TP, Prior JL (2011). Flagellar glycosylation in Burkholderia pseudomallei and Burkholderia thailandensis. J Bacteriol, 193(14), 3577-3587. Abstract.  Author URL. DOI.
Senior NJ, Bagnall MC, Champion OL, Reynolds SE, La Ragione RM, Woodward MJ, Salguero FJ, Titball RW (2011). Galleria mellonella as an infection model for Campylobacter jejuni virulence. J Med Microbiol, 60(Pt 5), 661-669. Abstract.  Author URL. DOI.
Thomas RM, Twine SM, Fulton KM, Tessier L, Kilmury SLN, Ding W, Harmer N, Michell SL, Oyston PCF, Titball RW, et al (2011). Glycosylation of DsbA in Francisella tularensis subsp. tularensis. J Bacteriol, 193(19), 5498-5509. Abstract.  Author URL. DOI.
Suwannasaen D, Mahawantung J, Chaowagul W, Limmathurotsakul D, Felgner PL, Davies H, Bancroft GJ, Titball RW, Letmemongkolchai G (2011). Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis. JOURNAL OF IMMUNOLOGY, 186 Author URL.
Suwannasaen D, Mahawantung J, Chaowagul W, Limmathurotsakul D, Felgner PL, Davies H, Bancroft GJ, Titball RW, Lertmemongkolchai G (2011). Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis. J Infect Dis, 203(7), 1002-1011. Abstract.  Author URL. DOI.
Kovacs-Simon A, Titball RW, Michell SL (2011). Lipoproteins of bacterial pathogens. Infect Immun, 79(2), 548-561. Abstract.  Author URL. DOI.
Conejero L, Patel N, de Reynal M, Oberdorf S, Prior J, Felgner PL, Titball RW, Salguero FJ, Bancroft GJ (2011). Low-dose exposure of C57BL/6 mice to burkholderia pseudomallei mimics chronic human melioidosis. Am J Pathol, 179(1), 270-280. Abstract.  Author URL. DOI.
Wand ME, Müller CM, Titball RW, Michell SL (2011). Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B. pseudomallei, B. thailandensis and B. oklahomensis. BMC Microbiol, 11(1). Abstract.  Author URL.  Full text. DOI.
Wang W, Hale C, Goulding D, Haslam SM, Tissot B, Lindsay C, Michell S, Titball R, Yu J, Toribio AL, et al (2011). Mannosidase 2, alpha 1 deficiency is associated with ricin resistance in embryonic stem (ES) cells. PLoS One, 6(8). Abstract.  Author URL.  Full text. DOI.
Bokori-Brown M, Savva CG, Fernandes da Costa SP, Naylor CE, Basak AK, Titball RW (2011). Molecular basis of toxicity of Clostridium perfringens epsilon toxin. FEBS J, 278(23), 4589-4601. Abstract.  Author URL. DOI.
Egge-Jacobsen W, Salomonsson EN, Aas FE, Forslund A-L, Winther-Larsen HC, Maier J, Macellaro A, Kuoppa K, Oyston PCF, Titball RW, et al (2011). O-linked glycosylation of the PilA pilin protein of Francisella tularensis: identification of the endogenous protein-targeting oligosaccharyltransferase and characterization of the native oligosaccharide. J Bacteriol, 193(19), 5487-5497. Abstract.  Author URL. DOI.
Vanaporn M, Wand M, Michell SL, Sarkar-Tyson M, Ireland P, Goldman S, Kewcharoenwong C, Rinchai D, Lertmemongkolchai G, Titball RW, et al (2011). Superoxide dismutase C is required for intracellular survival and virulence of Burkholderia pseudomallei. Microbiology, 157(Pt 8), 2392-2400. Abstract.  Author URL. DOI.
Norville I, O'Shea K, Sarkar-Tyson M, Zheng S, Titball RW, Varani G, Harmer NJ (2011). The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. Biochemical Journal, 437, 413-422. Abstract.
Norville IH, O'Shea K, Sarkar-Tyson M, Zheng S, Titball RW, Varani G, Harmer NJ (2011). The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development. Biochem J, 437(3), 413-422. Abstract.  Author URL. DOI.
Laws TR, Davey MS, Green C, Cooper IAM, Titball RW, Lukaszewski RA (2011). Yersinia pseudotuberculosis is resistant to killing by human neutrophils. Microbes Infect, 13(6), 607-611. Abstract.  Author URL. DOI.
Champion OL, Karlyshev A, Cooper IAM, Ford DC, Wren BW, Duffield M, Oyston PCF, Titball RW (2011). Yersinia pseudotuberculosis mntH functions in intracellular manganese accumulation, which is essential for virulence and survival in cells expressing functional Nramp1. Microbiology, 157(Pt 4), 1115-1122. Abstract.  Author URL. DOI.

2010

Oyston PCF, Mellado-Sanchez G, Pasetti MF, Nataro JP, Titball RW, Atkins HS (2010). A Yersinia pestis guaBA mutant is attenuated in virulence and provides protection against plague in a mouse model of infection. Microb Pathog, 48(5), 191-195. Abstract.  Author URL. DOI.
Nandi T, Ong C, Singh AP, Boddey J, Atkins T, Sarkar-Tyson M, Essex-Lopresti AE, Chua HH, Pearson T, Kreisberg JF, et al (2010). A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence. PLoS pathogens, 6(4). Full text.
Vachieri SG, Clark GC, Alape-Girón A, Flores-Díaz M, Justin N, Naylor CE, Titball RW, Basak AK (2010). Comparison of a nontoxic variant of Clostridium perfringens α-toxin with the toxic wild-type strain. Acta Crystallogr D Biol Crystallogr, 66(Pt 10), 1067-1074. Abstract.  Author URL. DOI.
Michell SL, Dean RE, Eyles JE, Hartley MG, Waters E, Prior JL, Titball RW, Oyston PCF (2010). Deletion of the Bacillus anthracis capB homologue in Francisella tularensis subspecies tularensis generates an attenuated strain that protects mice against virulent tularaemia. J Med Microbiol, 59(Pt 11), 1275-1284. Abstract.  Author URL. DOI.
Dowling AJ, Wilkinson PA, Holden MTG, Quail MA, Bentley SD, Reger J, Waterfield NR, Titball RW, Ffrench-Constant RH (2010). Genome-wide analysis reveals loci encoding anti-macrophage factors in the human pathogen Burkholderia pseudomallei K96243. PLoS One, 5(12). Abstract.  Author URL.  Full text. DOI.
Champion OL, Karlyshev AV, Senior NJ, Woodward M, La Ragione R, Howard SL, Wren BW, Titball RW (2010). Insect infection model for Campylobacter jejuni reveals that O-methyl phosphoramidate has insecticidal activity. J Infect Dis, 201(5), 776-782. Abstract.  Author URL. DOI.
Ngugi SA, Ventura VV, Qazi O, Harding SV, Kitto GB, Estes DM, Dell A, Titball RW, Atkins TP, Brown KA, et al (2010). Lipopolysaccharide from Burkholderia thailandensis E264 provides protection in a murine model of melioidosis. Vaccine, 28(47), 7551-7555. Abstract.  Author URL. DOI.
Laws TR, Davey MS, Titball RW, Lukaszewski R (2010). Neutrophils are important in early control of lung infection by Yersinia pestis. Microbes Infect, 12(4), 331-335. Abstract.  Author URL. DOI.
Sarkar-Tyson M, Titball RW (2010). Progress toward development of vaccines against melioidosis: a review. Clin Ther, 32(8), 1437-1445. Abstract.  Author URL. DOI.
Forslund A-L, Salomonsson EN, Golovliov I, Kuoppa K, Michell S, Titball R, Oyston P, Noppa L, Sjöstedt A, Forsberg A, et al (2010). The type IV pilin, PilA, is required for full virulence of Francisella tularensis subspecies tularensis. BMC Microbiol, 10 Abstract.  Author URL.  Full text. DOI.

