Biochemistry, Metabolism and Engineering Biology
Specialists:
- Dr Mike Deeks
- Dr Vicki Gold
- Dr Nic Harmer
- Dr Katherine Helliwell
- Dr Alison Hill
- Professor Jennifer Littlechild
- Professor John Love
- Dr Hans-Wilhelm Nuetzmann
- Dr Alexis Perry
- Dr Jonathan Phillips
- Professor Michael Schrader
- Dr Chloe Singleton
- Professor Nick Smirnoff
- Professor Austin Smith
- Dr Sam Stevens
- Dr Luke Surl
- Professor James Wakefield
- Dr Mark Wood
NagK shows coordinated conformational changes after substrate binding
The bacterial N-acetylglucosamine (GlcNAc) kinase NagK is a classical two-domain carbohydrate kinase (large domain in white, small domain in green).
On binding of substrate GlcNAc (left, upper) the domains close around it (small domain pink); when the second substrate ATP (left, lower) binds, a second conformational change (small domain orange) completes the active conformation.
Image prepared by Nicholas Harmer.