2009

Felgner PL, Kayala MA, Vigil A, Burk C, Nakajima-Sasaki R, Pablo J, Molina DM, Hirst S, Chew JSW, Wang D, et al (2009). A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens. Proc Natl Acad Sci U S A, 106(32), 13499-13504. Abstract.  Author URL. DOI.
Yang ZR, Lertmemongkolchai G, Tan G, Felgner PL, Titball R (2009). A genetic programming approach for Burkholderia pseudomallei diagnostic pattern discovery. Bioinformatics, 25(17), 2256-2262. Abstract.  Author URL. DOI.
Titball RW (2009). Bacterial Biothreat Agents. , 21-32. DOI.
Sarkar-Tyson M, Titball RW (2009). Burkholderia mallei and Burkholderia pseudomallei. , 831-843. DOI.
Titball RW (2009). Clostridium perfringens vaccines. Vaccine, 27 Suppl 4, D44-D47. Abstract.  Author URL. DOI.
Champion MD, Zeng Q, Nix EB, Nano FE, Keim P, Kodira CD, Borowsky M, Young S, Koehrsen M, Engels R, et al (2009). Comparative genomic characterization of Francisella tularensis strains belonging to low and high virulence subspecies. PLoS Pathog, 5(5). Abstract.  Author URL.  Full text. DOI.
Thomas RJ, Webber D, Collinge A, Stagg AJ, Bailey SC, Nunez A, Gates A, Jayasekera PN, Taylor RR, Eley S, et al (2009). Different pathologies but equal levels of responsiveness to the recombinant F1 and V antigen vaccine and ciprofloxacin in a murine model of plague caused by small- and large-particle aerosols. Infect Immun, 77(4), 1315-1323. Abstract.  Author URL. DOI.
Titball RW, Oyston PCF (2009). Francisella tularensis. , 1241-1253. DOI.
Champion OL, Cooper IAM, James SL, Ford D, Karlyshev A, Wren BW, Duffield M, Oyston PCF, Titball RW (2009). Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis. Microbiology, 155(Pt 5), 1516-1522. Abstract.  Author URL. DOI.
Thomas RJ, Webber D, Sellors W, Collinge A, Frost A, Stagg AJ, Bailey SC, Jayasekera PN, Taylor RR, Eley S, et al (2009). Generation of large droplet aerosols within microbiological containment using a novel flow-focussing technique. Aerobiologia, 25(2), 75-84. Abstract. DOI.
Champion OL, Wren BW, Titball RW (2009). Insecticide.  Abstract.
Hill J, Leary S, Smither S, Best A, Pettersson J, Forsberg A, Lingard B, Lipka A, Brown KA, Williamson ED, et al (2009). N255 is a key residue for recognition by a monoclonal antibody which protects against Yersinia pestis infection. Vaccine, 27(50), 7073-7079. Abstract.  Author URL. DOI.
Tippayawat P, Saenwongsa W, Mahawantung J, Suwannasaen D, Chetchotisakd P, Limmathurotsakul D, Peacock SJ, Felgner PL, Atkins HS, Titball RW, et al (2009). Phenotypic and functional characterization of human memory T cell responses to Burkholderia pseudomallei. PLoS Negl Trop Dis, 3(4). Abstract.  Author URL.  Full text. DOI.
Sarkar-Tyson M, Smither SJ, Harding SV, Atkins TP, Titball RW (2009). Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders. Vaccine, 27(33), 4447-4451. Abstract.  Author URL. DOI.
Halling-Brown M, Shaban R, Frampton D, Sansom CE, Davies M, Flower D, Duffield M, Titball RW, Brusic V, Moss DS, et al (2009). Proteins accessible to immune surveillance show significant T-cell epitope depletion: Implications for vaccine design. Mol Immunol, 46(13), 2699-2705. Abstract.  Author URL. DOI.
Dean RE, Ireland PM, Jordan JE, Titball RW, Oyston PCF (2009). RelA regulates virulence and intracellular survival of Francisella novicida. Microbiology, 155(Pt 12), 4104-4113. Abstract.  Author URL. DOI.
Van Immerseel F, Rood JI, Moore RJ, Titball RW (2009). Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens. Trends Microbiol, 17(1), 32-36. Abstract.  Author URL. DOI.
Stubben CJ, Duffield ML, Cooper IA, Ford DC, Gans JD, Karlyshev AV, Lingard B, Oyston PCF, de Rochefort A, Song J, et al (2009). Steps toward broad-spectrum therapeutics: discovering virulence-associated genes present in diverse human pathogens. BMC Genomics, 10 Abstract.  Author URL.  Full text. DOI.
Thwaite JE, Humphrey S, Fox MA, Savage VL, Laws TR, Ulaeto DO, Titball RW, Atkins HS (2009). The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains. J Med Microbiol, 58(Pt 7), 923-929. Abstract.  Author URL. DOI.
Phan M-D, Kidgell C, Nair S, Holt KE, Turner AK, Hinds J, Butcher P, Cooke FJ, Thomson NR, Titball R, et al (2009). Variation in Salmonella enterica serovar typhi IncHI1 plasmids during the global spread of resistant typhoid fever. Antimicrob Agents Chemother, 53(2), 716-727. Abstract.  Author URL. DOI.

2008

Halling-Brown M, Sansom CE, Davies M, Titball RW, Moss DS (2008). Are bacterial vaccine antigens T-cell epitope depleted?. Trends Immunol, 29(8), 374-379. Abstract.  Author URL. DOI.
Titball RW, Russell P, Cuccui J, Easton A, Haque A, Atkins T, Sarkar-Tyson M, Harley V, Wren B, Bancroft GJ, et al (2008). Burkholderia pseudomallei: animal models of infection. Trans R Soc Trop Med Hyg, 102 Suppl 1, S111-S116. Abstract.  Author URL. DOI.
Thomas RJ, Webber D, Sellors W, Collinge A, Frost A, Stagg AJ, Bailey SC, Jayasekera PN, Taylor RR, Eley S, et al (2008). Characterization and deposition of respirable large- and small-particle bioaerosols. Appl Environ Microbiol, 74(20), 6437-6443. Abstract.  Author URL. DOI.
Stabler RA, Dawson LF, Oyston PCF, Titball RW, Wade J, Hinds J, Witney AA, Wren BW (2008). Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux. BMC Microbiol, 8 Abstract.  Author URL.  Full text. DOI.
Gnanam AJ, Hall B, Shen X, Piasecki S, Vernados A, Galyov EE, Smither SJ, Kitto GB, Titball RW, Ellington AD, et al (2008). Development of aptamers specific for potential diagnostic targets in Burkholderia pseudomallei. Trans R Soc Trop Med Hyg, 102 Suppl 1, S55-S57. Abstract.  Author URL. DOI.
Thompson DB, Crandall K, Harding SV, Smither SJ, Kitto GB, Titball RW, Brown KA (2008). In silico analysis of potential diagnostic targets from Burkholderia pseudomallei. Trans R Soc Trop Med Hyg, 102 Suppl 1, S61-S65. Abstract.  Author URL. DOI.
Lukaszewski RA, Yates AM, Jackson MC, Swingler K, Scherer JM, Simpson AJ, Sadler P, McQuillan P, Titball RW, Brooks TJG, et al (2008). Presymptomatic prediction of sepsis in intensive care unit patients. Clin Vaccine Immunol, 15(7), 1089-1094. Abstract.  Author URL. DOI.
Eyles JE, Hartley MG, Laws TR, Oyston PCF, Griffin KF, Titball RW (2008). Protection afforded against aerosol challenge by systemic immunisation with inactivated Francisella tularensis live vaccine strain (LVS). Microb Pathog, 44(2), 164-168. Abstract.  Author URL. DOI.
Hoang TH, Hong HA, Clark GC, Titball RW, Cutting SM (2008). Recombinant Bacillus subtilis expressing the Clostridium perfringens alpha toxoid is a candidate orally delivered vaccine against necrotic enteritis. Infect Immun, 76(11), 5257-5265. Abstract.  Author URL. DOI.
Titball RW (2008). Vaccines against intracellular bacterial pathogens. Drug Discov Today, 13(13-14), 596-600. Abstract.  Author URL. DOI.

2007

Michell, S.L. Diaper, H. Wikstrom, P. Titball, RW (2007). A 55 kDa hypothetical membrane protein is an iron-regulated virulence factor of Francisella tularensis subspecies novicida U112. Journal of Medical Microbiology, 56, 1268-1276.
Isherwood, K.E. Michell, S.L. Diaper, H. Titball, RW (2007). A Francisella tularensis subspecies novicida purF mutant, but not a purA mutant, induces protective immunity to tularemia in mice. Vaccine, 25, 2011-2018.
Oyston, P. Titball, RW (2007). A plague upon fibrin. Nature Medicine, 13, 253-254.
Harland DN, Dassa E, Titball RW, Brown KA, Atkins HS (2007). ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei. BMC Genomics, 8 Abstract.  Author URL.  Full text. DOI.
Nelson, M. Titball, R.W. Galloway, D.R. (2007). Analysis of Peptide Mimotopes of Burkholderia pseudomallei Exopolysaccharide. Vaccine, 25, 7796-7805.
Neeson BN, Clark GC, Atkins HS, Lingard B, Titball RW (2007). Analysis of protection afforded by a Clostridium perfringens alpha-toxoid against heterologous clostridial phospholipases C. Microb Pathog, 43(4), 161-165. Abstract.  Author URL. DOI.
Kwaik YA, Metzger D, Nano F, Sjostedt A, Titball R (2007). Annals of the New York Academy: Preface. Annals of the New York Academy of Sciences, 1105 DOI.
Sjostedt, A. Pevelka, M.S. Nano, F. (2007). Biosafety and Selectable Markers. Annals of the New York Academy of Sciences, 1105, 405-417.
Butcher, W.A. Titball, R.W. Hill, J. (2007). Concomitant administration of Yersinia pestis specific monoclonal antibodies with plague vaccine has a detrimental effect on vaccine mediated immunity. Vaccine, 25, 7301-7306.
Cuccui J, Easton A, Chu KK, Bancroft GJ, Oyston PCF, Titball RW, Wren BW (2007). Development of signature-tagged mutagenesis in Burkholderia pseudomallei to identify genes important in survival and pathogenesis. Infect Immun, 75(3), 1186-1195. Abstract.  Author URL. DOI.
Duffield, M.L. Titball, R.W. Lindsay, C.D. (2007). Down-regulation of gene transcripts associated with ricin tolerance in human RPMI 2650 cells. Toxicology in vitro, 21, 509-520.
Titball RW, Petrosino JF (2007). Francisella tularensis genomics and proteomics. Ann N Y Acad Sci, 1105, 98-121. Abstract.  Author URL. DOI.
Griffin KF, Oyston PCF, Titball RW (2007). Francisella tularensis vaccines. FEMS Immunol Med Microbiol, 49(3), 315-323. Abstract.  Author URL. DOI.
Unal, B. Petersen, J.M. Hartley, G. (2007). From protein microarrays to diagnostic antigen discovery: a study of the pathogen F. tularensis. Bioinformatics, 23, 508-518.
Sundaresh S, Randall A, Unal B, Petersen JM, Belisle JT, Hartley MG, Duffield M, Titball RW, Davies DH, Felgner PL, et al (2007). From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis. England.  Abstract.  Author URL. DOI.
Chaudhuri RR, Ren C-P, Desmond L, Vincent GA, Silman NJ, Brehm JK, Elmore MJ, Hudson MJ, Forsman M, Isherwood KE, et al (2007). Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4. PLoS One, 2(4). Abstract.  Author URL.  Full text. DOI.
Smither SJ, Hill J, van Baar BLM, Hulst AG, de Jong AL, & Titball RW (2007). Identification of Outer Membrane Proteins of <em>Yersinia pestis</em> through Biotinylation. Journal of Microbiological Methods, 68, 26-31.
Chu, K. Hawue, A. Nelson, M. (2007). Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis. Infection and Immunity, 75, 4173-4180.
Duc LH, Hong HA, Atkins HS, Flick-Smith HC, Durrani Z, Ripkema S, Titball RW & Cutting SM (2007). Immunisation against anthrax using <em>Bacillus subtilis</em> spores expressing the anthrax protective antigen. Vaccine, 25, 346-355.
Clark, G.C. Atkins, H.S. Lingard, B. (2007). Immunisation of mice with a Clostridium perfringens &#945;-toxoid protects against heterologous Clostridial phospholipases C. Microbial Pathogen, 43, 161-165.
Atkins, H.S. Johnson, L. Titball, R.W. (2007). Immunization with Anthrolysin O or a genetic toxoid protects against challenge with the toxin but not against Bacillus anthracis. Vaccine, 25, 7197-7205.
Eyles JE, Unal B, Hartley MG, Newstead SL, Flick-Smith H, Prior JL, Oyston PCF, Randall A, Mu Y, Hirst S, et al (2007). Immunodominant Francisella tularensis antigens identified using proteome microarray. Proteomics, 7(13), 2172-2183. Abstract.  Author URL. DOI.
Wood RJ, Maynard-Smith MD, Robinson VL, Oyston PCF, Titball RW, Roach PL (2007). Kinetic analysis of Yersinia pestis DNA adenine methyltransferase activity using a hemimethylated molecular break light oligonucleotide. PLoS One, 2(8). Abstract.  Author URL.  Full text. DOI.
Stagg, A.J. Eley, S.M. Taylor, R. (2007). Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague. Vaccine, 25, 1142-1148.
Stokes MGM, Titball RW, Neeson BN, Galen JE, Walker NJ, Stagg AJ, Jenner DC, Thwaite JE, Nataro JP, Baillie LWJ, Atkins HS (2007). Oral administration of a Salmonella-based vaccine espressing Bacillus anthracis protective antigen confers protection against aerosolized <em>B. anthracis</em>. Infection and Immunity, 75, 1827-1834.
Garbom S, Olofsson M, Bjornfot AC, Srivastava MK, Robinson VL, Oyston PCF, Titball RW, Wolf-Watz H (2007). Phenotypic characterizartion of a virulence-associated protein, VagH, of <em>Yersinia pseudotuberculosis</em> reveals a tight link between VagH and the type III secretion system. Microbiology, 153, 1464-1473.
Thwaite, J.E. Harding, S.V. Smither, S.J. (2007). Polysaccharides and virulence of Burkholderia pseudomallei. Journal of Medical Microbiology, 56, 1005-1010.
Tanabe M, Mirza O, Bertrand T, Atkins HS, Titball RW, Iwata S, Brown KA, Byrne B (2007). Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains. Acta Crystallogr D Biol Crystallogr, 63(Pt 11), 1185-1193. Abstract.  Author URL. DOI.
Harding SV, Sarkar-Tyson M, Smither SJ, Atkins TP, Oyston PCF, Brown KA, Liu Y, Wait R, & Titball RW (2007). The identification of surface proteins of <em>Burkholeria pseudomallei</em>. Vaccine, 25, 2664-2672.
sm202, Grice ID, Griffin K, Hitchen PG (2007). The immunologically distinct O-antigens from Francisella tularensis subspecies tuarensis and Francisella novicida are both virulence determinants and protective antigens. Infection and Immunity, 75(1), 371-378. DOI.
Clark GC, Basak AK, Titball RW (2007). The rational design of bacterial toxin inhibitors. Current Computer-Aided Drug Design, 3(1), 1-12. Abstract. DOI.

2006

Rodrigues F, Sarkar-Tyson M, Harding SV, Sim SH, Chua HH, Lin CH, Han X, Krishna R, Karuturi M, Sung K, et al (2006). A global map of growth regulated gene expression in Burkholderia pseudomallei, the Causative Agent of Melioidosis. Journal of Bacteriology, 188, 8178-8188.
Chu, K. Easton, A. Stevens, M. (2006). A live vaccine against Burkholderia pseudomallei elicits CD4+ T cell-mediated immunity, priming T cells specific for 2 Type III secretion system proteins. Journal of Infectious Diseases, 194, 1241-1248.
Eyles, J.E. Elvin, S.J. Healey, G.D. (2006). Administration of antibody to the lung protects mice against pneumonic plague. Infection and Immunity, 74, 3068-3070.
Atkins, H.S. (2006). Bacillus. In Greenwood D, Slack R, Peutherer J, Barer M (Eds.) Medical Microbiology, 17th edition, Elsevier.
Bayer, C.R. Aldape, M.J. Wallace, R.J. (2006). Clostridium perfringens Phospholopase C-induced platelet/leukocyte interactions impede neutrophil diapedesis. Journal of Medical Microbiology, 55, 495-504.
Popoff, M. Titball, R.W. Cole, A. (2006). Clostridium perfringens ε-toxin. In Joseph JE, Michel M, Popoff (Eds.) The Comprehensive Sourcebook of Bacterial Protein Toxins, London: , 631-642.
Duffield, M. (2006). Comparative genomics – what do such studies tell us about the emergence and spread of. key pathogens. In Logan NA, Lappin-Scott HM, Oyston PCF (Eds.) Prokaryotic diversity: mechanisms and significance, Cambridge University Press, 175-186.
sm202, Bystrom A, Forslund AL, Johansson A (2006). Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis. Molecular Microbiology, 59(6), 1818-1830. DOI.
Taylor, R. Prior, J. Newstead, S. (2006). Grey variants of the live vaccine strain of <em>Francisella tularensis</em> lack lipopolysaccharide O-antigen, show reduced ability to survive in macrophages and do not induce protective immunity in mice. Vaccine, 24, 989-996.
Atkins, H.S. Harland, D.N. Elvin, S.J. (2006). Identification and evaluation of ABC transporter components that protect against <em>Yersinia pestis</em>. Infection and Immunity, 74, 3687-3691.
Basak, A.K. (2006). Membrane damaging and cytotoxic phospholipases. In Joseph JE, Michel M, Popopoff (Eds.) The Comprehensive Sourcebook of Bacterial Protein Toxins, London: Academic Press, 516-534.
Simpson, A.J. Titball, R.W. (2006). Plague. In Plotkin SA, Orenstein WA (Eds.) Vaccines 5th edn, Philadelphia: , 999-1010.
Hibbs, S. Titball, R.W. Atkins, T.P. (2006). Proteolytic degradation of the human antimicrobial peptide LL-37 by <em>Bacillus anthracis</em> may contribute to virulence. Antimicrobial Agents and Chemotherapy, 50, 2316-2322.
Morton, M. Griffin, K.F. Stockes, M. (2006). Recombinant Salmonella vaccines for biodefence. Vaccine, 24, 2710-2717.
Rasko, D.A. Cheung, J.K. Ravel, J. (2006). Skewed genomic variability in strains of the toxigenic bacterial pathogen, <em>Clostridium perfringens</em>. Genome Research, 16, 1031-1040.
Tanabe M, Atkins HS, Harland DN, Elvin SJ, Stagg AJ, Mirza O, Titball RW, Byrne B, Brown KA (2006). The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection. Infect Immun, 74(6), 3687-3691. Abstract.  Author URL. DOI.
Dassa, E. Walker, N.J. Griffin, K.F. (2006). The identification and evaluation of ATP-binding cassette systems in the intracellular bacterium <em>Francisella tularensis</em>. Research in Microbiology, 157, 593-604.
Laws TR, Atkins HS, Atkins TP, Titball RW (2006). The pathogen Pseudomonas aeruginosa negatively affects the attraction response of the nematode Caenorhabditis elegans to bacteria. Microb Pathog, 40(6), 293-297. Abstract.  Author URL. DOI.
Easton, A. Smith, D. O'Garra, A. (2006). The role of T-cells in innate and adptive immunity against murine <em>Burkholderia pseudomallei</em> infection. Journal of Infectious Diseases, 193, 370-379. Full text.
Michell S, Griffin, K.F. Titball, R.W. (2006). Tularemia Pathogenesis and Immunity. In Friedman H, Anderson B (Eds.) Microbial Infection and Bioterrorism, Kluwer Academic Publishers, 121-138.

2005

Oyston, P.C.F. Titball, R.W. (2005). A dam mutant of Yersinia pestis is attenuated and induces protection against plague. FEMS Microbiology Letters, 252, 251-256.
Boddey, J.A. Thomas, R. Smith, M.P. (2005). A type IV pilin, pilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo. Infection and Immunity, 73, 1260-1264.
Garmory, H.S. Brown, K.A. Titball, R.W. (2005). An association between ATP binding cassette systems, genome sizes and lifestyles of bacteria. Research in Microbiology, 156, 434-442.
Alape-Giron, A. Clark, G. Catimel, B. (2005). Cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C. Journal of Biological Chemistry, 280, 26680-26689.
Gates, A.J. Green, M. Eastaugh, L. (2005). CpG-DNA protects against a lethal orthopoxvirus infection in a murine model. Antiviral Research, 65, 87-95.
Perkins, S.D. Phillpotts, R.J. Titball, R.W. (2005). DNA vaccines for biodefence. Advanced Drug Delivery Reviews, 57, 1343-1361.
Choules, G. Rogers, D. Titball, R.W. (2005). Efficacy of the live attenuated Francisella tularensis vaccine (LVS) in a murine model of disease. Vaccine, 23, 2680-2686.
Oyston, P.C. Crossett, B. Fairweather, N.F. (2005). Functional characterization of OXA-57, a Class D &#946;-lactamase from <em>Burkholderia pseudomallei</em>. Antimicrobial Agents and Chemotherapy, 49, 1639-1641.
Titball, R.W. (2005). Gas gangrene: an open and closed case. Microbiology, 151, 2821-2828.
Forsman, M. Oyston, P. Titball, R. (2005). Genomics for Biodefence: Exploiting the Francisella tularensis genome sequence. In Lindler L, Lebeda F, Korch GW (Eds.) Biological Weapons Defense. Infectious Diseases and Counterbioterrorism, Totowa, USA: Humana Press Inc, 435-452.
Titball, R.W. (2005). Membrane active toxins. In Duerre P (Ed) Handbook on Clostridia, Boca Raton: Taylor & Francis, 451-490.
Harrison B, Raju D, Garmory HS, Brett MM, Titball RW, Sarker MR (2005). Molecular characterization of Clostridium perfringens isolates from humans with sporadic diarrhea: evidence for transcriptional regulation of the beta2-toxin-encoding gene. Appl Environ Microbiol, 71(12), 8362-8370. Abstract.  Author URL. DOI.
Krieg, A. Titball, R.W. (2005). Non-specific Immunomodulator Therapy; CpG. In Lindler L, Lebeda F, Korch GW (Eds.) Biological Weapons Defense. Infectious Diseases and Counterbioterrorism, Totowa, USA: Humana Press Inc, 317-331.
Taylor VL, Titball RW, Oyston PCF (2005). Oral immunization with a dam mutant of Yersinia pseudotuberculosis protects against plague. Microbiology, 151(6), 1919-1926. Abstract. DOI.
Taylor VL, Titball RW, Oyston PCF (2005). Oral immunization with a dam mutant of Yersinia pseudotuberculosis protects against plague. Microbiology, 151(Pt 6), 1919-1926. Abstract.  Author URL. DOI.
Oyston, P.C.F. (2005). Plague. In Lutwick LI, Lutwick SM (Eds.) Bioterror: the Weaponization of Infectious Diseases, New Jersey:.
Bedford, R. Townson, K. Phillpotts, R. (2005). Protective efficacy of a recombinant plague vaccine when co-administered with another sub-unit or live attenuated vaccine. FEMS Immunology and Medical Microbiology, 43, 425-430.
RT101, Andersson SGE, Chain P, Chu MC (2005). The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nature Genetics, 37(2), 153-159. DOI.
Laws TR, Smith SA, Smith MP, Harding SV, Atkins TP, Titball RW (2005). The nematode Panagrellus redivivus is susceptible to killing by human pathogens at 37 degrees C. FEMS Microbiol Lett, 250(1), 77-83. Abstract.  Author URL. DOI.
Isherwood KE, Titball RW, Davies DH, Felgner PL, Morrow WJW (2005). Vaccination strategies for Francisella tularensis. Adv Drug Deliv Rev, 57(9), 1403-1414. Abstract.  Author URL. DOI.

2004

Garmory, H.S. Perkins, S.D. O'Dowd, A.M. (2004). A Salmonella enterica serovar Typhi vaccine expressing Yersinia pestis F1 antigen on its surface provides protection against plague in mice. Vaccine, 22, 2524-2532.
Titball, R.W. (2004). ATP-Binding Cassette Transporters Are Targets for the Development of Antibacterial Vaccines and Therapies. Infection and Immunity, 72, 6757-6763.
TP, J. Cuccui, W. White, N. (2004). Absence of Yersinia pestis-specific DNA in human teeth from five European excavations of putative plague victims. Microbiology, 150, 341-354.
Laws TR, Harding SV, Smith MP, Atkins TP, Titball RW (2004). Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria. FEMS Microbiol Lett, 234(2), 281-287. Abstract.  Author URL. DOI.
Harding, S.V. Smith, M.P. Atkins, T.P. (2004). Aging and bacterial disease in the nematode <em>Caenorhabditis elegans</em>. FEMS Microbiology Letters, 234, 281-287.
Titball, R.W. (2004). An elusive serial killer. Nature, 430, 145-146.
Haque, A. Atkins, T. Hill, J. (2004). Attenuated virulence and protective efficacy of a <em>Burkholderia pseudomallei</em> bsa type III secretion mutant in a murine model of melioidosis. Microbiology, 150, 2669-2676.
Cole AR, Gilbert M, Popoff M, Moss DS, Titball RW, Basak A (2004). Clostridium perfringens epsilon toxin shows structural similarity with the pore forming toxin aerolysin. Nature Structural Biology, 11, 797-798.
Thelestam, T. Clark, G. Titball, R.W. (2004). Effects of Clostridium perfringens phospholipase C in mammalian cells. Anaerobe, 10, 115-123.
Prior, J.L. Lever, M.S. Jones, H.E. (2004). Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis. Journal of Medical Microbiology, 53, 1177-1182.
Rijnbrand, R.C. Wang, H. Ryman, K.D. (2004). Genetic Relationships and Evolution of Genotypes of Yellow Fever Virus and Other Members of the Yellow Fever Virus Group within the Flavivirus Genus Based on the 3' Noncoding Region. Journal of Virology, 78, 9652-9665.
RT101, Atkins T, Bason N, Beacham IR (2004). Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proceedings of the National Academy of Sciences, 101(39), 14240-14245. DOI.
Titball, R.W. Jepson, M. Bayer, C. (2004). Immunization with C-domain of alpha-toxin prevents lethal infection, localises tissue injury and promotes host response to challenge with viable <em>Clostridium perfringens</em>. Journal of Infectious Diseases, 190, 767-773. Full text.
Drancourt M, Raoult D, Gilbert MTP, Cuccui J, White W, Lynnerup N, Titball RW, Cooper A, Prentice MB (2004). Molecular detection of Yersinia pestis in dental pulp. Microbiology, 150(2), 263-265.
Titball RW (2004). Plague: the mysterious past and terrifying future of the world's most dangerous disease. NATURE, 430(6996), 145-146. Author URL. DOI.
Green, M. Choules, G.R. Ogers, D. (2004). Protection afforded by heat shock protein 60 from <em>Francisella tularensis</em> is due to co-purified lipopolysaccharide. Infection and Immunity, 72, 4109-4113.
Freeman, D. Brown, K.A. Titball, R.W. (2004). Protection against plague afforded by immunisation with DNA vaccines optimised for expression of the <em>Yersinia pestis</em> V antigen. Vaccine, 22, 947-957.
Gilbert MTP, Cuccui J, White W, Lynnerup N, Titball RW, Cooper A, Prentice MB (2004). Response to Drancourt and Raoult. MICROBIOLOGY-SGM, 150, 264-265. Author URL. DOI.
Titball RW (2004). Return of the black death: the world's greatest serial killer. NATURE, 430(6996), 145-146. Author URL. DOI.
Titball RW, Basak AK (2004). The bacterial zinc-metallophospholipases C. Journal of Toxicology - Toxin Reviews, 23(4), 509-554. Abstract. DOI.
Basak, A.K. (2004). The bacterial zinc-metallophospholipases C. Journal of Toxicology - Toxin Reviews, 23, 509-554.
Titball, R.W. Lindsay, C.D. (2004). The interaction of <em>Pseudomonas aeruginosa</em> PAK with human and animal respiratory tract cell lines. FEMS Microbiology Letters, 238, 49-55.
Leary, S. EC, K.F. Griffin, E.D. (2004). The use of live attenuated bacteria as a delivery system for heterologous antigens. Journal of Drug Targeting, 11, 471-479.
Sjostedt, A. Titball, R.W. (2004). Tularemia: bioterrorism defence renews interest in Francisella tularensis. Nature Reviews Microbiology, 2, 967-978.
Titball RW, Williamson ED (2004). Yersinia pestis (plague) vaccines. Expert Opin Biol Ther, 4(6), 965-973. Abstract.  Author URL. DOI.
Titball, R.W. (2004). Yersinia pestis. The Biochemist, 26, 11-14.

2003

WP, A. Karleyshev, M. Smith, K. (2003). A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface. Microbiology, 149, 3221-3229.
Titball RW, Oyston PCF (2003). A vaccine for tularaemia. Expert Opin Biol Ther, 3(4), 645-653. Abstract.  Author URL. DOI.
Mayers C, Duffield M, Rowe S, Miller J, Lingard B, Hayward S, Titball RW (2003). Analysis of known bacterial protein vaccine antigens reveals biased physical properties and amino acid composition. Comp Funct Genomics, 4(5), 468-478. Abstract.  Author URL.  Full text. DOI.
RT101, Hinchcliffe SJ, Hinds J, Isherwood KE (2003). Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis . Genome Research, 13(9), 2018-2029. DOI.
Prior JL, Prior RG, Hitchen PG, Diaper H, Griffin KF, Morris HR, Dell A, Titball RW (2003). Characterization of the O antigen gene cluster and structural analysis of the O antigen of Francisella tularensis subsp. tularensis. J Med Microbiol, 52(Pt 10), 845-851. Abstract.  Author URL. DOI.
Briggs, D.C. Karasawa, T. Wang, X. (2003). Clostridium absonum alpha-toxin: new insights into Clostridial alpha-toxin substrate binding and specificity. Journal of Molecular Biology, 333, 759-769.
Garmory HS, Titball RW, Brown KA, Bennett AM (2003). Construction and evaluation of a eukaryotic expression plasmid for stable delivery using attenuated Salmonella. Microb Pathog, 34(3), 115-119. Abstract.  Author URL.
Hinds, J. Witney, A.A. Isherwood, K. (2003). Construction of a <em>Yersinia pestis</em> microarray. Advances in Experimental Medicine and Biology, 529, 47-49.
Stabler RA, Hinds J, Witney AA, Isherwood K, Oyston P, Titball R, Wren B, Hinchliffe S, Prentice M, Mangan JA, et al (2003). Construction of a Yersinia pestis microarray. United States.  Author URL. DOI.
Oyston, P.C. Titball, R.W. (2003). DNA adenine methylation.
Garmory HS, Brown KA, Titball RW (2003). DNA vaccines: improving expression of antigens. Genet Vaccines Ther, 1(1). Abstract.  Author URL.  Full text. DOI.
Thomas R, Johansson A, Neeson B, Isherwood K, Sjöstedt A, Ellis J, Titball RW (2003). Discrimination of human pathogenic subspecies of Francisella tularensis by using restriction fragment length polymorphism. J Clin Microbiol, 41(1), 50-57. Abstract.  Author URL.
Donelli G, Fiorentini C, Matarrese P, Falzano L, Cardines R, Mastrantonio P, Payne DW, Titball RW (2003). Evidence for cytoskeletal changes secondary to plasma membrane functional alterations in the in vitro cell response to Clostridium perfringens epsilon-toxin. Comp Immunol Microbiol Infect Dis, 26(3), 145-156. Abstract.  Author URL.
Lever MS, Nelson M, Ireland PI, Stagg AJ, Beedham RJ, Hall GA, Knight G, Titball RW (2003). Experimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouse. J Med Microbiol, 52(Pt 12), 1109-1115. Abstract.  Author URL. DOI.
Oyston PCF, Prior JL, Kiljunen S, Skurnik M, Hill J, Titball RW (2003). Expression of heterologous O-antigen in Yersinia pestis KIM does not affect virulence by the intravenous route. J Med Microbiol, 52(Pt 4), 289-294. Abstract.  Author URL. DOI.
Titball RW, Sjostedt A (2003). Francisella tularensis: an overview. ASM NEWS, 69(11), 558-+. Author URL.
Broekhuijsen M, Larsson P, Johansson A, Byström M, Eriksson U, Larsson E, Prior RG, Sjöstedt A, Titball RW, Forsman M, et al (2003). Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis. J Clin Microbiol, 41(7), 2924-2931. Abstract.  Author URL.
Waters M, Savoie A, Garmory HS, Bueschel D, Popoff MR, Songer JG, Titball RW, McClane BA, Sarker MR (2003). Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets. J Clin Microbiol, 41(8), 3584-3591. Abstract.  Author URL.
Underwood, C.D. Sundberg, L. Astrom, H. (2003). Immunological characterisation of sub-units of the Yersinia type III secretion apparatus. Advances in Experimental Medicine and Biology, 529, 415-417.
Garmory HS, Griffin KF, Brown KA, Titball RW (2003). Oral immunisation with live aroA attenuated Salmonella enterica serovar Typhimurium expressing the Yersinia pestis V antigen protects mice against plague. Vaccine, 21(21-22), 3051-3057. Abstract.  Author URL.
Garmory HS, Titball RW, Griffin KF, Hahn U, Böhm R, Beyer W (2003). Salmonella enterica serovar typhimurium expressing a chromosomally integrated copy of the Bacillus anthracis protective antigen gene protects mice against an anthrax spore challenge. Infect Immun, 71(7), 3831-3836. Abstract.  Author URL.
Williamson, E.D. (2003). Second and third generation plague vaccines. Advances in Experimental Medicine and Biology, 529, 397-406.
Oyston PCF, Karlyshev AV, Wren BW, Titball RW (2003). Signature-tagged mutagenesis of Yersinia pestis. United States.  Author URL. DOI.
Hill J, Copse C, Leary S, Stagg AJ, Williamson ED, Titball RW (2003). Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis. Infect Immun, 71(4), 2234-2238. Abstract.  Author URL.
Titball, R.W. Lindsay, C.D. (2003). The development of tolderance to Clostridium perfringens type D &#949;-toxin in MDCK and G402 cells. Human & Experimental Toxicology, 22, 593-605.
Foynes S, Holley JL, Garmory HS, Titball RW, Fairweather NF (2003). Vaccination against type F botulinum toxin using attenuated Salmonella enterica var Typhimurium strains expressing the BoNT/F H(C) fragment. Vaccine, 21(11-12), 1052-1059. Abstract.  Author URL.
Titball RW, Williamson ED (2003). Vaccine development for potential bioterrorism agents. Curr Drug Targets Infect Disord, 3(3), 255-262. Abstract.  Author URL.
Titball RW, Johansson A, Forsman M (2003). Will the enigma of Francisella tularensis virulence soon be solved?. Trends Microbiol, 11(3), 118-123. Abstract.  Author URL.
Titball RW, Hill J, Lawton DG, Brown KA (2003). Yersinia pestis and plague. England.  Abstract.  Author URL.

2002

Smith MP, Laws TR, Atkins TP, Oyston PCF, de Pomerai DI, Titball RW (2002). A liquid-based method for the assessment of bacterial pathogenicity using the nematode Caenorhabditis elegans. FEMS Microbiol Lett, 210(2), 181-185. Abstract.  Author URL.
Atkins T, Prior RG, Mack K, Russell P, Nelson M, Oyston PCF, Dougan G, Titball RW (2002). A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis. Infect Immun, 70(9), 5290-5294. Abstract.  Author URL.
Flick-Smith HC, Walker NJ, Gibson P, Bullifent H, Hayward S, Miller J, Titball RW, Williamson ED (2002). A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection. Infect Immun, 70(3), 1653-1656. Abstract.  Author URL.
Atkins T, Prior R, Mack K, Russell P, Nelson M, Prior J, Ellis J, Oyston PCF, Dougan G, Titball RW, et al (2002). Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis. J Med Microbiol, 51(7), 539-547. Abstract.  Author URL. DOI.
Eaton JT, Naylor CE, Howells AM, Moss DS, Titball RW, Basak AK (2002). Crystal structure of the C. perfringens alpha-toxin with the active site closed by a flexible loop region. J Mol Biol, 319(2), 275-281. Abstract.  Author URL. DOI.
Lawton DG, Longstaff C, Wallace BA, Hill J, Leary SEC, Titball RW, Brown KA (2002). Interactions of the type III secretion pathway proteins LcrV and LcrG from Yersinia pestis are mediated by coiled-coil domains. J Biol Chem, 277(41), 38714-38722. Abstract.  Author URL. DOI.
Prior JL, Titball RW (2002). Monoclonal antibodies against Yersinia pestis lipopolysaccharide detect bacteria cultured at 28 degrees C or 37 degrees C. Mol Cell Probes, 16(4), 251-256. Abstract.  Author URL.
Howells AM, Bullifent HL, Dhaliwal K, Griffin K, García de Castro A, Frith G, Tunnacliffe A, Titball RW (2002). Role of trehalose biosynthesis in environmental survival and virulence of Salmonella enterica serovar typhimurium. Res Microbiol, 153(5), 281-287. Abstract.  Author URL.
Garmory HS, Brown KA, Titball RW (2002). Salmonella vaccines for use in humans: present and future perspectives. FEMS Microbiol Rev, 26(4), 339-353. Abstract.  Author URL.
Hinchliffe SJ, Isherwood KE, Stabler RA, Oyston PCF, Hinds J, Titbal RW, Wren BW (2002). Separated at birth? Microarray analysis of two strikingly similar yersinia species. Egypt.  Author URL.  Full text. DOI.
Baker MD, Papageorgiou AC, Titball RW, Miller J, White S, Lingard B, Lee JJ, Cavanagh D, Kehoe MA, Robinson JH, et al (2002). Structural and functional role of threonine 112 in a superantigen Staphylococcus aureus enterotoxin B. J Biol Chem, 277(4), 2756-2762. Abstract.  Author URL. DOI.
Hitchen PG, Prior JL, Oyston PCF, Panico M, Wren BW, Titball RW, Morris HR, Dell A (2002). Structural characterization of lipo-oligosaccharide (LOS) from Yersinia pestis: regulation of LOS structure by the PhoPQ system. Mol Microbiol, 44(6), 1637-1650. Abstract.  Author URL.
Garmory HS, Griffin KF, Leary SEC, Perkins SD, Brown KA, Titball RW (2002). The effect of recombinant plasmids on in vivo colonisation of Salmonella enterica serovar Typhimurium strains is not reflected by in vitro cellular invasion assays. Vaccine, 20(27-28), 3239-3243. Abstract.  Author URL.
Justin N, Walker N, Bullifent HL, Songer G, Bueschel DM, Jost H, Naylor C, Miller J, Moss DS, Titball RW, et al (2002). The first strain of Clostridium perfringens isolated from an avian source has an alpha-toxin with divergent structural and kinetic properties. Biochemistry, 41(20), 6253-6262. Abstract.  Author URL.
Ellis J, Oyston PCF, Green M, Titball RW (2002). Tularemia. CLINICAL MICROBIOLOGY REVIEWS, 15(4), 631-+. Author URL. DOI.
Ellis J, Oyston PCF, Green M, Titball RW (2002). Tularemia. Clin Microbiol Rev, 15(4), 631-646. Abstract.  Author URL.
Williamson ED, Titball RW (2002). Vaccines against dangerous pathogens. Br Med Bull, 62, 163-173. Abstract.  Author URL.

2001

Karlyshev AV, Oyston PC, Williams K, Clark GC, Titball RW, Winzeler EA, Wren BW (2001). Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes. Infect Immun, 69(12), 7810-7819. Abstract.  Author URL. DOI.
Prior JL, Hitchen PG, Williamson DE, Reason AJ, Morris HR, Dell A, Wren BW, Titball RW (2001). Characterization of the lipopolysaccharide of Yersinia pestis. Microb Pathog, 30(2), 49-57. Abstract.  Author URL. DOI.
RT101, Cerdeno-Tarraga AM, Chillingworth T, Churcher C (2001). Genome sequence of Yersinia pestis, the causative agent of plague. Nature, 413(6855), 523-527. DOI.
Tito MA, Miller J, Griffin KF, Williamson ED, Titball RW, Robinson CV (2001). Macromolecular organization of the Yersinia pestis capsular F1 antigen: insights from time-of-flight mass spectrometry. Protein Sci, 10(11), 2408-2413. Abstract.  Author URL. DOI.
Prior RG, Klasson L, Larsson P, Williams K, Lindler L, Sjöstedt A, Svensson T, Tamas I, Wren BW, Oyston PC, et al (2001). Preliminary analysis and annotation of the partial genome sequence of Francisella tularensis strain Schu 4. England.  Author URL.
Tito MA, Miller J, Walker N, Griffin KF, Williamson ED, Despeyroux-Hill D, Titball RW, Robinson CV (2001). Probing molecular interactions in intact antibody: antigen complexes, an electrospray time-of-flight mass spectrometry approach. Biophys J, 81(6), 3503-3509. Abstract.  Author URL. DOI.
Fulop M, Mastroeni P, Green M, Titball RW (2001). Role of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensis. Vaccine, 19(31), 4465-4472. Abstract.  Author URL.
Prior JL, Parkhill J, Hitchen PG, Mungall KL, Stevens K, Morris HR, Reason AJ, Oyston PC, Dell A, Wren BW, et al (2001). The failure of different strains of Yersinia pestis to produce lipopolysaccharide O-antigen under different growth conditions is due to mutations in the O-antigen gene cluster. FEMS Microbiol Lett, 197(2), 229-233. Abstract.  Author URL.
Jepson M, Bullifent HL, Crane D, Flores-Diaz M, Alape-Giron A, Jayasekeera P, Lingard B, Moss D, Titball RW (2001). Tyrosine 331 and phenylalanine 334 in Clostridium perfringens alpha-toxin are essential for cytotoxic activity. FEBS Lett, 495(3), 172-177. Abstract.  Author URL.
Titball RW, Williamson ED (2001). Vaccination against bubonic and pneumonic plague. Vaccine, 19(30), 4175-4184. Abstract.  Author URL.
Prentice MB, James KD, Parkhill J, Baker SG, Stevens K, Simmonds MN, Mungall KL, Churcher C, Oyston PC, Titball RW, et al (2001). Yersinia pestis pFra shows biovar-specific differences and recent common ancestry with a Salmonella enterica serovar Typhi plasmid. J Bacteriol, 183(8), 2586-2594. Abstract.  Author URL. DOI.

2000

Williamson ED, Eley SM, Stagg AJ, Green M, Russell P, Titball RW (2000). A single dose sub-unit vaccine protects against pneumonic plague. Vaccine, 19(4-5), 566-571. Abstract.  Author URL.
Shortt SJ, Titball RW, Lindsay CD (2000). An assessment of the in vitro toxicology of Clostridium perfringens type D epsilon-toxin in human and animal cells. Hum Exp Toxicol, 19(2), 108-116. Abstract.  Author URL. DOI.
Bullifent HL, Griffin KF, Jones SM, Yates A, Harrington L, Titball RW (2000). Antibody responses to Yersinia pestis F1-antigen expressed in Salmonella typhimurium aroA from in vivo-inducible promoters. Vaccine, 18(24), 2668-2676. Abstract.  Author URL.
Holley JL, Elmore M, Mauchline M, Minton N, Titball RW (2000). Cloning, expression and evaluation of a recombinant sub-unit vaccine against Clostridium botulinum type F toxin. Vaccine, 19(2-3), 288-297. Abstract.  Author URL.
Russell P, Eley SM, Ellis J, Green M, Bell DL, Kenny DJ, Titball RW (2000). Comparison of efficacy of ciprofloxacin and doxycycline against experimental melioidosis and glanders. England.  Abstract.  Author URL.
Byrne MP, Titball RW, Holley J, Smith LA (2000). Fermentation, purification, and efficacy of a recombinant vaccine candidate against botulinum neurotoxin type F from Pichia pastoris. Protein Expr Purif, 18(3), 327-337. Abstract.  Author URL. DOI.
Walker C, Goodyear C, Anderson D, Titball RW (2000). Identification of arsenic-resistant bacteria in the soil of a former munitions factory at Locknitz, Germany. Land Contamination and Reclamation, 8(1), 13-18. Abstract.
Alape-Girón A, Flores-Díaz M, Guillouard I, Naylor CE, Titball RW, Rucavado A, Lomonte B, Basak AK, Gutiérrez JM, Cole ST, et al (2000). Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene. Eur J Biochem, 267(16), 5191-5197. Abstract.  Author URL.
Walker N, Holley J, Naylor CE, Flores-Díaz M, Alape-Girón A, Carter G, Carr FJ, Thelestam M, Keyte M, Moss DS, et al (2000). Identification of residues in the carboxy-terminal domain of Clostridium perfringens alpha-toxin (phospholipase C) which are required for its biological activities. Arch Biochem Biophys, 384(1), 24-30. Abstract.  Author URL. DOI.
Wright A, Andrews PL, Titball RW (2000). Induction of emetic, pyrexic, and behavioral effects of Staphylococcus aureus enterotoxin B in the ferret. Infect Immun, 68(4), 2386-2389. Abstract.  Author URL.
Williams K, Oyston PC, Dorrell N, Li S, Titball RW, Wren BW (2000). Investigation into the role of the serine protease HtrA in Yersinia pestis pathogenesis. FEMS Microbiol Lett, 186(2), 281-286. Abstract.  Author URL.
Garmory HS, Chanter N, French NP, Bueschel D, Songer JG, Titball RM (2000). Occurrence of Clostridium perfringens beta 2-toxin amongst animals, determined using genotyping and subtyping PCR assays (vol 124, pg 61, 2000). EPIDEMIOLOGY AND INFECTION, 125(1), 227-227. Author URL. DOI.
Garmory HS, Chanter N, French NP, Bueschel D, Songer JG, Titball RW (2000). Occurrence of Clostridium perfringens beta2-toxin amongst animals, determined using genotyping and subtyping PCR assays. Epidemiol Infect, 124(1), 61-67. Abstract.  Author URL.
Titball RW, Naylor CE, Miller J, Moss DS, Basak AK (2000). Opening of the active site of Clostridium perfringens alpha-toxin may be triggered by membrane binding. Germany.  Abstract.  Author URL.
Karlsson J, Prior RG, Williams K, Lindler L, Brown KA, Chatwell N, Hjalmarsson K, Loman N, Mack KA, Pallen M, et al (2000). Sequencing of the Francisella tularensis strain Schu 4 genome reveals the shikimate and purine metabolic pathways, targets for the construction of a rationally attenuated auxotrophic vaccine. Microb Comp Genomics, 5(1), 25-39. Abstract.  Author URL. DOI.
Bullifent HL, Dhaliwal K, Howells AM, Goan K, Griffin K, Lindsay CD, Tunnacliffe A, Titball RW (2000). Stabilisation of Salmonella vaccine vectors by the induction of trehalose biosynthesis. Vaccine, 19(9-10), 1239-1245. Abstract.  Author URL.
Jepson M, Titball R (2000). Structure and function of clostridial phospholipases C. Microbes Infect, 2(10), 1277-1284. Abstract.  Author URL.
Oyston PC, Dorrell N, Williams K, Li SR, Green M, Titball RW, Wren BW (2000). The response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in Yersinia pestis. Infect Immun, 68(6), 3419-3425. Abstract.  Author URL.

1999

Williamson ED, Vesey PM, Gillhespy KJ, Eley SM, Green M, Titball RW (1999). An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse model. Clin Exp Immunol, 116(1), 107-114. Abstract.  Author URL.
Naylor CE, Jepson M, Crane DT, Titball RW, Miller J, Basak AK, Bolgiano B (1999). Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin. J Mol Biol, 294(3), 757-770. Abstract.  Author URL. DOI.
Jepson M, Howells A, Bullifent HL, Bolgiano B, Crane D, Miller J, Holley J, Jayasekera P, Titball RW (1999). Differences in the carboxy-terminal (Putative phospholipid binding) domains of Clostridium perfringens and Clostridium bifermentans phospholipases C influence the hemolytic and lethal properties of these enzymes. Infect Immun, 67(7), 3297-3301. Abstract.  Author URL.
Kenny DJ, Russell P, Rogers D, Eley SM, Titball RW (1999). In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp. Antimicrob Agents Chemother, 43(11), 2773-2775. Abstract.  Author URL.
Bennett AM, Lescott T, Phillpotts RJ, Mackett M, Titball RW (1999). Recombinant vaccinia viruses protect against Clostridium perfringens alpha-toxin. Viral Immunol, 12(2), 97-105. Abstract.  Author URL. DOI.
Justin N, Eaton J, Naylor C, Howells A, Moss D, Titball R, Basak A (1999). Structure Function Studies of Clostridium perfringens Alpha-Toxin; a Gas Gangrene Causing Protein. Journal of Chemical Society of Pakistan, 21(3), 239-247.
Titball RW, Naylor CE, Basak AK (1999). The Clostridium perfringens alpha-toxin. Anaerobe, 5(2), 51-64. Abstract.  Author URL. DOI.
Green M, Rogers D, Russell P, Stagg AJ, Bell DL, Eley SM, Titball RW, Williamson ED (1999). The SCID/Beige mouse as a model to investigate protection against Yersinia pestis. FEMS Immunol Med Microbiol, 23(2), 107-113. Abstract.  Author URL.
Pettersson J, Holmström A, Hill J, Leary S, Frithz-Lindsten E, von Euler-Matell A, Carlsson E, Titball R, Forsberg A, Wolf-Watz H, et al (1999). The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation. Mol Microbiol, 32(5), 961-976. Abstract.  Author URL.
Leary SE, Griffin KF, Galyov EE, Hewer J, Williamson ED, Holmström A, Forsberg A, Titball RW (1999). Yersinia outer proteins (YOPS) E, K and N are antigenic but non-protective compared to V antigen, in a murine model of bubonic plague. Microb Pathog, 26(3), 159-169. Abstract.  Author URL. DOI.

1998

Titball RW (1998). Bacterial phospholipases. Journal of Applied Microbiology Symposium Supplement, 84(27). Abstract.
Titball RW (1998). Bacterial phospholipases. Symp Ser Soc Appl Microbiol, 27, 127S-137S. Abstract.  Author URL.
Basak AK, Howells A, Eaton JT, Moss DS, Naylor CE, Miller J, Titball RW (1998). Crystallization and preliminary X-ray diffraction studies of alpha-toxin from two different strains (NCTC8237 and CER89L43) of Clostridium perfringens. Acta Crystallogr D Biol Crystallogr, 54(Pt 6 Pt 2), 1425-1428. Abstract.  Author URL.
Russell P, Eley SM, Green M, Stagg AJ, Taylor RR, Nelson M, Beedham RJ, Bell DL, Rogers D, Whittington D, et al (1998). Efficacy of doxycycline and ciprofloxacin against experimental Yersinia pestis infection. J Antimicrob Chemother, 41(2), 301-305. Abstract.  Author URL.
Carter G, White P, Fernie M, King S, McLean G, Titball R, Carr FJ (1998). Enhanced antitumour effect of liposomal daunorubicin using antibody-phospholipase C conjugates or fusion protein. Int J Oncol, 13(4), 819-825. Abstract.  Author URL.
Miller J, Williamson ED, Lakey JH, Pearce MJ, Jones SM, Titball RW (1998). Macromolecular organisation of recombinant Yersinia pestis F1 antigen and the effect of structure on immunogenicity. FEMS Immunol Med Microbiol, 21(3), 213-221.